Rituximab ndi Hyaluronidase Jekeseni Wamunthu

Zamkati

• Asanalandire jekeseni wa rituximab ndi hyaluronidase,
• Rituximab ndi hyaluronidase jekeseni wamunthu imatha kuyambitsa zovuta.Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Rituximab ndi hyaluronidase jakisoni wamunthu wadzetsa mavuto owopsa pakhungu ndi pakamwa. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: zilonda zopweteka pakhungu, milomo, kapena pakamwa; matuza; zidzolo; kapena khungu losenda.

Mutha kukhala ndi kachilombo ka hepatitis B (kachilombo kamene kamagwira chiwindi ndipo kakhoza kuwononga chiwindi kwambiri) koma osakhala ndi zisonyezo za matendawa. Poterepa, kulandira jakisoni wa rituximab ndi hyaluronidase kumatha kuonjezera chiopsezo kuti matenda anu akhoza kukhala owopsa kapena owopseza moyo ndipo mudzakhala ndi zizindikilo. Uzani dokotala wanu ngati mwakhala mukudwala matenda opatsirana kwambiri, kuphatikizapo matenda a hepatitis B virus. Dokotala wanu amalamula kuti mukayezetse magazi kuti muwone ngati muli ndi matenda opatsirana a hepatitis B. Ngati ndi kotheka, dokotala wanu angakupatseni mankhwala kuti muchepetse matendawa musanachitike komanso mukamalandira chithandizo chamankhwala a rituximab ndi hyaluronidase. Dokotala wanu adzakuyang'anirani ngati muli ndi matenda a chiwindi cha B mkati ndi miyezi ingapo mutalandira chithandizo. Ngati mukumane ndi zizindikiro izi mukamalandira chithandizo kapena mutalandira chithandizo, itanani dokotala wanu mwachangu: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako, kunyoza kapena kusanza, kupweteka kwa minofu, kupweteka m'mimba, kapena mkodzo wakuda.

Anthu ena omwe adalandira jekeseni wa rituximab ndi hyaluronidase adayamba kukhala ndi leukoencephalopathy (PML; matenda opatsirana aubongo omwe sangachiritsidwe, kupewa, kapena kuchiritsidwa ndipo nthawi zambiri amayambitsa imfa kapena kulemala kwambiri) atalandira chithandizo. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kusintha kwatsopano kapena mwadzidzidzi pakuganiza kapena kusokonezeka; kuvuta kulankhula kapena kuyenda; kutaya malire; kutaya mphamvu; kusintha kwatsopano kapena kwadzidzidzi m'masomphenya; kapena zizindikiro zina zachilendo zomwe zimachitika mwadzidzidzi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu limayankhira jekeseni wa rituximab ndi hyaluronidase.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa rituximab ndipo nthawi iliyonse yomwe mumalandira mankhwala. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito jekeseni wa rituximab ndi hyaluronidase.

Rituximab ndi hyaluronidase jekeseni wa anthu amagwiritsidwa ntchito paokha kapena ndi mankhwala ena kuti athetse mitundu yosiyanasiyana ya non-Hodgkin's lymphoma (NHL; mtundu wa khansa womwe umayambira mumtundu wama cell oyera omwe nthawi zambiri amalimbana ndi matenda). Rituximab ndi hyaluronidase jakisoni waumunthu amagwiritsidwanso ntchito ndi mankhwala ena kuti athetse khansa ya m'magazi (CLL; mtundu wa khansa yamagazi oyera). Jekeseni wa Rituximab ndi hyaluronidase uli mgulu la mankhwala otchedwa ma monoclonal antibodies. Imagwira mitundu yosiyanasiyana ya NHL ndi CLL popha ma cell a khansa.

Rituximab ndi hyaluronidase jakisoni wamunthu amabwera ngati yankho (madzi) oti alandire jakisoni (pansi pa khungu, m'mimba) pafupifupi mphindi 5 mpaka 7. Kukhazikika kwanu kudzadalira momwe muliri, mankhwala ena omwe mukugwiritsa ntchito, komanso momwe thupi lanu limayankhira kuchipatala.

Jekeseni wa Rituximab ndi hyaluronidase wa munthu amatha kuyambitsa mavuto ena mukalandira mankhwala kapena mkati mwa maola 24 mutalandira mankhwala. Mulandila jakisoni aliyense wa rituximab ndi hyaluronidase kuchipatala, ndipo dokotala kapena namwino adzakuwunikirani mosamala mukalandira mankhwalawo komanso kwa mphindi 15 mutalandira mankhwalawo. Mudzalandira mankhwala ena othandizira kupewa zovuta musanalandire mlingo uliwonse wa jekeseni wa rituximab ndi hyaluronidase.

Muyenera kulandira mulingo wanu woyamba ngati mankhwala opangira jekeseni wa rituximab wobayidwa pang'onopang'ono kudzera mumitsempha (mumtsempha). Pambuyo pa mlingo woyamba, mutha kulandira rituximab ndi hyaluronidase jakisoni wamunthu pansi pa khungu, kutengera momwe mumayankhira ndikulowetsedwa ndi mankhwala a rituximab.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa rituximab ndi hyaluronidase,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la rituximab, hyaluronidase, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu rituximab ndi hyaluronidase jakisoni wa anthu. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa.
• auzeni adotolo ngati muli ndi zina mwazomwe zatchulidwa mgulu la Chenjezo LOFUNIKA ndipo ngati mwakhalapo ndi hepatitis C kapena ma virus ena monga nkhuku, herpes (kachilombo kamene kangayambitse zilonda zoziziritsa kapena kuphulika kwa matuza kumaliseche dera), ma shingles, kachilombo ka West Nile (kachilombo kamene kamafalikira kudzera mu udzudzu ndipo kumatha kuyambitsa matenda akulu), parvovirus B19 (matenda achisanu; kachilombo kofala mwa ana komwe kumangobweretsa mavuto akulu mwa akulu ena), kapena cytomegalovirus (a kachilombo koyambitsa matendawa kamene kamangobweretsa zizindikiro zoopsa mwa anthu omwe afooketsa chitetezo cha mthupi kapena omwe ali ndi kachilombo pobadwa), kugunda kwamtima kosazolowereka, kupweteka pachifuwa, mavuto ena amtima, kapena mavuto am'mapapo kapena impso. Komanso uzani dokotala wanu ngati muli ndi matenda aliwonse pano kapena ngati muli ndi matenda omwe sangachoke kapena matenda omwe amabwera ndikutha.
• uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala a rituximab ndi hyaluronidase munthu komanso kwa miyezi 12 mutalandira mankhwala omaliza. Lankhulani ndi dokotala wanu za mitundu yoletsa yomwe ingakuthandizeni. Mukakhala ndi pakati mukamagwiritsa ntchito jakisoni wa rituximab ndi hyaluronidase, itanani dokotala wanu. Rituximab itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala a rituximab ndi hyaluronidase jekeseni wamunthu komanso kwa miyezi 6 mutatha kumwa mankhwala.
• Funsani dokotala ngati mukufuna kulandira katemera musanayambe mankhwala anu ndi rituximab ndi jakisoni wa hyaluronidase. Musakhale ndi katemera uliwonse mukamalandira chithandizo popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi kuti mulandire jekeseni wa rituximab ndi hyaluronidase, pitani kuchipatala nthawi yomweyo.

Rituximab ndi hyaluronidase jekeseni wamunthu imatha kuyambitsa zovuta.Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kuchapa
• kutayika tsitsi
• kupweteka, kupsa mtima, kutupa, kufiira kapena kuyabwa pamalo pomwe munabayidwa jakisoni
• minofu, olowa, kapena kupweteka kwa msana

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• ming'oma, zidzolo, kuyabwa, kutupa kwa milomo, lilime, kapena pakhosi, kupuma movutikira, kupuma movutikira kapena kumeza
• kupuma
• chizungulire kapena kukomoka
• kufooka
• kutsegula m'mimba
• kusowa mphamvu
• kupweteka pachifuwa
• kugunda kapena kugunda kwamtima kosazolowereka
• zilonda zapakhosi, malungo, kuzizira, chifuwa, kupweteka khutu, kupweteka mutu, kapena zizindikilo zina za matenda
• zigamba zoyera pakhosi kapena mkamwa
• kukodza kovuta, kowawa, kapena pafupipafupi
• kufiira, kukoma mtima, kutupa kapena kutentha kwa khungu

Rituximab ndi hyaluronidase jekeseni wamunthu imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Chikhalidwe cha Rituxan^®