Funsani Katswiri: Chizindikiro kapena Zotsatira Zoyipa?

Zamkati

• 1. Kodi pali kusiyana kotani pakati pa kunjenjemera ndi dyskinesia?
• Kugwedezeka kwa Parkinson
• 2. Kodi pali njira zowonekera zosiyanitsira kunjenjemera ndi dyskinesia?
• 3. Kodi ndizizindikiro ziti za dyskinesia yomwe imayambitsa mankhwala osokoneza bongo?
• Kugwedezeka kwa Parkinson
• 4. Nchifukwa chiyani mankhwala ena a Parkinson amachititsa dyskinesia?
• 5. Kodi ndingatani kuti ndithane ndi mankhwala opatsirana pogwiritsa ntchito mankhwala osokoneza bongo? Siyani?
• Parkinson yotulutsa dyskinesia
• 6. Kodi mavuto ena a dyskinesia ndi ati?

1. Kodi pali kusiyana kotani pakati pa kunjenjemera ndi dyskinesia?

Kugwedezeka komwe kumawoneka mu matenda a Parkinson ndi chimodzi mwazizindikiro zodziwika bwino za vutoli. Ndi chimodzi mwazizindikiro zamagalimoto a Parkinson zomwe zikuwonetsa kusintha ndi mankhwala.

Kumbali inayi, dyskinesia imakonda kuwonekera pambuyo pake pakakhala matenda ngati zotsatira zazitali za mankhwala omwe amagwiritsidwa ntchito pochizira a Parkinson. Nthawi zina zimakhala zovuta kudziwa ngati mayendedwe achilendo ali kunjenjemera kapena dyskinesia.

Kugwedezeka kwa Parkinson

Kawirikawiri, ndi Parkinson, munthuyo wawonjezeka kwambiri pamene manja akupuma kapena kuthandizidwa ndi thupi motsutsana ndi mphamvu yokoka ndiyeno bwino pamene mikono ikuyenda.

Dr. Crunch Youtube

2. Kodi pali njira zowonekera zosiyanitsira kunjenjemera ndi dyskinesia?

Kusiyanitsa kwakukulu ndikuti kunjenjemera kumakhala koyenda bwino, makamaka mozungulira limodzi. Dyskinesia sikuti imangodzipangira, komanso nthawi zambiri imasokonezeka. Kugwedezeka komwe kumalumikizidwa ndi Parkinson nthawi zambiri kumatha kuponderezedwa ndikusuntha komanso kuchita, pomwe dyskinesia sichoncho.

3. Kodi ndizizindikiro ziti za dyskinesia yomwe imayambitsa mankhwala osokoneza bongo?

Zimachitika ndi chithandizo chanthawi yayitali cha mankhwala a matenda a Parkinson, makamaka levodopa (Sinemet, Duopa). Kutalika komwe munthu amakhala ndi vutoli komanso ngati akhala akumamwa mankhwala (makamaka pamiyeso yayikulu), chiopsezo chachikulu chokhala ndi dyskinesia yomwe imayambitsa mankhwala.

Kugwedezeka kwa Parkinson

Kupsinjika, chisangalalo, ndi kuchuluka kwa kupumula zonse zimakhudza kuopsa kwa kunjenjemera kwa Parkinson.

alireza

4. Nchifukwa chiyani mankhwala ena a Parkinson amachititsa dyskinesia?

Sizikudziwika bwinobwino chifukwa chake mankhwala a Parkinson amachititsa dyskinesia. Mumikhalidwe yabwinobwino, pamakhala zolimbikitsa mosalekeza ndi dopamine. Mu Parkinson's, chizindikiro cha dopamine chikusowa. Komabe, mankhwala opangidwa kuti asinthe chizindikiro cha dopamine amabweretsa "zokopa" zopangira dopamine. Zimaganiziridwa kuti kukwera-ndi-kutsika kwa siginolo ya dopamine ndi komwe kumayambitsa matenda opatsirana ndi mankhwala osokoneza bongo.

5. Kodi ndingatani kuti ndithane ndi mankhwala opatsirana pogwiritsa ntchito mankhwala osokoneza bongo? Siyani?

Kusamalira ma dyskinesia omwe amayamba chifukwa cha mankhwala osokoneza bongo kungakhale kovuta. Njira imodzi yothandiza ndikuchepetsa kuchuluka kwa mankhwala, makamaka levodopa. Komabe, izi zitha kubweretsa zina mwazizindikiro zamagalimoto zokhudzana ndi Parkinson kubwerera.

Mitundu yatsopano ndi njira zoperekera mankhwala zimapereka kutulutsidwa kwakanthawi kwamankhwala ndikuthandizira kuchepetsa zizindikiro za dyskinesia. Mafotokozedwe olimbikitsidwa ndi kulowetsedwa m'matumbo mwachindunji ndi zitsanzo za njirazi.

Mibadwo yatsopano yamankhwala osakhala levodopa, monga safinamide, Xadago (a monoamine oxidase B inhibitor), ndi opicapone (catechol-O-methyltransferase inhibitor) awonetsanso lonjezo pochepetsa dyskinesia.

Kuchita opaleshoni ya Parkinson, monga kuzama kwa ubongo (DBS), kumathandizanso kuchepetsa zizindikilo za dyskinesia. Izi mwina chifukwa DBS imathandizira pafupipafupi kuchepetsa kuchuluka kwa mankhwala omwe amafunikira a Parkinson.

Parkinson yotulutsa dyskinesia

Pogwiritsira ntchito mankhwala a Parkinson kwa nthawi yayitali, monga levodopa, munthu amatha kudwala matenda osokonekera, ngakhale mankhwalawa atathandizira zizindikiritso za Parkinson koyambirira kwa matendawa.

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6. Kodi mavuto ena a dyskinesia ndi ati?

Mofanana ndi zizindikilo zina za matenda a Parkinson, dyskinesia imatha kusokoneza zochitika za tsiku ndi tsiku monga kudya ndi kumwa. Komabe, dyskinesia yokha sichizindikiro cha zoopsa zomwe zimayambitsa. Zimasonyeza kukula kwa matendawa.

Choopsa chachikulu pakukula kwa mankhwala opatsirana pogwiritsa ntchito mankhwala osokoneza bongo ndi kutalika kwa nthawi yomwe munthu wakhala ndi Parkinson. Dyskinesia ikayamba, zikutanthauzanso kuti munthuyo sangakhale womvera pamankhwala azachizolowezi. Zitha kutanthauza kuti ayenera kusintha magwiridwe antchito kapena kapangidwe ka mankhwala.

Dr. Seunggu Jude Han ndi pulofesa wothandizira wa zamitsempha ku Oregon Health and Sciences University ku Portland, Oregon. Wakhala akuwunika zamankhwala ku Healthline kuyambira 2016 ndipo awunikiranso nkhani zopitilira 200.