Encorafenib

Zamkati

• Musanatenge encorafenib,
• Encorafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Encorafenib imagwiritsidwa ntchito limodzi ndi binimetinib (Mektovi) kuchiza mitundu ina ya khansa ya khansa (mtundu wa khansa yapakhungu) yomwe yafalikira mbali zina za thupi kapena yomwe singachotsedwe ndi opaleshoni. Amagwiritsidwanso ntchito ndi cetuximab (Erbitux) pochiza khansa yamtundu wina mwa akulu yomwe yafalikira mbali zina za thupi pambuyo pa chithandizo china. Encorafenib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Encorafenib imabwera ngati kapisozi wotenga pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani encorafenib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani encorafenib ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati musanza mutamwa mankhwala, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepa kapena kwakanthawi kapena kuyimitsa chithandizo chanu kutengera ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha encorafenib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge encorafenib,

• uzani dokotala ndi wamankhwala ngati simukugwirizana ndi encorafenib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'makapisozi a encorafenib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu zakumwa zina mankhwala ndi mavitamini, mavitamini, zowonjezera zakudya, ndi zitsamba} zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Teril, ena), citalopram (Celexa), clarithromycin (Biaxin, ku Prevpac), diltiazem (Cardizem, Cartia, Diltzac, ena), disopyramide (Norpace), erythromycin (EES, PCE, ena), efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, modafinil (Provigil), nefazodone, nelfinavir (Viracept) ), phenobarbital, phenytoin (Dilantin, Phenytek), procainamide, quinidine (ku Nuedexta), rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater), ritonavir (Norvir, ku Kaletra), sotalol (Betapace, Sotaplize), Calan, Verelan, ku Tarka). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi encorafenib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St John's wort.
• auzeni adotolo ngati mwakhalapo ndi kutalika kwa nthawi ya QT (mtima wosakhazikika womwe ungayambitse kukomoka, kutaya chidziwitso, kukomoka, kapena kufa mwadzidzidzi), potaziyamu kapena magnesium m'magazi anu, mtima kulephera, kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyezetsa mimba musanayambe mankhwala. Muyenera kugwiritsa ntchito njira yolera yopanda mahomoni kuti muchepetse kutenga pakati mukamalandira encorafenib komanso masabata awiri mutatha kumwa. Encorafenib ikhoza kuchepetsa mphamvu yolera yakumwa (mapiritsi oletsa kubereka), chifukwa chake ndikofunikira kwambiri kugwiritsa ntchito njira yolera yopanda mahomoni. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga encorafenib, itanani dokotala wanu mwachangu. Encorafenib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Osamayamwa mukamamwa encorafenib komanso kwa masabata awiri mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kotenga encorafenib.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati pakadutsa maola 12 kuchokera pa mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Encorafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa
• malungo
• nseru
• kupweteka m'mimba
• kudzimbidwa
• mutu
• chizungulire
• kufiira, kutupa, dzanzi komanso khungu la khungu ndi mapazi
• kukulitsa khungu
• zidzolo
• khungu lowuma
• kutayika tsitsi
• kulumikizana kapena kupweteka kwa minofu
• sintha kukoma
• kupweteka kwa msana
• ziphuphu
• mphuno kutuluka magazi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• chizungulire, kukomoka, kapena kukomoka
• masomphenya amasintha
• kusintha kwa khungu monga nkhwangwa yatsopano, chotupa chofiira kapena chofiira chomwe sichichira, kusintha kukula kapena mtundu wa mole
• kutuluka mwachilendo kapena kuphwanya
• wakuda, wodikira, kapena chimbudzi chamagazi
• kutsokomola magazi

Encorafenib itha kubweretsa chiopsezo chowonjezeka chokhala ndi khansa, kuphatikiza khansa yapakhungu. Dokotala wanu amayang'ana khungu lanu musanalandire chithandizo, miyezi iwiri iliyonse mukamalandira chithandizo, komanso kwa miyezi isanu ndi umodzi mutatha kumwa mankhwala omaliza a encorafenib ngati muli ndi khansa yapakhungu. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Encorafenib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Musachotse desiccant (wouma) mu botolo.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu, dotolo wamaso, ndi labotale. Dokotala wanu adzaitanitsa mayeso a labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi encorafenib. Dokotala wanu amatha kuyitanitsa mayeso ena a labu, kuphatikiza mayeso amaso, kuti muwone momwe thupi lanu likuyankhira ku encorafenib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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