Upadacitinib

Zamkati

• Musanatenge upadacitinib,
• Upadacitinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Kutenga upadacitinib kungachepetse kuthekera kwanu kothana ndi matenda ndikuwonjezera chiopsezo choti mutenge matenda akulu, kuphatikiza fungus, mabakiteriya, kapena ma virus omwe amafalikira mthupi lonse. Matendawa angafunike kuthandizidwa kuchipatala ndipo atha kupha. Uzani dokotala wanu ngati nthawi zambiri mumakhala ndi matenda aliwonse kapena ngati mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Izi zimaphatikizapo matenda ang'onoang'ono (monga mabala otseguka kapena zilonda), matenda omwe amabwera ndikadutsa (monga zilonda zozizira), ndi matenda opatsirana omwe samatha. Uzaninso adotolo ngati mwadwalapo kapena munakhalapo ndi matenda a shuga, kachilombo ka HIV, matenda opatsirana mthupi (Edzi), matenda am'mapapo, kapena vuto lina lililonse lomwe limakhudza chitetezo chamthupi. Muyeneranso kuuza adotolo ngati mukukhala kapena mudakhalako m'malo monga zigwa za Ohio kapena Mississippi komwe matenda ofala a fungus amapezeka kwambiri. Funsani dokotala wanu ngati simukudziwa ngati matendawa ndiofala m'dera lanu. Uzani dokotala wanu ngati mukumwa mankhwala omwe amachepetsa chitetezo chamthupi monga awa: azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate (Otrexup, Rasuvo , Trexall); steroids kuphatikizapo dexamethasone, methylprednisolone (Medrol), prednisolone (Prelone), ndi prednisone (Rayos); sulfasalazine; kapena tacrolimus (Astagraf, Envarsus XR, Prograf).

Dokotala wanu adzakuyang'anirani ngati muli ndi matendawa mukamalandira chithandizo chake. Ngati muli ndi zizindikiro zotsatirazi musanayambe kumwa mankhwala kapena ngati mukukumana ndi zizindikiro zotsatirazi mukamalandira chithandizo kapena mutangochoka kumene, pitani kuchipatala nthawi yomweyo: malungo; thukuta; kuzizira; kupweteka kwa minofu; chifuwa; kupuma movutikira; kuonda; khungu lofunda, lofiira, kapena lopweteka; zilonda pakhungu; kumverera pafupipafupi, kupweteka, kapena kutentha nthawi yokodza; kutsegula m'mimba, kapena kutopa kwambiri.

Mutha kukhala kuti mwadwala kale chifuwa chachikulu (TB; matenda akulu am'mapapo) koma mulibe zizindikiro zilizonse za matendawa. Poterepa, kutenga upadacitinib kungapangitse matenda anu kukhala owopsa ndikupangitsani kukhala ndi zizindikilo. Dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi kachilombo koyambitsa matenda a TB musanayambe kumwa mankhwala ndi upadacitinib. Ngati ndi kotheka, dokotala wanu adzakupatsani mankhwala ochizira matendawa musanayambe kugwiritsa ntchito upadacitinib. Uzani dokotala ngati mwadwalapo kapena munakhalapo ndi TB, ngati munakhalako kapena munapitako kudziko kumene TB imafala, kapena ngati munakhalapo ndi munthu amene ali ndi TB. Ngati muli ndi zizindikiro zotsatirazi za chifuwa chachikulu cha TB, kapena ngati muli ndi zina mwazizindikiro mukamalandira chithandizo, pitani kuchipatala nthawi yomweyo: kutsokomola, kutsokomola ntchofu zamagazi, kuonda, kuchepa kwa minofu, kapena malungo.

Kutenga upadacitinib kungapangitse chiopsezo kuti mukhale ndi lymphoma (khansa yomwe imayamba m'maselo omwe amalimbana ndi matenda) kapena mitundu ina ya khansa monga khansa yapakhungu. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi khansa yamtundu uliwonse.

Upadacitinib itha kuwonjezera chiopsezo cha magazi owopsa m'mapapu kapena m'miyendo. Ngati mukumane ndi zotsatirazi, itanani dokotala wanu kapena pitani kuchipatala mwachangu: kupweteka pachifuwa kapena kulemera pachifuwa; kupuma movutikira; chifuwa; kupweteka, kutentha, kufiira, kutupa, kapena kukoma kwa mwendo; kapena kutentha kozizira m'manja, manja, kapena miyendo; kapena kupweteka kwa minofu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira upadacitinib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi upadacitinib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za chiopsezo chotenga upadacitinib.

Upadacitinib imagwiritsidwa ntchito yokha kapena ndi mankhwala ena kuchiza nyamakazi (momwe thupi limagwirira mafupa ake omwe amachititsa kupweteka, kutupa, ndi kutayika kwa ntchito) mwa anthu omwe sanayankhe bwino ku methotrexate (Otrexup, Rasuvo, Trexall). Upadacitinib ali mgulu la mankhwala otchedwa Janus kinase (JAK) inhibitors. Zimagwira ntchito pochepetsa magwiridwe antchito amthupi.

Upadacitinib imabwera ngati pulogalamu yotulutsa (yotenga nthawi yayitali). Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani upadacitinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani upadacitinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi otulutsidwa otalikiratu; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu angafunikire kusiya kwakanthawi kapena kwamuyaya mankhwala mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge upadacitinib,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la upadacitinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi otulutsidwa a upadacitinib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: mankhwala ena oletsa mafangasi monga itraconazole (Onmel, Sporanox) ndi ketoconazole; aspirin ndi mankhwala ena osagwiritsa ntchito zotupa (NSAIDs) monga ibuprofen (Advil, Motrin) ndi naproxen (Naprosyn, Aleve); barbiturates monga phenobarbital kapena phenytoin (Dilantin, Phenytek); carbamazepine (Carbatrol, Tegretol, Equetro, ena); clarithromycin (Biaxin, mu Prevpac); enzalutamide (Xtandi); mankhwala ena a HIV kuphatikiza efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); nefazodone; rifabutin (Mycobutin); kapena rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi upadacitinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• Uzani dokotala wanu ngati muli ndi zilonda (zilonda mkatikati mwa m'mimba kapena m'matumbo), diverticulitis (kutupa kwa akalowa m'matumbo akulu), herpes zoster (ming'alu; zotupa zomwe zingachitike mwa anthu omwe adakhalapo ndi nkhuku m'mbuyomu ), kapena kuchepa kwa magazi (ochepera kuchuluka kwa maselo ofiira amwazi), kapena matenda a chiwindi, kuphatikiza hepatitis B kapena C.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyezetsa mimba musanayambe mankhwala ndi upadacitinib. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa milungu ingapo ya 4 mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito. Mukakhala ndi pakati, itanani dokotala wanu mwachangu. Upadacitinib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala ndi upadacitinib komanso masiku 6 mutapatsidwa mankhwala omaliza.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa upadacitinib.
• uzani dokotala wanu ngati mwalandira kumene kapena mukuyenera kulandira katemera uliwonse. Ngati mukufuna katemera aliyense, mungafunike kulandira katemerawo ndikudikirira kaye musanayambe mankhwala anu ndi upadacitinib. Musakhale ndi katemera uliwonse mukamalandira chithandizo popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Upadacitinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• yothina kapena yothamanga m'mphuno
• nseru

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• chikasu cha khungu kapena maso, kusowa kwa njala, mkodzo wakuda, kapena matumbo ofiira ofiira
• kupuma movutikira, kutopa, kapena khungu lotumbululuka

Upadacitinib ingayambitse kuchuluka kwa mafuta m'magazi a cholesterol. Dokotala wanu adzayitanitsa mayeso kuti muwone kuchuluka kwa cholesterol yanu mukamamwa mankhwala ndi upadacitinib. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Upadacitinib itha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Sungani izo mufiriji kapena kutentha kutentha komanso kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®