Elexacaftor, Tezacaftor, ndi Ivacaftor

Zamkati

• Musanatenge kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor,
• Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumagwiritsidwa ntchito pochiza mitundu ina ya cystic fibrosis (matenda obadwa nawo omwe amayambitsa mavuto kupuma, chimbudzi, ndi kubereka) mwa akulu ndi ana azaka 12 kapena kupitilira apo. Iyenera kugwiritsidwa ntchito mwa anthu omwe ali ndi vuto linalake. Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti akuthandizeni kusankha ngati mankhwalawa ndi oyenera kwa inu. Elexacaftor ndi tezacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) okonza. Ivacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Mankhwalawa amagwira ntchito pokonzanso magwiridwe antchito a thupi m'thupi kuti achepetse kuchuluka kwa ntchofu m'mapapu ndikusintha zina za cystic fibrosis.

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumabwera ngati mapiritsi oti atenge pakamwa. Mlingo uliwonse watsiku ndi tsiku uli ndi mapiritsi osiyanasiyana: piritsi limodzi ndi kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor ndipo piritsi linalo ndi ivacaftor. Tengani elexacaftor, tezacaftor, ndi ivacaftor (mapiritsi awiri a lalanje) m'mawa uliwonse ndi chakudya chamafuta ndi ivacaftor (piritsi limodzi la buluu) madzulo aliwonse ndi chakudya chamafuta, olekana maola 12. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani mankhwalawa monga momwe adanenera. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Tengani kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor ndi zakudya zamafuta monga mazira, batala, mtedza, chiponde, pizza wa tchizi, ndi mkaka wonse (monga mkaka wonse, tchizi, ndi yogurt). Lankhulani ndi dokotala wanu za zakudya zina zamafuta zoti mudye ndi mankhwalawa.

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumayang'anira cystic fibrosis, koma sikuchiritsa.Pitirizani kumwa mankhwalawa ngakhale mutakhala bwino. Osasiya kumwa mankhwalawa osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la elexacaftor, tezacaftor, ndi ivacaftor mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa mu elexacaftor, tezacaftor, ndi mapiritsi a ivacaftor. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maantibayotiki ena monga clarithromycin (Biaxin, mu PrevPac) ndi erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin); maantifungal ena monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), ndi voriconazole (Vfend); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pravastatin (Pravachol), rosuvastatin (Crestor), ndi simvastatin (Zocor, ku Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Wothandizira, Zortress); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (Diabeta); njira zolerera za mahomoni (mapiritsi olera, zigamba, mphete, zopangira, kapena jakisoni); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); gulu; repaglinide; rifabutin (Mycobutin); rifampin (Rifadin, ku Rifamate, ku Rifater, Rimactane); mankhwala (Rapamune); tacrolimus (Astagraf, Prograf), kapena warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi elexacaftor, tezacaftor, kapena ivacaftor, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. Dokotala wanu mwina angakuuzeni kuti musatenge wort ya St. John mukamamwa mafuta ophatikizana a elexacaftor, tezacaftor, ndi ivacaftor.
• auzeni adotolo ngati mwadwalapo chiwindi kapena impso.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga limodzi la elexacaftor, tezacaftor, ndi ivacaftor, itanani dokotala wanu.
• Muyenera kudziwa kuti mankhwalawa akhoza kukupangitsani kugona. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mukukumbukira m'mawa kapena madzulo omwe mwaphonya mlingo mkati mwa maola 6 kuchokera nthawi yomwe mudayenera kumwa, tengani mlingo womwe umasowa nthawi yomweyo ndi chakudya chokhala ndi mafuta ndikupitiliza dongosolo lanu lokhazikika. Komabe, ngati maola opitilira 6 adutsa kuyambira nthawi yomwe mumamwa m'mawa, tengani mlingo wam'mawa posachedwa ndikudumpha mlingo wamadzulo, kenako pitilizani dongosolo lanu lokhazikika. Ngati maola opitilira 6 adutsa kuyambira nthawi yoti mutenge mlingo wamadzulo, tulukani mlingo wamadzulo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wam'mawa ndi wamadzulo palimodzi kuti mupange zomwe mwaphonya.

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• mphuno yothamanga, kuyetsemula, ndi kunyinyirika; malungo; chifuwa; kapena zizindikiro zina za matenda
• kupweteka m'mimba kapena kutupa
• kutsegula m'mimba
• zidzolo
• mpweya
• diso la pinki
• kuyabwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• chikasu cha khungu kapena maso
• kusowa chilakolako
• nseru
• kusanza
• mipando yotumbululuka
• kupweteka m'mimba
• mkodzo wakuda

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumatha kuyambitsa matenda amiso (kutsekemera kwa mandala a diso omwe angayambitse mavuto owonera) mwa ana ndi achinyamata. Ana ndi achinyamata omwe amatenga elexacaftor, tezacaftor, ndi ivacaftor ayenera kukaonana ndi dokotala wamaso asanafike komanso akamalandira chithandizo. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopatsa elexacaftor, tezacaftor, ndi ivacaftor kwa mwana wanu.

Kuphatikiza kwa elexacaftor, tezacaftor, ndi ivacaftor kumatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzalamula kuyezetsa maso (kwa ana ndi achinyamata) ndi mayeso ena a labu monga kuyesa kwa chiwindi musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira elexacaftor, tezacaftor, ndi ivacaftor.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®