Atripla (efavirenz / emtricitabine / tenofovir disoproxil fumarate)

Zamkati

• Atripla ndi chiyani?
• Atripla generic
• Zotsatira zoyipa za Atripla
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Kulemera
• Pancreatitis
• Zotsatira zoyipa mwa ana
• Chitupa
• Matenda okhumudwa
• Kupewa kudzipha
• Mtengo wa Atripla
• Thandizo lazachuma komanso inshuwaransi
• Atripla amagwiritsa ntchito
• Atripla wa HIV
• Ntchito zomwe sizivomerezedwa
• Atripla ya ana
• Mlingo wa Atripla
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa HIV
• Mlingo wa ana
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa kwa nthawi yayitali?
• Kutsatira dongosolo lanu la mankhwala a Atripla
• Njira zina ku Atripla
• Mankhwala ena ophatikizana
• Mankhwala payekha
• Atripla motsutsana ndi Genvoya
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Atripla vs. mankhwala ena
• Atripla vs. Truvada
• Atripla vs. Complera
• Momwe mungatenge Atripla
• Kusunga nthawi
• Kutenga Atripla pamimba yopanda kanthu
• Kodi Atripla itha kuphwanyidwa?
• Atripla ndi mowa
• Kuyanjana kwa Atripla
• Atripla ndi mankhwala ena
• Atripla ndi Viagra
• Atripla ndi zitsamba ndi zowonjezera
• Atripla ndi zakudya
• Momwe Atripla amagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Kodi ndiyenera kumwa mankhwalawa kwa nthawi yayitali?
• Atripla ndi mimba
• Atripla ndi kuyamwitsa
• Mafunso wamba okhudza Atripla
• Kodi Atripla ingayambitse kukhumudwa?
• Kodi Atripla amachiza HIV?
• Kodi Atripla ingapewe kachilombo ka HIV?
• Kodi chimachitika ndi chiyani ndikaphonya magawo angapo a Atripla?
• Machenjezo a Atripla
• Chenjezo la FDA: Kukula kwa chiwindi cha B (HBV)
• Machenjezo ena
• Atripla bongo
• Zizindikiro zambiri za bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Kutha kwa Atripla
• Zambiri za Atripla
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Atripla ndi chiyani?

Atripla ndi mankhwala odziwika omwe amagwiritsidwa ntchito pochiza HIV kwa akulu ndi ana. Amaperekedwa kwa anthu omwe amalemera osachepera 88 mapaundi (40 kilogalamu).

Atripla itha kugwiritsidwa ntchito yokha ngati mtundu wathunthu wamankhwala (dongosolo). Itha kugwiritsidwanso ntchito limodzi ndi mankhwala ena. Imabwera ngati piritsi limodzi lokhala ndi mankhwala atatu:

• efavirenz (600 mg), yomwe ndi non-nucleoside reverse transcriptase inhibitor (NNRTI)
• tenofovir disoproxil fumarate (300 mg), yomwe ndi nucleoside analog reverse transcriptase inhibitor (NRTI)
• emtricitabine (200 mg), yemwenso ndi nucleoside analog reverse transcriptase inhibitor (NRTI)

Malangizo apano samalimbikitsa Atripla ngati chithandizo choyambirira kwa anthu ambiri omwe ali ndi HIV. Izi ndichifukwa choti pali mankhwala atsopano omwe angakhale otetezeka kapena othandiza kwa anthu ambiri. Komabe, Atripla itha kukhala yoyenera kwa anthu ena. Dokotala wanu adzakusankhirani chithandizo chabwino kwambiri kwa inu.

Ndikofunika kuzindikira kuti Atripla sivomerezedwa kuti tipewe HIV.

Atripla generic

Atripla imangopezeka ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Atripla ili ndi zinthu zitatu zomwe zimagwiritsidwa ntchito popanga mankhwala: efavirenz, emtricitabine, ndi tenofovir disoproxil fumarate. Iliyonse ya mankhwalawa imapezeka m'mitundu yosiyanasiyana. Pakhoza kukhalanso mankhwala ena osakanikirana omwe amapezeka ngati zowonjezera.

Zotsatira zoyipa za Atripla

Atripla imatha kuyambitsa zovuta kapena zoyipa. Mndandanda wotsatirawu muli zovuta zina zomwe zingachitike mukamamwa Atripla. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Atripla, kapena maupangiri amomwe mungachitire ndi zovuta zina, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Atripla zitha kuphatikiza:

• kutsegula m'mimba
• nseru
• mutu
• mphamvu zochepa
• maloto achilendo
• zovuta kulingalira
• chizungulire
• kuvuta kugona
• kukhumudwa
• zotupa kapena khungu loyabwa
• kuchuluka kwa cholesterol

Zotsatira zoyipa zambiri mndandandandawu ndizosavuta m'chilengedwe. Ngati ali ovuta kwambiri kapena amalephera kupitiriza kumwa mankhwala anu, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Atripla sizofala, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi zachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Kukula kwakukulu kwa chiwindi cha B (HBV). Zizindikiro zimatha kuphatikiza:
  • kutopa
  • mkodzo wamtundu wakuda
  • kupweteka kwa thupi ndi kufooka
  • chikasu cha khungu lako ndi oyera m'maso mwako
• Chitupa. Izi zimachitika mkati mwa milungu iwiri kuyambira Atripla ndipo zimatha zokha patatha mwezi umodzi. Zizindikiro zimatha kuphatikiza:
  • ofiira, khungu loyabwa
  • ziphuphu pakhungu
• Kuwonongeka kwa chiwindi. Zizindikiro zimatha kuphatikiza:
  • chikasu cha khungu lako ndi oyera m'maso mwako
  • kupweteka kumtunda chakumanja kwa mimba yanu (mmimba)
  • nseru ndi kusanza
• Khalidwe limasintha. Zizindikiro zimatha kuphatikiza:
  • kukhumudwa
  • Maganizo ofuna kudzipha
  • nkhanza
  • Kusokonezeka maganizo
• Mavuto amanjenje amanjenje. Zizindikiro zimatha kuphatikiza:
  • kuyerekezera zinthu m'maganizo
• Kuwonongeka kwa impso. Zizindikiro zimatha kuphatikiza:
  • kupweteka kwa mafupa
  • kupweteka m'manja kapena miyendo yanu
  • kuphwanya mafupa
  • kupweteka kwa minofu kapena kufooka
• Kutaya mafupa. Zizindikiro zimatha kuphatikiza:
  • kupweteka kwa mafupa
  • kupweteka m'manja kapena miyendo yanu
  • kuphwanya mafupa
• Kugwedezeka. Zizindikiro zimatha kuphatikiza:
  • kutaya chidziwitso
  • kutuluka kwa minofu
  • mano okuta mano
• Kupanga kwa lactic acid ndi kuwonongeka kwa chiwindi. Zizindikiro zimatha kuphatikiza:
  • kutopa
  • kupweteka kwa minofu ndi kufooka
  • kupweteka kapena kusapeza bwino m'mimba mwanu (m'mimba)
• Immune reconstitution syndrome (chitetezo chamthupi chikamakula bwino ndikuyamba "kugwira ntchito mopitirira muyeso"). Zizindikiro zimatha kuphatikiza:
  • malungo
  • kutopa
  • matenda
  • zotupa zam'mimba zotupa
  • zotupa kapena chilonda cha khungu
  • kuvuta kupuma
  • kutupa mozungulira maso anu
• Kusintha kwamayendedwe amafuta ndi mawonekedwe amthupi. Zizindikiro zimatha kuphatikiza:
  • kuchulukitsa mafuta kuzungulira pakati panu (torso)
  • Kukula kwa mtanda wamafuta kumbuyo kwamapewa anu
  • mawere okulitsidwa (mwa amuna ndi akazi)
  • kuchepa thupi pamaso, mikono, ndi miyendo

Kulemera

Kunenepa kunalibe vuto lina lomwe linachitika m'maphunziro azachipatala a Atripla. Komabe, chithandizo chamankhwala ambiri a HIV chimatha kunenepa. Izi ndichifukwa choti kachilombo ka HIV kangachepetse thupi, chifukwa chake kuchiza vutoli kumatha kubweretsanso kulemera komwe kudatayika.

Anthu omwe amatenga Atripla amatha kuzindikira kuti mafuta awo asunthira kumadera osiyanasiyana mthupi lawo. Izi zimatchedwa lipodystrophy. Mafuta amthupi amatha kusunthira pakatikati pa thupi lanu, monga m'chiuno mwanu, m'mawere, ndi m'khosi. Itha kusunthira kutali ndi mikono ndi miyendo yanu.

Sizikudziwika ngati zotsatirazi zimatha pakapita nthawi, kapena ngati zitatha mutasiya kugwiritsa ntchito Atripla. Ngati mukumva izi, uzani dokotala wanu. Angakusinthireni ku mankhwala ena.

Pancreatitis

Ndizochepa, koma kapamba (zotupa zotupa) zakhala zikuwoneka mwa anthu omwe amamwa mankhwala omwe amakhala ndi efavirenz. Efavirenz ndi amodzi mwa mankhwala atatu omwe amapezeka ku Atripla.

Kuchuluka kwa michere ya kapamba yawonedwa mwa anthu ena omwe amatenga efavirenz, koma sizikudziwika ngati izi zinali zolumikizidwa ndi kapamba.

Uzani dokotala wanu ngati mukukumana ndi zizindikiro za kapamba. Izi zimaphatikizira kupweteka kwa torso, nseru kapena kusanza, kugunda kwamtima, komanso m'mimba wofewa kapena wotupa. Dokotala wanu akhoza kukupatsani mankhwala ena.

Zindikirani: Pancreatitis imadziwika kawirikawiri pogwiritsa ntchito mankhwala ena a HIV monga didanosine.

Zotsatira zoyipa mwa ana

M'maphunziro azachipatala a Atripla, zovuta zoyipa zambiri mwa ana zinali zofanana ndi za akulu. Rash ndi imodzi mwazovuta zomwe zimachitika kawirikawiri mwa ana.

Ziphuphu zidachitika mwa ana 32%, pomwe akulu 26% okha ndi omwe adachita zotupa. Kutupa kwa ana nthawi zambiri kumawonekera masiku 28 atayamba chithandizo ndi Atripla. Pofuna kupewa kupsa mtima kwa mwana wanu, adokotala angawauze kuti azigwiritsa ntchito mankhwala osagwirizana ndi mankhwalawa ngati antihistamines asanayambe chithandizo cha Atripla.

Zotsatira zina zoyipa zomwe zimawonedwa mwa ana koma osati achikulire zimaphatikizapo kusintha kwa khungu, monga ziphuphu kapena khungu lakuda. Izi zimakonda kupezeka m'manja kapena pamapazi. Zotsatira zoyipazi zimaphatikizanso kuchepa kwa magazi m'thupi, ndizizindikiro monga kuchepa kwa mphamvu, kugunda kwamtima, komanso manja ndi mapazi ozizira.

Chitupa

Rash ndi vuto lofala kwambiri la mankhwala a Atripla.

M'mayesero azachipatala, ziphuphu zidachitika mwa 26% mwa achikulire omwe adalandira efavirenz, imodzi mwa mankhwala ku Atripla. Pakhala pali malipoti onena za zotupa zoyipa zomwe zidagwiritsidwa ntchito ndi efavirenz, koma zidangochitika mwa 0,1% yaanthu omwe adaphunzira. Ziphuphu zomwe zimayambitsa matuza kapena zilonda zotseguka zidachitika mwa anthu 0,9%.

Ziphuphu zambiri zomwe zimawonedwa ndi efavirenz zinali zofewa mpaka zolimbitsa thupi, zokhala ndi malo ofiira komanso otakasuka komanso zina zotupa pakhungu. Ziphuphu zamtunduwu zimatchedwa maculopapular rash. Zotupazi zimapezeka mkati mwa masabata awiri kuyambira pomwe mankhwala a efavirenz adayamba ndipo zidatha mwezi umodzi kuchokera pomwe zidayamba.

Uzani dokotala wanu ngati mutayamba kupsa mtima mukamamwa Atripla. Mukakhala ndi zotupa kapena malungo, siyani kumwa Atripla ndikuyimbira dokotala nthawi yomweyo. Dokotala wanu akhoza kukupatsani mankhwala kuti athetse vutoli. Ngati zotupazo ndizolimba, atha kukusinthani mankhwala ena.

Zindikirani: Munthu akangotenga kachilombo ka HIV, kupupuluma kumatha kukhala chizindikiro choyambirira. Kuthamanga uku kumatha milungu iwiri kapena 4. Koma ngati mwakhala muli ndi kachilombo ka HIV kwakanthawi ndipo mwangoyamba kumene kulandira chithandizo ndi Atripla, kuphulika kwatsopano kumatha kukhala chifukwa cha Atripla.

Matenda okhumudwa

Matenda okhumudwa anali vuto lofala pakuyesedwa kwa Atripla. Zinachitika mu 9% ya anthu omwe amamwa mankhwalawa.

Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro za kukhumudwa. Izi zitha kuphatikiza kukhumudwa, kutaya chiyembekezo, komanso kusachita chidwi ndi zochitika za tsiku ndi tsiku. Dokotala wanu akhoza kukusinthani mankhwala ena a HIV. Angathenso kulangiza chithandizo cha matenda anu ovutika maganizo.

Kupewa kudzipha

• Ngati mumadziwa wina yemwe ali pachiwopsezo chodzivulaza, kudzipha, kapena kukhumudwitsa munthu wina:
• Imbani 911 kapena nambala yadzidzidzi yakomweko.
• Khalani ndi munthuyu kufikira akatswiri atafika.
• Chotsani zida zilizonse, mankhwala, kapena zinthu zina zomwe zitha kuvulaza.
• Mverani munthuyo popanda chiweruzo.
• Ngati inu kapena munthu wina amene mumamudziwa ali ndi malingaliro ofuna kudzipha, foni yochepetsera ikhoza kuthandizira. National Suicide Prevention Lifeline imapezeka maola 24 patsiku pa 800-273-8255.

Mtengo wa Atripla

Monga mankhwala onse, mtengo wa Atripla umasiyana.

Mtengo wanu weniweni umatengera inshuwaransi yanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Atripla, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Gilead Sciences, Inc., wopanga Atripla, amapereka pulogalamu yotchedwa Advancing Access. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 800-226-2056 kapena pitani patsamba lino.

Atripla amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Atripla kuti athetse mavuto ena. Atripla wavomerezedwa kokha kuchiza kachilombo ka HIV.

Atripla wa HIV

Atripla imavomerezedwa kuchiza kachilombo ka HIV mwa akulu ndi ana omwe amalemera pafupifupi mapaundi 88 (40 kilograms). Atripla imagwiritsidwa ntchito yokha kapena kuphatikiza mankhwala ena a HIV.

Mankhwala atsopano a kachilombo ka HIV amavomerezedwa kwa anthu omwe sanamwe mankhwala a HIV kapena osakhazikika pa mankhwala ena a HIV. Atripla alibe kugwiritsa ntchito koteroko kovomerezeka.

Ntchito zomwe sizivomerezedwa

Atripla sivomerezedwa ndi ntchito zina zilizonse. Iyenera kugwiritsidwa ntchito pochiza HIV.

Atripla wa hepatitis B

Atripla sivomerezeka chifukwa cha matenda a chiwindi a B ndipo sayenera kugwiritsidwa ntchito pochiza. Komabe, imodzi mwa mankhwala ku Atripla (tenofovir disoproxil fumarate) amagwiritsidwa ntchito kuchiza matenda otupa chiwindi a B.

Atripla wa PEP

Atripla sivomerezedwa ndipo sayenera kugwiritsidwa ntchito pa post-exposure prophylaxis (PEP). PEP amatanthauza kugwiritsa ntchito mankhwala a HIV mukatha kupezeka ndi kachilombo ka HIV kuti mupewe kutenga kachiromboka.

Kuphatikiza apo, Atripla sivomerezedwa ndipo sayenera kugwiritsidwa ntchito pa pre-exposure prophylaxis (PrEP). PrEP amatanthauza kugwiritsa ntchito mankhwala a HIV musanathenso kupezeka ndi HIV kuti muteteze matenda.

Mankhwala okhawo ovomerezeka ndi FDA a PrEP ndi Truvada, omwe ali ndi emtricitabine ndi tenofovir disoproxil fumarate. Ngakhale Atripla ili ndi mankhwala onsewa, sanawerengedwe ngati njira yodzitetezera ku HIV.

Atripla ya ana

Atripla itha kugwiritsidwa ntchito kuchiza kachilombo ka HIV mwa anthu amisinkhu iliyonse bola atalemera pafupifupi mapaundi 88 (40 kilograms). Izi zimaphatikizapo ana.

Mlingo wa Atripla

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani.

Mitundu ya mankhwala ndi mphamvu

Atripla imabwera ngati piritsi. Piritsi lililonse lili ndi mankhwala atatu:

• 600 mg wa efavirenz
• 300 mg wa tenofovir disoproxil fumarate
• 200 mg wa emtricitabine

Mlingo wa HIV

Piritsi limodzi la Atripla liyenera kutengedwa kamodzi tsiku lililonse pamimba yopanda kanthu (popanda chakudya). Nthawi zambiri, zimayenera kumwa nthawi yogona.

Mlingo wa ana

Mlingo wa Atripla wa ana ndi wofanana ndi kuchuluka kwa akulu. Mlingowu sukusintha kutengera zaka.

Ndingatani ngati ndaphonya mlingo?

Ngati mukumwa Atripla ndikuphonya mlingo, tengani mlingo wotsatira mukakumbukira. Ngati ili pafupi nthawi ya mlingo wanu wotsatira, ingotengani mlingo wotsatirawo. Simuyenera kuwirikiza kawiri mlingo wanu kuti muwonjeze mlingo womwe mwaphonya.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa kwa nthawi yayitali?

Ngati inu ndi dokotala mukuganiza kuti Atripla ndi chithandizo chabwino kwa inu, muyenera kuyitenga nthawi yayitali.

Mukangoyamba kulandira chithandizo, musasiye kumwa Atripla osalankhula ndi dokotala poyamba.

Kutsatira dongosolo lanu la mankhwala a Atripla

Kutenga mapiritsi a Atripla ndendende momwe dokotala akukuuzani ndikofunikira. Kutenga Atripla pafupipafupi kumakulitsa mwayi wanu wachipatala.

Mlingo wosowa ungakhudze momwe Atripla amagwirira ntchito pochizira HIV. Ngati mwaphonya mlingo, mutha kukana Atripla. Izi zikutanthauza kuti mankhwalawa sagwiranso ntchito kuchiza kachilombo ka HIV.

Ngati muli ndi hepatitis B komanso HIV, muli ndi chiopsezo chowonjezera. Mlingo wosowa wa Atripla ungayambitse matenda anu a chiwindi a B.

Onetsetsani kuti mwatsatira malangizo a dokotala wanu ndikutenga Atripla kamodzi patsiku, tsiku lililonse, pokhapokha dokotala atakuwuzani zina. Kugwiritsira ntchito chida chokumbutsani kungakhale kothandiza poonetsetsa kuti mumatenga Atripla tsiku lililonse.

Ngati muli ndi mafunso kapena nkhawa za mankhwala anu a Atripla, lankhulani ndi dokotala wanu. Amatha kuthana ndi zovuta zilizonse zomwe mungakhale nazo ndikuthandizira kuwonetsetsa kuti Atripla akukuchitirani zabwino.

Njira zina ku Atripla

Kuphatikiza pa Atripla, pali mankhwala ena ambiri omwe angachiritse HIV. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Atripla, lankhulani ndi dokotala kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Mankhwala ena ophatikizana

Anthu onse omwe ali ndi kachilombo ka HIV amayenera kumwa mankhwala oposa mmodzi. Pachifukwa ichi, pali mankhwala ambiri osakaniza a HIV omwe alipo. Mankhwalawa ali ndi mankhwala opitilira umodzi. Atripla ndi mankhwala osakaniza omwe ali ndi mankhwala atatu: emtricitabine, tenofovir disoproxil fumarate, ndi efavirenz.

Zitsanzo za mankhwala ena ophatikizira omwe amapezeka pochiza HIV ndi awa:

• Biktarvy (bictegravir, emtricitabine, ndi tenofovir alafenamide)
• Complera (emtricitabine, rilpivirine, ndi tenofovir disoproxil fumarate)
• Descovy (emtricitabine ndi tenofovir alafenamide)
• Genvoya (elvitegravir, cobicistat, emtricitabine, ndi tenofovir alafenamide)
• Juluca (dolutegravir ndi rilpivirine)
• Odefsey (emtricitabine, rilpivirine, ndi tenofovir alafenamide)
• Stribild (elvitegravir, cobicistat, emtricitabine, ndi tenofovir disoproxil fumarate)
• Symtuza (darunavir, cobicistat, emtricitabine, ndi tenofovir alafenamide)
• Triumeq (abacavir, dolutegravir, ndi lamivudine)
• Truvada (emtricitabine ndi tenofovir disoproxil fumarate)

Mankhwala payekha

Kwa munthu aliyense yemwe ali ndi kachilombo ka HIV, dokotala wake amamukonzera dongosolo lamankhwala lomwe adzawathandizire makamaka. Izi zikhoza kukhala mankhwala osakaniza, kapena akhoza kukhala osiyana mankhwala.

Mankhwala ambiri omwe amapezeka mwa kuphatikiza mankhwala a HIV amapezeka paokha. Dokotala wanu akhoza kukuwuzani zambiri zamankhwala omwe atha kukuthandizani.

Atripla motsutsana ndi Genvoya

Mutha kudabwa momwe Atripla amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa, tikuwona momwe Atripla ndi Genvoya alili ofanana komanso osiyana.

Ntchito

Atripla ndi Genvoya ali ovomerezeka kuchiza kachilombo ka HIV. Genvoya imavomerezedwa kuti igwiritsidwe ntchito kwa anthu amisinkhu iliyonse bola atalemera pafupifupi mapaundi 55 (25 kilogalamu). Atripla, kumbali inayo, imavomerezedwa kuti igwiritsidwe ntchito kwa anthu amisinkhu iliyonse bola atalemera pafupifupi mapaundi 88 (40 kilograms).

Mafomu azamankhwala ndi makonzedwe

Onse Atripla ndi Genvoya amabwera ngati mapiritsi amkamwa omwe amatengedwa kamodzi tsiku lililonse. Genvoya ayenera kumwedwa ndi chakudya, pomwe Atripla ayenera kumwedwa wopanda kanthu. Ndipo ngakhale Genvoya atha kumwedwa nthawi iliyonse masana, tikulimbikitsidwa kuti mutenge Atripla nthawi yogona kuti muteteze zovuta zina.

Piritsi lililonse la Atripla limakhala ndi mankhwalawa emtricitabine, efavirenz, ndi tenofovir disoproxil fumarate. Piritsi lililonse la Genvoya limakhala ndi mankhwala emtricitabine, elvitegravir, cobicistat, ndi tenofovir alafenamide.

Zotsatira zoyipa ndi zoopsa

Atripla ndi Genvoya ali ndi zovuta zofananira mthupi ndipo zimayambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Atripla, ndi Genvoya, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Atripla:
  • kukhumudwa
  • matenda opatsirana apamwamba
  • nkhawa
  • chikhure
  • kusanza
  • chizungulire
  • zidzolo
  • kuvuta kugona
• Zitha kuchitika ndi Genvoya:
  • kuchuluka kwa cholesterol cha LDL
• Zitha kuchitika ndi Atripla ndi Genvoya:
  • kutsegula m'mimba
  • nseru
  • mutu
  • kutopa
  • kuchulukitsa kuchuluka kwa mafuta m'thupi

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Atripla, ndi Genvoya, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Atripla:
  • kusintha kwaumoyo wamaganizidwe, monga kukhumudwa koopsa kapena nkhanza
  • kusokonezeka
  • kusintha kwamafuta mthupi lonse
• Zitha kuchitika ndi Genvoya:
  • zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi Atripla ndi Genvoya:
  • kutaya mafupa
  • Kukula kwakukulu kwa matenda a chiwindi a B * (ngati muli ndi kachilombo kale)
  • immune reconstitution syndrome (chitetezo chamthupi chikamakula bwino ndikuyamba "kugwira ntchito mopitirira muyeso")
  • kuwonongeka kwa impso * *
  • lactic acidosis (asidi owopsa m'thupi)
  • matenda aakulu a chiwindi (chiwindi chokulitsa ndi steatosis)

* Atripla ndi Genvoya onse ali ndi chenjezo lolembedwa kuchokera ku FDA lonena za kuwonjezeka kwa chiwindi cha hepatitis B. Chenjezo lomwe lili m'bokosi ndilo chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

* * Tenofovir, imodzi mwa mankhwala ku Genvoya ndi Atripla, adalumikizidwa ndi kuwonongeka kwa impso. Komabe, mtundu wa tenofovir ku Genvoya (tenofovir alafenamide) uli ndi chiopsezo chochepa chakuwonongeka kwa impso kuposa mtundu womwe uli ku Atripla (tenofovir disoproxil fumarate).

Kuchita bwino

Mankhwalawa sanayerekezeredwe mwachindunji m'maphunziro azachipatala, koma kafukufuku wapeza kuti Atripla ndi Genvoya ndi othandiza pochiza HIV.

Komabe, palibe mankhwala omwe amalimbikitsidwa ngati chisankho choyambirira kwa anthu omwe ali ndi HIV. Izi ndichifukwa choti Atripla ndi Genvoya onse ndi mankhwala achikulire a HIV, ndipo pali mankhwala atsopano omwe nthawi zambiri amakhala njira zabwino. Mankhwala atsopano a HIV nthawi zambiri amakhala othandiza ndipo amakhala ndi zovuta zochepa kuposa mankhwala akale.

Atripla ndi Genvoya atha kukhala oyenera kwa anthu ena, koma ambiri, si chisankho choyamba chomwe madotolo angavomereze kwa anthu ambiri.

Mtengo

Atripla ndi Genvoya onse ndi mankhwala omwe amadziwika ndi dzina. Sizimapezeka m'mafomu achibadwa, omwe nthawi zambiri amakhala otsika mtengo kuposa mankhwala osokoneza bongo.

Malinga ndi kuyerekezera kwa GoodRx.com, Atripla itha kukhala yotsika pang'ono kuposa Genvoya. Mtengo weniweni womwe mungalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Atripla vs. mankhwala ena

Kuphatikiza pa Genvoya (pamwambapa), mankhwala ena amaperekedwa kuti athetse HIV. M'munsimu pali kufananizira pakati pa Atripla ndi mankhwala ena a HIV.

Atripla vs. Truvada

Atripla ndi mankhwala osakaniza omwe ali ndi mankhwala emtricitabine, tenofovir disoproxil fumarate, ndi efavirenz. Truvada ndi mankhwala osakanikirana, ndipo ili ndi mankhwala awiri omwewo omwe ali ku Atripla: emtricitabine ndi tenofovir disoproxil fumarate.

Ntchito

Atripla ndi Truvada amavomerezedwa kuti akalandire kachilombo ka HIV. Atripla imavomerezedwa kuti igwiritsidwe ntchito payokha, koma Truvada imavomerezedwa kuti igwiritsidwe ntchito ndi dolutegravir (Tivicay) kapena mankhwala ena a HIV.

Atripla imavomerezedwa kuti igwiritsidwe ntchito kwa anthu azaka zilizonse bola atalemera pafupifupi mapaundi 88 (40 kilograms). Truvada imavomerezedwa kuchiza kachilombo ka HIV mwa anthu amisinkhu iliyonse bola atalemera pafupifupi mapaundi 37 (kilogalamu 17).

Truvada imavomerezedwanso kuti athetse HIV. Atripla imangovomerezedwa kuchiza kachilombo ka HIV.

Mafomu azamankhwala ndi makonzedwe

Onse Atripla ndi Truvada amabwera ngati mapiritsi amkamwa omwe amatengedwa kamodzi tsiku lililonse. Truvada ikhoza kumwedwa ndi chakudya kapena popanda chakudya, pomwe Atripla iyenera kutengedwa yopanda kanthu. Ndipo ngakhale Truvada itha kutengedwa nthawi iliyonse masana, tikulimbikitsidwa kuti mutenge Atripla nthawi yogona kuti mupewe zovuta zina.

Zotsatira zoyipa ndi zoopsa

Atripla ili ndi mankhwala ofanana ndi Truvada, kuphatikiza efavirenz. Chifukwa chake, ali ndi zovuta zofananira.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Atripla ndi Truvada (akatengedwa payekha). Zindikirani: Zotsatira zoyipa za Truvada zomwe zalembedwa pano ndi zochokera kuchipatala komwe Truvada adamutenga ndi efavirenz.

• Zitha kuchitika ndi Atripla ndi Truvada:
  • kutsegula m'mimba
  • nseru ndi kusanza
  • chizungulire
  • mutu
  • kutopa
  • kuvuta kugona
  • chikhure
  • matenda opuma
  • maloto achilendo
  • zidzolo
  • kuchulukitsa kuchuluka kwa mafuta m'thupi

Zotsatira zoyipa

Mndandandawu uli ndi zitsanzo za zovuta zoyipa zomwe zingachitike ndi Atripla kapena ndi mankhwala onse (akamwedwa payekha). Zindikirani: Zotsatira zoyipa za Truvada zomwe zalembedwa pano ndi zochokera kuchipatala komwe Truvada adamutenga ndi efavirenz.

• Zitha kuchitika ndi Atripla:
  • kusokonezeka
  • kusintha kwamafuta mthupi lonse
• Zitha kuchitika ndi Atripla ndi Truvada:
  • kusintha kwaumoyo wamaganizidwe, monga kukhumudwa koopsa kapena nkhanza
  • Kukula kwakukulu kwa matenda a chiwindi a B * (ngati muli ndi kachilombo kale)
  • immune reconstitution syndrome (chitetezo chamthupi chikamakula bwino ndikuyamba "kugwira ntchito mopitirira muyeso")
  • kutaya mafupa
  • kuwonongeka kwa impso * *
  • lactic acidosis (asidi owopsa m'thupi)
  • matenda aakulu a chiwindi (chiwindi chokulitsa ndi steatosis)

Atripla ndi Truvada onse ali ndi chenjezo lolembedwa kuchokera ku FDA lonena za kukulirakulira kwa matenda a chiwindi a hepatitis B. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafuna. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

* * Tenofovir, imodzi mwa mankhwala ku Truvada ndi Atripla, adalumikizidwa ndi kuwonongeka kwa impso.

Kuchita bwino

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala, koma kafukufuku wapeza kuti Atripla ndi Truvada ndi othandiza pochiza HIV.

Ngakhale Atripla atha kukhala othandiza pochiza kachilombo ka HIV, sikulimbikitsidwa ngati chithandizo choyambirira cha HIV. Izi ndichifukwa choti mankhwala atsopano amathanso kutenga kachilombo ka HIV koma atha kukhala ndi zoyipa zochepa kuposa Atripla.

Truvada yogwiritsidwa ntchito limodzi ndi dolutegravir (Tivicay), komabe, ikulimbikitsidwa ngati chithandizo choyambirira kwa anthu ambiri omwe ali ndi HIV.

Mtengo

Atripla ndi Truvada onse ndi mankhwala odziwika. Sizimapezeka m'mafomu achibadwa, omwe nthawi zambiri amakhala otsika mtengo kuposa mankhwala amtundu.

Malinga ndi kuyerekezera kwa GoodRx.com, Atripla itha kukhala yotsika pang'ono kuposa Truvada. Mtengo weniweni womwe mungalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Atripla vs. Complera

Atripla ndi mankhwala osakaniza omwe ali ndi mankhwala emtricitabine, tenofovir disoproxil fumarate, ndi efavirenz. Complera ndi mankhwala osakanikirana, ndipo ili ndi mankhwala awiri omwewo omwe ali ku Atripla: emtricitabine ndi tenofovir disoproxil fumarate. Chida chake chachitatu cha mankhwala ndi rilpivirine.

Ntchito

Atripla ndi Complera amavomerezedwa kuti akalandire kachilombo ka HIV.

Atripla imavomerezedwa kuti igwiritsidwe ntchito kwa anthu amisinkhu iliyonse bola atalemera pafupifupi mapaundi 88 (40 kilograms). Complera, kumbali inayo, imavomerezedwa kuti igwiritsidwe ntchito kwa anthu azaka zilizonse bola atalemera pafupifupi makilogalamu 35.

Complera imagwiritsidwa ntchito mwa anthu omwe ali ndi chiwopsezo chochepa kwambiri asanayambe kulandira chithandizo. Atripla alibe choletsedwachi.

Mafomu azamankhwala ndi makonzedwe

Onse Atripla ndi Complera amabwera ngati mapiritsi akumwa omwe amatengedwa kamodzi tsiku lililonse. Complera iyenera kutengedwa ndi chakudya, pomwe Atripla iyenera kutengedwa yopanda kanthu. Ndipo ngakhale kuti Complera imatha kutengedwa nthawi iliyonse masana, tikulimbikitsidwa kuti mutenge Atripla nthawi yogona kuti mupewe zovuta zina.

Zotsatira zoyipa ndi zoopsa

Atripla ndi Complera ali ndi mankhwala ofanana. Chifukwa chake, ali ndi zovuta zofananira.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Atripla, ndi Complera, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Atripla:
  • zotsatira zochepa wamba wamba
• Zitha kuchitika ndi Complera:
  • zotsatira zochepa wamba wamba
• Zitha kuchitika ndi Atripla ndi Complera:
  • kutsegula m'mimba
  • nseru ndi kusanza
  • chizungulire
  • mutu
  • kutopa
  • kuvuta kugona
  • chikhure
  • matenda opatsirana apamwamba
  • maloto achilendo
  • zidzolo
  • kukhumudwa
  • nkhawa
  • kuchulukitsa kuchuluka kwa mafuta m'thupi

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Atripla, ndi Complera, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Atripla:
  • kusokonezeka
  • kusintha kwamafuta mthupi lonse
• Zitha kuchitika ndi Complera:
  • kutupa ndulu yanu
  • miyala yamtengo wapatali
• Zitha kuchitika ndi Atripla ndi Complera:
  • kusintha kwaumoyo wamaganizidwe, monga kukhumudwa koopsa kapena nkhanza
  • Kukula kwakukulu kwa matenda a chiwindi a B * (ngati muli ndi kachilombo kale)
  • immune reconstitution syndrome (chitetezo chamthupi chikamakula bwino ndikuyamba "kugwira ntchito mopitirira muyeso")
  • kutaya mafupa
  • kuwonongeka kwa impso * *
  • lactic acidosis (asidi owopsa m'thupi)
  • matenda aakulu a chiwindi (chiwindi chokulitsa ndi steatosis)

Atripla ndi Complera onse ali ndi chenjezo lolembedwa kuchokera ku FDA lonena za kuwonjezeka kwa matenda a chiwindi a hepatitis B. Chenjezo lomwe lili m'bokosi ndilo chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

* * Tenofovir, imodzi mwa mankhwala ku Complera ndi Atripla, adalumikizidwa ndi kuwonongeka kwa impso.

Kuchita bwino

Kugwiritsa ntchito mankhwala omwe amapezeka ku Atripla (efavirenz, emtricitabine, ndi tenofovir disoproxil fumarate) kuyerekezedwa mwachindunji ndi kugwiritsa ntchito Complera mu kafukufuku wamankhwala. Mankhwala awiriwa adapezeka kuti amathandizanso mothandizidwa ndi kachilombo ka HIV.

Mwa anthu omwe anali asanalandirepo kachilombo ka HIV kale, Complera komanso kuphatikiza mankhwala a Atripla anali ndi kupambana kwa 77% sabata ya 96. Chithandizo chimawerengedwa kuti ndichopambana ngati kuchuluka kwa ma virus a munthuyo kunali kochepera 50 kumapeto kwa kafukufukuyu.

Komabe, anthu 8% omwe adatenga mankhwala a Atripla analibe phindu, pomwe anthu 14% omwe adatenga Complera sanapindule nawo. Izi zikusonyeza kuti Complera atha kukhala ndi chithandizo chochulukirapo kuposa mankhwala a Atripla.

Atripla kapena Complera samalimbikitsidwa ngati chithandizo choyambirira kwa anthu ambiri omwe ali ndi HIV. Mankhwalawa atha kukhala oyenera kwa anthu ena, koma ambiri, mankhwala atsopano amalimbikitsidwa pafupipafupi. Izi ndichifukwa choti mankhwala atsopano, monga Biktarvy kapena Triumeq, atha kugwira ntchito bwino ndikukhala ndi zovuta zochepa.

Mtengo

Atripla ndi Complera onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mafomu omwe angapezeke ngati mankhwala. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Atripla ndi Complera nthawi zambiri amawononga ndalama zofanana. Mtengo weniweni womwe mungalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Momwe mungatenge Atripla

Muyenera kutenga Atripla malinga ndi malangizo a dokotala kapena wothandizira zaumoyo.

Kusunga nthawi

Muyenera kumwa Atripla nthawi yomweyo tsiku lililonse, makamaka mukamagona. Kutenga nthawi yogona kungathandize kuchepetsa mavuto ena, monga kuvuta kuyang'ana komanso chizungulire.

Kutenga Atripla pamimba yopanda kanthu

Muyenera kumwa Atripla pamimba yopanda kanthu (yopanda chakudya). Kutenga Atripla ndi chakudya kumatha kuwonjezera zotsatira za mankhwala. Kukhala ndi mankhwala ochulukirapo m'dongosolo lanu kumatha kubweretsa zovuta zoyipa.

Kodi Atripla itha kuphwanyidwa?

Mwambiri, sikulimbikitsidwa kugawanika, kuphwanya, kapena kutafuna mapiritsi a Atripla. Ayenera kumeza kwathunthu.

Ngati mukuvutika kumeza mapiritsi athunthu, lankhulani ndi dokotala wanu za mankhwala ena omwe atha kukuthandizani.

Atripla ndi mowa

Ndi bwino kupewa kumwa mowa mukamamwa Atripla. Izi ndichifukwa chophatikiza mowa ndi Atripla kumatha kubweretsa zovuta zina kuchokera ku mankhwalawa. Izi zingaphatikizepo:

• chizungulire
• mavuto ogona
• chisokonezo
• kuyerekezera zinthu m'maganizo
• zovuta kulingalira

Ngati muli ndi vuto lopewa kumwa mowa, auzeni dokotala musanayambe kumwa mankhwala ndi Atripla. Amatha kunena za mankhwala ena.

Kuyanjana kwa Atripla

Atripla amatha kulumikizana ndi mankhwala osiyanasiyana komanso zowonjezera zina ndi zakudya.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, ena amatha kusokoneza momwe mankhwala amagwirira ntchito, pomwe ena amatha kuyambitsa zovuta zina.

Atripla ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Atripla. Mndandandawu mulibe mankhwala onse omwe atha kuyanjana ndi Atripla. Pali mankhwala ena ambiri omwe amatha kuyanjana ndi Atripla.

Musanatenge Atripla, onetsetsani kuti muwauze adotolo komanso asayansi wanu zamankhwala onse, pa-counter ndi mankhwala ena omwe mumamwa. Komanso, auzeni za mavitamini, zitsamba, ndi zowonjezera zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Mankhwala ena a HIV

Atripla imagwirizana ndi mankhwala ena ambiri a HIV. Osayamba kumwa mankhwala angapo a HIV pokhapokha atalangizidwa ndi dokotala wanu. Kutenga Atripla ndi mankhwala ena a kachilombo ka HIV kungachepetse zotsatira za mankhwalawa kapena kuonjezera chiopsezo chanu.

Zitsanzo za mankhwalawa a HIV ndi awa:

• protease inhibitors, monga:
  • atazanavir
  • fosamprenavir calcium
  • kutchfuneralhome
  • darunavir / ritonavir
  • lopinavir / ritonavir
  • mwambo
  • alireza
• non-nucleoside reverse transcriptase inhibitors (NNRTIs), monga:
  • alireza
  • etravirine
  • doravirine
• maraviroc, yemwe ndi wotsutsana ndi CCR5
• didanosine, yomwe ndi nucleoside reverse transcriptase inhibitor (NRTI)
• raltegravir, yomwe ndi integrase inhibitor

Mankhwala ena a hepatitis C.

Kutenga Atripla ndi mankhwala ena a hepatitis C kungapangitse kuti mankhwalawa asagwire ntchito. Zingapangitsenso kuti thupi lanu likhale losagwirizana ndi mankhwala a hepatitis C. Ndi kukana, mankhwalawa sangakugwireni konse. Kwa mankhwala ena a hepatitis C, kumwa Atripla nawo kumatha kukulitsa zovuta za Atripla.

Zitsanzo za mankhwala a hepatitis C omwe sayenera kutengedwa ndi Atripla ndi awa:

• Epclusa (sofosbuvir / velpatasvir)
• Harvoni (ledipasvir / sofosbuvir)
• Mavyret (glecaprevir / pibrentasvir)
• Olysio (simeprevir)
• Victrelis (yoyeprevir)
• Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
• Zepatier (elbasvir / grazoprevir)

Mankhwala osokoneza bongo

Kutenga Atripla ndi mankhwala ena oletsa mafungulo kumatha kupangitsa kuti mankhwalawa asamagwire ntchito. Zingathenso kuwonjezera zovuta zina. Zitsanzo za mankhwalawa ndi awa:

• chithu
• ketoconazole
• posaconazole
• alireza

Mankhwala omwe angakhudze impso

Kutenga Atripla ndi mankhwala ena omwe amakhudza momwe impso zanu zimagwirira ntchito kumatha kukulitsa zovuta za Atripla. Izi zitha kubweretsa zovuta zina. Zitsanzo za mankhwalawa ndi monga:

• mankhwala ena antiviral, monga:
  • acyclovir
  • adefovir dipivoxil
  • cidofovir
  • ganciclovir
  • kutchfuneral
  • alirezatalischi
• aminoglycosides, monga gentamicin
• mankhwala osagwiritsidwa ntchito poletsa kutupa (NSAIDs), monga ibuprofen, piroxicam, kapena ketorolac, akagwiritsidwa ntchito limodzi kapena muyezo waukulu

Mankhwala omwe zotsatira zake zitha kuchepetsedwa

Pali mankhwala ambiri omwe zotsatira zake zitha kuchepetsedwa mukamamwa ndi Atripla. Zitsanzo za mankhwalawa ndi monga:

• ma anticonvulsants, monga:
  • carbamazepine
  • muthoni
  • anayankha
• mankhwala opatsirana pogonana, monga:
  • bupropion
  • alirezatalischi
• zotsekemera za calcium, monga:
  • alireza
  • felodipine
  • alireza
  • nifedipine
  • alireza
• ma statins ena (mankhwala a cholesterol), monga:
  • alirezatalischi
  • alireza
  • alirezatalischi
• mankhwala ena omwe amachepetsa kugwira ntchito kwa chitetezo chamthupi, monga:
  • cyclosporine
  • tacrolimus
  • sirolimus
• mapiritsi ena oletsa kubereka, monga ethinyl estradiol / norgestimate
• mankhwala ena omwe amagwiritsidwa ntchito pazida zolerera, monga etonogestrel
• chithuchithu
• kutuloji
• mankhwala ena omwe amachiza malungo, monga:
  • artemether / lumefantrine
  • atovaquone / proguanil
  • methadone

Warfarin

Kutenga Atripla ndi warfarin (Coumadin, Jantoven) kungapangitse warfarin kukhala yogwira mtima kwambiri. Ngati mutenga warfarin, kambiranani ndi dokotala wanu za zomwe zingachitike mukamamwa mankhwalawa limodzi.

Rifampin

Kutenga Atripla ndi rifampin kungapangitse Atripla kukhala yovuta kwambiri. Izi ndichifukwa choti zimatha kuchepetsa kuchuluka kwa efavirenz mthupi lanu. Efavirenz ndi imodzi mwa mankhwala omwe amapezeka ku Atripla.

Ngati dokotala waganiza kuti muyenera kumwa Atripla ndi rifampin, angakulimbikitseni kumwa 200 mg patsiku la efavirenz.

Atripla ndi Viagra

Atripla imatha kukulitsa momwe sildenafil (Viagra) imadutsa mwachangu mthupi lanu. Izi zitha kupangitsa kuti Viagra isamagwire bwino ntchito.

Ngati mukufuna kutenga Viagra mukamamwa mankhwala ndi Atripla, lankhulani ndi dokotala poyamba. Amatha kukulangizani ngati Viagra ndiye njira yabwino kwambiri kwa inu, kapena ngati pali mankhwala ena omwe angagwire ntchito bwino.

Atripla ndi zitsamba ndi zowonjezera

Kutenga wort ya St. John ndi Atripla kungapangitse Atripla kukhala yovuta kwambiri. Ngati mukufuna kutenga zinthuzi pamodzi, lankhulani ndi dokotala wanu poyamba ngati zili zotetezeka.

Ndipo onetsetsani kuti dokotala wanu ndi wamankhwala adziwe za zinthu zilizonse zomwe mumatenga, ngakhale mukuganiza kuti ndizachilengedwe komanso zotetezeka. Izi zimaphatikizapo tiyi, monga tiyi wobiriwira, ndi mankhwala achikhalidwe, monga ma-huang.

Atripla ndi zakudya

Kudya zipatso zamphesa pamene mutenga Atripla kumawonjezera kuchuluka kwa mankhwala m'thupi lanu. Izi zitha kukulitsa zovuta kuchokera ku Atripla, monga nseru ndi kusanza. Pewani kumwa zipatso zamtengo wapatali kapena madzi amphesa mukamamwa mankhwala ndi Atripla.

Momwe Atripla amagwirira ntchito

HIV ndi kachilombo kamene kamawononga chitetezo cha mthupi, chomwe ndi chitetezo cha thupi kumatenda. HIV ikapanda kuchiritsidwa, imatenga maselo amthupi omwe amatchedwa CD4. HIV imagwiritsa ntchito maselowa kuti azisanzira (kupanga okha) ndikufalikira mthupi lonse.

Popanda chithandizo, HIV imatha kukhala Edzi. Ndi Edzi, chitetezo cha mthupi chimakhala chofooka kwambiri kotero kuti munthu amatha kudwala matenda ena monga chibayo kapena lymphoma. Potsirizira pake, AIDS ingafupikitse moyo wa munthu.

Atripla ndi mankhwala osakaniza omwe ali ndi mankhwala atatu ochepetsa mphamvu ya kachilombo ka HIV. Mankhwalawa ndi awa:

• efavirenz, yomwe ndi non-nucleoside reverse transcriptase inhibitor (NNRTI)
• emtricitabine, yomwe ndi nucleoside analog reverse transcriptase inhibitors (NRTI)
• tenofovir disoproxil fumarate, yemwenso ndi NRTI

Mankhwala atatuwa amagwira ntchito poletsa kutenga kachirombo ka HIV. Izi zimachepetsa pang'onopang'ono kuchuluka kwa ma virus a munthu, omwe ndi kuchuluka kwa HIV mthupi. Mulingo uwu ukakhala wotsika kwambiri kwakuti kachilombo ka HIV sikupezeka pamayeso oyesera kachilombo ka HIV, amatchedwa osawoneka. Kuchuluka kwa mavitamini osadziwika ndi cholinga cha chithandizo cha HIV.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Pazithandizo zilizonse za kachirombo ka HIV, kuphatikiza Atripla, zimatenga masabata 8 mpaka 24 kuti zifike pamtundu wodziwika wa kachilombo ka HIV. Izi zikutanthauza kuti munthu adzakhalabe ndi kachilombo ka HIV, koma ali pamunsi wotsika kwambiri kuti sapezeka mwa kuyesa.

Kodi ndiyenera kumwa mankhwalawa kwa nthawi yayitali?

Pakadali pano palibe mankhwala a HIV. Chifukwa chake, kuti muchepetse kuchuluka kwa kachilombo ka HIV, anthu ambiri nthawi zonse amafunika kumwa mankhwala amtundu wa HIV.

Ngati inu ndi adotolo mukuganiza kuti Atripla akukuchitirani bwino, muyenera kuyitenga nthawi yayitali.

Atripla ndi mimba

Mimba iyenera kupewedwa mukamalandira chithandizo cha Atripla, komanso kwa milungu 12 pambuyo poti mankhwala atha. Izi ndichifukwa choti Atripla imatha kuvulaza mimba yanu.

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, lankhulani ndi dokotala wanu. Akhoza kukupatsani chithandizo china cha kachilombo ka HIV. Ndipo mukakhala ndi pakati mukatenga Atripla, itanani dokotala wanu nthawi yomweyo.

Ngati mutenga Atripla muli ndi pakati, mungaganizire kulowa nawo Registry ya Mimba ya Antiretroviral. Kaundula ameneyu amalondola thanzi ndi mimba ya anthu omwe amamwa mankhwala ochepetsa mphamvu ya kachilombo ka HIV akakhala ndi pakati. Dokotala wanu akhoza kukuwuzani zambiri.

Atripla ndi kuyamwitsa

Mankhwala ku Atripla amapita mkaka wa m'mawere. Anthu omwe akutenga Atripla sayenera kuyamwa, chifukwa mwana wawo amatha kumwa mankhwalawa kudzera mkaka wa m'mawere. Izi zikachitika, mwanayo amatha kukhala ndi zovuta zina chifukwa cha mankhwalawa, monga kutsegula m'mimba.

Kuganizira kwina ndikuti kachilombo ka HIV kangadutse kwa mwana kudzera mkaka wa m'mawere. Ku United States, Centers for Disease Control and Prevention (CDC) imalimbikitsa kuti anthu omwe ali ndi kachilombo ka HIV apewe kuyamwitsa.

Komabe, World Health Organisation (WHO) ikulimbikitsabe kuyamwitsa anthu omwe ali ndi HIV m'maiko ena ambiri.

Mafunso wamba okhudza Atripla

Nawa mayankho pamafunso omwe amafunsidwa zambiri za Atripla.

Kodi Atripla ingayambitse kukhumudwa?

Inde, Atripla imatha kubweretsa kukhumudwa. M'maphunziro azachipatala, 9% ya anthu omwe amamwa mankhwalawa adayamba kukhumudwa.

Mukawona kusintha kulikonse kwanu mukamamwa Atripla, lankhulani ndi dokotala nthawi yomweyo. Atha kusintha chithandizo cha kachirombo ka HIV, ndipo atha kukupatsirani malangizo ena othandizira omwe angakuthandizeni kuti muchepetse nkhawa.

Kodi Atripla amachiza HIV?

Ayi, pakadali pano palibe mankhwala a HIV. Koma mankhwala othandiza ayenera kupangitsa kuti kachilomboka kasaoneke. Izi zikutanthauza kuti munthu adzakhalabe ndi kachilombo ka HIV, koma ali pamunsi wotsika kwambiri kuti sapezeka mwa kuyesa. A FDA pano akuwona gawo losawoneka ngati chipambano cha mankhwala.

Kodi Atripla ingapewe kachilombo ka HIV?

Ayi, Atripla sivomerezedwa kuti tipewe HIV. Mankhwala okhawo omwe amavomerezedwa kuti ateteze HIV ndi Truvada, omwe amagwiritsidwa ntchito pa pre-exposure prophylaxis (PrEP). Ndi PrEP, mankhwala amatengedwa asanatenge kachilombo ka HIV kuti athandize kufalitsa kachilomboka.

Atripla sanaphunzire za ntchitoyi, ngakhale ili ndi mankhwala onse omwe amapezeka ku Truvada (emtricitabine ndi tenofovir disoproxil fumarate). Chifukwa chake, Atripla sayenera kugwiritsidwa ntchito pazinthu izi.

Munthu yemwe alibe kachilombo ka HIV koma ali ndi mwayi wotenga kachilomboka ayenera kulankhula ndi dokotala wake. Atha kulangiza njira zodzitetezera monga PrEP kapena post-exposure prophylaxis (PEP). Angathenso kupereka njira zina zodzitetezera, monga kugwiritsa ntchito kondomu nthawi zonse pogonana kapena kumatako.

Kodi chimachitika ndi chiyani ndikaphonya magawo angapo a Atripla?

Ngati mwaphonya Mlingo wambiri wa Atripla, musatenge milingo ingapo kuti mupange omwe mwaphonya. M'malo mwake, lankhulani ndi dokotala posachedwa. Akudziwitsani zomwe muyenera kutsatira.

Ndikofunika kutenga Atripla tsiku lililonse. Izi ndichifukwa choti mukaphonya Mlingo, thupi lanu limatha kukana Atripla. Ndi mankhwala osokoneza bongo, mankhwala sakugwiranso ntchito kuti athetse vuto linalake.

Koma ngati mwangophonya mlingo umodzi, ambiri, muyenera kumwa mankhwalawo mukangokumbukira.

Machenjezo a Atripla

Mankhwalawa amabwera ndi machenjezo angapo.

Chenjezo la FDA: Kukula kwa chiwindi cha B (HBV)

Mankhwalawa ali ndi chenjezo la nkhonya. Ili ndiye chenjezo lalikulu kwambiri kuchokera ku Food and Drug Administration (FDA). Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

• Kwa anthu omwe amatenga Atripla komanso omwe ali ndi HIV ndi HBV, kuyimitsa Atripla kumatha kubweretsa kukulira HBV. Izi zitha kubweretsa mavuto monga kuwonongeka kwa chiwindi.
• Odwala onse ayenera kuyezetsa HBV asanayambe kulandira chithandizo ndi Atripla. Komanso, simuyenera kusiya kumwa Atripla pokhapokha dokotala atakuwuzani.
• Ngati muli ndi kachilombo ka HIV ndi HBV ndipo musiye kumwa Atripla, dokotala wanu ayenera kuyang'anitsitsa chiwindi chanu kwa miyezi ingapo. HBV yanu ikafika poipa, dokotala wanu akhoza kukuyambitsani pa chithandizo cha HBV.

Machenjezo ena

Musanatenge Atripla, kambiranani ndi dokotala za mbiri yanu. Atripla mwina sangakhale yoyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Hypersensitivity kwa Atripla kapena zosakaniza zake. Ngati mwakhala mukuvutika kwambiri ndi Atripla kapena mankhwala aliwonse omwe ali nawo, muyenera kupewa kumwa Atripla. Ngati dokotala wanu akukulemberani Atripla, onetsetsani kuti mwawauza zomwe mwachita musanamwe mankhwalawo.

Zindikirani: Kuti mumve zambiri paza zotsatira zoyipa za Atripla, onani gawo la "Zotsatira zoyipa" pamwambapa.

Atripla bongo

Kumwa mankhwalawa mopitirira muyeso kungapangitse kuti mukhale ndi zovuta zina.

Zizindikiro zambiri za bongo

Maphunziro azachipatala a Atripla sananene zomwe zingachitike ngati atamwa kwambiri mankhwala. Koma kafukufuku wina wasonyeza kuti kumwa kwambiri efavirenz, mankhwala omwe amapezeka ku Atripla, kumatha kukulitsa zovuta zina za mankhwalawa. Izi zikuphatikiza:

• chizungulire
• kuvuta kugona
• chisokonezo
• kuyerekezera zinthu m'maganizo
• kugwedezeka kwa minofu

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mutenga piritsi limodzi la Atripla patsiku, uzani dokotala wanu. Ndipo onetsetsani kuti mumawauza zakusintha kulikonse pazotsatira zanu kapena momwe mumamvera mumtima mwanu.

Ngati mukuganiza kuti mwatenga Atripla kwambiri, itanani dokotala wanu kapena funsani malangizo kuchokera ku American Association of Poison Control Center ku 800-222-1222 kapena kudzera pa chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Kutha kwa Atripla

Atripla ataperekedwa kuchokera ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito patsamba lolemba. Tsikuli limakhala chaka chimodzi kuyambira tsiku lomwe adaperekera mankhwala.

Cholinga cha masiku otha ntchitowa ndikutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito.

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mankhwalawo amasungidwira. Mapiritsi a Atripla ayenera kusungidwa kutentha, pafupifupi 77 ° F (25 ° C). Ayeneranso kusungidwa mu chidebe chawo choyambirira, chivindikirocho chitatsekedwa mwamphamvu.

Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Zambiri za Atripla

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Njira yogwirira ntchito

Atripla ndi piritsi limodzi lophatikiza ma ARV lomwe lili ndi efavirenz, yomwe ndi non-nucleoside reverse transcriptase inhibitors (NNRTI), ndi emtricitabine ndi tenofovir disoproxil fumarate, omwe onse ndi ma nucleoside analog reverse transcriptase inhibitors (NRTIs).

NNRTIs ndi NRTIs onse amamangirira HIV reverse transcriptase, yomwe imayimitsa kutembenuka kwa HIV RNA kukhala HIV DNA. Komabe, amagwira ntchito m'malo osiyana pang'ono a enzyme ya HIV reverse transcriptase.

Pharmacokinetics ndi metabolism

Atripla ayenera kumwedwa wopanda kanthu m'mimba. Mankhwala onse atatu ku Atripla amalowetsedwa mwachangu. Efavirenz imatenga nthawi yayitali kwambiri kuti ifike pamagulu okhazikika (masiku 6-10). Kutha kwa moyo wa mankhwala atatuwa ndi izi:

• efavirenz: maola 40-55
• emtricitabine: maola 10
• tenofovir disoproxil fumarate: maola 17

Atripla siyikulimbikitsidwa kuti igwiritsidwe ntchito kwa anthu omwe ali ndi chiwindi chowopsa kapena chowopsa. Chifukwa efavirenz imagwiritsidwa ntchito ndi michere ya chiwindi (CYP P450), kugwiritsa ntchito Atripla mwa anthu omwe ali ndi vuto lililonse la chiwindi kuyenera kuchitidwa mosamala.

Kugwiritsa ntchito Atripla sikuvomerezeka kwa anthu omwe ali ndi vuto lopweteka kwambiri (CrCl <50 mL / min).

Zotsutsana

Atripla sayenera kugwiritsidwa ntchito mwa anthu omwe ali ndi vuto losagwirizana ndi efavirenz, yomwe ndi imodzi mwa mankhwala ku Atripla.

Atripla sayeneranso kugwiritsidwa ntchito mwa anthu omwe akumwetsanso voriconazole kapena elbasvir / grazoprevir.

Yosungirako

Atripla iyenera kusungidwa kutentha firiji 77 ° F (25 ° C), yomata bwino mchidebe chake choyambirira.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.