Aubagio (teriflunomide)

Zamkati

• Aubagio ndi chiyani?
• Aubagio generic
• Zotsatira za Aubagio
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Mtengo wa Aubagio
• Thandizo lazachuma
• Aubagio amagwiritsa ntchito
• Aubagio ya MS
• Aubagio ndi mowa
• Kuyanjana kwa Aubagio
• Aubagio ndi mankhwala ena
• Mlingo wa Aubagio
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa mitundu yobwereranso ya MS
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Njira zina ku Aubagio
• Aubagio vs. Tecfidera
• Zosakaniza
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Aubagio vs.Gilenya
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Momwe mungatengere Aubagio
• Kusunga nthawi
• Kutenga Aubagio ndi chakudya
• Kodi Aubagio akhoza kuphwanyidwa, kutafuna, kapena kugawanika?
• Ndifunikira mayeso ati ndisanayambe kumwa mankhwala?
• Momwe Aubagio amagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Aubagio ndi pakati
• Aubagio ndi kuyamwitsa
• Mafunso wamba onena za Aubagio
• Kodi Aubagio ndi immunosuppressant?
• Kodi ndimachita bwanji kusamba kwa Aubagio?
• Kodi ndiyenera kugwiritsa ntchito njira zakulera ndikamamwa Aubagio?
• Kodi Aubagio imayambitsa kuthamanga?
• Kodi ndidzasiya kusuta ndikasiya kumwa Aubagio?
• Kodi Aubagio ingayambitse khansa? Kodi yakhala ikugwirizanitsidwa ndi imfa iliyonse?
• Machenjezo a Aubagio
• Machenjezo a FDA
• Machenjezo ena
• Aubagio bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Kutha kwa Aubagio, kusunga, ndi kutaya
• Yosungirako
• Kutaya
• Zambiri za Aubagio
• Zikuonetsa
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Aubagio ndi chiyani?

Aubagio ndi mankhwala omwe amadziwika kuti ndi mankhwala. Amagwiritsidwa ntchito pochiza mitundu yobwereranso ya multiple sclerosis (MS) mwa akulu. MS ndimatenda momwe chitetezo chamthupi chanu chimagonjetsera dongosolo lanu lamanjenje.

Aubagio imakhala ndi mankhwala teriflunomide, omwe ndi pyrimidine synthesis inhibitor. Mankhwala osokoneza bongo m'kalasiyi amathandiza kuteteza maselo amthupi kuti asachulukane msanga. Izi zimathandiza kuchepetsa kutupa (kutupa).

Aubagio amabwera ngati piritsi lomwe mumameza. Mankhwalawa amapezeka mwamphamvu ziwiri: 7 mg ndi 14 mg.

Aubagio adafaniziridwa ndi placebo (palibe chithandizo) m'mayesero anayi azachipatala. Anthu omwe adatenga Aubagio anali ndi:

• kubwereranso pang'ono (zolakwitsa)
• kukula pang'onopang'ono kwa kulemala (kulumala kwawo sikunakulireko mwachangu)
• chiopsezo chotsika cha zotupa zatsopano (minofu yofiira) muubongo

Kuti mudziwe zambiri kuchokera ku maphunzirowa, onani gawo la "Ntchito za Aubagio".

Aubagio generic

Aubagio pakadali pano imangokhala ngati mankhwala odziwika.

Aubagio ili ndi chinthu chogwira ntchito teriflunomide. Mu 2018, Food and Drug Administration (FDA) idavomereza mtundu wa teriflunomide, koma sichikupezeka pano.

Zotsatira za Aubagio

Aubagio imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zovuta zina zomwe zingachitike mukamamwa Aubagio. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri paza zotsatira za Aubagio, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere zovuta zilizonse zovuta.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Aubagio zitha kuphatikiza:

• mutu
• alopecia (kupatulira tsitsi kapena kutayika tsitsi)
• kuchepa kwa milingo ya phosphate
• kuchepa kwa maselo oyera a magazi
• nseru
• kutsegula m'mimba
• kuchuluka kwa michere ya chiwindi (itha kukhala chizindikiro cha kuwonongeka kwa chiwindi)
• kuthamanga kwa magazi
• dzanzi kapena kumva kulasalasa m'manja kapena m'mapazi
• kupweteka pamodzi

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Thupi lawo siligwirizana. Zizindikiro zimatha kuphatikiza:
• kutupa kumaso kapena m'manja
• kuyabwa kapena ming'oma
• kutupa kapena kumenyedwa mkamwa kapena kukhosi
• kufinya pachifuwa
• kuvuta kupuma
• Kuwonongeka kwa chiwindi, kuphatikizapo kulephera kwa chiwindi. Zizindikiro za mavuto a chiwindi zimatha kuphatikiza:
• nseru
• kusanza
• kupweteka m'mimba mwako
• kusowa chilakolako
• kutopa
• mkodzo wakuda
• chikasu cha khungu lako kapena kuyera kwa maso ako
• Maseŵera otsika a maselo oyera. Zizindikiro zimatha kuphatikiza:
• malungo
• kutopa
• kupweteka kwa thupi
• kuzizira
• nseru
• kusanza
• Kusintha kwakukulu pakhungu. Zizindikiro zimatha kuphatikiza:
• Matenda a Stevens-Johnson (zilonda zopweteka pakamwa panu, pakhosi, m'maso, kapena kumaliseche)
• Kuvulala kapena kutuluka magazi mosadziwika
• kutupa
• khungu kapena khungu
• zilonda mkamwa mwako, maso, mphuno, kapena pakhosi
• Kuthamanga kwa magazi. Zizindikiro zimatha kuphatikiza:
• mutu
• kutopa kapena kusokonezeka
• masomphenya amasintha
• kugunda kwamtima kosasintha
• Mavuto opuma, kuphatikiza matenda am'mapapo amkati. Zizindikiro zimatha kuphatikiza:
• kupuma movutikira
• kukhosomola kapena kutentha thupi

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa, kapena ngati zovuta zina zake zimakhudza. Nazi zina mwazovuta zomwe mankhwalawa angapangitse kapena sangayambitse.

Matupi awo sagwirizana

Monga momwe zimakhalira ndi mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Aubagio. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro zakukhudzidwa kwambiri zimatha kuphatikiza:

• angioedema (kutupa pansi pa khungu lanu, makamaka m'maziso anu, milomo, manja, kapena mapazi)
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma
• khungu lofiira kapena losenda

Itanani dokotala wanu nthawi yomweyo ngati mukudwala Aubagio. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Mavuto akhungu / zotupa

Aubagio imatha kuyambitsa khungu lalikulu. Izi zikuphatikiza matenda a Stevens-Johnson, omwe ndi achipatala mwadzidzidzi. Zimayambitsa zilonda zopweteka pakamwa panu, pakhosi, m'maso, kapena kumaliseche.

Zinanenedwa kuti munthu m'modzi yemwe adatenga Aubagio adayamba poizoni wa epidermal necrolysis (TEN), yomwe idapha. TEN ndi matenda a Stevens-Johnson omwe amakhudza thupi lanu kuposa 30%. Zimayamba ngati zotupa zopweteka ndimafupa onga chimfine, kenako matuza amakula.

Ngati khungu lanu lasungunuka kapena kukhala lofiira, kutupa, kapena matuza, uzani dokotala wanu nthawi yomweyo. Ngati muli ndi matenda a Stevens-Johnson kapena TEN, mungafunike kupita kuchipatala.

Kuwonongeka kwa chiwindi

M'mayesero azachipatala, pafupifupi 6% ya anthu omwe adatenga Aubagio anali ndi michere yambiri ya chiwindi. Pafupifupi 4% ya anthu omwe anali ndi placebo (palibe chithandizo) anali atachulukitsa kuchuluka kwa ma enzyme a chiwindi.

Aubagio imatha kukulitsa michere ya chiwindi, yomwe imatha kukhala chizindikiro cha mavuto akulu a chiwindi. Uzani dokotala wanu ngati muli ndi izi:

• nseru
• kusanza
• kupweteka m'mimba mwako
• kusowa chilakolako
• kutopa
• mkodzo wakuda
• chikasu cha khungu lako kapena kuyera kwa maso ako

Musanayambe kumwa Aubagio, dokotala wanu akupatsani mayeso a magazi kuti muwone momwe chiwindi chanu chikuyendera. Adzakupatsaninso mayeso pamwezi mukamapita ku Aubagio kuti muwone momwe chiwindi chanu chikugwirira ntchito.

Kutaya tsitsi

Chimodzi mwazotsatira zoyipa kwambiri za Aubagio ndi alopecia (kupatulira tsitsi kapena kutaya tsitsi).

M'mayesero azachipatala, pafupifupi 13% ya anthu omwe adatenga Aubagio anali ndi alopecia. Anthu ambiri anali ndi zizindikiro za alopecia pasanathe miyezi itatu atamwa mankhwalawo. Alopecia idatha miyezi yosachepera isanu ndi umodzi. Izi zidachitika kwakanthawi, ndipo milandu yambiri idakula pomwe anthu akupitiliza kutenga Aubagio.

Ngati mukutenga Aubagio ndipo mukudandaula za kutayika kwa tsitsi, lankhulani ndi dokotala wanu.

Kutsekula m'mimba

Kutsekula m'mimba ndi zotsatira zoyipa za Aubagio.

M'mayesero azachipatala, pafupifupi 14% ya anthu omwe adatenga Aubagio adatsegula m'mimba. Izi zikuyerekeza ndi 8% ya anthu omwe anali ndi placebo (palibe chithandizo). Matenda ambiri otsekula m'mimba anali ocheperako pang'ono ndipo amangochoka pawokha.

Kuti muchepetse kutsekula m'mimba pang'ono, imwani madzi ambiri kapena ma electrolyte mayankho othandizira thupi lanu kuti lisinthe madzi otayika. Ngati kutsekula m'mimba kumatenga masiku angapo, itanani dokotala wanu. Amatha kupereka malingaliro ochepetsa zizindikiro zanu.

PML (osati zotsatira zoyipa)

Kupita patsogolo kwa leukoencephalopathy (PML) sikubwera chifukwa cha Aubagio. PLM ndi matenda omwe amawononga dongosolo lanu lamanjenje.

Pa lipoti la milandu, munthu m'modzi adapanga PML atasinthira ku Aubagio kuchokera ku natalizumab, mankhwala omwe amagwiritsidwa ntchito pochiza multiple sclerosis (MS). Natalizumab ya mankhwala ali ndi chenjezo lolembedwa kuchokera ku Food and Drug Administration (FDA) lokhuza chiopsezo chowonjezeka chokhala ndi PML. Chenjezo la bokosi ndi chenjezo loopsa kwambiri kuchokera ku FDA. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Ndizokayikitsa kwambiri kuti Aubagio adapangitsa kuti munthuyo akhale ndi PML. Ndizotheka kuti natalizumab adayambitsa.

Mukasamukira ku Aubagio mutatenga natalizumab, dokotala wanu adzakuyang'anirani ku PML.

Kutopa (osati zotsatira zoyipa)

Kutopa (kusowa mphamvu) sizomwe zimachitika chifukwa cha Aubagio. Komabe, kutopa ndi chizindikiritso chofala cha multiple sclerosis (MS). Kutopa kungakhalenso chizindikiro cha kuwonongeka kwa chiwindi.

Ngati mukuda nkhawa ndi kutopa mukamatenga Aubagio, lankhulani ndi dokotala wanu. Amatha kudziwa zomwe zingayambitse ndikupatsanso njira zokulitsira mphamvu zanu.

Kuchepetsa thupi kapena kunenepa (osati zotsatira zoyipa)

Kuchepetsa thupi ndi kunenepa sizinali zoyipa za Aubagio m'maphunziro azachipatala. Simungataye kapena kunenepa mukamamwa Aubagio.

Komabe, chimodzi mwazizindikiro zodziwika bwino za multiple sclerosis (MS) ndikutopa (kusowa mphamvu). Mphamvu zanu zikakhala zochepa, mwina simungakhale otakataka. Izi zitha kukupangitsani kuti mukhale wonenepa. Ngati nanunso muli ndi matenda ovutika maganizo, mumatha kudya kwambiri kapena moperewera, zomwe zingapangitse kuti muchepetse kapena muchepetse thupi.

Ngati mukudandaula za kusintha kwa kulemera kwanu, lankhulani ndi dokotala wanu. Amatha kupereka malangizo othandiza othandiza kapena amalangiza katswiri wazakudya kuti awonetsetse kuti mwapeza chakudya choyenera.

Khansa (osati zotsatira zoyipa)

Kutenga mankhwala omwe amakhudza chitetezo cha mthupi, monga Aubagio, kumatha kuwonjezera chiopsezo cha khansa. Komabe, mayesero azachipatala a Aubagio sanafotokoze kuwonjezeka kwa anthu omwe adadwala khansa.

Ngati mukudandaula za matenda a khansa, lankhulani ndi dokotala wanu.

Matenda okhumudwa (osati zotsatira zoyipa)

Matenda okhumudwa si zotsatira zoyipa za Aubagio. Komabe, kukhumudwa ndichizindikiro chodziwika bwino cha MS.

Ngati muli ndi zizindikiro zakukhumudwa, auzeni dokotala wanu. Mankhwala angapo opanikizika amapezeka omwe angathandize kuchepetsa zizindikilo zanu.

Mtengo wa Aubagio

Monga mankhwala onse, mtengo wa Aubagio umasiyana.

Mtengo weniweni womwe mudzalipira utengera inshuwaransi yanu, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Thandizo lazachuma

Ngati mukufuna thandizo lazachuma kuti mulipire Aubagio, thandizo lilipo. Genzyme Corporation, wopanga Aubagio, amapereka Aubagio Co-Pay Program. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 855-676-6326 kapena pitani patsamba lino.

Aubagio amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Aubagio kuti athetse mavuto ena.

Aubagio ya MS

Aubagio ndivomerezedwa ndi FDA kuti athetse achikulire omwe ali ndi mitundu yobwereranso ya multiple sclerosis (MS). MS ndi matenda osatha (a nthawi yayitali) omwe amachititsa kuti chitetezo chamthupi chanu chiwononge myelin (wosanjikiza wakunja) pamitsempha m'maso mwanu, ubongo, ndi msana. Izi zimapanga zilonda zamiyendo, zomwe zimapangitsa kuti ubongo wanu ukhale wovuta kutumiza ziwalo mbali zina za thupi lanu.

Pakuyesa kwamankhwala, anthu opitilira 1,000 omwe anali ndi MS obwerezabwereza (flare-ups) adatenga Aubagio kapena placebo (palibe chithandizo). Mu gulu la Aubagio, 57% mwa iwo adakhalabe osayambiranso kumwa mankhwalawo. Izi zimafanizidwa ndi 46% ya gulu la placebo. Anthu omwe adatenga Aubagio adabwereranso 31% poyerekeza ndi omwe adatenga malowa.

Mayesero omwewo akuwonetsa kuti, poyerekeza ndi gulu la placebo, anthu omwe adatenga Aubagio anali:

• kamodzi kokha amabwereranso zaka zisanu ndi chimodzi akumwa mankhwalawo
• kukula pang'onopang'ono kwa kulemala (kulumala kwawo sikunakulireko mwachangu)
• zotupa zatsopano (zotupa zochepa) muubongo

Kafukufuku wina adawunika momwe Aubagio alili wogwira mtima:

• Pa kuyesedwa kwachipatala, pafupifupi 72% ya anthu omwe adatenga Aubagio adakhala osabwerezabwereza panthawi yophunzira. Izi zikuyerekeza ndi 62% ya anthu omwe adatenga malowa.
• Maphunziro awiri azachipatala adayang'ana anthu omwe ali ndi MS obwereranso. Pakafukufuku wina, iwo omwe adatenga Aubagio adabwereranso 31% poyerekeza ndi omwe adatenga malowa. Mu kafukufuku wina, chiwerengerocho chinali 36%.
• M'mayesero azachipatala, anthu osachepera 80% omwe adatenga Aubagio sanapite patsogolo pakulemala kwawo. Izi zikutanthauza kuti kulemala kwawo sikunakulire msanga. Kwa ambiri mwa anthuwa, izi zidachitika mpaka zaka 7.5.

Mu kafukufuku wina wazachipatala, anthu adatenga Aubagio mu 14-mg kapena 7-mg. Ofufuza apeza kuti poyerekeza ndi anthu omwe adatenga malowa:

• 80% ya anthu omwe ali mgululi la 14-mg anali ndi zotupa zatsopano
• 57% ya anthu omwe ali mgululi la 7-mg anali ndi zotupa zatsopano

Aubagio ndi mowa

Palibe mgwirizano wodziwika pakati pa Aubagio ndi mowa. Komabe, kumwa mowa mukamamwa Aubagio kungapangitse chiopsezo chanu pazovuta zina, monga:

• nseru
• kutsegula m'mimba
• mutu

Kumwa mowa kwambiri mukamamwa Aubagio kungapangitsenso chiopsezo cha chiwindi.

Mukatenga Aubagio, lankhulani ndi dokotala wanu ngati zili bwino kumwa mowa.

Kuyanjana kwa Aubagio

Aubagio amatha kulumikizana ndi mankhwala ena angapo. Itha kulumikizananso ndi zowonjezera zowonjezera ndi zakudya.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito. Kuyanjana kwina kumatha kukulitsa zovuta zina kapena kuwapangitsa kukhala owopsa.

Aubagio ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Aubagio. Mndandandawu mulibe mankhwala onse omwe angagwirizane ndi Aubagio.

Musanatenge Aubagio, lankhulani ndi dokotala komanso wamankhwala. Auzeni zamankhwala onse omwe mumalandira, pa-pakauntala, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Katemera wa Aubagio ndi chimfine

Ndibwino kuti mutenge chimfine mutatenga Aubagio. Katemera wa chimfine sagwira ntchito, zomwe zikutanthauza kuti wapangidwa kuchokera ku kachilombo koyambitsa matenda kamene kakuphedwa.

Katemera wamoyo, komano, ndi omwe amakhala ndi mtundu wofooka wa nyongolosi. Ngati muli ndi chitetezo chamthupi chofooka, nthawi zambiri mumalangizidwa kuti musalandire katemera wamoyo. Izi ndichifukwa choti kangapo, katemera wamoyo amatha kubwerera ku nyongolosi yamphamvu yomwe imayambitsa matenda. Izi zikachitika, anthu omwe ali ndi chitetezo chamthupi chofooka amakhala pachiwopsezo chachikulu chotenga matenda omwe amayenera kupewa katemerayu.

Ngati mukumwa Aubagio, simuyenera kulandira katemera wamoyo. Aubagio imatha kufooketsa chitetezo cha mthupi lanu, chifukwa chake kupeza katemera wamoyo kumatha kukuikani pachiwopsezo cha matenda omwe akuyenera kukutetezani.

Ngati muli ndi mafunso okhudzana ndi katemera mukamamwa Aubagio, lankhulani ndi dokotala wanu.

Aubagio ndi leflunomide

Arava (leflunomide) ndi mankhwala omwe amagwiritsidwa ntchito pochiza nyamakazi (RA). Kutenga Aubagio ndi leflunomide kumatha kukulitsa kuchuluka kwa Aubagio mthupi lanu. Izi zitha kuvulaza chiwindi chanu. Osatenga Aubagio ndi leflunomide limodzi.

Ngati mukutenga Arava ndipo mukufuna kutenga Aubagio, lankhulani ndi dokotala wanu. Amatha kunena za mankhwala ena a RA.

Aubagio ndi warfarin

Kutenga Aubagio ndi warfarin kumatha kupangitsa warfarin kukhala yosagwira (osagwira ntchito mthupi lanu). Zotsatira zake, magazi anu amatha kuphimba.

Ngati mukumwa warfarin, lankhulani ndi dokotala wanu. Adzakuyesa magazi asanafike komanso mukamalandira chithandizo cha Aubagio.

Aubagio ndi ma immunosuppressants

Mankhwala ena, monga mankhwala a khansa, amatha kufooketsa chitetezo chamthupi. Amatchedwa immunosuppressants. Aubagio amathanso kufooketsa chitetezo chanu chamthupi. Mukatenga mankhwala a khansa limodzi ndi Aubagio, chitetezo chanu chamthupi sichingakhale cholimba mokwanira kulimbana ndi majeremusi. Izi zitha kukulitsa chiopsezo chotenga matenda.

Zitsanzo za mankhwalawa ndi awa:

• bendamustine (Bendeka, Treanda, Belrapzo)
• cladribine (Mavenclad)
• erlotinib (Tarceva) Chizindikiro

Ngati mukumwa mankhwala a khansa kapena mankhwala ena omwe amaletsa chitetezo chanu chamthupi, lankhulani ndi dokotala wanu. Angaganizire kusintha mapulani anu.

Aubagio ndi njira zakulera zam'kamwa

Njira zakulera zakumwa (mapiritsi oletsa kubereka) ndi mankhwala omwe amathandiza kupewa kutenga mimba. Kutenga Aubagio ndi mapiritsi ena oletsa kubereka kumatha kukulitsa mahomoni amthupi lanu m'mapiritsi oletsa kubereka. Izi zitha kuyambitsa kusamvana kwama hormone anu.

Zitsanzo za mankhwalawa ndi awa:

• ethinyl estradiol
• levonorgestrel (Dongosolo B Njira imodzi, Mirena, Skyla)
• ethinyl estradiol / levonogestrel (Lutera, Vienva)

Ngati mukumwa mapiritsi olera, lankhulani ndi dokotala wanu. Amatha kulangiza mtundu womwe sungachite mwamphamvu ndi Aubagio.

Mankhwala a Aubagio ndi cholesterol

Kutenga Aubagio ndi mankhwala ochepetsa mafuta m'thupi kungakulitse kuchuluka kwa mankhwalawa m'thupi lanu. Izi zitha kuyambitsa zovuta zina kuchokera ku mankhwala a cholesterol.

Zitsanzo za mankhwalawa ndi awa:

• atorvastatin (Lipitor)
• pravastatin (Pravachol)
• simvastatin (Zocor, FloLipid)
• rosuvastatin

Ngati mukumwa mankhwala kuti muchepetse cholesterol, lankhulani ndi dokotala wanu. Ayang'ana mlingo wanu wa mankhwala aliwonse ndikuonetsetsa kuti ali otetezeka kutenga nawo limodzi.

Aubagio ndi mankhwala ena

Aubagio amatha kulumikizana ndi mankhwala osiyanasiyana. Ndipo zina mwa mankhwalawa zimatha kukhudza momwe Aubagio amagwirira ntchito. Izi ndichifukwa choti thupi lanu limagwiritsa ntchito mankhwala a Aubagio ndi mankhwala ena ambiri chimodzimodzi. Mankhwala akathyoledwa limodzi, nthawi zina amatha kulumikizana.

Aubagio itha kupangitsa thupi lanu kuwononga mankhwala ena mwachangu kapena pang'onopang'ono.Izi zitha kukulitsa kapena kuchepetsa kuchuluka kwa mankhwalawa mthupi lanu. Ngati ichulukitsa milingo, itha kubweretsa chiopsezo chanu chazovuta. Ngati ichepetsanso milingo, mankhwalawa sangagwire ntchito.

Zitsanzo za mankhwalawa ndi awa:

• alireza
• asunaprevir
• Mapulogalamu a Bacillus Calmette-Guerin (BCG)
• elagolix (Orilissa)
• ziweto
• natalizumab (Tysabri)
• pazopanib (Wotchuka)
• pimecrolimus (Elidel)
• chiwonetsero (Yupelri)
• apakhungu tacrolimus
• topotecan (Hycamtin)
• zochita

Ngati mukumwa mankhwala aliwonsewa, lankhulani ndi dokotala wanu. Adzawunika milingo ya mankhwalawa m'thupi lanu mukamamwa Aubagio.

Mlingo wa Aubagio

Mlingo wa Aubagio omwe dokotala wanu akukulemberani udalira pazinthu zingapo. Izi zingaphatikizepo:

• mtundu ndi kuuma kwa chikhalidwe chomwe mukutengera Aubagio
• zaka zanu
• mawonekedwe a Aubagio omwe mumatenga
• matenda ena omwe mungakhale nawo

Nthawi zambiri, dokotala wanu amakupangitsani muyeso wochepa. Kenako azisintha pakapita nthawi kuti afike pamlingo woyenera kwa inu. Potsirizira pake adzapereka mankhwala ochepetsetsa omwe amapereka zomwe mukufuna.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Aubagio amabwera ngati piritsi lomwe mumameza. Amapezeka mu mphamvu ziwiri: 7 mg ndi 14 mg.

Mlingo wa mitundu yobwereranso ya MS

Dokotala wanu akhoza kukuyambitsani pa 7 mg, kamodzi patsiku. Ngati muyeso woyambawu sukukuthandizani, atha kukulitsa mlingo wa 14 mg, kamodzi patsiku.

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya mlingo, tengani mlingo wanu posachedwa mukakumbukira. Ngati muli pafupi ndi nthawi ya mlingo wanu wotsatira, tulukani mlingo womwe mwaphonya ndikubwerera ku nthawi yanu yanthawi zonse. Musatenge mankhwala awiri nthawi imodzi kapena mankhwala ena owonjezera.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Aubagio amayenera kugwiritsidwa ntchito ngati chithandizo chanthawi yayitali pakubwezeretsanso mitundu yambiri ya sclerosis. Ngati inu ndi adotolo mumazindikira kuti Aubagio ndiyotetezeka komanso yothandiza kwa inu, mungatenge nthawi yayitali. Onetsetsani kuti mukumwa mankhwalawo ndendende momwe dokotala akukuuzani.

Njira zina ku Aubagio

Mankhwala ena alipo omwe angachiritse mitundu yobwereranso ya multiple sclerosis (MS). Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Aubagio, lankhulani ndi dokotala kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochiza mitundu yobwereranso ya MS ndi awa:

• ma interferon a beta (Rebif, Avonex)
• ocrelizumab (Ocrevus)
• dimethyl fumarate (Tecfidera)
• glatiramer nthochi (Copaxone)
• fingolimod (Gilenya)
• natalizumab (Tysabri)
• alemtuzumab (Lemtrada)
• kutchfuneralhome

Aubagio vs. Tecfidera

Mutha kudabwa momwe Aubagio amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa tikuwona momwe Aubagio ndi Tecfidera alili ofanana komanso osiyana.

Zosakaniza

Aubagio ili ndi chinthu chogwira ntchito teriflunomide. Ndizo pyrimidine synthesis inhibitor drug class.

Tecfidera ili ndi chinthu china chogwira ntchito, dimethyl fumarate. Ndizochita za mankhwala osokoneza bongo.

Ntchito

Food and Drug Administration (FDA) yavomereza Aubagio ndi Tecfidera kuti athetse mitundu yobwereranso ya multiple sclerosis (MS).

Mafomu azamankhwala ndi makonzedwe

Aubagio amabwera ngati piritsi. Mumamwa pakamwa (mumameza) kamodzi patsiku.

Tecfidera imabwera ngati kapisozi. Mumamwa pakamwa (mumameza) kawiri patsiku.

Zotsatira zoyipa ndi zoopsa

Aubagio ndi Tecfidera amagwira ntchito m'njira zosiyanasiyana koma amakhala ndi zovuta zina. Zitsanzo za zovuta zoyipa komanso zoyipa za mankhwala aliwonse alembedwa pansipa.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Aubagio, ndi Tecfidera, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Aubagio:
• alopecia (kupatulira tsitsi kapena kutayika tsitsi)
• kuchuluka kwa michere ya chiwindi (itha kukhala chizindikiro cha kuwonongeka kwa chiwindi)
• mutu
• kuchepa kwa milingo ya phosphate
• dzanzi kapena kumva kulasalasa m'manja kapena m'mapazi
• kupweteka pamodzi
• Zitha kuchitika ndi Tecfidera:
• Kutentha (kutentha ndi kufiira pakhungu lanu)
• zotupa pakhungu
• kupweteka m'mimba mwako
• Zitha kuchitika ndi Aubagio ndi Tecfidera:
• nseru
• kutsegula m'mimba

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Aubagio, ndi Tecfidera, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aubagio:
• zotupa zina zazikulu, monga matenda a Stevens-Johnson (zilonda zopweteka pakamwa panu, pakhosi, m'maso, kapena kumaliseche)
• kuthamanga kwa magazi
• Zitha kuchitika ndi Tecfidera:
• kupita patsogolo kwamatenda ambiri a leukoencephalopathy (PML), matenda amtundu wa mitsempha yayikulu
• Zitha kuchitika ndi Aubagio ndi Tecfidera:
• kuwonongeka kwa chiwindi
• chiwindi kulephera
• magulu ochepa a magazi oyera
• kwambiri thupi lawo siligwirizana

Kuchita bwino

Multiple sclerosis (MS) ndi vuto lokhalo lomwe Aubagio ndi Tecfidera amagwiritsidwa ntchito pochiza.

Kafukufuku wamankhwala adayerekezera momwe Aubagio ndi Tecfidera anali othandiza pochizira MS. Ofufuzawa adayang'ana pa maginito opanga maginito (MRI) a anthu omwe amamwa mankhwalawa. Mwa anthu omwe adatenga Aubagio, 30% anali ndi zotupa zatsopano kapena zazikulu (zopweteka). Izi zidafanizidwa ndi 40% ya anthu omwe adatenga Tecfidera.

Mankhwala awiriwa anali othandiza. Komabe, poyang'ana momwe mankhwalawa adakhudzira ubongo wonse, Aubagio adapeza bwino kuposa Tecfidera.

Izi zati, chifukwa panali anthu 50 okha phunziroli, kafukufuku wina amafunika kuti tifananitse pakati pa mankhwalawa.

Mtengo

Aubagio ndi Tecfidera onse ndi mankhwala osokoneza bongo. Alibe mawonekedwe achibadwa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Tecfidera nthawi zambiri imawononga zambiri kuposa Aubagio. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Aubagio vs.Gilenya

Kuphatikiza pa Tecfidera (pamwambapa), Gilenya imagwiritsidwanso ntchito kuchiza matenda ofoola ziwalo. Apa tikuwona momwe Aubagio ndi Gilenya alili ofanana komanso osiyana.

Ntchito

Food and Drug Administration (FDA) yavomereza onse a Aubagio ndi Gilenya kuti athandize achikulire omwe abwereranso ndi mitundu yambiri ya sclerosis (MS). Koma a Gilenya adavomerezanso kuchiza MS mwa ana azaka zazaka 10 zokha.

Aubagio ili ndi chinthu chogwira ntchito teriflunomide. Gilenya ili ndi chinthu china chogwira ntchito, fingolimod hydrochloride. Mankhwala awiriwa sali mgulu lomwelo la mankhwala, choncho amagwira ntchito m'njira zosiyanasiyana pochiza MS.

Mafomu azamankhwala ndi makonzedwe

Aubagio amabwera ngati piritsi lomwe mumameza. Mumamwa mankhwalawa kamodzi patsiku. Gilenya amabwera ngati kapisozi yemwe mumameza. Mumamwa mankhwalawa kamodzi patsiku.

Zotsatira zoyipa ndi zoopsa

Aubagio ndi Gilenya amagwira ntchito m'njira zosiyanasiyana koma amakhala ndi zovuta zina. Zitsanzo za zovuta zoyipa komanso zoyipa za mankhwala aliwonse alembedwa pansipa.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Aubagio, ndi Gilenya, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aubagio:
• alopecia (kupatulira tsitsi kapena kutayika tsitsi)
• nseru
• dzanzi kapena kumva kulasalasa m'manja kapena m'mapazi
• kupweteka pamodzi
• kuchepa kwa milingo ya phosphate
• Zitha kuchitika ndi Gilenya:
• kupweteka m'mimba mwako
• chimfine
• kupweteka kwa msana
• chifuwa
• Zitha kuchitika ndi onse Aubagio ndi Gilenya:
• kutsegula m'mimba
• kuchuluka kwa michere ya chiwindi (yomwe ikhoza kukhala chizindikiro cha kuwonongeka kwa chiwindi)
• mutu

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Aubagio, ndi Gilenya, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Aubagio:
• zotupa pakhungu, monga matenda a Stevens-Johnson (zilonda zopweteka pakamwa panu, pakhosi, m'maso, kapena kumaliseche)
• zilema zobereka
• magulu ochepa a magazi oyera
• thupi lawo siligwirizana
• Zitha kuchitika ndi Gilenya:
• khansa yapakhungu
• mavuto a masomphenya
• chisokonezo mwadzidzidzi
• Zitha kuchitika ndi onse Aubagio ndi Gilenya:
• kuthamanga kwa magazi
• mavuto opuma
• kuwonongeka kwa chiwindi
• chiwindi kulephera

Kuchita bwino

Pakafukufuku wazachipatala, Aubagio adafananizidwa mwachindunji ndi Gilenya mwa anthu omwe ali ndi sclerosis (MS). Anthu omwe adatenga Gilenya anali ndi 0,88 MS chaka chilichonse, pomwe anthu omwe adatenga Aubagio anali ndi 0,24 MS omwe amabwerera chaka chilichonse. Koma mankhwala awiriwa nawonso anali othandiza pochepetsa kukula kwa olumala. Izi zikutanthauza kuti kulemala kwa anthu sikunawonjezeke mwachangu.

Mtengo

Aubagio ndi Gilenya onse ndi mankhwala osokoneza bongo. Alibe mawonekedwe achibadwa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Gilenya imawononga ndalama zambiri kuposa Aubagio. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Momwe mungatengere Aubagio

Muyenera kutenga Aubagio monga dokotala wanu kapena wothandizira zaumoyo akukuwuzani.

Kusunga nthawi

Tengani Aubagio kamodzi patsiku pafupifupi nthawi yomweyo tsiku lililonse.

Kutenga Aubagio ndi chakudya

Mutha kutenga Aubagio kapena wopanda chakudya. Kumwa mankhwalawa ndi chakudya sikungakhudze momwe mankhwalawa amagwirira ntchito m'thupi lanu.

Kodi Aubagio akhoza kuphwanyidwa, kutafuna, kapena kugawanika?

Sitikulimbikitsidwa kuti Aubagio aphwanyidwe, agawanike, kapena kutafuna. Sipanakhaleko maphunziro omwe adachitika kuti adziwe ngati kuchita izi kungasinthe momwe Aubagio amagwirira ntchito m'thupi.

Mankhwala osokoneza bongo ku Aubagio, teriflunomide, amadziwika kuti amanyamula kulawa kowawa, motero ndikulimbikitsidwa kuti mutenge Aubagio yonse.

Ndifunikira mayeso ati ndisanayambe kumwa mankhwala?

Musanatenge Aubagio, dokotala wanu amayesa mayeso kuti awonetsetse kuti mankhwalawa ndi otetezeka kwa inu. Izi zikuphatikiza:

• Kuyezetsa magazi kuti muwone ngati chiwindi chanu chili ndi thanzi lokwanira.
• Kuyesedwa kwa khungu la TB (TB) kapena kuyezetsa magazi kuti muwone ngati muli ndi TB.
• Kuwerengera kwathunthu kwa magazi kuti muwone ngati ali ndi matenda, kuphatikiza kupita patsogolo kwa multifocal leukoencephalopathy (PML). (Onani gawo la "Zotsatira zoyipa" pamwambapa kuti mudziwe zambiri za PML.)
• Kuyezetsa mimba. Simuyenera kutenga Aubagio ngati muli ndi pakati.
• Kufufuza magazi. Kutenga Aubagio kumatha kukulitsa kuthamanga kwa magazi, kotero dokotala adzawona ngati muli ndi vuto la kuthamanga kwa magazi.
• Kujambula kwa maginito (MRI) musanatenge komanso mukatenga Aubagio. Dokotala wanu adzawona ubongo wanu ngati pali kusintha kulikonse kwa zotupa (minofu yofiira).

Mukamamwa Aubagio, adokotala amakupatsani mayeso amwezi pamwezi kuti muwone chiwindi chanu. Adzasunganso kuthamanga kwa magazi anu.

Momwe Aubagio amagwirira ntchito

Multiple sclerosis (MS) ndi matenda osachiritsika (a nthawi yayitali). Zimapangitsa kuti chitetezo chamthupi chanu chiwononge myelin (wosanjikiza wakunja) pamitsempha m'maso mwanu, ubongo, ndi msana. Izi zimapanga zilonda zam'mimbazi, zomwe zimapangitsa kuti ubongo wanu ukhale wovuta kutumiza ziwalo m'thupi lanu.

Aubagio amagwira ntchito mosiyana ndi mankhwala ena a MS. Ndi pyrimidine yokha synthesis inhibitor yochizira MS.

Momwe Aubagio amagwirira ntchito sizikumveka bwino. Amaganiziridwa kuti teriflunomide, mankhwala omwe amagwira ntchito ku Aubagio, amatseka enzyme inayake. Maselo a chitetezo amateteza enzyme kuti ichuluke msanga. Enzyme ikatsekedwa, maselo amthupi sangathe kufalikira ndikuukira myelin.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Aubagio imayamba kugwira ntchito nthawi yomweyo mutangotenga. Komabe, mwina simukuwona kusiyana kwa zizindikiritso zanu ngakhale mankhwalawa atayamba kugwira ntchito. Ndi chifukwa chakuti zimagwira ntchito pothandiza kupewa kubwereranso komanso zotupa zatsopano, zomwe ndi zochita zomwe mwina sizingawonekere mwachindunji.

Aubagio ndi pakati

Kutenga Aubagio mukakhala ndi pakati kumatha kubweretsa zovuta zazikulu kubadwa. Musamwe mankhwalawa ngati muli ndi pakati. Ngati mungakhale ndi pakati ndipo simukugwiritsa ntchito njira yodalirika yolerera, simuyenera kutenga Aubagio.

Mukakhala ndi pakati mukamagwiritsa ntchito Aubagio, siyani kumwa mankhwalawo ndikuuza dokotala nthawi yomweyo. Uzani dokotala wanu ngati mukufuna kutenga pakati pasanathe zaka ziwiri. Poterepa, atha kukuyambitsani pamankhwala kuti muchotse mwachangu Aubagio m'dongosolo lanu (onani "Mafunso wamba onena za Aubagio" pansipa).

Aubagio amatha kukhala m'magazi anu kwa nthawi yayitali, mwina mpaka zaka ziwiri mutasiya kumwa mankhwala. Njira yokhayo yodziwira ngati Aubagio akadali m'dongosolo lanu ndikupita kukayezetsa magazi. Gwiritsani ntchito ndi dokotala wanu kuti ayese mayeso anu kuti muwonetsetse kuti kukhala ndi pakati ndikotetezeka. Mpaka mutadziwa kuti Aubagio wachoka m'dongosolo lanu, ndikofunikira kuti mupitilize kugwiritsa ntchito njira zakulera.

Mutha kulembetsanso kaundula kamene kamathandiza kusonkhanitsa zambiri zazomwe mwakumana nazo. Olembetsa oyembekezera amatenga mwayi kwa madotolo kudziwa momwe mankhwala ena amakhudzira amayi ndi pakati. Kuti mulembetse, imbani 800-745-4447 ndikusindikiza njira 2.

Ngati mukuda nkhawa kuti mukhale ndi pakati mukatenga Aubagio, lankhulani ndi dokotala wanu. Angatchule njira zabwino zolerera.

Kwa amuna: Amuna omwe amatenga Aubagio ayeneranso kugwiritsa ntchito njira yolerera yolera. Ayeneranso kudziwitsa dokotala ngati wokondedwa wawo akufuna kukhala ndi pakati.

Aubagio ndi kuyamwitsa

Sizikudziwika ngati Aubagio amadutsa mkaka wa m'mawere.

Musanatenge Aubagio, uzani dokotala ngati mukuyamwitsa mwana wanu kapena mukufuna kuyamwitsa. Amatha kukambirana nanu za kuopsa ndi zabwino zakumwa mankhwalawa mukamayamwitsa.

Mafunso wamba onena za Aubagio

Nawa mayankho pamafunso omwe amafunsidwa pafupipafupi okhudza Aubagio.

Kodi Aubagio ndi immunosuppressant?

Aubagio sadziwika kuti ndi immunosuppressant, koma imatha kufooketsa chitetezo chanu cha mthupi. Ngati chitetezo chanu chamthupi sichikhala chokwanira kulimbana ndi majeremusi, mumakhala ndi matenda ambiri.

Ngati mukuda nkhawa ndi matenda omwe angachitike mukamamwa Aubagio, lankhulani ndi dokotala wanu.

Kodi ndimachita bwanji kusamba kwa Aubagio?

Ngati mukutenga Aubagio ndikukhala ndi pakati kapena mukufuna kukhala ndi pakati, uzani dokotala nthawi yomweyo. Amatha kugwira ntchito kuti achotse Aubagio mthupi lanu mwachangu.

Aubagio amatha kukhalabe m'dongosolo lanu mpaka zaka ziwiri mutasiya kumwa. Kuti mudziwe ngati muli ndi Aubagio m'dongosolo lanu, muyenera kuyesa magazi.

Kuti "musambe", kapena kuti muchotse mwachangu, ku Aubagio, dokotala wanu akupatseni cholestyramine kapena ufa wamakala wouma.

Kodi ndiyenera kugwiritsa ntchito njira zakulera ndikamamwa Aubagio?

Inde, muyenera kugwiritsa ntchito njira yolerera mukamamwa Aubagio.

Ngati ndinu wamkazi yemwe angatenge mimba, dokotala wanu adzakupimitsani mayeso musanayambe mankhwala a Aubagio. Ndikofunika kuti musakhale ndi pakati mukamamwa Aubagio chifukwa mankhwalawa amatha kupangitsa kubadwa.

Amuna omwe amatenga Aubagio ayeneranso kugwiritsa ntchito njira zolera zothandiza. Ayeneranso kudziwitsa dokotala ngati wokondedwa wawo akufuna kukhala ndi pakati.

Kodi Aubagio imayambitsa kuthamanga?

Ayi. Kafukufuku wa Aubagio sananene kuti kutuluka (kutentha ndi kufiira pakhungu lanu) ngati zotsatira zoyipa zakumwa mankhwalawa.

Komabe, kutsuka kumatha kukhala zotsatira zoyipa zamankhwala ena omwe amachiza multiple sclerosis (MS), monga Tecfidera.

Kodi ndidzasiya kusuta ndikasiya kumwa Aubagio?

Zotsatira zobwezeretsa sizinafotokozeredwe m'maphunziro a Aubagio. Chifukwa chake sizotheka kuti mudzakhala ndi zizindikiritso zakutha mukasiya mankhwala a Aubagio.

Komabe, zizindikiro zanu za multiple sclerosis (MS) zitha kukulirakulira mukasiya kumwa Aubagio. Izi zitha kuwoneka ngati yankho lobwezera, koma sizofanana.

Osasiya kutenga Aubagio osalankhula ndi dokotala poyamba. Amatha kukuthandizani kuthana ndi vuto lanu la MS.

Kodi Aubagio ingayambitse khansa? Kodi yakhala ikugwirizanitsidwa ndi imfa iliyonse?

M'maphunziro azachipatala a Aubagio, khansa siyomwe idachitika. Komabe, mu lipoti la milandu, mayi yemwe ali ndi multiple sclerosis adayamba follicular lymphoma atatenga Aubagio kwa miyezi isanu ndi itatu. Ripotilo silinanene kuti Aubagio ndiye woyambitsa khansara, koma sizinathetse kuthekera kumeneko.

M'maphunziro azachipatala a Aubagio, anthu anayi adamwalira ndi mavuto amtima. Awa anali anthu pafupifupi 2,600 omwe amamwa mankhwalawa. Koma sizinawonetsedwe kuti kutenga Aubagio kunayambitsa imfayi.

Machenjezo a Aubagio

Mankhwalawa amabwera ndi machenjezo angapo.

Machenjezo a FDA

Mankhwalawa ali ndi machenjezo. Chenjezo la nkhonya ndiye chenjezo loopsa kwambiri kuchokera ku Food and Drug Administration (FDA). Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

• Kuwonongeka kwakukulu kwa chiwindi. Aubagio imatha kubweretsa mavuto akulu pachiwindi, kuphatikiza kulephera kwa chiwindi. Kutenga Aubagio ndi mankhwala ena omwe angakhudze chiwindi chanu kumatha kuwonjezera kuchuluka kwa Aubagio mthupi lanu. Izi zitha kuwononga chiwindi chanu. Imodzi mwa mankhwalawa ndi Arava (leflunomide), yomwe imaperekedwa kuti ichiritse nyamakazi. Dokotala wanu adzakuyesani magazi musanatenge Aubagio kuti muwone chiwindi chanu.
• Kuopsa kwa zilema zobereka. Ngati muli ndi pakati, simuyenera kutenga Aubagio chifukwa imatha kubweretsa zovuta zazikulu zobereka. Ngati mungakhale ndi pakati ndipo simukugwiritsa ntchito njira yodalirika yolerera, simuyenera kutenga Aubagio. Mukakhala ndi pakati mukatenga Aubagio, siyani kumwa ndikumuuza dokotala nthawi yomweyo.

Machenjezo ena

Musanatenge Aubagio, lankhulani ndi dokotala wanu za mbiri yanu. Aubagio sangakhale oyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Matenda a chiwindi. Aubagio imatha kuwononga chiwindi chachikulu. Ngati muli ndi matenda a chiwindi, Aubagio akhoza kukulitsa.
• Zotsatira zam'mbuyo zam'mbuyo. Pewani kutenga Aubagio ngati mwakumana ndi izi:
• aliraza
• chinyama
• zosakaniza zina ku Aubagio

Aubagio bongo

Pali zochepa pazomwe mungagwiritse ntchito mopitilira muyeso wa Aubagio.

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwatenga Aubagio kwambiri, itanani dokotala wanu. Muthanso kuyitanitsa American Association of Poison Control Center ku 800-222-1222 kapena kugwiritsa ntchito chida chawo pa intaneti. Koma ngati mukuganiza kuti mukukumana ndi vuto lachipatala, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Kutha kwa Aubagio, kusunga, ndi kutaya

Mukapeza Aubagio kuchokera ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pa cholembedwacho. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe adapereka mankhwalawo.

Tsiku lothera ntchito limathandizira kutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito. Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Yosungirako

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mungasungire mankhwalawo.

Sungani mapiritsi a Aubagio kutentha kwapakati pa 68 ° F mpaka 77 ° F (20 ° C mpaka 25 ° C).

Kutaya

Ngati simukufunikiranso kumwa Aubagio ndikukhala ndi mankhwala otsala, ndikofunikira kuwataya mosamala. Izi zimathandiza kupewa ena, kuphatikiza ana ndi ziweto, kuti amwe mankhwalawo mwangozi. Zimathandizanso kuti mankhwalawa asawononge chilengedwe.

Tsamba la FDA limapereka malangizo angapo othandiza pakutha mankhwala. Muthanso kufunsa wamankhwala wanu kuti mumve momwe mungathere mankhwala anu.

Zambiri za Aubagio

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zikuonetsa

Aubagio amawonetsedwa kuti amathandizira anthu omwe ali ndi mitundu yobwereranso ya multiple sclerosis (MS).

Njira yogwirira ntchito

Aubagio ili ndi chinthu chogwira ntchito teriflunomide. Teriflunomide imaletsa michere ya mitochondrial yotchedwa dihydroorotate dehydrogenase, yomwe imakhudzidwa ndi de novo pyrimidine synthesis. Aubagio itha kugwiranso ntchito pochepetsa kuchuluka kwa ma lymphocyte omwe ali mkati mwa dongosolo lamanjenje.

Pharmacokinetics ndi metabolism

Pambuyo poyendetsa pakamwa, kuchuluka kwakukulu kumachitika mkati mwa maola anayi. Aubagio makamaka amapangidwa ndi hydrolysis ndipo amapukusidwa ndi ma metabolites ang'onoang'ono. Njira zachiwiri zamagetsi zimaphatikizapo kulumikizana, makutidwe ndi okosijeni, ndi N-acetylation.

Aubagio ndi CYP1A2 inducer ndipo imaletsa CYP2C8, efflux transporter khansa ya m'mawere yolimbana ndi protein (BCRP), OATP1B1, ndi OAT3.

Aubagio amakhala ndi theka la masiku 18 mpaka 19 ndipo amatulutsidwa makamaka mchimbudzi (pafupifupi 38%) ndi mkodzo (pafupifupi 23%).

Zotsutsana

Aubagio imatsutsana ndi odwala omwe ali ndi:

• kuwonongeka kwakukulu kwa chiwindi
• Mbiri ya hypersensitivity kwa teriflunomide, leflunomide, kapena zinthu zina zilizonse za mankhwalawa
• Kugwiritsa ntchito limodzi ndi leflunomide
• kuthekera koyembekezera popanda kugwiritsa ntchito njira zakulera kapena ali ndi pakati

Yosungirako

Aubagio iyenera kusungidwa kutentha kwapakati pakati pa 68 ° F mpaka 77 ° F (20 ° C mpaka 25 ° C).

Chodzikanira: Medical News Today yachita zonse zotheka kuti zitsimikizire kuti zidziwitso zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.