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Zamkati

• Musanamwe siponimod,
• Siponimod ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Siponimod imagwiritsidwa ntchito popewa zizindikilo ndikuchepetsa kukulirakulira kwa anthu achikulire omwe ali ndi mawonekedwe obwereranso (matenda omwe zizindikiro zimayamba kuwonjezeka nthawi ndi nthawi) za multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu atha kukhala ndi kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto amaso, olankhula, komanso kuwongolera chikhodzodzo). Siponimod ali mgulu la mankhwala otchedwa sphingosine l-phosphate receptor modulators. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

Siponimod imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku kapena wopanda chakudya. Tengani siponimod mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani siponimod ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Dokotala wanu mwina angakuyambitseni ndi siponimod yochepa ndipo pang'onopang'ono muwonjezere mlingo wanu masiku 4 kapena 5 oyamba,

Siponimod ingayambitse kugunda kwa mtima, makamaka patadutsa maola 6 mutangotenga mankhwala anu oyamba. Mukalandira electrocardiogram (ECG; mayeso omwe amalemba zamagetsi zamagetsi mumtima) musanamwe mankhwala anu oyambiranso patadutsa maola 6 mutamwa. Mutenga mlingo wanu woyamba wa siponimod muofesi ya dokotala kapena chipatala china. Muyenera kukhala kuchipatala kwa maola osachepera asanu ndi limodzi mutamwa mankhwalawo kuti athe kuyang'aniridwa. Mungafunike kukhala kuchipatala kwa nthawi yayitali kuposa maola 6 kapena usiku ngati muli ndi vuto linalake kapena kumwa mankhwala ena omwe angapangitse kuti kugunda kwa mtima kwanu kuzengeke kapena ngati kugunda kwanu kukucheperapo kuposa momwe amayembekezera kapena kukupitilira kuchepa pambuyo pa 6 yoyamba maola. Mwinanso mungafunike kukhala kuchipatala kwa maola osachepera 6 mutatenga mlingo wanu wachiwiri ngati kugunda kwa mtima kwanu kumachedwa kwambiri mukamamwa mankhwala anu oyamba. Uzani dokotala wanu ngati mukuchita chizungulire, kutopa, kupweteka pachifuwa, kapena kugunda kwapang'onopang'ono kapena kosagwirizana nthawi iliyonse mukamalandira chithandizo.

Siponimod itha kuthandizira kuwongolera sclerosis koma singachiritse. Osasiya kumwa siponimod osalankhula ndi dokotala. Ngati simutenga siponimod kwa tsiku limodzi kapena kupitilira apo m'masiku 4 kapena 5 oyambilira a chithandizo kapena kwa masiku 4 kapena kupitilira sabata yoyamba ya chithandizo, lankhulani ndi dokotala musanayambirenso kumwa. Mutha kukumana ndi kuchepa kwa mtima mukamayambiranso kumwa siponimod, chifukwa chake muyenera kuyambiranso mankhwalawo pamlingo wochepa kuofesi ya dokotala wanu ndikuwonjezera pang'onopang'ono mlingo wamasiku 4 kapena 5.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi siponimod ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanamwe siponimod,

• uzani dokotala ndi wazamankhwala ngati mankhwala ena aliwonse sakupatsirani mankhwala, kapena mankhwala ena aliwonse m'mapiritsi a siponimod. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers monga atenolol (Tenormin, mu Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, ku Dutoprol, ku Lopressor HCT), nadolol (Corgard, ku Corzide), nebivolol (Bystolic, ku Byvalson ), propranolol (Inderal LA, Innopran XL), ndi timolol; carbamazepine (Carbatrol, Equetro, Tegretol, ena); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, ena); efavirenz (Sustiva, ku Atripla, ku Symfi); fluconazole (Diflucan); ivabradine (Corlanor); modafinil (Provigil); kupeza; quinidine (mu Nuedexta); rifampin (Rifadin, Rimactane, ku Rifamate, ena); sotalol (Betapace, Sorine, Sotylize); ndi verapamil (Calan, Verelan, ku Tarka). Komanso muuzeni adotolo ngati mukumwa mankhwala aliwonse otsatirawa, kapena ngati mudamwa kale: corticosteroids monga dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos); mankhwala a khansa; ndi mankhwala ofooketsa kapena kuwongolera chitetezo cha mthupi monga glatiramer acetate (Copaxone, Glatopa) ndi interferon beta (Betaseron, Extavia, Plegridy). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi siponimod, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati mwakhala mukukumana ndi izi m'miyezi isanu ndi umodzi yapita: matenda amtima, angina (kupweteka pachifuwa), sitiroko kapena sitiroko yaying'ono, kapena kulephera kwa mtima. Komanso muuzeni dokotala ngati muli ndi vuto la mtima wosasintha. Dokotala wanu angakuuzeni kuti musamwe siponimod.
• uzani dokotala wanu ngati munakomoka, munadwala matenda a mtima, sitiroko, kapena sitiroko yaying'ono; ngati muli ndi malungo kapena zizindikilo zina za matenda kapena ngati muli ndi matenda omwe amabwera ndikutha kapena omwe samatha; ndipo ngati mwakhalapo kapena mwakhalapo ndi matenda ashuga; kugona tulo (vuto lomwe mumasiya kupuma kangapo usiku) kapena mavuto ena opuma; kuthamanga kwa magazi; uveitis (kutupa kwa diso) kapena mavuto ena amaso; kugunda pang'onopang'ono; khansa yapakhungu, kapena matenda amtima kapena a chiwindi. Uzaninso dokotala wanu ngati mwalandira katemera posachedwa.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati, kapena mukuyamwitsa. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa masiku osachepera 10 mutapatsidwa mankhwala omaliza. Mukakhala ndi pakati mukatenga siponimod kapena pasanathe masiku 10 mutapatsidwa mankhwala omaliza, itanani dokotala wanu.
• mulibe katemera kwa sabata limodzi musanayambe mankhwala anu ndi siponimod, mukamamwa mankhwala, kapena kwa mwezi umodzi mutatha kumwa mankhwala anu osalankhula ndi dokotala. Lankhulani ndi dokotala wanu za katemera omwe mungafunike kuti mulandire musanayambe mankhwala anu ndi siponimod.
• uzani dokotala wanu ngati simunakhalepo ndi nthomba ndipo simunalandire katemera wa nthomba. Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti muwone ngati mwapezapo kachilombo ka nkhuku. Mungafunike kulandira katemera wa nthomba ndikudikirira mwezi umodzi musanayambe kumwa mankhwala ndi siponimod.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, tulukani mlingo womwe mwaphonya ndikuimbira dokotala musanamwe mankhwala ena. Mungafunike kuyang'aniridwa pamene mukuyambiranso mankhwala anu pamlingo wochepa ndipo mlingowu ukuwonjezeka pang'onopang'ono pamasiku 4 kapena 5. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Siponimod ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kufooka
• kupweteka kwa mikono, miyendo, manja, kapena mapazi
• kutsegula m'mimba
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kugunda kochedwa mtima
• zilonda zapakhosi, kupweteka kwa thupi, malungo, kuzizira, chifuwa, ndi zizindikilo zina za matendawa komanso mukamalandira chithandizo kwa mwezi umodzi mutalandira chithandizo
• kupweteka kwa mutu, kuuma kwa khosi, malungo, kuzindikira kuwala, nseru, kapena kusokonezeka mukamalandira chithandizo kwa mwezi umodzi mutalandira chithandizo
• kupweteka mutu modzidzimutsa, kusokonezeka, kusintha masomphenya, kapena kugwidwa
• blurry, mithunzi, kapena malo akhungu pakati pa masomphenya anu; kutengeka ndi kuwala; mtundu wachilendo pamasomphenya anu kapena zovuta zina zamasomphenya
• kufooka mbali imodzi ya thupi kapena kusakhazikika kwa mikono kapena miyendo yomwe imakulira pakapita nthawi; kusintha kwa malingaliro anu, kukumbukira, kapena kulinganiza; chisokonezo kapena kusintha kwa umunthu; kapena kutaya mphamvu
• kupuma kwatsopano kapena kukulira
• nseru, kusanza, kusowa chilakolako, kupweteka m'mimba, chikasu cha khungu kapena maso, kapena mkodzo wakuda

Siponimod imatha kuwonjezera chiopsezo chokhala ndi khansa yapakhungu. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Kuwonjezeka kwadzidzidzi kwa zizindikiro za MS ndikuwonjezeka kwaulema kumatha kuchitika mutasiya kumwa siponimod. Uzani dokotala wanu ngati matenda anu a MS achulukirachulukira mukasiya siponimod.

Siponimod ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Sungani zotengera zosatsegulidwa za mankhwalawa mufiriji. Mapaketi ndi mabotolo omwe atsegulidwa amatha kusungidwa kutentha komanso kutali ndi kutentha ndi chinyezi (osati kubafa) kwakanthawi. Phukusi lotseguka limatha kusungidwa kutentha mpaka 1 sabata mutagwiritsa ntchito koyamba. Mabotolo otsegulidwa amatha kusungidwa kutentha mpaka mwezi umodzi mutagwiritsa ntchito koyamba.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kugunda kwapang'onopang'ono kapena kosasintha

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena a labu, mayeso amaso, ndikuwunika kuthamanga kwa magazi anu musanachitike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti muyambe kumwa kapena kupitiriza kumwa siponimod.

Musanapite kukayezetsa labotale, uzani adotolo ndi ogwira nawo ntchito kuti mukumwa siponimod.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Mayzent^®