Upangiri Wanu ku Anti-Androgens

Zamkati

• Kodi amazigwiritsa ntchito motani?
• Kwa akazi
• Kwa azimayi opatsirana pogonana komanso anthu osagwiritsa ntchito mabakiteriya
• Kwa amuna
• Kodi ndi ziti zomwe zimakhala zofala?
• Flutamide
• Spironolactone
• Cyproterone
• Zotsatira zake ndi ziti?
• Mfundo yofunika

Kodi anti-androgens ndi chiyani?

Androgens ndi mahomoni omwe amawongolera kukula kwa mikhalidwe yogonana. Nthawi zambiri, anthu obadwa ndi machitidwe ogonana amuna amakhala ndi ma androgens ambiri. Anthu obadwa ndi zikhalidwe za akazi amakhala ndi mayendedwe otsika a androgens. M'malo mwake, ali ndi ma estrogen ambiri.

Mankhwala a anti-androgen amagwira ntchito poletsa zotsatira za ma androgens, monga testosterone. Amachita izi pomanga mapuloteni otchedwa androgen receptors. Amamangirira kuzilandira izi kuti ma androgens sangathe.

Pali mitundu ingapo yama anti-androgens. Nthawi zambiri amatengedwa ndi mankhwala ena kapena panthawi ya opaleshoni.

Kodi amazigwiritsa ntchito motani?

Ma anti-androgens ali ndi ntchito zambiri, kuyambira kuyang'anira khansa ya prostate mpaka kuchepetsa tsitsi losafunika la nkhope.

Kwa akazi

Amayi onse mwachilengedwe amatulutsa ma androgens ochepa. Komabe, azimayi ena amabala zambiri kuposa ena.

Mwachitsanzo, amayi omwe ali ndi polycystic ovary syndrome (PCOS) amakhala ndi milingo yambiri ya androgen. Izi zitha kupangitsa kukula kwa tsitsi, ziphuphu, ndi ovulation. Anti-androgens atha kuthandiza kuchepetsa izi kwa azimayi omwe ali ndi PCOS.

Zina zomwe zimayambitsa ma androgens azimayi ndi monga:

• adrenal hyperplasia
• zotupa zamchiberekero
• zotupa za adrenal gland

Anti-androgens amatha kuthandizira kuthana ndi izi ndikupewa zovuta zomwe zimadza chifukwa cha milingo yayikulu ya azimayi. Mavutowa ndi awa:

• matenda ashuga
• cholesterol yambiri
• kuthamanga kwa magazi
• matenda amtima

Kwa azimayi opatsirana pogonana komanso anthu osagwiritsa ntchito mabakiteriya

Kwa anthu omwe akusintha, anti-androgens amatha kuthandizira kuletsa zina mwa masculinizing za testosterone. Amatha kuchepetsa machitidwe ena achimuna, monga:

• dazi lachimuna
• Kukula kwa tsitsi kumaso
• zosintha m'mawa

Anti-androgens ndi othandiza kwambiri kwa amayi opatsirana pogonana akamatengedwa ndi estrogen, mahomoni ogonana oyamba achikazi. Kuphatikiza pakupangitsa kukula kwa mawonekedwe achikazi, monga mabere, estrogen imachepetsanso milingo ya testosterone. Kutenga anti-androgens ndi estrogen kungathandize kuthana ndi zikhalidwe zachimuna ndikulimbikitsa zachikazi.

Kwa anthu omwe amadziwika kuti siosankhika, kutenga anti-androgens kokha kumatha kuchepetsa machitidwe achimuna.

Kwa amuna

Androgens amachititsa kuti maselo a khansa akule mu prostate. Kuchepetsa mayendedwe a androgen, kapena kuteteza ma androgens kuti asafikire maselo a khansa, kumatha kuchepetsa khansa. Zingathenso kuchepetsa zotupa zomwe zilipo kale.

Kumayambiriro koyamba, maselo a kansa ya prostate amadalira ma androgens kuti adyetse kukula kwawo. Anti-androgens amagwira ntchito poletsa ma androgens kuti asamangidwe ndi ma androgen receptors m'maselo a kansa ya prostate. Izi zimapha njala maselo a khansa a androgens omwe amafunikira kuti akule.

Komabe, anti-androgens samasiya kupanga androgen. Nthawi zambiri amagwiritsidwa ntchito limodzi ndi mankhwala ena, monga opaleshoni kapena kupopera mankhwala. Kuphatikiza kumeneku kumatchedwanso:

• kuphatikiza kutsekedwa kwa androgen
• wathunthu androgen blockade
• okwana androgen blockade

Kodi ndi ziti zomwe zimakhala zofala?

Pali ma anti-androgens angapo omwe amapezeka, iliyonse imagwiritsidwa ntchito mosiyanasiyana. Nazi zina mwazofala kwambiri.

Flutamide

Flutamide ndi mtundu wa anti-androgen womwe umagwiritsidwa ntchito ndi mankhwala ena kuti athetse mitundu ina ya khansa ya prostate. Flutamide imamangiriza ndi ma receptors a androgen m'maselo a khansa ya prostate, omwe amaletsa ma androgens kuti asamangidwe kumalandila. Izi zimalepheretsa ma androgens kuti asalimbikitse kukula kwa maselo a khansa ya prostate.

Spironolactone

Spironolactone (Aldactone) ndi mtundu wa anti-androgen womwe wagwiritsidwa ntchito pochizira ziphuphu zam'madzi komanso tsitsi lalitali kwambiri. Kusintha kwa anthu kumatha kuzitenga kuti muchepetse zikhalidwe zachimuna. Ngakhale kulibe umboni wochepa wotsimikizira kugwiritsidwa ntchito kwake, aperekeni kwa dazi lachitsanzo lachikazi.

Cyproterone

Cyproterone inali imodzi mwa anti-androgens yoyamba. Ndi mankhwala ena ochizira amayi omwe ali ndi PCOS. Zikuwonetsedwanso pamlingo wa testosterone komanso kupanga kwamafuta opangitsa ziphuphu.

Itha kugwiritsidwanso ntchito kuchepetsa zikhalidwe zachimuna mwa akazi opitilira muyeso. Komabe, chifukwa cha zovuta zake, nthawi zambiri samakondedwa.

Zotsatira zake ndi ziti?

Anti-androgens amatha kupanga zovuta zingapo, kutengera mtundu ndi mtundu womwe mumatenga.

Zotsatira zina zoyipa ndizo:

• kugonana kotsika
• chiopsezo chowonjezeka cha kukhumudwa
• okwera michere ya chiwindi
• tsitsi la nkhope ndi thupi lochepetsedwa
• chiopsezo chachikulu cha zopunduka zobadwa ngati mutamwita pakati
• matenda a chiwindi
• kuvulala kwa chiwindi
• Kulephera kwa erectile
• kutsegula m'mimba
• chikondi cha m'mawere
• kutentha
• kusasamba kwa msambo
• zotupa pakhungu
• anti-androgen kukana, kutanthauza kuti mankhwala amasiya kugwira ntchito

Dokotala wanu akhoza kukuthandizani kusankha anti-androgen yomwe ikugwirizana bwino ndi zosowa zanu ndipo imabwera ndi zotsatira zochepa kwambiri.

Mfundo yofunika

Anti-androgens amagwiritsidwa ntchito kwambiri kwa amuna, akazi, ndi anthu pakusintha kwa jenda, pawokha komanso molumikizana ndi mankhwala ndi mankhwala ena. Komabe, anti-androgens ndi mankhwala amphamvu omwe angayambitse zovuta zina. Gwiritsani ntchito ndi dokotala kuti muone ubwino ndi kuipa kwa kumwa anti-androgens.