Methotrexate

Zamkati

• Musanatenge methotrexate,
• Methotrexate imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

Methotrexate imatha kubweretsa zovuta zoyipa kwambiri. Muyenera kungotenga methotrexate kuti muthane ndi khansa kapena zinthu zina zovuta kwambiri zomwe sizingachiritsidwe ndi mankhwala ena. Lankhulani ndi dokotala wanu za kuopsa kotenga methotrexate pa matenda anu.

Uzani dokotala wanu ngati mwakhalapo ndi madzi owonjezera m'mimba mwanu kapena malo ozungulira mapapu anu komanso ngati mwakhalapo ndi matenda a impso. Komanso uzani dokotala ngati mukumwa mankhwala osagwiritsa ntchito zotupa (ma NSAID) monga aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), kapena salsalate. Izi ndi mankhwala atha kukulitsa chiopsezo kuti mungakhale ndi zotsatirapo zoyipa za methotrexate. Dokotala wanu adzakuyang'anirani mosamala kwambiri ndipo angafunike kukupatsirani mankhwala ochepa a methotrexate kapena kuyimitsa mankhwala anu ndi methotrexate.

Methotrexate ingayambitse kuchepa kwa maselo amwazi omwe amapangidwa ndi mafupa. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi nambala yocheperako yamaselo amwazi kapena vuto lina lililonse lama cell amwazi wanu. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: zilonda zapakhosi, kuzizira, malungo, kapena zizindikilo zina za matenda; kuvulaza kapena kutuluka mwachilendo; kutopa kwambiri; khungu lotumbululuka; kapena kupuma movutikira.

Methotrexate imatha kuwononga chiwindi, makamaka ikamamwa nthawi yayitali. Ngati mumamwa kapena mumamwa mowa wambiri kapena ngati mwakhalapo ndi matenda a chiwindi, dokotala wanu angakuuzeni kuti musatenge methotrexate pokhapokha mutakhala ndi khansa yowopsa moyo chifukwa muli pachiwopsezo chachikulu kukhala chiwindi kuwonongeka. Chiwopsezo choti chiwindi chimatha kuwonanso chimakhala chachikulu ngati ndinu okalamba, onenepa kwambiri, kapena muli ndi matenda ashuga. Uzani dokotala wanu ngati mukumwa mankhwala aliwonse awa: acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), kapena tretinoin (Vesanoid). Funsani dokotala wanu za zakumwa zoledzeretsa pamene mukumwa methotrexate. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: kunyansidwa, kutopa kwambiri, kusowa mphamvu, kusowa njala, kupweteka kumtunda kwakumimba, chikasu pakhungu kapena m'maso, kapena zizindikiro ngati chimfine. Dokotala wanu amatha kuyitanitsa ma biopsies a chiwindi (kuchotsa kachidutswa kakang'ono ka chiwindi kuti kayezedwe mu labotale) musanachitike komanso mukamalandira mankhwala a methotrexate.

Methotrexate imatha kuwononga mapapo. Uzani dokotala wanu ngati mwakhalapo ndi matenda am'mapapo. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: chifuwa chouma, malungo, kapena kupuma movutikira.

Methotrexate imatha kuwononga mkamwa mwanu, m'mimba, kapena m'matumbo. Uzani dokotala wanu ngati mwakhalapo ndi zilonda zam'mimba kapena ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda mkatikati mwa matumbo [matumbo akulu] ndi thumbo). Ngati mukukumana ndi izi, siyani kumwa methotrexate ndikuyimbira dokotala nthawi yomweyo: zilonda zam'kamwa, kutsegula m'mimba, zakuda, zochedwa, kapena malo amwazi, kapena masanzi omwe ali amwazi kapena owoneka ngati khofi.

Kutenga methotrexate kumachulukitsa chiopsezo choti mungakhale ndi lymphoma (khansa yomwe imayamba m'maselo amthupi). Ngati mukukhala ndi lymphoma, imatha kutha popanda mankhwala mukasiya kumwa methotrexate, kapena mungafunike kuthandizidwa ndi chemotherapy.

Ngati mukumwa methotrexate kuchiza khansa, mutha kukhala ndi zovuta zina popeza methotrexate imagwira ntchito yowononga ma cell a khansa. Dokotala wanu amayang'anitsitsa mosamala ndikuchiza mavutowa akachitika.

Methotrexate imatha kuyambitsa khungu kapena kuwononga khungu. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: malungo, zotupa, zotupa, kapena khungu losenda.

Methotrexate imatha kuchepa chitetezo chamthupi mwanu, ndipo mutha kudwala matenda akulu. Uzani dokotala wanu ngati muli ndi matenda amtundu uliwonse ndipo ngati mwakhalapo kapena mudakhalapo ndi vuto lililonse lomwe limakhudza chitetezo chamthupi. Dokotala wanu angakuuzeni kuti simuyenera kumwa methotrexate pokhapokha mutakhala ndi khansa yoopsa. Mukakhala ndi zizindikilo za matenda monga zilonda zapakhosi, chifuwa, malungo, kapena kuzizira, itanani dokotala wanu mwachangu.

Ngati mutenga methotrexate mukamalandira chithandizo cha radiation kwa khansa, methotrexate imatha kuonjezera ngozi kuti mankhwalawa atha kuwononga khungu, mafupa, kapena ziwalo zina za thupi lanu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayesero ena a labu asanayambe, nthawi, komanso mutalandira chithandizo chanu kuti muwone momwe thupi lanu likuyankhira ku methotrexate ndikuthandizira zovuta zisanakhale zovuta.

Uzani dokotala wanu ngati inu kapena mnzanu muli ndi pakati kapena mukufuna kutenga pakati. Ngati ndinu wamkazi, muyenera kuyezetsa musanatenge methotrexate. Gwiritsani ntchito njira yodalirika yolerera kuti inu kapena mnzanu musakhale ndi pakati mukamalandira mankhwala kapena mukangomaliza kumene kulandira mankhwala. Ngati ndinu wamwamuna, inu ndi akazi anu muyenera kupitiliza kugwiritsa ntchito njira zakulera kwa miyezi itatu mutasiya kumwa methotrexate. Ngati ndinu wamkazi, muyenera kupitiriza kugwiritsa ntchito njira zakulera mpaka mutasiya kusamba kamodzi mutasiya kumwa methotrexate. Ngati inu kapena mnzanu mutakhala ndi pakati, itanani dokotala wanu nthawi yomweyo. Methotrexate itha kuvulaza kapena kupha mwana wosabadwayo.

Methotrexate imagwiritsidwa ntchito pochiza psoriasis yoopsa (matenda akhungu momwe mawonekedwe ofiira ofiira amatuluka m'malo ena amthupi) omwe sangathe kuwongoleredwa ndi mankhwala ena. Methotrexate imagwiritsidwanso ntchito limodzi ndi kupumula, kulimbitsa thupi, ndipo nthawi zina mankhwala ena kuti athetse matenda a nyamakazi (RA; vuto lomwe thupi limagunda mafupa ake, kupweteketsa, kutupa, komanso kutayika kwa ntchito) zomwe sizingayang'aniridwe ndi mankhwala ena. Methotrexate imagwiritsidwanso ntchito kuthana ndi mitundu ina ya khansa kuphatikiza khansa yomwe imayamba m'matumba omwe amapanga dzira la umuna m'chiberekero, khansa ya m'mawere, khansa yam'mapapo, khansa zina za mutu ndi khosi, mitundu ina ya lymphoma, ndi leukemia (khansa zomwe zimayambira m'maselo oyera a magazi). Methotrexate ili mgulu la mankhwala otchedwa antimetabolites. Methotrexate imathandizira khansa pochepetsa kukula kwa maselo a khansa. Methotrexate imathandizira psoriasis pochepetsa kukula kwa khungu pakhungu kuti zileke masikelo kuti asapangidwe. Methotrexate imatha kuchiza nyamakazi pochepetsa chitetezo chamthupi.

Methotrexate imabwera ngati piritsi kuti itenge pakamwa. Dokotala wanu angakuuzeni kangati zomwe muyenera kumwa methotrexate. Ndandanda imadalira momwe muliri komanso momwe thupi lanu limayankhira mankhwalawo.

Dokotala wanu angakuuzeni kuti mutenge methotrexate panthawi yoyenda yomwe imasinthasintha masiku angapo mukamamwa methotrexate ndi masiku angapo kapena milungu ingapo musamamwe mankhwala. Tsatirani malangizowa mosamala ndikufunsani dokotala kapena wamankhwala ngati simukudziwa nthawi yomwe mumamwa mankhwala anu.

Ngati mukumwa methotrexate kuti muchiritse psoriasis kapena nyamakazi, dokotala wanu akhoza kukuwuzani kuti mumwe mankhwala kamodzi pa sabata. Samalirani kwambiri malangizo a dokotala wanu. Anthu ena omwe molakwa amatenga methotrexate kamodzi tsiku lililonse m'malo kamodzi sabata iliyonse amakhala ndi zovuta zoyipa kapena amwalira.

Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani methotrexate ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati mukumwa methotrexate kuchiza psoriasis kapena nyamakazi, dokotala wanu akhoza kukuyambitsani pamlingo wochepa wa mankhwalawo ndikuwonjezera mlingo wanu pang'onopang'ono. Tsatirani malangizowa mosamala.

Ngati mukumwa methotrexate kuchiza nyamakazi, zimatha kutenga masabata 3 mpaka 6 kuti zizindikilo zanu ziyambe kusintha, komanso masabata 12 kapena kupitilira apo kuti mumve bwino methotrexate. Pitirizani kumwa methotrexate ngakhale mukumva bwino. Osasiya kumwa methotrexate osalankhula ndi dokotala.

Methotrexate imagwiritsidwanso ntchito pochiza matenda a Crohn (momwe chitetezo chamthupi chimagwirira ntchito m'mimba, kuchititsa kupweteka, kutsegula m'mimba, kuchepa thupi ndi malungo), multiple sclerosis (MS; momwe chitetezo chamthupi chimagwetsera misempha, kuyambitsa kufooka, dzanzi, kuchepa kwa kulumikizana kwa minofu, komanso mavuto amaso, malankhulidwe, ndi chikhodzodzo), ndi matenda ena amthupi okha (zomwe zimachitika pomwe chitetezo chamthupi chimagunda maselo athanzi mthupi mosazindikira). Funsani dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa chifukwa cha matenda anu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge methotrexate,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la methotrexate, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a methotrexate. Funsani dokotala wanu kapena wamankhwala mndandanda wa zosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe alembedwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: maantibayotiki ena monga chloramphenicol (chloromycetin), penicillin, ndi tetracyclines; folic acid (imapezeka yokha kapena ngati chophatikiza mu ma multivitamini ena); mankhwala ena a nyamakazi; phenytoin (Dilantin); ma probenecid (Benemid); sulfonamides monga co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), ndi sulfisoxazole (Gantrisin); ndi theophylline (Theochron, Theolair). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwakhala mukukhalapo ndi zina mwazomwe zatchulidwa mgawo la CHENJEZO LOFUNIKA kapena mulingo wochepa wamagazi m'magazi anu.
• osayamwitsa mkaka mukamamwa methotrexate.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa methotrexate.
• konzekerani kupeŵa kuwunika kosafunikira kapena kwakanthawi kwa kuwala kwa dzuwa kapena kuwala kwa ultraviolet (mabedi ofufuta ndi zowunikira) ndi kuvala zovala zoteteza, magalasi a dzuwa, ndi zotchinga dzuwa. Methotrexate imapangitsa khungu lanu kuzindikira kuwala kwa dzuwa kapena kuwala kwa ultraviolet. Ngati muli ndi psoriasis, zilonda zanu zitha kukulirakulira mukayika khungu lanu padzuwa mukamamwa methotrexate.
• mulibe katemera uliwonse mukamalandira mankhwala a methotrexate osalankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Methotrexate imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chizungulire
• Kusinza
• mutu
• kutupa m'kamwa
• kuchepa kudya
• maso ofiira
• kutayika tsitsi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kusawona bwino kapena kutaya masomphenya mwadzidzidzi
• kugwidwa
• chisokonezo
• kufooka kapena kuvuta kusuntha mbali imodzi kapena zonse ziwiri za thupi
• kutaya chidziwitso

Methotrexate imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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