Malangizo

Zamkati

• Musanatenge pralsetinib,
• Pralsetinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi kapena izi zomwe zalembedwa mu ZISANGIZO ZAPADERA, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Pralsetinib amagwiritsidwa ntchito pochiza khansa yamtundu wam'magazi (NSCLC) mwa akulu yomwe yafalikira mbali zina za thupi. Amagwiritsidwanso ntchito kuchiritsa mtundu wina wa khansa ya chithokomiro mwa akulu ndi ana azaka 12 kapena kupitilira zomwe zikukulirakulira kapena zomwe zafalikira mbali zina za thupi. Pralsetinib amagwiritsidwa ntchito pochiza khansa yamtundu wa chithokomiro mwa akulu ndi ana azaka 12 kapena kupitilira apo zomwe zikukulirakulira kapena zomwe zafalikira mbali zina za thupi ndipo sizingachiritsidwe ndi ayodini wa radioactive. Pralsetinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa kuchitapo kanthu mwachilengedwe komwe kumafunikira kuti maselo a khansa achulukane.

Pralsetinib imabwera ngati kapisozi wotenga pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse osadya kanthu, osachepera maola 2 kale komanso osachepera ola limodzi mutadya. Tengani pralsetinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani pralsetinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati musanza mutamwa pralsetinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha pralsetinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge pralsetinib,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la pralsetinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a pralsetinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: Mankhwala oletsa antifungal kuphatikiza itraconazole (Onmel, Sporanox) ndi ketoconazole; clarithromycin (mu Biaxin); mankhwala ena a HIV monga efavirenz (Sustiva, ku Atripla, Symfi), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra, Viekira Pak), ndi saquinavir (Invirase); oxcarbazepine (Oxtellar XR, Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, ku Oseni, Duetact); rifabutin (Mycobutin); ndi rifampin (Rifadin, Rimactane, ku Rifater). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati mwakhalapo ndi vuto la m'mapapo kapena kupuma kupatula khansa ya m'mapapo, mavuto akutuluka magazi, kuthamanga kwa magazi, kapena matenda a chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Pralsetinib itha kusokoneza zochita za njira zolerera za mahomoni (mapiritsi oletsa kubala, zigamba, mphete, zopangira, kapena jakisoni), chifukwa chake simuyenera kugwiritsa ntchito njirayi yokhayo yolerera panthawi yachipatala. Muyenera kugwiritsa ntchito njira yolera yopanda mahomoni monga chotchinga (chotchinga chomwe chimatseketsa umuna kuti usalowe muchiberekero monga kondomu kapena diaphragm). Funsani dokotala wanu kuti akuthandizeni kusankha njira yolerera yomwe ingakuthandizeni. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira mankhwala, ndipo muyenera kugwiritsa ntchito njira zolera zosagwiritsira ntchito mahomoni kuti muchepetse kutenga pakati mukamalandira chithandizo komanso kwa milungu iwiri mutalandira mankhwala. Ngati ndinu wamwamuna ndipo mnzanu atha kutenga pakati, muyenera kugwiritsa ntchito njira yoletsa yoletsa kupewa kutenga mimba mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa abambo ndi amai; komabe, simuyenera kuganiza kuti simungatenge mimba kapena kuti simungapatse wina mimba. Ngati inu kapena mnzanu mumakhala ndi pakati mukatenga pralsetinib, itanani dokotala wanu. Pralsetinib itha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa pralsetinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito pralsetinib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa pralsetinib. Dokotala wanu angakuuzeni kuti musamwe pralsetinib masiku asanu musanachite opaleshoni yanu ndipo angakuuzeni nthawi yoyambiranso kumwa mankhwalawo.
• muyenera kudziwa kuti kuthamanga kwa magazi kwanu kumatha kukulira nthawi yochizira ndi pralsetinib. Dokotala wanu amayang'anitsitsa kuthamanga kwa magazi mosamala, ndipo amatha kukupatsani mankhwala kuti athetse kuthamanga kwa magazi ngati kutuluka.
• muyenera kudziwa kuti mutha kukhala ndi chotupa cha lysis (TLS; vuto lomwe limayamba chifukwa cha kuwonongeka kwamaselo a khansa omwe angayambitse impso ndi zovuta zina) mukamachiza pralsetinib. Pofuna kuchepetsa chiopsezo chokumana ndi TLS, dokotala wanu akhoza kukupemphani kuti mumwe madzi musanamwe komanso mukamalandira chithandizo, ndipo nthawi iliyonse mukawonjezera mlingo. Kuphatikiza apo, dokotala wanu adzakupatsani mankhwala oti muzimwa musanayambe komanso mukamalandira chithandizo kuti muteteze izi. Ngati mukukumana ndi zizindikiro zotsatirazi za TLS, itanani dokotala wanu nthawi yomweyo: malungo, kuzizira, mseru, kusanza, kusokonezeka, kupuma movutikira, kukomoka, kugunda kwamtima mosasinthasintha, mkodzo wamdima kapena wamtambo, kutopa kwachilendo, kapena kupweteka kwa minofu kapena kulumikizana.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo wosowa tsiku lomwelo mutangomukumbukira. Kenako, pitilizani pulogalamu yanu yokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Pralsetinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kutsegula m'mimba
• pakamwa pouma
• kupweteka kwa minofu kapena mafupa
• kutupa kwa manja, akakolo, kapena mapazi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi kapena izi zomwe zalembedwa mu ZISANGIZO ZAPADERA, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• chisokonezo, mutu, kupuma movutikira, chizungulire, kapena kupweteka pachifuwa
• malungo, kupuma movutikira, kapena kutsokomola
• khungu lotuwa, kutopa, kapena kupuma movutikira
• chikasu cha khungu kapena maso, mkodzo wamdima, kutuluka magazi kapena kuvulaza mosavuta kuposa zachilendo, kusowa kwa njala, kuchepa mphamvu, kapena kupweteka kumanja kwa m'mimba
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando
• masanzi amagazi
• kusanza komwe kumawoneka ngati malo a khofi
• kutsokomola magazi
• kutuluka mwachilendo kapena kuphwanya
• kutuluka kwachilendo kwachilendo
• Kutuluka magazi m'mphuno pafupipafupi
• Kugona, kusokonezeka, kupweteka mutu, kapena kulephera kulankhula

Pralsetinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso a labu musanalandire chithandizo kuti mudziwe ngati khansa yanu imatha kuthandizidwa ndi pralsetinib. Dokotala wanu adzaitanitsanso mayeso ena a labu asanadye, nthawi, ndi pambuyo pa chithandizo chanu kuti muwone kuyankha kwa thupi lanu ku pralsetinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Gavreto^®