Jekeseni wa Brexucabtagene Autoleucel

Zamkati

• Asanalandire brexucabtagene autoleucel,
• Brexucabtagene autoleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

Brexucabtagene autoleucel jekeseni imatha kuyambitsa vuto lalikulu kapena lowopsa lomwe limatchedwa cytokine release syndrome (CRS). Dokotala kapena namwino adzakuyang'anirani mosamala mukamalowetsedwa komanso kwa milungu ingapo pambuyo pake. Uzani dokotala wanu ngati muli ndi vuto lotupa kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Mupatsidwa mankhwala kwa mphindi 30 mpaka 60 musanalowetsedwe kuti muthane ndi zovuta za brexucabtagene autoleucel. Ngati mukumane ndi zizindikiro zotsatirazi mukamudyetsedwa, uzani dokotala nthawi yomweyo: malungo, kuzizira, kugunda kwamtima kapena kusakhazikika, kupweteka kwa minofu, kugwedezeka, kutsegula m'mimba, kutopa, kufooka, kupuma movutikira, kupuma movutikira, chifuwa, chisokonezo, nseru, kusanza, chizungulire, kapena mutu wopepuka.

Brexucabtagene autoleucel jekeseni imatha kuyambitsa machitidwe owopsa kapena owopsa amoyo. Izi zimatha kuchitika pambuyo pothandizidwa ndi brexucabtagene autoleucel. Uzani dokotala wanu ngati mudagwidwa, kudwala sitiroko, kapena kukumbukira kukumbukira. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka mutu, chizungulire, kuvutika kugona kapena kugona, kusakhazikika, kusokonezeka, nkhawa, kugwedezeka kosalamulirika kwa gawo lina la thupi, kutaya chikumbumtima, kubvutika, kugwidwa, kutaya kusamala, kapena kuvutika kuyankhula.

Brexucabtagene autoleucel jekeseni imangopezeka kudzera mu pulogalamu yoletsa yogawa chifukwa cha kuwopsa kwa CRS ndi mitsempha ya poizoni wamitsempha. Mutha kulandila mankhwala kuchokera kwa adotolo ndi malo azaumoyo omwe amatenga nawo mbali pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza pulogalamuyi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu lingayankhire kwa brexucabtagene autoleucel.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso zaopanga (Medication Guide) mukayamba chithandizo ndi brexucabtagene autoleucel ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Brexucabtagene autoleucel imagwiritsidwanso ntchito pochizira mantle cell lymphoma (khansa yomwe ikukula mwachangu yomwe imayambira m'maselo amthupi) mwa akulu omwe abwerera kapena osamvera mankhwala ena. Brexucabtagene autoleucel jekeseni ali mgulu la mankhwala otchedwa autologous cellular immunotherapy, mtundu wa mankhwala omwe amakonzedwa pogwiritsa ntchito maselo am'magazi a wodwalayo. Zimagwira ntchito poyambitsa chitetezo cha mthupi (gulu la maselo, zotupa, ndi ziwalo zomwe zimateteza thupi kuti lisagwidwe ndi mabakiteriya, mavairasi, ma cell a khansa, ndi zinthu zina zomwe zimayambitsa matenda) kulimbana ndi ma cell a khansa.

Brexucabtagene autoleucel imabwera ngati kuyimitsidwa (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino muofesi ya udokotala kapena malo olowererapo. Nthawi zambiri amaperekedwa kwa mphindi 30 ngati gawo limodzi. Musanalandire brexucabtagene autoleucel dose, dokotala kapena namwino wanu adzakupatsani mankhwala ena a chemotherapy kuti akonzekeretse thupi lanu kuti likhale ndi brexucabtagene autoleucel.

Musanaperekedwe jakisoni wanu wa brexucabtagene autoleucel, maselo anu oyera amwazi adzatengedwa kumalo osungira maselo pogwiritsa ntchito leukapheresis (njira yomwe imachotsa maselo oyera amthupi). Chifukwa mankhwalawa amapangidwa kuchokera m'maselo anu, ayenera kuperekedwa kwa inu nokha. Ndikofunika kukhala munthawi yake komanso kuti musaphonye nthawi yomwe mumakonzekera kusonkhanitsidwa kwama cell kapena kulandira mankhwala anu. Muyenera kukonzekera kukhala pafupi ndi komwe mudalandira mankhwala anu a brexucabtagene autoleucel kwa milungu yosachepera 4 mutatha kumwa mankhwala. Wothandizira zaumoyo wanu adzawona ngati chithandizo chanu chikugwira ntchito ndikukuyang'anirani zotsatira zoyipa zilizonse. Lankhulani ndi dokotala wanu za momwe mungakonzekerere leukapheresis ndi zomwe muyenera kuyembekezera mukamachita izi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire brexucabtagene autoleucel,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la brexucabtagene autoleucel, mankhwala ena aliwonse, kapena chilichonse chosakaniza mu brexucabtagene autoleucel. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• Uzani dokotala wanu ngati mwakhalapo ndi matenda am'mapapo, impso, mtima, kapena chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kukhala ndi mayeso amimba musanayambe brexucabtagene autoleucel. Mukakhala ndi pakati mukalandira brexucabtagene autoleucel, itanani dokotala wanu mwachangu.
• Muyenera kudziwa kuti brexucabtagene autoleucel jekeseni imatha kukupangitsani kugona komanso kuyambitsa chisokonezo, kufooka, chizungulire, khunyu, komanso mavuto amgwirizano. Osayendetsa galimoto kapena kugwiritsa ntchito makina kwa masabata osachepera 8 mutatha kumwa brexucabtagene autoleucel dose.
• musapereke magazi, ziwalo, ziwalo, kapena maselo kuti mumupatse mukalandira jekeseni wanu wa brexucabtagene autoleucel.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera musanalankhule ndi dokotala kwa milungu isanu ndi umodzi musanayambe chemotherapy, mukamamwa mankhwala a brexucabtagene autoleucel, mpaka dokotala wanu atakuwuzani kuti chitetezo chamthupi chanu chayamba.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yosankhidwa kuti mudzatenge maselo anu, muyenera kuyimbira dokotala wanu ndi malo osonkhanitsira nthawi yomweyo. Ngati mwaphonya nthawi kuti mulandire brexucabtagene autoleucel dose, muyenera kuyimbira dokotala nthawi yomweyo.

Brexucabtagene autoleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kupweteka m'mimba
• kusowa chilakolako
• kupweteka pakamwa
• zovuta kumeza
• zidzolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• khungu lotuwa kapena kupuma movutikira
• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• amachepetsa kukodza pafupipafupi kapena kuchuluka
• dzanzi, kupweteka, kumva kulasalasa, kapena kutentha pamiyendo kapena manja

Kubayira kwa Brexucabtagene autoleucel kumatha kukulitsa chiopsezo chokhala ndi khansa ina. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Brexucabtagene autoleucel jekeseni imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani nthawi yonse yokumana ndi dokotala wanu, malo osungira maselo, ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jekeseni wa brexucabtagene autoleucel.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza brexucabtagene autoleucel.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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