Nelfinavir

Zamkati

• Musanatenge nelfinavir,
• Nelfinavir angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Nelfinavir imagwiritsidwa ntchito limodzi ndi mankhwala ena kuchiza kachilombo ka HIV. Nelfinavir ali mgulu la mankhwala otchedwa protease inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka HIV m'magazi. Ngakhale nelfinavir sichiza kachilombo ka HIV, imatha kuchepetsa mwayi wanu wopeza matenda a immunodeficiency syndrome (AIDS) ndi matenda okhudzana ndi HIV monga matenda akulu kapena khansa. Kumwa mankhwalawa pamodzi ndi kugonana mosatekeseka ndikusintha zina pamoyo wanu kumachepetsa chiopsezo chotenga kachirombo ka HIV kwa anthu ena.

Nelfinavir amabwera ngati piritsi komanso ufa woti amwe. Nthawi zambiri amatengedwa kawiri kapena katatu patsiku ndi chakudya. Tengani nelfinavir mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani nelfinavir ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati mukulephera kumeza phale, mutha kuliyika mugalasi ndikusungunula m'madzi pang'ono. Sakanizani madziwo, ndipo imwani nthawi yomweyo. Tsukani galasi ndi madzi ambiri ndikumeza chisakanizo chonse kuti muwonetsetse kuti mwamwa mankhwala onse.

Nelfinavir ufa wothira amatha kuwonjezeredwa m'madzi, mkaka, mkaka, mkaka wa soya, kapena zowonjezera zakudya. Sakanizani bwino, ndipo imwani madzi onse nthawi yomweyo kuti mutenge mokwanira. Chizindikiro chanu chamankhwala chimakuwuzani kuchuluka kwa ufa wa nelfinavir wowonjezera pamadzi. Ngati osakaniza satengedwa nthawi yomweyo amayenera kusungidwa mufiriji ndikutengedwa mkati mwa maola 6. Osasakaniza ufa wa m'kamwa wa nelfinavir ndi chakudya cha acidic kapena madzi (madzi a lalanje, msuzi wa apulo, kapena msuzi wa apulo). Osasakaniza nelfinavir ndi madzi mumtsuko wapachiyambi.

Nelfinavir imayang'anira kachilombo ka HIV koma siyimachiza. Pitirizani kumwa nelfinavir ngakhale mukumva bwino. Osasiya kumwa nelfinavir osalankhula ndi dokotala. Mukasiya kumwa nelfinavir kapena kudumpha mlingo, matenda anu amatha kukulirakulira kapena kusagwirizana ndi mankhwala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa nthawi zina amapatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge nelfinavir,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la nelfinavir, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a nelfinavir kapena ufa. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa alfuzosin (Uroxatral); amiodarone (Cordarone, Nexterone, Pacerone); cisapride (Propulsid; sikupezeka ku U.S.); mankhwala amtundu wa ergot monga bromocriptine (Cycloset, Parlodel), dihydroergotamine (D.H 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (Ergomar, ku Cafergot, ku Migergot), ndi methylergonovine (Methergine); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Ndime) pakamwa; pimozide (Orap); quinidine (mu Nuedexta); rifampin (Rimactane, Rifadin, ku Rifater, ku Rifamate); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); simvastatin (Zocor, ku Vytorin); Chingwe cha St. ndi triazolam (Halcion). Dokotala wanu angakuuzeni kuti musamwe nelfinavir ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('opopera magazi') monga warfarin (Coumadin, Jantoven); azithromycin (Azasite, Zithromax, Zmax); chifuwa (Tracleer); mankhwala ena oletsa calcium-amlodipine (Norvasc, ku Prestalia, ku Twynsta, ena), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), nimodipine (Nymalize), ndi nisoldipine (Sular); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, ena); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet) ndi rosuvastatin (Crestor); colchicine (Colcrys, Mitigare); delavirdine (Wolemba) fluticasone (Flonase, Flovent; ku Advair); indinavir (Crixivan); mankhwala omwe amaletsa chitetezo cha mthupi monga cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune, Torisel), ndi tacrolimus (Astagraf XL, Prograf); methadone (Dolophine, Methadose); nevirapine (Viramune); ena a phosphodiesterase inhibitors (PDE-5 inhibitors) omwe amagwiritsidwa ntchito pa erectile dysfunction monga sildenafil (Viagra), tadalafil (Adcirca, Cialis), ndi vardenafil (Levitra); phenobarbital; phenytoin (Dilantin, Phenytek); proton-pump inhibitors monga esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ndi rabeprazole (AcipHex); quetiapine (Seroquel); rifabutin (Mycobutin); ritonavir (Norvir, ku Kaletra, ku Viekira Pak); salmeterol (Serevent, ku Advair); saquinavir (Invirase); ndi trazodone. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi nelfinavir, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa didanosine (Videx), imwani ola limodzi musanadutse kapena kupitirira maola awiri kuchokera pa nelfinavir.
• uzani dokotala wanu ngati mukumwa mapiritsi oletsa kubereka. Nelfinavir ikhoza kuchepetsa mphamvu yolera yakumwa. Muyenera kugwiritsa ntchito njira ina yolerera mukamamwa mankhwalawa. Lankhulani ndi dokotala wanu za zakulera mukamamwa nelfinavir.
• auzeni adotolo ngati mwadwalapo kapena munadwalapo matenda a shuga, hemophilia (gulu la zovuta zobadwa nazo zotuluka magazi momwe kuthekera kwa magazi kuundana sikuli kwachilendo), kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga nelfinavir, itanani dokotala wanu. Simuyenera kuyamwa ngati muli ndi kachilombo ka HIV ndipo mukumwa nelfinavir.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa nelfinavir.
• muyenera kudziwa kuti mafuta amthupi lanu amatha kuchuluka kapena kusunthira mbali zosiyanasiyana za thupi lanu, monga msana wanu wam'mwamba, khosi ('buffalo hump'), mabere, komanso mozungulira m'mimba mwanu. Mutha kuwona kutaya mafuta m'thupi, kumaso, miyendo, ndi mikono.
• muyenera kudziwa kuti mutha kukhala ndi hyperglycemia (kuchuluka kwa shuga m'magazi anu) mukamamwa mankhwalawa, ngakhale mulibe matenda ashuga. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi mukamamwa nelfinavir: ludzu lokwanira, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kapena kufooka. Ndikofunika kuyimbira dokotala wanu mukangomva izi, chifukwa shuga wambiri yemwe samalandira mankhwala amatha kuyambitsa vuto lalikulu lotchedwa ketoacidosis. Ketoacidosis imatha kukhala pangozi ngati singachiritsidwe koyambirira. Zizindikiro za ketoacidosis zimaphatikizira pakamwa pouma, nseru ndi kusanza, kupuma movutikira, mpweya womwe umanunkhira zipatso, ndikuchepetsa chidziwitso.
• ngati muli ndi phenylketonuria (PKU, mkhalidwe wobadwa nawo momwe muyenera kudya chakudya chapadera kuti muchepetse kuchepa kwamaganizidwe), muyenera kudziwa kuti nelfinavir ufa wothira umakomedwa ndi aspartame yomwe imapanga phenylalanine.
• muyenera kudziwa kuti pamene mukumwa mankhwala ochizira kachilombo ka HIV, chitetezo chanu cha mthupi chingakhale champhamvu ndikuyamba kulimbana ndi matenda ena omwe anali kale mthupi lanu. Izi zitha kukupangitsani kukhala ndi zizindikilo za matendawa. Ngati muli ndi zizindikilo zatsopano kapena zowonjezereka nthawi iliyonse mukamachiza nelfinavir, onetsetsani kuti mwauza dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Nelfinavir angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• nseru
• mpweya
• kupweteka m'mimba
• kusowa chilakolako
• zidzolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• ming'oma
• kuyabwa
• kuvuta kupuma kapena kumeza

Nelfinavir ili ndi mankhwala omwe amapezeka kuti amayambitsa khansa m'matumba a labotale. Food and Drug Administration (FDA) yapempha wopanga kuti asinthe momwe nelfinavir amapangidwira kuti achepetse kuchuluka kwa mankhwalawa muzogulitsa za nelfinavir. Kuopsa kwa anthu sikudziwika koma kungakhale kwakukulu kwa ana ndi amayi apakati. Lankhulani ndi dokotala wanu za kuopsa kwakumwa nelfinavir.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Pambuyo pa ufa wa nelfinavir utawonjezera madzi, osakaniza amatha kusungidwa kutentha mpaka maola 6.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone kuyankha kwanu ku nelfinavir.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Sungani nelfinavir pafupi. Musayembekezere mpaka mutatsala pang'ono kumwa mankhwala kuti mudzaze mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Viracept^®