Cladribine

Zamkati

• Musanatenge cladribine,
• Cladribine angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Cladribine akhoza kuonjezera chiopsezo kuti mungakhale ndi khansa. Uzani dokotala wanu ngati mwakhalapo ndi khansa. Dokotala wanu akhoza kukuwuzani kuti musatenge cladribine.Lankhulani ndi dokotala wanu zomwe muyenera kuchita kuti muwone ngati muli ndi khansa monga kudziyesa nokha komanso kuyesa mayeso.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito cladribine.

Musatenge cladribine ngati muli ndi pakati kapena mukukonzekera kutenga pakati. Mukakhala ndi pakati mukatenga cladribine, siyani kumwa cladribine ndipo itanani dokotala wanu mwachangu. Pali chiopsezo kuti cladribine itha kubweretsa kutaya kwa mimba kapena kupangitsa kuti mwana abadwe ali ndi zilema zobadwa (zovuta zomwe zimakhalapo pobadwa).

Dokotala wanu adzawona ngati muli ndi pakati musanayambe chithandizo chilichonse. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse kutenga mimba nthawi iliyonse yamankhwala ndi cladribine komanso osachepera miyezi isanu ndi umodzi mutalandira mankhwala anu omaliza. Ngati mukugwiritsa ntchito njira yolerera ya mahomoni (estrogen) (mapiritsi oletsa kubala, zigamba, mphete, zopangira, kapena jakisoni) muyenera kugwiritsanso ntchito njira ina yolerera panthawi iliyonse yamankhwala ndi cladribine komanso kwa milungu ingapo mutangomaliza kumwa mankhwala njira iliyonse yothandizira. Ngati ndinu wamwamuna wokhala ndi bwenzi lachikazi lomwe lingatenge mimba, onetsetsani kuti mukugwiritsa ntchito njira yolerera panthawi iliyonse yamankhwala ndi cladribine komanso kwa miyezi isanu ndi umodzi mutatha kumwa mankhwala anu omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamalandira chithandizo komanso mukalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi cladribine ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Cladribine amagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yobwereranso ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo), kuphatikizapo mitundu yobwereranso (matenda omwe matenda amawonekera nthawi ndi nthawi) ndi mitundu ina yopita patsogolo (matenda omwe amatsatira njira yobwereranso pomwe zizindikilo zimakula pang'onopang'ono pakapita nthawi). Cladribine imagwiritsidwa ntchito kwa odwala omwe ayesapo kale chithandizo china cha MS. Cladribine m'kalasi la mankhwala otchedwa purine antimetabolites. Zimagwira ntchito poletsa maselo ena amthupi kuti asawononge mitsempha.

Cladribine amabwera ngati piritsi kuti atenge pakamwa ndi madzi. Nthawi zambiri amatengedwa kapena wopanda chakudya, kamodzi patsiku kwa masiku 4 kapena 5 motsatizana. Njira yachiwiri yothandizira iyenera kubwerezedwa masiku 23 mpaka 27 kuti amalize njira imodzi yothandizira. Njira yachiwiri (mayendedwe awiri amankhwala) nthawi zambiri imaperekedwa osachepera milungu 43 kuchokera kumapeto kwa gawo lachiwiri. Tengani cladribine mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani cladribine ndendende monga mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Chotsani piritsi mu blister pack ndi manja owuma ndikumeza piritsi nthawi yomweyo. Chepetsani nthawi yomwe piritsi limalumikizana ndi khungu lanu. Pewani kugwira mphuno, maso, ndi ziwalo zina za thupi lanu. Mukamwa mankhwala, sambani m'manja ndi madzi. Ngati piritsili likulumikizana ndi malo aliwonse kapena ziwalo zina za thupi lanu, musambitsenso bwino ndi madzi nthawi yomweyo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge cladribine,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi cladribine, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a cladribine. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: cilostazol; dipyridamole (Persantine, mu Aggrenox); elrombopag (Promacta); furosemide (Lasix); gabapentin (Gralise, Horizant, Neurontin); ibuprofen (Advil, Midol, Motrin, ena); interferon beta (Avonex, Betaseron, Extavia, Rebif); lamivudine (Epivir, mu Epzicom); mankhwala omwe amaletsa chitetezo chamthupi monga azathioprine (Azasan), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), ndi tacrolimus (Astagraf, Envarsus, Prograf); nifedipine (Adalat, Procardia); nimodipine (Nymalize); kuperekanso; ribavirin (Rebetol, Ribasphere, Virazole); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); ritonavir (Norvir, ku Kaletra, ku Technivie, ku Viekira); stavudine (Zerit); ma steroids monga dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), ndi prednisone (Rayos); sulindac; ndi zidovudine (Retrovir, ku Combivir, ku Trizivir). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi cladribine, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa mankhwala ena aliwonse pakamwa, imwani maola 3 musanadye kapena maola atatu kuchokera ku cladribine.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka curcumin ndi wort wa St.
• auzeni adotolo ngati muli ndi kachilombo ka HIV, matenda a chiwindi (kachilombo kamene kamagwira chiwindi ndipo kakhoza kuwononga chiwindi kwambiri), chifuwa chachikulu (TB; matenda akulu omwe amakhudza mapapo ndipo nthawi zina mbali zina za thupi), kapena matenda ena opitilira. Dokotala wanu angakuuzeni kuti musatenge cladribine.
• uzani dokotala wanu ngati mwakhalapo ndi chiwindi, impso, kapena matenda a mtima.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mkaka wamankhwala, komanso kwa masiku 10 pambuyo pa mlingo womaliza wa mankhwala.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa cladribine.
• mulibe katemera aliyense mkati mwa milungu 4 mpaka 6 isanachitike, nthawi, kapena mutalandira chithandizo chamankhwala osalankhula ndi dokotala. Lankhulani ndi dokotala wanu ngati mungalandire katemera musanayambe kumwa mankhwala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira tsiku lomwelo. Komabe, ngati satengedwa tsiku lomwe lakonzedweratu, ndiye kuti tengani mlingo womwe wasowa tsiku lotsatira ndikuwonjezeranso tsiku lina pamankhwalawo. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Cladribine angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• nseru
• kupweteka kwa msana
• kupweteka pamodzi ndi kuuma
• kuvuta kugona kapena kugona
• kukhumudwa
• kutayika tsitsi
• kuyabwa, kuyabwa, kapena zilonda zotentha m'kamwa, milomo, kapena pakamwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• malungo, zilonda zapakhosi, kuzizira, kupweteka kapena minofu yopweteka, chifuwa, kapena zizindikilo zina za matenda
• chifuwa, kupweteka pachifuwa, kutsokomola magazi kapena ntchofu, kufooka kapena kutopa, kuonda, kusowa njala, kuzizira, malungo, thukuta usiku
• zotupa zopweteka ndi matuza
• kutentha, kumva kulasalasa, kuchita dzanzi, kapena kuyabwa pakhungu
• zidzolo, kupuma movutikira kapena kumeza, kutupa kapena kuyabwa nkhope, milomo, lilime, kapena mmero
• kuzizira, malungo, nseru, kusanza, kupweteka msana, mbali, kapena kubuula, kukodza pafupipafupi komanso kowawa
• kutuluka mwachilendo kapena kuphwanya
• kufooka mbali imodzi ya thupi lanu, kutayika kwa mgwirizano m'manja kapena miyendo yanu, kuchepa mphamvu, mavuto moyenera, chisokonezo, kusintha kwa masomphenya anu, kuganiza, kukumbukira, kapena umunthu
• kupuma pang'ono, kugunda kwamtima, mutu, chizungulire, khungu loyera, kusokonezeka, kutopa
• nseru, kusanza, kutopa kwambiri, kusowa kwa njala, kupweteka kumtunda wakumanja kwa m'mimba, chikasu cha khungu kapena maso, mkodzo wakuda
• kupuma movutikira, kuthamanga mwachangu kapena mosasinthasintha, kutupa m'mbali ya thupi lanu

Cladribine amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse a dokotala komanso labotale. Dokotala wanu adzaitanitsa mayeso ena musanalandire, nthawi, komanso mutalandira chithandizo chanu kuti muwone ngati zili bwino kuti mutenge cladribine ndikuwunika momwe thupi lanu likuyankhira ku cladribine.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Mavenclad^®