Aimovig (erenumab-aooe)

Zamkati

• Aimovig ndi chiyani?
• Mtundu watsopano wa mankhwala
• Aimovig generic
• Zotsatira zoyipa za Aimovig
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Matupi awo sagwirizana
• Kuchepetsa thupi / kunenepa
• Zotsatira zazitali
• Kudzimbidwa
• Kutaya tsitsi
• Nseru
• Kutopa
• Kutsekula m'mimba
• Kusowa tulo
• Kupweteka kwa minofu
• Kuyabwa
• Mtengo wa Aimovig
• Thandizo lazachuma
• Aimovig amagwiritsa ntchito
• Aimovig wa mutu wa migraine
• Ntchito zomwe sizivomerezedwa
• Mlingo wa Aimovig
• Mafomu ndi mphamvu
• Mlingo wa migraine
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Njira zina ku Aimovig
• Otsutsa a CGRP
• Aimovig vs. mankhwala ena
• Aimovig vs. Ajovy
• Aimovig vs. Botox
• Aimovig vs. Emgality
• Aimovig motsutsana ndi Topamax
• Aimovig ndi mowa
• Kuyanjana kwa Aimovig
• Momwe Aimovig amapangidwira
• Malangizo a momwe mungatengere Aimovig
• Momwe mungapangire jakisoni
• Kusunga nthawi
• Kutenga Aimovig ndi chakudya
• Yosungirako
• Momwe Aimovig amagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Aimovig ndi mimba
• Aimovig ndi kuyamwitsa
• Mafunso wamba okhudza Aimovig
• Kodi kuyimitsa Aimovig kumapangitsa kuti achoke?
• Kodi Aimovig ndi biologic?
• Kodi mungagwiritse ntchito Aimovig kuchiza mutu waching'alang'ala?
• Kodi Aimovig amachiza mutu waching'alang'ala?
• Kodi Aimovig amasiyana bwanji ndi mankhwala ena a migraine?
• Ngati nditenga Aimovig, kodi ndingaleke kumwa mankhwala anga ena?
• Aimovig bongo
• Zizindikiro zambiri za bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Machenjezo a Aimovig
• Kutha kwa Aimovig ndikusunga
• Zambiri zamaluso za Aimovig
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Aimovig ndi chiyani?

Aimovig ndi mankhwala odziwika ndi dzina la mankhwala omwe amagwiritsidwa ntchito popewera mutu wa mutu wa mutu kwa akulu. Imabwera mu cholembera chodzipangira chokha. Mumagwiritsa ntchito autoinjector kuti mudzipatse jakisoni kunyumba kamodzi pamwezi. Aimovig itha kulamulidwa muyezo umodzi: 70 mg pamwezi kapena 140 mg pamwezi.

Aimovig ili ndi mankhwala erenumab. Erenumab ndi antioclonal antibody, womwe ndi mtundu wa mankhwala opangidwa labu. Ma antibodies a monoclonal ndi mankhwala opangidwa kuchokera kuma cell a immune system. Amagwira ntchito poletsa zochitika za mapuloteni ena m'thupi lanu.

Aimovig itha kugwiritsidwa ntchito popewa episodic migraine komanso matenda opweteka a migraine. American Headache Society ilimbikitsa Aimovig kwa anthu omwe:

• sangachepetse kuchuluka kwawo kwa mutu waching'alang'ala wa migraine wokwanira ndi mankhwala ena
• sangathe kumwa mankhwala ena a migraine chifukwa cha zovuta zina kapena kulumikizana ndi mankhwala

Aimovig yawonetsedwa kuti ndiyothandiza pamaphunziro azachipatala. Kwa anthu omwe ali ndi migraine episodic, pakati pa 40 peresenti ndi 50 peresenti ya omwe adatenga Aimovig kwa miyezi isanu ndi umodzi adachepetsa masiku awo a migraine osachepera theka. Ndipo kwa anthu omwe ali ndi mutu waching'alang'ala wosatha, pafupifupi 40 peresenti ya omwe adatenga Aimovig adachepetsa masiku awo a migraine ndi theka kapena kupitilira apo.

Mtundu watsopano wa mankhwala

Aimovig ndi gawo la mankhwala atsopano otchedwa calcitonin peptide okhudzana ndi majini (CGRP) antagonists. Mankhwala amtunduwu adapangidwa kuti ateteze mutu waching'alang'ala.

Aimovig adalandira chilolezo cha Food and Drug Administration (FDA) mu Meyi 2018. Anali mankhwala oyamba kuvomerezedwa mgulu la omwe amatsutsana nawo a CGRP.

Mankhwala ena awiri m'kalasiyi adavomerezedwa pambuyo pa Aimovig: Emgality (galcanezumab) ndi Ajovy (fremanezumab). Mankhwala achinayi, otchedwa eptinezumab, pakadali pano akuwerengedwa m'mayesero azachipatala.

Aimovig generic

Aimovig sikupezeka mu mawonekedwe achibadwa. Zimangobwera ngati mankhwala odziwika ndi dzina.

Aimovig ili ndi mankhwala erenumab, omwe amatchedwanso erenumab-aooe. Nthawi zina "-aooe" nthawi zina amawonjezeredwa kuti asonyeze kuti mankhwalawa ndi osiyana ndi mankhwala ofanana omwe angapangidwe mtsogolo. Mankhwala ena oteteza ku monoclonal amakhalanso ndi mawonekedwe ngati awa.

Zotsatira zoyipa za Aimovig

Aimovig imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukatenga Aimovig. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Aimovig, kapena maupangiri amomwe mungachitire ndi zovuta zomwe mungakumane nazo, lankhulani ndi dokotala kapena wamankhwala.

Zindikirani: Food and Drug Administration (FDA) imatsata zotsatira zoyipa zamankhwala omwe avomereza. Ngati mukufuna kufotokozera FDA zotsatira zoyipa zomwe mudakhala nazo ndi Aimovig, mutha kutero kudzera ku MedWatch.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Aimovig zitha kuphatikiza:

• zochita za jakisoni (kufiira, khungu loyabwa, kupweteka)
• kudzimbidwa
• kukokana kwa minofu
• kutuluka kwa minofu

Zambiri mwa zotsatirazi zimatha pambuyo masiku angapo kapena milungu ingapo. Itanani dokotala wanu kapena wamankhwala ngati muli ndi zovuta zina kapena zovuta zomwe sizimatha.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Aimovig zitha kuchitika, koma sizofala. Zotsatira zoyipa zazikulu za Aimovig ndizowopsa kwambiri. Onani pansipa kuti mumve zambiri.

Matupi awo sagwirizana

Anthu ena amakumana ndi zovuta atatenga Aimovig. Izi ndizotheka ndi mankhwala ambiri. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• wokhala ndi zotupa pakhungu lako
• kumva kuyabwa
• kutenthedwa (kukhala ndi kutentha ndi kufiira pakhungu lanu)

Nthawi zambiri, zovuta zowopsa zimatha kuchitika. Zizindikiro zakukhudzidwa kwambiri zimatha kuphatikizira izi:

• kukhala ndi kutupa pansi pa khungu lanu (makamaka m'makope anu, milomo, manja, kapena mapazi)
• kumva kupuma movutikira kapena kupuma movutikira
• Kutupa lilime, pakamwa, kapena pakhosi

Itanani dokotala wanu nthawi yomweyo ngati mukuganiza kuti mukuvutika ndi Aimovig. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukudwala mwadzidzidzi.

Kuchepetsa thupi / kunenepa

Kuchepetsa thupi ndi kunenepa kunanenedwa m'maphunziro azachipatala a Aimovig. Komabe, anthu ena amatha kuwona kusintha kwakulemera kwawo pa chithandizo cha Aimovig. Izi zikhoza kukhala chifukwa cha migraine yokha osati Aimovig.

Anthu ena samva njala isanakwane, nthawi, kapena itatha migraine. Ngati izi zimachitika pafupipafupi, zimatha kubweretsa kuchepa thupi kosafunikira. Mukataya njala mukamadwala mutu waching'alang'ala, gwirani ntchito ndi dokotala kuti mupange dongosolo lazakudya lomwe limatsimikizira kuti mwapeza zakudya zonse zofunika.

Pamapeto ena a masewerawa, kunenepa kapena kunenepa kwambiri kumakhala kofala kwa anthu omwe ali ndi migraine. Ndipo kafukufuku wamankhwala awonetsa kuti kunenepa kwambiri kumatha kukhala pachiwopsezo cha kupweteka kwa mutu waching'alang'ala kapena mutu wambiri wama migraine.

Ngati mukuda nkhawa ndi momwe kulemera kwanu kumakhudzira mutu wanu wa migraine, lankhulani ndi dokotala wanu za njira zochepetsera kulemera kwanu.

Zotsatira zazitali

Aimovig ndi mankhwala omwe avomerezedwa posachedwa mgulu latsopano la mankhwala. Chotsatira chake, pali kafukufuku wochepa kwambiri wa nthawi yayitali wopezeka pa chitetezo cha Aimovig, ndipo ndizochepa zomwe zimadziwika pazotsatira zake zazitali.

Mu kafukufuku wina wazaka zambiri wazachitetezo yemwe adatenga pafupifupi zaka zitatu, zoyipa zomwe zimafotokozedwa ndi Aimovig zinali:

• kupweteka kwa msana
• matenda opuma opuma (monga chimfine kapena matenda a sinus)
• zizindikiro ngati chimfine

Ngati muli ndi zotsatirazi ndipo ali ovuta kapena osapita, lankhulani ndi dokotala wanu.

Kudzimbidwa

Kudzimbidwa kunachitika mpaka anthu 3 pa anthu 100 alionse omwe adatenga Aimovig m'maphunziro azachipatala.

Izi zitha kukhala chifukwa cha momwe Aimovig amakhudzira peptide yokhudzana ndi jini ya calcitonin (CGRP) mthupi lanu. CGRP ndi puloteni yomwe imapezeka m'matumbo ndipo imathandizira kuyenda bwino kwa matumbo. Aimovig amatseka zochitika za CGRP, ndipo izi zitha kuteteza matumbo kuti asachitike.

Ngati mukumva kudzimbidwa mukamamwa mankhwala ndi Aimovig, lankhulani ndi dokotala kapena wamankhwala zamankhwala omwe angakuthandizeni.

Kutaya tsitsi

Kutaya tsitsi si zotsatira zoyipa zomwe zakhudzana ndi Aimovig. Mukawona kuti tsitsi lanu likutha, kambiranani ndi adokotala pazomwe zingayambitse komanso chithandizo.

Nseru

Nausea si zotsatira zoyipa zomwe zidanenedwa ndikugwiritsa ntchito Aimovig. Komabe, anthu ambiri omwe ali ndi mutu waching'alang'ala amatha kumva kunyansidwa pakamutu ka mutu waching'alang'ala.

Ngati mukumva nseru pamutu wa mutu waching'alang'ala, zimatha kukhala m'malo amdima, opanda phokoso, kapena kutuluka panja kuti mupume mpweya wabwino. Muthanso kufunsa dokotala kapena wamankhwala za mankhwala omwe angathandize kupewa kapena kuchiza nseru.

Kutopa

Kutopa (kusowa kwa mphamvu) sizotsatira zoyipa zomwe zakhudzana ndi Aimovig. Koma kumva kutopa ndichizindikiro chodziwika bwino cha mutu waching'alang'ala chomwe anthu ambiri amamva musanafike, mkati, kapena mutatha mutu waching'alang'ala.

Kafukufuku wina wachipatala adawonetsa kuti anthu omwe ali ndi migraine omwe ali ndi mutu wopweteka kwambiri amatha kumva kutopa.

Ngati mukuvutitsidwa ndi kutopa, kambiranani ndi dokotala wanu za njira zowonjezera mphamvu zanu.

Kutsekula m'mimba

Kutsekula m'mimba si zotsatira zoyipa zomwe zagwiritsidwa ntchito ndi Aimovig. Komabe, ndi chizindikiro chosowa cha migraine. Pakhoza kukhala kulumikizana pakati pa migraine ndi matenda opweteka am'mimba ndi zovuta zina zam'mimba.

Ngati muli ndi kutsekula m'mimba komwe kumatenga nthawi yayitali kuposa masiku ochepa, lankhulani ndi dokotala wanu.

Kusowa tulo

Kusowa tulo (kuvutika kugona) si zotsatira zoyipa zomwe zapezeka m'maphunziro azachipatala a Aimovig. Komabe, kafukufuku wina wazachipatala adapeza kuti anthu omwe ali ndi mutu waching'alang'ala omwe ali ndi vuto losowa tulo amakonda kukhala ndi mutu waching'alang'ala wambiri. M'malo mwake, kusowa tulo kumatha kuyambitsa mutu wa migraine ndikuwonjezera chiopsezo chokhala ndi mutu waching'alang'ala.

Ngati muli ndi vuto la kugona ndipo mukuganiza kuti mwina likukukhudzani mutu wa migraine, lankhulani ndi dokotala wanu za njira zopezera kugona bwino.

Kupweteka kwa minofu

M'maphunziro azachipatala, anthu omwe adalandira Aimovig sanamve kupweteka kwa minofu. Ena anali ndi ziwopsezo zam'mimba ndi zotupa, ndipo pakuphunzira kwachitetezo cha nthawi yayitali, anthu omwe amatenga Aimovig adamva kuwawa kwammbuyo.

Ngati muli ndi ululu wam'mimba mukamamwa Aimovig, mwina chifukwa cha zifukwa zina. Mwachitsanzo, kupweteka kwa minofu m'khosi kungakhale chizindikiro cha migraine kwa anthu ena. Komanso, mayendedwe amalo obayira jekeseni, kuphatikiza kupweteka m'dera lozungulira jakisoni, kumatha kumva ngati kupweteka kwa minofu. Ululu wamtunduwu uyenera kutha patangopita masiku ochepa kuchokera mu jakisoni.

Ngati muli ndi kupweteka kwa minofu komwe sikumatha kapena kukukhudzani moyo wanu, kambiranani ndi dokotala wanu pazomwe mungachite kuti muchepetse ululu.

Kuyabwa

Kukhazikika konseko si vuto lomwe lidawoneka m'maphunziro azachipatala a Aimovig. Komabe, khungu loyabwa m'dera lomwe Aimovig adayikidwa limadziwika.

Khungu loyabwa pafupi ndi malo opangira jekeseni liyenera kutha patangopita masiku ochepa. Ngati muli ndi vuto lomwe silimatha, kapena ngati kuyabwa kuli kovuta, lankhulani ndi dokotala wanu.

Mtengo wa Aimovig

Monga mankhwala onse, mitengo ya Aimovig imatha kusiyanasiyana.

Mtengo wanu weniweni umadalira kukutetezani kwanu pa inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Thandizo lazachuma

Ngati mukufuna thandizo lazachuma kuti mulipire Aimovig, thandizo lilipo.

Amgen ndi Novartis, omwe amapanga Aimovig, amapereka pulogalamu ya Aimovig Ally Access Card yomwe ingakuthandizeni kulipira ndalama zochepa pobwezeretsanso mankhwala aliwonse. Kuti mumve zambiri komanso kuti mudziwe ngati ndinu woyenera, imbani 833-246-6844 kapena pitani patsamba lino.

Aimovig amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Aimovig kuti athetse kapena kupewa zina.

Aimovig wa mutu wa migraine

Aimovig ndivomerezedwa ndi FDA popewa mutu wa migraine mwa akulu. Kupweteka kwa mutu kumeneku ndi chizindikiro chofala kwambiri cha mutu waching'alang'ala, womwe ndi matenda amitsempha.

Zizindikiro zina zimatha kuchitika ndi mutu wa migraine, monga:

• nseru
• kusanza
• kutengeka ndi kuwala ndi mawu
• kuyankhula molakwika

Migraine imatha kuwerengedwa kuti ndi yaying'ono kapena yayikulu, malinga ndi International Headache Society. Aimovig imavomerezedwa kuti ipewe episodic migraine komanso kupweteka kwa mutu waching'alang'ala. Kusiyanitsa pakati pa mitundu iyi ya migraine ndi:

• episodic migraine imayambitsa kuchepa kwa mutu kwa 15 kapena masiku a migraine pamwezi
• Matenda a migraine amayamba masiku 15 kapena kupitilira apo pamwezi kwa miyezi itatu, osachepera masiku asanu ndi atatu kukhala masiku a migraine

Ntchito zomwe sizivomerezedwa

Aimovig itha kugwiritsidwanso ntchito ngati cholembera pazinthu zina. Kugwiritsa ntchito mankhwala osokoneza bongo ndi pamene mankhwala omwe amavomerezedwa kuti athetse vuto limodzi amalembedwa kuti athetse vuto lina.

Aimovig yamutu wamagulu

Aimovig sivomerezedwa ndi FDA kuti iteteze mutu wamagulu, koma itha kugwiritsidwa ntchito ngati cholembera pachifukwa ichi. Sikudziwika pano ngati Aimovig ndiwothandiza popewera mutu wamagulu.

Mutu wamagulu ndi zopweteka zomwe zimachitika m'magulu (mutu wambiri pakanthawi kochepa). Zitha kukhala zazing'ono kapena zosatha. Mitu yamagulu a Episodic imakhala ndi nthawi yayitali pakati pamasango amutu. Mutu wamagulu wamagulu amakhala ndi nthawi yayifupi pakati pamasango amutu.

Aimovig sanayesedwe kuti athetse mutu wamagulu m'maphunziro azachipatala. Komabe, mankhwala ena omwe ali m'gulu lomwelo la mankhwala monga Aimovig, kuphatikiza Emgality ndi Ajovy, adayesedwa.

Pakafukufuku wina wamankhwala, Emgality adapezeka kuti amathandizira kupewa mutu wama episodic. Koma poyesa kwachipatala kwa Ajovy, wopanga mankhwalawa adayimitsa kafukufukuyu koyambirira chifukwa Ajovy sanali kugwira ntchito kuti achepetse kuchuluka kwa mutu wamagulu osadukiza kwa anthu omwe akuphunzira.

Aimovig wamutu wamphesa

Aimovig sivomerezedwa ndi FDA kuti ateteze kapena kuchiritsa mutu wam'mutu. Kupweteka kwa vestibular kumakhala kosiyana ndi mutu wakale wa migraine chifukwa nthawi zambiri samakhala wopweteka. Anthu omwe ali ndi mutu wovala zovala amatha kumva chizungulire kapena kumva chizungulire. Zizindikirozi zimatha masekondi mpaka maola.

Kafukufuku wamankhwala sanachitikepo kuti awonetse ngati Aimovig ndiwothandiza popewa kapena kuchiritsa mutu wopindika. Koma madotolo ena amatha kusankha kupatsanso mankhwalawo pamankhwalawa.

Mlingo wa Aimovig

Mlingo wa Aimovig womwe dokotala amakupatsani umadalira pazinthu zingapo. Izi zikuphatikizapo kuopsa kwa zomwe mukugwiritsa ntchito Aimovig pochiza.

Nthawi zambiri, dokotala wanu amakupangitsani muyeso wochepa ndikusintha pakapita nthawi kuti mufike pamlingo woyenera kwa inu. Potsirizira pake adzapereka mankhwala ochepetsetsa omwe amapereka zomwe mukufuna.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mafomu ndi mphamvu

Aimovig imabwera muyezo umodzi, wopangira ma autoinjector omwe amagwiritsidwa ntchito kupangira jakisoni wocheperako (jakisoni yemwe amapita pansi pa khungu). The autoinjector amabwera mu mphamvu imodzi: 70 mg pa jakisoni. Choyimira chilichonse chimayenera kugwiritsidwa ntchito kamodzi kokha kenako nkuchotsa.

Mlingo wa migraine

Aimovig itha kuperekedwa muyezo umodzi: 70 mg kapena 140 mg. Mulingo uliwonse umatengedwa kamodzi pamwezi.

Ngati dokotala wanu akupatsani 70 mg, mudzadzipatsa jekeseni kamodzi pamwezi (pogwiritsa ntchito autoinjector imodzi). Ngati dokotala wanu akupatsani 140 mg, mudzadzipatsa jakisoni awiri pamwezi, wina pambuyo pake (pogwiritsa ntchito ma autoinjectors awiri).

Dokotala wanu ayamba kumwa mankhwala anu pa 70 mg pamwezi. Ngati mlingowu sukuchepetsa masiku anu a migraine, dokotala akhoza kukulitsa mlingo wanu mpaka 140 mg pamwezi.

Ndingatani ngati ndaphonya mlingo?

Tengani mlingo mukazindikira kuti mwaphonya imodzi. Mlingo wanu wotsatira uyenera kukhala mwezi umodzi pambuyo pake. Kumbukirani tsiku latsopanoli kuti mukonzekere zoyembekezera zanu zamtsogolo.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Ngati Aimovig ali othandiza kupewa mutu wa migraine kwa inu, inu ndi dokotala mungasankhe kupitiliza chithandizo ndi Aimovig nthawi yayitali.

Njira zina ku Aimovig

Mankhwala ena alipo kuti athandize kupewa mutu waching'alang'ala. Ena atha kukuthandizani kuposa ena. Ngati mukufuna kuyesa chithandizo china kupatula Aimovig, lankhulani ndi dokotala kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe FDA imavomereza popewa mutu waching'alang'ala ndi awa:

• Otsutsa ena a peptide okhudzana ndi majini a calcitonin (CGRP):
• fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Emgality)
• mankhwala ena olanda, monga:
• divalproex sodium (Depakote)
• topiramate (Topamax, Trokendi XR)
• mankhwala a neurotoxin onabotulinumtoxinA (Botox)
• beta-blocker propranolol (Inderal, Inderal LA)

Mankhwala ena amagwiritsidwa ntchito ngati chizindikiro kuti ateteze mutu waching'alang'ala. Mankhwalawa ndi awa:

• mankhwala opatsirana pogonana, monga amitriptyline kapena venlafaxine (Effexor XR)
• mankhwala ena olanda, monga valproate sodium
• ena beta-blockers, monga metoprolol (Lopressor, Toprol XL) kapena atenolol (Tenormin)

Otsutsa a CGRP

Aimovig ndi gawo la mankhwala atsopano otchedwa calcitonin gene-peptide (CGRP) antagonists. Aimovig adavomerezedwa ndi a FDA ku 2018 kuteteza mutu waching'alang'ala. Otsutsa ena awiri a CGRP otchedwa Ajovy and Emgality nawonso avomerezedwa posachedwa. Mankhwala achinayi mkalasi (eptinezumab) akuyembekezeka kuvomerezedwa posachedwa.

Momwe amagwirira ntchito

Otsutsa ovomerezeka a CGRP amagwira ntchito mofananamo popewa mutu wa migraine.

CGRP ndi mapuloteni m'thupi lanu omwe adalumikizidwa ndi kutupa ndi vasodilation (kukulira kwa mitsempha yamagazi) muubongo. Kutupa uku ndi vasodilation kumatha kubweretsa kupweteka kwamutu wa migraine. Kuti izi zitheke, CGRP iyenera kumangiriza (kulumikizana) ndi ma receptors ake, omwe ndi malo omwe ali pamwamba pama cell amubongo wanu.

Ajovy ndi Emgality zonse zimagwira ntchito mongodzipangira CGRP yokha. Zotsatira zake, CGRP siyingathe kumangika kwa omwe amalandila. Mosiyana ndi mankhwala ena awiri mkalasi muno, Aimovig amagwira ntchito pomanga ma cell cell receptors. Izi zimalepheretsa CGRP kuchita izi.

Poletsa CGRP kuti isalumikizane ndi cholandirira chake, mankhwala onse atatuwa amathandizira kuletsa kutupa ndi kupuma magazi. Izi zitha kuthandiza kupewa mutu wa migraine.

Mbali ndi mbali

Tchatichi pansipa chikufanizira chidziwitso chofunikira cha mankhwala atatu ovomerezeka a FDA mkalasi iyi omwe amagwiritsidwa ntchito popewa mutu waching'alang'ala. Kuti mudziwe zambiri za momwe Aimovig amafananira ndi mankhwalawa, onani gawo lotsatirali ("Aimovig vs. mankhwala ena").

Mitengo imatha kusiyanasiyana kutengera komwe muli, mankhwala omwe amagwiritsidwa ntchito, inshuwaransi yanu, ndi mapulogalamu othandizira opanga.

Aimovig vs. mankhwala ena

Mutha kudabwa momwe Aimovig amafanizira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. M'munsimu pali kufananizira pakati pa Aimovig ndi mankhwala angapo.

Aimovig vs. Ajovy

Aimovig ili ndi mankhwala erenumab, omwe ndi antioclonal antibody. Ajovy muli mankhwala fremanezumab, yemwenso ndi antioclonal antibody. Ma antibodies a monoclonal ndi mankhwala omwe amapangidwa labu. Mankhwalawa amapangidwa kuchokera ku ma chitetezo amthupi. Amagwira ntchito poletsa zochitika za mapuloteni ena m'thupi lanu.

Aimovig ndi Ajovy onse amasiya ntchito ya protein yotchedwa calcitonin peptide yokhudzana ndi jini (CGRP). CGRP imayambitsa kutupa ndi vasodilation (kukulira kwa mitsempha yamagazi) muubongo, zomwe zimatha kubweretsa mutu wa migraine. Kuletsa CGRP kumathandiza kupewa mutu waching'alang'ala.

Ntchito

Aimovig ndi Ajovy onse ndi ovomerezeka ndi FDA kuti ateteze mutu waching'alang'ala mwa akulu.

Mafomu ndi makonzedwe

Aimovig ndi Ajovy onse amabwera mu mawonekedwe ojambulidwa omwe amaperekedwa pansi pa khungu lanu (subcutaneous). Mutha kudzipatsa jekeseni kunyumba. Mankhwala onsewa amatha kudzipangira jekeseni m'malo ena, monga:

• mimba yako
• patsogolo pa ntchafu zanu
• kumbuyo kwa mikono yanu yakumtunda

Aimovig imaperekedwa ngati autoinjector imodzi ya mlingo umodzi. Nthawi zambiri amaperekedwa ngati jakisoni wa 70-mg kamodzi pamwezi. Komabe, anthu ena amapatsidwa mlingo wokwanira wa 140 mg mwezi uliwonse.

Ajovy amaperekedwa ngati jakisoni woyambira limodzi. Itha kuperekedwa ngati jakisoni umodzi wa 225 mg kamodzi pamwezi. Kapena itha kuperekedwa ngati jakisoni atatu a 225 mg kamodzi pamiyezi itatu iliyonse.

Zotsatira zoyipa ndi zoopsa

Aimovig ndi Ajovy amagwira ntchito mofananamo ndipo amayambitsa zovuta zina. Zotsatira zofala komanso zoyipa zamankhwala onsewa zili pansipa.

Zotsatira zofala kwambiri

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Aimovig, ndi Ajovy, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• kudzimbidwa
• kukokana kwa minofu kapena kuphipha
• matenda opuma opuma (monga chimfine kapena matenda a sinus)
• zizindikiro ngati chimfine
• kupweteka kwa msana
• Zitha kuchitika ndi Ajovy:
• Palibe zovuta zodziwika bwino
• Zitha kuchitika ndi Aimovig ndi Ajovy:
• zochita za jakisoni monga kupweteka, kuyabwa, kapena kufiira

Zotsatira zoyipa

Zotsatira zoyipa zoyipa kwa Aimovig ndi Ajovy ndizowopsa. Kuchita kotero sikofala, koma ndizotheka. (Kuti mumve zambiri, onani "Allergic reaction" pansi pa "Zotsatira za Aimovig" pamwambapa).

Chitetezo cha mthupi

M'mayesero azachipatala omwe adachitidwira Aimovig ndi Ajovy, anthu ochepa anali ndi chitetezo chamthupi chifukwa cha mankhwalawa. Izi zidapangitsa kuti matupi awo apange ma antibodies motsutsana ndi mankhwalawa.

Ma antibodies ndi mapuloteni opangidwa ndi chitetezo cha mthupi kuti athane ndi zinthu zakunja mthupi lanu. Thupi lanu limatha kupanga ma antibodies kuzinthu zilizonse zakunja, kuphatikiza ma monoclonal antibodies. Ngati thupi lanu limapanga ma antibodies kwa Aimovig kapena Ajovy, mankhwalawa sangakuthandizeninso.

M'mayesero azachipatala a Aimovig, anthu opitilira 6 peresenti adapanga ma antibodies a mankhwalawa. M'maphunziro azachipatala omwe akuchitika, ochepera 2 peresenti ya anthu adapanga ma antibodies ku Ajovy.

Chifukwa Aimovig ndi Ajovy adavomerezedwa mu 2018, kudakali molawirira kwambiri kuti mudziwe momwe izi zingakhalire zofala komanso momwe zingakhudzire momwe anthu adzagwiritsire ntchito mankhwalawa mtsogolo.

Kuchita bwino

Aimovig ndi Ajovy onse ndi othandiza poletsa mutu waching'alang'ala, koma sanafanane mwachindunji m'mayesero azachipatala.

Komabe, malangizo othandizira odwala mutu waching'alang'ala amalimbikitsa kugwiritsa ntchito mankhwala osokoneza bongo ngati njira kwa anthu ena. Ena mwa iwo ndi awa:

• sangathe kuchepetsa masiku awo a migraine mwezi uliwonse mokwanira ndi mankhwala ena
• sangathe kulekerera mankhwala ena chifukwa cha zovuta zina kapena kulumikizana ndi mankhwala

Migraine ya episodic

Kafukufuku wosiyanasiyana wa Aimovig ndi Ajovy adawonetsa zothandiza popewa mutu wama episodic migraine.

• M'maphunziro azachipatala a Aimovig, pafupifupi 40% ya anthu omwe ali ndi episodic migraine omwe amalandira 70 mg ya mankhwalawa pamwezi amadula masiku awo a migraine osachepera theka la miyezi isanu ndi umodzi. Mpaka 50 peresenti ya anthu omwe adalandira 140 mg anali ndi zotsatira zofananira.
• Pa kafukufuku wamankhwala wa Ajovy, pafupifupi 48% ya anthu omwe ali ndi episodic migraine omwe amalandila chithandizo mwezi uliwonse ndi mankhwalawa adachepetsa masiku awo a migraine osachepera theka la miyezi itatu. Pafupifupi 44 peresenti ya anthu omwe amalandira Ajovy miyezi itatu iliyonse anali ndi zotsatira zofananira.

Migraine yosatha

Kafukufuku wosiyanasiyana wa Aimovig ndi Ajovy adawonetsanso zothandiza popewa mutu wopweteka wa migraine.

• Mu kafukufuku wazachipatala wa miyezi itatu wa Aimovig, pafupifupi 40% ya anthu omwe ali ndi mutu waching'alang'ala omwe amalandila 70 mg kapena 140 mg ya mankhwalawa mwezi uliwonse anali ndi theka la masiku a migraine kapena ochepera.
• Mu kafukufuku wazachipatala wa miyezi itatu wa Ajovy, pafupifupi 41% ya anthu omwe ali ndi migraine osachiritsika omwe amalandila chithandizo cha mwezi ndi mwezi cha Ajovy anali ndi theka la masiku a migraine atalandira chithandizo kapena ochepera. Mwa anthu omwe amalandira Ajovy miyezi itatu iliyonse, pafupifupi 37% anali ndi zotsatira zofananira.

Mtengo

Aimovig ndi Ajovy onse ndi mankhwala omwe amadziwika ndi dzina. Palibe mitundu yabwinobwino ya mankhwala omwe alipo. Mankhwala omwe amatchulidwa ndi dzina nthawi zambiri amakhala okwera mtengo kuposa mafomu achibadwa.

Kutengera kuwerengera kochokera ku GoodRx.com, Aimovig ndi Ajovy amawononga ndalama zofanana. Mtengo weniweni womwe mungalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito. Mtengo wanu wa Aimovig udadaliranso ndi kuchuluka kwanu.

Aimovig vs. Botox

Aimovig ili ndi antioclonal antibody yotchedwa erenumab. Wotsutsana ndi monoclonal ndi mtundu wa mankhwala opangidwa mu labu. Mankhwalawa amapangidwa kuchokera ku ma chitetezo amthupi. Aimovig amayesetsa kupewa mutu waching'alang'ala potseka ntchito ya mapuloteni ena omwe angawayambitse.

Botox ili ndi mankhwala onabotulinumtoxinA. Mankhwalawa ndi a gulu la mankhwala otchedwa ma neurotoxin. Botox imagwira ntchito polepheretsa kwakanthawi minofu yomwe idalowetsedwa. Izi zimalepheretsa zizindikiritso zopweteka m'minyewa kuti zisagwiritsidwe ntchito.Zimaganiziridwa kuti njirayi imathandiza kupewa mutu wa migraine asanayambe.

Ntchito

Aimovig imavomerezedwa ndi FDA kuti ipewe ma episodic kapena matenda opweteka a migraine mwa akulu.

Botox ndivomerezedwa ndi FDA kuti ateteze matenda opweteka a migraine akulu. Botox imavomerezedwanso kuthana ndi mavuto ena angapo, monga:

• khomo lachiberekero dystonia (khosi lopindika lopweteka)
• kupweteka kwa chikope
• chikhodzodzo chopitirira muyeso
• kufalikira kwa minofu
• thukuta kwambiri

Mafomu ndi makonzedwe

Aimovig imabwera ngati dotolo lokhazikika lokhazikitsa autoinjector. Amapatsidwa ngati jakisoni pansi pa khungu lanu (subcutaneous) yomwe mutha kudzipatsa nokha kunyumba. Amapatsidwa mlingo wa 70 mg kapena 140 mg pamwezi.

Aimovig itha kubayidwa m'malo ena amthupi. Izi ndi:

• mimba yako
• patsogolo pa ntchafu zanu
• kumbuyo kwa mikono yanu yakumtunda

Botox imangoperekedwa ku ofesi ya dokotala. Imabayidwa ndi syringe mu mnofu (intramuscular), nthawi zambiri pamasabata 12 aliwonse. Malo omwe anthu amapangira jakisoni ndi awa:

• pamphumi panu
• kumbuyo kwa khosi lanu ndi mapewa
• Pamwamba komanso pafupi ndi makutu anu
• pafupi ndi tsitsi lanu kumapeto kwa khosi lanu

Dokotala wanu amakupatsani majakisoni ang'onoang'ono 31 m'malo awa nthawi iliyonse.

Zotsatira zoyipa ndi zoopsa

Aimovig ndi Botox onse amagwiritsidwa ntchito popewa mutu waching'alang'ala, koma amagwira ntchito m'njira zosiyanasiyana. Chifukwa chake, ali ndi zovuta zina zofanana ndipo zina zosiyana.

Zotsatira zofala kwambiri

Mndandandawu uli ndi zitsanzo za zovuta zoyipa zomwe zingachitike ndi Aimovig, ndi Botox, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• kudzimbidwa
• kukokana kwa minofu
• kutuluka kwa minofu
• kupweteka kwa msana
• matenda opuma opuma (monga chimfine kapena matenda a sinus)
• Zitha kuchitika ndi Botox:
• kupweteka mutu kapena kukulira migraine
• chikope kugwa
• ziwalo zaminyewa yamaso
• kupweteka kwa khosi
• kuuma minofu
• kupweteka kwa minofu ndi kufooka
• Zitha kuchitika ndi Aimovig ndi Botox:
• jakisoni malo zochita
• zizindikiro ngati chimfine

Zotsatira zoyipa

Mndandandawu uli ndi zitsanzo za zovuta zoyipa zomwe zingachitike ndi Aimovig, ndi Botox, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi Botox:
• kufalikira kwa ziwalo ku minofu yapafupi *
• vuto kumeza komanso kupuma
• matenda akulu
• Zitha kuchitika ndi Aimovig ndi Botox:
• aakulu thupi lawo siligwirizana

* Botox ali ndi chenjezo lochokera ku FDA lonena za kufalikira kwa ziwalo ku minofu yapafupi yotsatira jakisoni. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Chokhacho chomwe Aimovig ndi Botox amagwiritsidwa ntchito popewa ndi mutu waching'onoting'ono wa migraine.

Malangizo azachipatala amalimbikitsa Aimovig ngati njira kwa anthu omwe sangachepetse kuchuluka kwa migraine masiku ndi mankhwala osagwiritsidwa ntchito masiku onse. Zimalimbikitsidwanso kwa anthu omwe sangathe kumwa mankhwala ena chifukwa cha zovuta kapena kugwiritsa ntchito mankhwala osokoneza bongo.

Botox ikulimbikitsidwa ndi American Academy of Neurology ngati njira yothandizira anthu omwe ali ndi mutu waching'alang'ala.

Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, m'maphunziro osiyana, Aimovig ndi Botox onse adapeza zotsatira zabwino popewa mutu wopweteka wa migraine.

• Pa kafukufuku wamankhwala wa Aimovig, pafupifupi 40% ya anthu omwe ali ndi migraine osachiritsika omwe adalandira 70 mg kapena 140 mg anali ndi theka la masiku a migraine kapena ochepera miyezi itatu.
• M'maphunziro azachipatala a anthu omwe ali ndi mutu waching'alang'ala, Botox adachepetsa masiku akumutu mpaka masiku 9.2 pafupifupi pamwezi, pamasabata 24. Pakafukufuku wina, pafupifupi 47 peresenti ya anthu adachepetsa masiku awo akumutu ndi theka.

Mtengo

Aimovig ndi Botox onse ndi mankhwala omwe ali ndi mayina. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Botox nthawi zambiri imakhala yotsika mtengo kuposa Aimovig. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Aimovig vs. Emgality

Aimovig ili ndi antioclonal antibody yotchedwa erenumab. Mphamvu yaumwini imakhala ndi antioclonal antibody yotchedwa galcanezumab. Wotsutsana ndi monoclonal ndi mtundu wa mankhwala opangidwa mu labu. Mankhwalawa amapangidwa kuchokera ku ma chitetezo amthupi. Amagwira ntchito poletsa ntchito ya mapuloteni ena m'thupi lanu.

Aimovig ndi Emgality onse amaletsa ntchito ya mapuloteni mthupi lanu otchedwa calcitonin peptide yokhudzana ndi jini (CGRP). CGRP imayambitsa kutupa ndi vasodilation (kukulira kwa mitsempha yamagazi) muubongo, zomwe zimatha kubweretsa mutu wa migraine. Poletsa ntchito ya CGRP, mankhwalawa amathandiza kuletsa kutupa ndi kupuma magazi. Izi zimathandiza kupewa mutu waching'alang'ala.

Ntchito

Aimovig ndi Emgality onse ndi ovomerezeka ndi FDA kuti ateteze mutu waching'alang'ala mwa akulu.

Mafomu ndi makonzedwe

Aimovig imaperekedwa muyezo umodzi wokha wa autoinjector. Mphamvu zimapatsidwa mphamvu mu jakisoni woyambira m'modzi umodzi komanso cholembera chimodzi chodalira kamodzi. Mankhwala onsewa amaperekedwa ngati jakisoni wocheperako khungu (jakisoni pansi pa khungu). Mutha kudzipatsa jakisoni nokha kunyumba kamodzi pamwezi.

Mankhwala onsewa akhoza kubayidwa pansi pa khungu m'malo ena amthupi lanu. Izi ndi:

• mimba yako
• patsogolo pa ntchafu zanu
• kumbuyo kwa mikono yanu yakumtunda

Mphamvu imatha kubayidwa pansi pa khungu la matako anu.

Aimovig amalembedwa ngati 70-mg kapena 140-mg mwezi uliwonse. Mphamvu imaperekedwa ngati jakisoni wa 120-mg pamwezi.

Zotsatira zoyipa ndi zoopsa

Aimovig ndi Emgality ndi mankhwala ofanana omwe amayambitsa zovuta zomwezo. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Aimovig, ndi Emgality, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• kudzimbidwa
• kukokana kwa minofu
• kutuluka kwa minofu
• zizindikiro ngati chimfine
• Zitha kuchitika ndi Emgality:
• chikhure
• Zitha kuchitika ndi Aimovig ndi Emgality:
• jakisoni malo zochita
• kupweteka kwa msana
• matenda opatsirana apamwamba (monga chimfine kapena matenda a sinus)

Zotsatira zoyipa

Zomwe zimayambitsa matendawo ndizovuta kwambiri kwa Aimovig ndi Emgality. (Kuti mumve zambiri, onani "Allergic reaction" pansi pa "Zotsatira za Aimovig" pamwambapa).

Chitetezo cha mthupi

M'mayesero azachipatala pamankhwala aliwonse, anthu ochepa anali ndi chitetezo chamthupi cha Aimovig ndi Emgality. Ndi zoterezi, chitetezo cha mthupi chimapanga ma antibodies motsutsana ndi mankhwalawa.

Ma antibodies ndi mapuloteni mthupi lanu omwe amalimbana ndi zinthu zakunja mthupi lanu. Thupi lanu limatha kupanga ma antibodies kuzinthu zilizonse zakunja, kuphatikiza ma monoclonal antibody monga Aimovig ndi Emgality.

Ngati thupi lanu limapanga ma antibodies ku imodzi mwa mankhwalawa, ndizotheka kuti mankhwalawa sagwiranso ntchito popewera mutu wa migraine.

M'maphunziro azachipatala a Aimovig, opitilira 6 peresenti ya anthu omwe amamwa mankhwalawa adapanga ma antibodies kwa iwo. Ndipo m'maphunziro azachipatala a Emgality, pafupifupi 5% ya anthu adapanga ma antibodies a Emgality.

Chifukwa Aimovig ndi Emgality adavomerezedwa mu 2018, ndizoyambirira kwambiri kudziwa kuti ndi anthu angati omwe angakhale ndi zoterezi. Ndizofulumira kwambiri kudziwa momwe zingakhudzire momwe anthu adzagwiritsire ntchito mankhwalawa mtsogolo.

Kuchita bwino

Aimovig ndi Emgality sizinafananidwe m'maphunziro azachipatala, koma zonsezi ndizothandiza popewa mutu waching'alang'ala.

Maupangiri azithandizo amalimbikitsa Aimovig ndi Emgality ngati njira zosankhira anthu omwe ali ndi episodic kapena chronic migraine omwe:

• sangamwe mankhwala ena chifukwa cha zovuta zina kapena chifukwa chogwiritsa ntchito mankhwala osokoneza bongo
• sangathe kuchepetsa kuchuluka kwa masiku awo a migraine mwezi ndi mankhwala ena

Migraine ya episodic

Kafukufuku wosiyanasiyana wa Aimovig ndi Emgality adawonetsa kuti mankhwala onsewa ndi othandiza poletsa mutu wa episodic migraine:

• M'maphunziro azachipatala a Aimovig, mpaka 50 peresenti ya anthu omwe ali ndi episodic migraine omwe adalandira 140 mg ya mankhwalawa amachepetsa masiku awo a migraine osachepera theka la miyezi isanu ndi umodzi. Pafupifupi 40 peresenti ya anthu omwe adalandira 70 mg adawona zoterezi.
• M'maphunziro azachipatala a Emgality a anthu omwe ali ndi episodic migraine, pafupifupi 60% ya anthu adachepetsa masiku awo a migraine osachepera theka la miyezi isanu ndi umodzi ya Emgality chithandizo. Mpaka 16 peresenti anali opanda migraine pambuyo pa miyezi isanu ndi umodzi yothandizidwa.

Migraine yosatha

Kafukufuku wosiyanasiyana wa Aimovig ndi Emgality adawonetsa kuti mankhwala onsewa ndi othandiza kupewa mutu wopweteka wa migraine:

• Mu kafukufuku wazachipatala wa miyezi itatu wa anthu omwe ali ndi mutu waching'alang'ala, pafupifupi 40% ya anthu omwe adatenga 70 mg kapena 140 mg ya Aimovig anali ndi masiku theka la migraine kapena ochepera ndi chithandizo.
• Mu kafukufuku wazachipatala wa miyezi itatu wa anthu omwe ali ndi mutu waching'alang'ala, pafupifupi 30% ya anthu omwe adatenga Emgality miyezi itatu anali ndi theka la masiku a migraine kapena ochepera ndi chithandizo.

Mtengo

Aimovig ndi Emgality onse ndi mankhwala omwe amadziwika ndi dzina. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala osokoneza bongo nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Aimovig ndi Emgality amawononga pafupifupi ndalama zofananira. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Aimovig motsutsana ndi Topamax

Aimovig ili ndi antioclonal antibody yotchedwa erenumab. A monoclonal antibody ndi mtundu wa mankhwala opangidwa kuchokera ku ma chitetezo amthupi. Mankhwala amtunduwu amapangidwa mu labu. Aimovig amathandiza kupewa mutu waching'alang'ala pomaletsa ntchito ya mapuloteni omwe amawayambitsa.

Topamax imakhala ndi topiramate, mtundu wa mankhwala omwe amagwiritsidwanso ntchito kuthana ndi khunyu. Sizikudziwika bwino momwe Topamax imagwirira ntchito popewa mutu waching'alang'ala. Amaganiziridwa kuti mankhwalawa amachepetsa ma cell aminyewa ochulukirapo muubongo omwe angayambitse mutu waching'alang'ala.

Ntchito

Aimovig ndi Topamax onse ndi ovomerezeka ndi FDA kuti ateteze mutu waching'alang'ala. Aimovig imavomerezedwa kuti igwiritsidwe ntchito kwa akulu, pomwe Topamax imavomerezedwa kuti igwiritsidwe ntchito kwa akulu ndi ana azaka 12 kapena kupitilira apo.

Topamax imavomerezanso kuchiza khunyu.

Mafomu ndi makonzedwe

Aimovig amabwera mu pulogalamu imodzi yokha yoyikirapo autoinjector. Amapatsidwa ngati jakisoni pansi pa khungu lanu (subcutaneous) yomwe mumadzipereka kwanu kamodzi pamwezi. Mlingowu ndi 70 mg, koma anthu ena atha kupindula ndi kuchuluka kwa 140-mg.

Topamax imabwera ngati kapisozi wamlomo kapena piritsi yamlomo. Mlingo wamba ndi 50 mg womwe umatengedwa kawiri tsiku lililonse. Kutengera malingaliro a dokotala wanu, mutha kuyamba pamlingo wotsika ndikuwonjezera pamlingo woyenera kwa miyezi ingapo.

Zotsatira zoyipa ndi zoopsa

Aimovig ndi Topamax amagwira ntchito m'njira zosiyanasiyana m'thupi motero amakhala ndi zovuta zina. Zina mwazovuta zomwe zimachitika chifukwa cha mankhwalawa ndi pansipa. Mndandanda womwe uli pansipa mulibe zovuta zonse zomwe zingachitike.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Aimovig, ndi Topamax, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• jakisoni malo zochita
• kupweteka kwa msana
• kudzimbidwa
• kukokana kwa minofu
• kutuluka kwa minofu
• zizindikiro ngati chimfine
• Zitha kuchitika ndi Topamax:
• chikhure
• kutopa
• paresthesia (kumverera kwa "zikhomo ndi singano")
• nseru
• kutsegula m'mimba
• kuonda
• kusowa chilakolako
• zovuta kulingalira
• Zitha kuchitika ndi Aimovig ndi Topamax:
• matenda opatsirana (monga chimfine kapena matenda a sinus)

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Aimovig, ndi Topamax, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Aimovig:
• zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi Topamax:
• mavuto a masomphenya, kuphatikizapo khungu
• kuchepa thukuta (kulephera kuwongolera kutentha kwa thupi)
• kagayidwe kachakudya acidosis
• malingaliro ofuna kudzipha
• mavuto olingalira monga kusokonezeka ndi kukumbukira zinthu
• kukhumudwa
• encephalopathy (matenda aubongo)
• impso miyala
• kuwonjezeka kwa kugwidwa pamene mankhwala amaletsedwa mwadzidzidzi (pamene mankhwala amagwiritsidwa ntchito pochiza chithandizo)
• Zitha kuchitika ndi Aimovig ndi Topamax:
• aakulu thupi lawo siligwirizana

Kuchita bwino

Cholinga chokhacho Aimovig ndi Topamax ndi FDA -vomerezedwa ndi kupewa migraine.

Malangizo azachipatala amalangiza Aimovig ngati njira yolepheretsa kupweteka kwa mutu kwa anthu omwe:

• sangamwe mankhwala ena chifukwa cha zovuta zina kapena chifukwa chogwiritsa ntchito mankhwala osokoneza bongo
• sangachepetse kuchuluka kwawo kwa migraine mwezi uliwonse yokwanira ndi mankhwala ena

Malangizo azachipatala amalimbikitsa Topiramate ngati njira yopewa kupwetekedwa kwa mutu wamankhwala amisala.

Kafukufuku wamankhwala sanafananitse mwachindunji momwe mankhwalawa amagwirira ntchito popewa mutu waching'alang'ala. Koma mankhwalawa adaphunziridwa mosiyana.

Migraine ya episodic

Kafukufuku wosiyanasiyana wa Aimovig ndi Topamax adawonetsa kuti mankhwala onsewa anali othandiza popewera mutu wa episodic migraine:

• M'maphunziro azachipatala a Aimovig, mpaka 50 peresenti ya anthu omwe ali ndi episodic migraine omwe adalandira 140 mg adadula masiku awo a migraine osachepera theka la miyezi isanu ndi umodzi yothandizidwa. Pafupifupi 40 peresenti ya anthu omwe adalandira 70 mg adawona zoterezi.
• M'maphunziro azachipatala a anthu omwe ali ndi episodic migraine omwe adatenga Topamax, omwe ali ndi zaka 12 kapena kupitirira anali ndi mutu wochepa wa migraine mwezi uliwonse. Ana azaka zapakati pa 12 mpaka 17 omwe ali ndi episodic migraine anali ndi mutu wochepa wamutu waching'onoting'ono mwezi uliwonse.

Migraine yosatha

Kafukufuku wosiyanasiyana wa mankhwalawa adawonetsa kuti onse Aimovig ndi Topamax anali othandiza popewera mutu wopweteka wa migraine:

• Mu kafukufuku wazachipatala wa miyezi itatu wa Aimovig, pafupifupi 40% ya anthu omwe ali ndi mutu wopweteka wa migraine omwe amalandira 70 mg kapena 140 mg anali ndi masiku osachepera theka la migraine kapena ochepa atalandira chithandizo.
• Pakafukufuku yemwe adayang'ana zotsatira za mayesero angapo azachipatala adapeza kuti mwa anthu omwe ali ndi mutu waching'alang'ala, Topamax adachepetsa kuchuluka kwa migraine kapena kupweteka kwa mutu pafupifupi 5 mpaka 9 mwezi uliwonse.

Mtengo

Aimovig ndi Topamax onse ndi mankhwala omwe amadziwika ndi dzina. Mankhwala omwe amadziwika ndi dzina lawo nthawi zambiri amawononga ndalama zambiri kuposa mankhwala wamba. Aimovig sichipezeka mu mawonekedwe achibadwa, koma Topamax imabwera ngati generic yotchedwa topiramate.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Topamax itha kukhala yotsika mtengo kuposa Aimovig, kutengera mtundu wanu. Ndipo topiramate, mawonekedwe abwinobwino a Topamax, amawononga ndalama zochepa kuposa Topamax kapena Aimovig.

Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Aimovig ndi mowa

Palibe kulumikizana pakati pa Aimovig ndi mowa.

Komabe, anthu ena angaganize kuti mankhwalawa sagwira ntchito ngati amamwa mowa akamamwa Aimovig. Izi ndichifukwa choti mowa ungayambitse migraine kwa anthu ambiri. Ngakhale mowa pang'ono ungawapangitse mutu waching'alang'ala.

Muyenera kupewa zakumwa zomwe mumakhala ndi mowa mukazindikira kuti mowa umapweteka kwambiri kapena kupweteka mutu kwa mutu waching'alang'ala.

Kuyanjana kwa Aimovig

Mankhwala ambiri amatha kuyanjana ndi mankhwala ena. Zotsatira zosiyanasiyana zimatha kuyambitsidwa ndi kulumikizana kosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito, pomwe ena amatha kuyambitsa zovuta zina.

Aimovig nthawi zambiri samakhala ndi zochitika zamankhwala. Izi ndichifukwa cha momwe Aimovig amasinthidwa mthupi lanu.

Momwe Aimovig amapangidwira

Mankhwala ambiri, zitsamba, ndi zowonjezera zimapukusidwa (kukonzedwa) ndi michere m'chiwindi chanu. Koma mankhwala opatsirana a monoclonal antibody, monga Aimovig, samasinthidwa m'chiwindi. M'malo mwake, mankhwala amtunduwu amasinthidwa mkati mwa ma cell ena mthupi lanu.

Chifukwa Aimovig samakonzedwa m'chiwindi monga mankhwala ena ambiri, nthawi zambiri sagwirizana ndi mankhwala ena.

Ngati muli ndi nkhawa zakuphatikiza Aimovig ndi mankhwala ena omwe mwina mukumwa, lankhulani ndi dokotala wanu. Ndipo onetsetsani kuwauza zamankhwala onse, owonjezera pa counter, ndi mankhwala ena omwe mumamwa. Muyeneranso kuwauza za zitsamba zilizonse, mavitamini, ndi zowonjezera zakudya zomwe mumagwiritsa ntchito.

Malangizo a momwe mungatengere Aimovig

Aimovig imabwera ngati jakisoni yemwe amaperekedwa pansi pa khungu lanu (subcutaneous). Mumadzipatsa jakisoni kunyumba kamodzi pamwezi. Nthawi yoyamba yomwe mumalandira mankhwala a Aimovig, wothandizira zaumoyo wanu adzafotokoza momwe mungadziperekere jakisoni.

Aimovig amabwera mu mlingo umodzi (70 mg) autoinjector. Magalimoto aliwonse amakhala ndi gawo limodzi lokha ndipo amayenera kuti azigwiritsidwa ntchito kamodzi ndikuponyedwa. (Ngati dokotala wanu akupatsani 140 mg pamwezi, mumagwiritsa ntchito ma autoinjectors awiri mwezi uliwonse.)

Pansipa pali zambiri zamomwe mungagwiritsire ntchito syringe woyikiratu. Kuti mumve zambiri, kanema, ndi zithunzi za malangizo a jakisoni, onani tsamba la wopanga.

Momwe mungapangire jakisoni

Dokotala wanu adzakupatsani 70 mg kamodzi pamwezi kapena 140 mg kamodzi pamwezi. Ngati mwapatsidwa 70 mg pamwezi, mudzadzipatsa jekeseni imodzi. Ngati mwapatsidwa 140 mg pamwezi, mudzadzipatsa jakisoni awiri osiyana, wina ndi mnzake.

Kukonzekera jekeseni

• Tengani galimoto yanu ya Aimovig autoinjector mufiriji mphindi 30 musanakonzekere kubaya jekeseni wanu. Izi zithandizira kuti mankhwalawa azitha kutentha. Siyani kapu pazida zamagalimoto mpaka mutakonzeka kubaya mankhwalawo.
• Musayese kutentha autoinjector mwachangu poika ma microwave kapena kuyendetsa madzi otentha. Komanso, musagwedeze autoinjector. Kuchita izi kumatha kupanga Aimovig kukhala otetezeka komanso ogwira ntchito.
• Ngati mwangozi mwasiya autoinjector, musagwiritse ntchito. Zigawo zazing'ono za autoinjector zitha kuthyoka mkati, ngakhale simukuwona kuwonongeka kulikonse.
• Pamene mukuyembekezera Aimovig kuti abwere kutentha, fufuzani zina zomwe mungafune. Izi zikuphatikiza:
• kupukuta mowa
• mipira ya thonje kapena gauze
• zomangira zomatira
• chidebe chotayira chakuthwa
• Chongani autoinjector ndipo onetsetsani kuti mankhwala sakuwoneka ngati mitambo. Iyenera kukhala yopanda utoto wonyezimira kwambiri. Ngati imawoneka yotuwa, mitambo, kapena ili ndi zidutswa zolimba m'madzi, musazigwiritse ntchito. Ngati kuli kotheka, funsani dokotala wanu za kupeza chatsopano. Komanso, onani nthawi yomwe chipangizocho chitha kugwiritsa ntchito kuti muwonetsetse kuti mankhwalawo sanathe.
• Mukasamba m'manja ndi sopo, sankhani malo obayira jekeseni. Aimovig itha kubayidwa m'malo awa:
• mimba yanu (osachepera mainchesi awiri kuchokera kumimba kwanu)
• patsogolo pa ntchafu zanu (mainchesi awiri pamwamba pa bondo lanu kapena mainchesi awiri pansi pa kubuula kwanu)
• kumbuyo kwa mikono yanu yakumtunda (ngati wina akukupatsani jekeseni)
• Gwiritsani ntchito chopukutira mowa kuti muchotse malo omwe mukufuna kubaya. Lolani mowa uume kaye musanabaye mankhwalawo.
• Osabaya Aimovig mdera la khungu lomwe laphwanyidwa, lolimba, lofiira, kapena lofewa.

Kugwiritsa ntchito autoinjector

1. Kokani chipewa choyera molunjika pa autoinjector. Chitani izi pasanathe mphindi zisanu musanagwiritse ntchito chipangizocho.
2. Tambasulani kapena tsinani malo akhungu pomwe mukufuna kubayira mankhwalawo. Pangani malo olimba a khungu pafupifupi mainchesi awiri mulifupi mwa jekeseni wanu.
3. Ikani autoinjector pakhungu lanu pamakona a 90-degree. Tsimikizani molimba pakhungu lanu momwe mungathere.
4. Dinani botani loyambira lofiirira pamwamba pa autoinjector mpaka mutamva pitani.
5. Tulutsani batani loyambira koma pitilizani kugwiritsira ntchito autoinjector pakhungu lanu mpaka zenera la autoinjector litasanduka lachikasu. Muthanso kumva kapena dinani "dinani". Izi zitha kutenga masekondi 15. Ndikofunika kuchita izi kuti muwonetsetse kuti mwalandira mlingo wonse.
6. Chotsani autoinjector pakhungu lanu ndikuchotsa mu chidebe chanu chakuthwa.
7. Ngati pali magazi aliwonse pamalo opangira jekeseni, kanikizani mpira kapena thonje pakhungu, koma osapaka. Gwiritsani zomangira zomatira ngati zingafunike.
8. Ngati mulingo wanu ndi 140 mg pamwezi, bweretsani izi ndi wachiwiri wamagalimoto. Musagwiritse ntchito tsamba lomwenso munali jakisoni woyamba.

Kusunga nthawi

Aimovig ayenera kumwedwa kamodzi pamwezi. Ikhoza kumwedwa nthawi iliyonse patsiku.

Ngati mwaphonya mlingo, tengani Aimovig mukangokumbukira. Mlingo wotsatira uyenera kukhala mwezi umodzi mutamulandira. Kugwiritsa ntchito chida chokumbutsirani mankhwala kumatha kukuthandizani kukumbukira kukumbukira kutenga Aimovig panthawi yake.

Kutenga Aimovig ndi chakudya

Aimovig amatha kumwedwa kapena wopanda chakudya.

Yosungirako

Aimovig iyenera kusungidwa m'firiji. Itha kutulutsidwa mufiriji koma iyenera kugwiritsidwa ntchito pasanathe masiku asanu ndi awiri. Osayiikanso mufiriji ikangotulutsidwa ndikubweretsa firiji.

Osamaundana Aimovig. Komanso, sungani mu phukusi lake loyambirira kuti muteteze ku kuwala.

Momwe Aimovig amagwirira ntchito

Aimovig ndi mankhwala otchedwa monoclonal antibody. Mankhwala amtunduwu amapangidwa mu labu kuchokera ku mapuloteni amthupi. Aimovig amagwira ntchito poletsa ntchito ya protein m'thupi lanu yotchedwa pepcide yokhudzana ndi jini ya calcitonin (CGRP). CGRP imatha kuyambitsa kutupa ndi vasodilation (kukulira kwa mitsempha yamagazi) muubongo wanu.

Kutupa ndi vasodilation zomwe zimabwera ndi CGRP ndizomwe zimayambitsa mutu wa migraine. M'malo mwake, pamene mutu waching'alang'ala ukuyamba kuchitika, anthu amakhala ndi CGRP m'magazi awo ambiri. Aimovig amathandiza kupewa mutu waching'alang'ala poletsa ntchito za CGRP.

Ngakhale mankhwala ambiri amagwira ntchito pokhudzana ndi zinthu zambiri mthupi lanu, ma antibodies monoclonal monga Aimovig amagwiritsa ntchito protein imodzi yokha mthupi. Chifukwa chaichi, Aimovig imatha kuyambitsa kuchepa kwa mankhwala ndi zovuta zina. Izi zitha kukhala njira yabwino yochizira anthu omwe sangamwe mankhwala ena chifukwa cha zovuta zina kapena kulumikizana.

Aimovig amathanso kukhala njira yabwino yothandizira anthu omwe sanapeze mankhwala ena omwe angachepetse masiku awo a migraine.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Mukayamba kumwa Aimovig, zimatha kutenga milungu ingapo kuti muwone kusintha kwa mutu wanu wa migraine. Aimovig atha kugwira ntchito patadutsa miyezi ingapo.

Anthu ambiri omwe adatenga Aimovig panthawi yamayesero azachipatala anali ndi masiku ochepa a migraine m'mwezi umodzi asanayambe mankhwalawa. Anthu analinso ndi masiku ochepa a migraine atapitiliza kulandira chithandizo kwa miyezi ingapo.

Aimovig ndi mimba

Sipanakhale maphunziro okwanira kuti adziwe ngati Aimovig ndiwotheka kutenga nthawi yapakati. Kafukufuku wazinyama sanawonetse chiopsezo chilichonse pamimba pomwe Aimovig adapatsidwa mayi wapakati. Komabe, maphunziro a nyama samaneneratu nthawi zonse ngati mankhwala azikhala otetezeka mwa anthu.

Ngati muli ndi pakati kapena mukuganiza zokhala ndi pakati, lankhulani ndi dokotala wanu kuti muwone ngati Aimovig ali woyenera kwa inu. Mungafunike kudikirira mpaka simudzakhalanso ndi pakati kuti mugwiritse ntchito Aimovig.

Aimovig ndi kuyamwitsa

Sizikudziwika ngati Aimovig amadutsa mkaka wa m'mawere. Chifukwa chake, sizikudziwika ngati Aimovig ndiotetezeka kugwiritsa ntchito poyamwitsa.

Ngati mukuganiza zothandizidwa ndi Aimovig mukamayamwitsa mwana wanu, lankhulani ndi dokotala wanu za maubwino ndi zoopsa zake. Mungafunike kusiya kuyamwa mukayamba kumwa Aimovig.

Mafunso wamba okhudza Aimovig

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Aimovig.

Kodi kuyimitsa Aimovig kumapangitsa kuti achoke?

Sipanakhalepo malipoti azachuma atasiya Aimovig. Komabe, Aimovig adangovomerezedwa ndi FDA, mu 2018. Chiwerengero cha anthu omwe agwiritsa ntchito ndikuyimitsa mankhwala a Aimovig akadali ochepa.

Kodi Aimovig ndi biologic?

Inde. Aimovig ndi antioclonal antibody, yomwe ndi mtundu wa biologic. Biologic ndi mankhwala omwe amapangidwa kuchokera kuzinthu zakuthupi, osati mankhwala.

Chifukwa amalumikizana ndi maselo amthupi komanso mapuloteni, ma biologics monga Aimovig amalingaliridwa kuti ali ndi zovuta zochepa poyerekeza ndi mankhwala omwe amakhudza machitidwe amthupi ambiri, monga mankhwala ena a migraine amachitira.

Kodi mungagwiritse ntchito Aimovig kuchiza mutu waching'alang'ala?

Ayi. Aimovig amangogwiritsidwa ntchito popewa mutu waching'alang'ala usanayambike. Sizigwira ntchito yochiza mutu waching'alang'ala womwe wayamba kale.

Kodi Aimovig amachiza mutu waching'alang'ala?

Ayi, Aimovig sachiza mutu waching'alang'ala. Palibe mankhwala omwe alipo pakadali pano ochiza migraine.

Kodi Aimovig amasiyana bwanji ndi mankhwala ena a migraine?

Aimovig ndiyosiyana ndi mankhwala ena ambiri a migraine chifukwa anali mankhwala oyamba ovomerezeka a FDA omwe amapangidwa makamaka kuti ateteze mutu waching'alang'ala. Aimovig ndi gawo la mankhwala atsopano otchedwa calcitonin gene-peptide (CGRP) antagonists.

Mankhwala ambiri omwe amagwiritsidwa ntchito popewera mutu waching'alang'ala kwenikweni adapangidwa pazifukwa zina, monga kuchiza khunyu, kuthamanga kwa magazi, kapena kukhumudwa. Ambiri mwa mankhwalawa amagwiritsidwa ntchito osalemba kuti apewe mutu waching'alang'ala.

Kukhala jakisoni pamwezi kumapangitsanso Aimovig kukhala wosiyana ndi mankhwala ena ambiri opewera migraine. Ambiri mwa mankhwalawa amabwera ngati mapiritsi kapena mapiritsi. Botox ndi mankhwala ena omwe amabwera ngati jakisoni. Komabe, imayenera kuperekedwa ku ofesi ya dokotala kamodzi pa miyezi itatu iliyonse. Mutha kudzipatsa jakisoni wa Aimovig kunyumba.

Ndipo mosiyana ndi mankhwala ena ambiri opewera migraine, Aimovig ndi antioclonal antibody. Ichi ndi mtundu wa mankhwala opangidwa mu labu. Amapangidwa kuchokera kuma cell a immune system.

Ma antibodies a monoclonal amathyoledwa mkati mwa maselo osiyanasiyana mthupi. Mankhwala ena oteteza ku migraine amathyoledwa ndi chiwindi. Chifukwa cha kusiyana kumeneku, ma anti-monoclonal antibodies monga Aimovig amakonda kukhala ndi zocheperako pang'ono kuposa mankhwala ena omwe amagwiritsidwa ntchito popewa mutu waching'alang'ala.

Ngati nditenga Aimovig, kodi ndingaleke kumwa mankhwala anga ena?

Mwina. Thupi la munthu aliyense lidzayankha Aimovig mosiyana. Ngati Aimovig amachepetsa kuchuluka kwa mutu wa migraine womwe muli nawo, mutha kusiya kumwa mankhwala ena oteteza. Koma mukangoyamba kumene chithandizo chamankhwala, dokotala wanu angakulimbikitseni kuti muyambe kumwa Aimovig limodzi ndi mankhwala ena oteteza.

Mutamutenga Aimovig kwa miyezi iwiri kapena itatu, dokotala wanu adzakambirana nanu za momwe mankhwalawa akugwirira ntchito kwa inu. Inu ndi dokotala mutha kukambirana zosiya mankhwala ena oteteza omwe mumamwa kapena kuchepetsa kuchuluka kwa mankhwalawa.

Aimovig bongo

Kubaya jakisoni wambiri wa Aimovig kumatha kukulitsa chiopsezo chazobedwa patsamba lanu. Ngati muli ndi matupi awo sagwirizana ndi Aimovig kapena latex (chophatikizira m'mapaketi a Aimovig), mutha kukhala pachiwopsezo chazovuta zina.

Zizindikiro zambiri za bongo

Zizindikiro za bongo zingaphatikizepo:

• kupweteka kwambiri, kuyabwa, kapena kufiira mdera lomwe lili pafupi ndi jakisoni
• kuchapa
• ming'oma
• angioedema (kutupa pansi pakhungu)
• kutupa kwa lilime, mmero, kapena pakamwa
• kuvuta kupuma

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu kapena funsani malangizo kuchokera ku American Association of Poison Control Center ku 800-222-1222 kapena kudzera pa chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Machenjezo a Aimovig

Musanatenge Aimovig, lankhulani ndi dokotala wanu za mbiri yanu. Aimovig mwina sangakhale yoyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Zodzitetezela ziwengo. Aimovig autoinjector ili ndi mawonekedwe a mphira wofanana ndi latex. Izi zitha kuyambitsa vuto kwa anthu omwe sagwirizana ndi latex. Ngati muli ndi mbiri yokhudzana kwambiri ndi mankhwala omwe ali ndi latex, Aimovig mwina sangakhale mankhwala oyenera kwa inu.

Kutha kwa Aimovig ndikusunga

Aimovig akatulutsidwa ku pharmacy, wamankhwalayo adzawonjezera tsiku lomwe lidzalembedwe pa botolo. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe mankhwalawa adaperekedwa.

Cholinga cha masiku otha ntchitowa ndikutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito.

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mankhwalawo amasungidwira.

Aimovig yoyikapo autoinjector iyenera kusungidwa m'firiji. Itha kusungidwa kunja kwa firiji kwa masiku asanu ndi awiri. Osabwereranso mufiriji ikangotha ​​kutentha.

Musagwedezeke kapena kuundana ndi autoinjector wa Aimovig. Ndipo sungani autoinjector muzoyika zoyambirira kuti muteteze ku kuwala.

Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Zambiri zamaluso za Aimovig

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Njira yogwirira ntchito

Aimovig (erenumab) ndi anti-monoclonal antibody yomwe imamangiriza ku calcitonin peptide yokhudzana ndi majini (CGRP) receptor ndikulepheretsa CGRP ligand kuyambitsa cholandilira.

Pharmacokinetics ndi metabolism

Aimovig imayendetsedwa mwezi uliwonse ndipo imafika pakakhazikika pambuyo pamagawo atatu. Kutalika kwakukulu kumafikira masiku asanu ndi limodzi. Metabolism sizimachitika kudzera pa cytochrome P450 pathways.

Kulumikiza ku CGRP ndikokwanira ndipo kumayendetsa kuthekera pang'ono. Pamalo okwera kwambiri, Aimovig imachotsedwa kudzera munjira zapadera za proteolytic. Kuwonongeka kwa mphuno kapena chiwindi sikuyembekezeredwa kukhudza ma pharmacokinetic.

Zotsutsana

Palibe zotsutsana ndi ntchito ya Aimovig.

Yosungirako

Aimovig yoyikiratu autoinjector iyenera kusungidwa mufiriji pakatentha pakati pa 36⁰F ndi 46⁰F (2⁰C ndi 8⁰C). Itha kuchotsedwa mufiriji ndikusungidwa kutentha (mpaka 77⁰F, kapena 25⁰C) masiku asanu ndi awiri.

Sungani Aimovig muzoyika zoyambirira kuti muteteze ku kuwala. Osayiikanso mufiriji ikangotha ​​kutentha. Osamaundana kapena kugwedeza chojambula cha Aimovig.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.