Pemigatinib

Zamkati

• Musanatenge pemigatinib,
• Pemigatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Pemigatinib imagwiritsidwa ntchito kwa achikulire omwe adalandira kale mankhwala amtundu wina wa cholangiocarcinoma (khansa ya bile) yomwe yafalikira kumatenda oyandikira kapena ziwalo zina za thupi ndipo sangathe kuchotsedwa ndi opaleshoni. Pemigatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Pemigatinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa wopanda chakudya kamodzi tsiku lililonse kwa masiku 14 oyambira masiku 21. Kuzungulira kumatha kubwerezedwa monga momwe dokotala akuwalimbikitsira. Tengani pemigatinib nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani pemigatinib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga pemigatinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha ngati mukukumana ndi zovuta zina. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira pemigatinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge pemigatinib,

• uzani dokotala wanu komanso wamankhwala ngati mukugwirizana ndi pemigatinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse pamapiritsi a pemigatinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungals monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), ndi voriconazole (Vfend); carbamazepine (Epitol, Tegretol, Teril, ena); clarithromycin (Biaxin); erythromycin (EES, Erythrocin, ena); mankhwala ena ochizira kachilombo ka HIV monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, mwa ena), kapena saquinavir (Invirase); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate); ndi verapamil (Calan, Verelan, ena). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi pemigatinib, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati mukuvutika kumeza mapiritsi kapena ngati mwakhalapo ndi matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa sabata limodzi mutangomaliza kumwa mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga pemigatinib, itanani dokotala wanu mwachangu. Pemigatinib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa pemigatinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amatha kuyambitsa maso owuma. Dokotala wanu angakuuzeni kuti mugwiritse ntchito misozi yokumba kapena mafuta amaso m'maso mukamamwa ndi pemigatinib.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mwaphonya mlingo wa pemigatinib osakwana maola 4, tengani mlingo womwe mwaphonya mukangokumbukira kenako mutenge mlingo wotsatira panthawiyo. Komabe, ngati mwaphonya mlingo ndi maola 4 kapena kupitilira apo, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Pemigatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• nseru
• kusintha kwa kukoma
• kusanza
• kusowa chilakolako
• kuonda
• kudzimbidwa
• kupweteka m'mimba
• zilonda pamilomo, mkamwa, kapena pakhosi
• pakamwa pouma ndi / kapena khungu; kuchepa pokodza; kapena kugunda kwamtima
• misomali
• kutayika tsitsi
• mutu
• kutopa
• kulumikizana kapena kupweteka kwa msana
• kutentha kapena kukodza kopweteka
• kupweteka kapena kutupa kwa manja, mapazi, miyendo kapena akakolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kusawona bwino, kuyandama m'maso, kuwona kuwala, kapena kusintha kwina kwamasomphenya
• kukokana minofu, dzanzi, kapena kumva kulasalasa moyamwa

Pemigatinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help.Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu, dotolo wamaso, ndi labotale. Dokotala wanu adzaitanitsa mayeso a labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi pemigatinib. Dokotala wanu adzaitanitsanso mayeso ena a labu ndi maso musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira pemigatinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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