Chiyeso cha Chibadwa cha BCR ABL

Zamkati

• Kodi kuyesa kwa majini a BCR-ABL ndi chiyani?
• Amagwiritsidwa ntchito yanji?
• Chifukwa chiyani ndikufunika mayeso amtundu wa BCR-ABL?
• Kodi chimachitika ndi chiyani pakuyesa kwa majini a BCR-ABL?
• Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?
• Kodi pali zoopsa zilizonse pamayeso?
• Kodi zotsatirazi zikutanthauza chiyani?
• Kodi pali china chilichonse chomwe ndiyenera kudziwa chokhudza kuyesedwa kwa majini a BCR-ABL?
• Zolemba

Kodi kuyesa kwa majini a BCR-ABL ndi chiyani?

Kuyezetsa magazi kwa BCR-ABL kumayang'ana kusintha kwa majini (kusintha) pa chromosome inayake.

Ma chromosomes ndi magawo am'maselo anu omwe ali ndi majini anu. Chibadwa ndi mbali za DNA zomwe zapatsidwa kuchokera kwa amayi ndi abambo anu. Amanyamula zidziwitso zomwe zimatsimikizira mikhalidwe yanu yapadera, monga kutalika ndi mtundu wamaso.

Anthu nthawi zambiri amakhala ndi ma chromosomes 46, ogawika m'magulu 23 awiriawiri, m'selo iliyonse. Mmodzi mwa ma chromosomes awiri amachokera kwa amayi anu, ndipo awiriwo amachokera kwa abambo anu.

BCR-ABL ndi kusintha komwe kumapangidwa ndi kuphatikiza kwa majini awiri, otchedwa BCR ndi ABL. Nthawi zina amatchedwa jini losakanikirana.

• Gulu la BCR nthawi zambiri limakhala pa chromosome nambala 22.
• Mtundu wa ABL nthawi zambiri umakhala pa chromosome nambala 9.
• Kusintha kwa BCR-ABL kumachitika zidutswa za majini a BCR ndi ABL zimachoka ndikusintha malo.
• Kusintha kumawonekera pa chromosome 22, pomwe chidutswa cha chromosome 9 chadziphatika.
• Chromosome 22 yosinthika imatchedwa chromosome ya ku Philadelphia chifukwa ndi mzinda womwe ofufuza adazindikira koyamba.
• Gulu la BCR-ABL si mtundu wa kusintha komwe kumatengera kwa makolo anu. Ndi mtundu wamasinthidwe ena, kutanthauza kuti simunabadwe nawo. Mumachipeza pambuyo pake m'moyo.

Gulu la BCR-ABL limapezeka mwa odwala omwe ali ndi mitundu ina ya khansa ya m'magazi, khansa ya m'mafupa ndi maselo oyera amwazi. BCR-ABL imapezeka pafupifupi pafupifupi odwala onse omwe ali ndi mtundu wa khansa ya m'magazi yotchedwa chronic myeloid leukemia (CML). Dzina lina la CML ndilanthawi yayitali zamatsenga khansa ya m'magazi. Mayina onsewa amatanthauza matenda omwewo.

Gulu la BCR-ABL limapezekanso mwa odwala ena omwe ali ndi mtundu wa acute lymphoblastic leukemia (ALL) ndipo samakonda odwala omwe ali ndi leukemia (AML).

Mankhwala ena a khansa amathandiza kwambiri pochiza odwala khansa ya m'magazi omwe ali ndi kusintha kwa majini a BCR-ABL. Mankhwalawa amakhalanso ndi zovuta zochepa poyerekeza ndi mankhwala ena a khansa. Mankhwala omwewo sagwira ntchito pochiza mitundu yosiyanasiyana ya leukemia kapena khansa ina.

Mayina ena: BCR-ABL1, BCR-ABL1 fusion, Philadelphia chromosome

Amagwiritsidwa ntchito yanji?

Kuyezetsa magazi kwa BCR-ABL kumakonda kugwiritsidwa ntchito pozindikira kapena kutulutsa matenda a khansa ya m'magazi (CML) kapena mtundu wina wa leukemia ya acute lymphoblastic (ALL) yotchedwa Ph-positive ALL. Ph-positive amatanthauza kuti chromosome yaku Philadelphia idapezeka. Mayesowa sanagwiritsidwe ntchito pozindikira mitundu ina ya khansa ya m'magazi.

Mayesowo amathanso kugwiritsidwa ntchito:

• Onani ngati chithandizo cha khansa ndichothandiza.
• Onani ngati wodwala wayamba kukana chithandizo china. Izi zikutanthauza kuti mankhwala omwe kale anali othandiza sakugwiranso ntchito.

Chifukwa chiyani ndikufunika mayeso amtundu wa BCR-ABL?

Mungafunike kuyesa kwa BCR-ABL ngati muli ndi zizindikilo za myeloid leukemia (CML) kapena Ph-positive acute lymphoblastic leukemia (ALL). Izi zikuphatikiza:

• Kutopa
• Malungo
• Kuchepetsa thupi
• Kutuluka thukuta usiku (kutuluka thukuta kwambiri uku mukugona)
• Kuphatikizana kapena kupweteka kwa mafupa

Anthu ena omwe ali ndi CML kapena Ph-positive ONSE alibe zisonyezo, kapena zoziziritsa kwambiri, makamaka kumayambiriro kwa matendawa. Chifukwa chake wothandizira zaumoyo wanu akhoza kuyitanitsa mayesowa ngati kuchuluka kwathunthu kwa magazi kapena kuyezetsa magazi kwina kukuwonetsa zotsatira zomwe sizinali zachilendo. Muyeneranso kudziwitsa omwe akukuthandizani ngati muli ndi zizindikilo zomwe zimakukhudzani. CML ndi Ph-positive ZONSE ndizosavuta kuchiza zikapezeka msanga.

Muthanso kuyesedwa ngati mukuchiritsidwa ndi CML kapena Ph-positive ALL. Mayesowo atha kuthandiza omwe akukuthandizani kuwona ngati chithandizo chanu chikugwira ntchito.

Kodi chimachitika ndi chiyani pakuyesa kwa majini a BCR-ABL?

Kuyezetsa kwa BCR-ABL nthawi zambiri kumayesa magazi kapena njira yotchedwa kukhumba mafuta m'mafupa ndi biopsy.

Ngati mukupima magazi, Katswiri wa zamankhwala adzatenga magazi kuchokera mumtsinje wamkono mwanu, pogwiritsa ntchito singano yaying'ono. Singanoyo italowetsedwa, magazi ang'onoang'ono amatengedwa mu chubu choyesera. Mutha kumva kuluma pang'ono singano ikamalowa kapena kutuluka. Izi nthawi zambiri zimatenga mphindi zosakwana zisanu.

Ngati mukupeza chiyembekezo cha mafuta m'mafupa, Njira yanu itha kukhala ndi izi:

• Mudzagona chammbali kapena m'mimba, kutengera fupa liti lomwe lidzagwiritsidwe ntchito poyesa. Mayeso ambiri am'mafupa amachotsedwa m'chiuno.
• Thupi lanu lidzakutidwa ndi nsalu, kotero kuti malo okha ozungulira malo oyesera ndi omwe akuwonetsedwa.
• Tsambali lidzatsukidwa ndi mankhwala opha tizilombo.
• Mupeza jakisoni wa yankho lodzidzimutsa. Itha kuluma.
• Dera likangokhala dzanzi, wothandizira zaumoyo atenga chitsanzocho. Muyenera kunama mutayesedwa.
  • Pofuna kulakalaka mafuta m'mafupa, omwe nthawi zambiri amachitika koyamba, wothandizira zaumoyo amalowetsa singano kupyola fupa ndikutulutsa madzi m'mafupa ndi m'maselo. Mungamve kupweteka kwakuthwa koma kwakanthawi kochepa pamene singano iikidwa.
  • Pazitsulo zam'mafupa, wothandizira zaumoyo adzagwiritsa ntchito chida chapadera chomwe chimapindika mu fupa kuti atengeko gawo la mafupa. Mutha kumva kukakamizidwa pamalopo pomwe zitsanzo zikutengedwa.
• Zimatenga pafupifupi mphindi 10 kuchita mayeso onsewa.
• Pambuyo pa kuyezetsa, wothandizira zaumoyo adzaphimba malowo ndi bandeji.
• Konzani kuti wina azikuthamangitsani kupita nanu kunyumba, chifukwa mutha kukupatsani mankhwala ogonetsa musanayesedwe, zomwe zingakupangitseni kuti mugone.

Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?

Nthawi zambiri simusowa kukonzekera kwapadera kokayezetsa magazi kapena m'mafupa.

Kodi pali zoopsa zilizonse pamayeso?

Pali chiopsezo chochepa kwambiri choyesedwa magazi. Mutha kukhala ndi ululu pang'ono kapena kuvulala pamalo pomwe singano idayikidwapo, koma zizindikiro zambiri zimatha msanga.

Pambuyo poyesedwa m'mafupa, mumatha kumva kuti ndinu olimba kapena opweteka pamalo obayira. Izi zimatha masiku angapo. Wothandizira zaumoyo wanu akhoza kukulangizani kapena kukupatsani mankhwala ochepetsa ululu kuti akuthandizeni.

Kodi zotsatirazi zikutanthauza chiyani?

Ngati zotsatira zanu zikuwonetsa kuti muli ndi jini la BCR-ABL, komanso kuchuluka kwa maselo oyera amwazi, mutha kupezeka kuti muli ndi myeloid leukemia (CML) kapena Ph-positive, acute lymphoblastic leukemia (ALL).

Ngati mukulandira CML kapena Ph-positive ZONSE, zotsatira zanu zitha kuwonetsa:

• Kuchuluka kwa BCR-ABL m'magazi anu kapena m'mafupa kukukulira. Izi zikhoza kutanthauza kuti mankhwala anu sakugwira ntchito ndipo / kapena mwakhala mukugonjetsedwa ndi mankhwala ena.
• Kuchuluka kwa BCR-ABL m'magazi anu kapena m'mafupa akuchepa. Izi zikutanthauza kuti chithandizo chanu chikugwira ntchito.
• Kuchuluka kwa BCR-ABL m'magazi anu kapena m'mafupa simukuwonjezeka kapena kutsika. Izi zikhoza kutanthauza kuti matenda anu ndi okhazikika.

Ngati muli ndi mafunso pazotsatira zanu, lankhulani ndi omwe amakuthandizani.

Dziwani zambiri zamayeso a labotale, magawo owerengera, ndi zotsatira zakumvetsetsa.

Kodi pali china chilichonse chomwe ndiyenera kudziwa chokhudza kuyesedwa kwa majini a BCR-ABL?

Chithandizo cha matenda a myeloid leukemia (CML) ndi Ph-positive, acute lymphoblastic leukemia (ALL) chachita bwino mwa odwala omwe ali ndi khansa ya m'magazi. Ndikofunika kuwona wothandizira zaumoyo wanu pafupipafupi kuti muwonetsetse kuti mankhwala anu akupitilirabe. Ngati mukugonjetsedwa ndi chithandizo, omwe amakupatsani mwayi akhoza kulangiza mitundu ina ya mankhwala a khansa.

Zolemba

1. American Cancer Society [Intaneti]. Atlanta: Bungwe la American Cancer Society Inc .; c2018. Zomwe Zimayambitsa Matenda a Myeloid Leukemia [zosinthidwa 2018 Jun 19; yatchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.cancer.org/cancer/chronic-myeloid-leukemia/causes-risks-prevention/what-causes.html
2. Cancer.net [Intaneti]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Khansa ya m'magazi: Myeloid Yosatha: CML: Kuyamba; 2018 Mar [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/introduction
3. Cancer.net [Intaneti]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Khansa ya m'magazi: Myeloid Yosatha: CML: Zosankha Zamankhwala; 2018 Mar [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/treatment-options
4. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC: American Association for Clinical Chemistry; c2001–2018. BCR-ABL1 [yasinthidwa 2017 Dec 4; yatchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/tests/bcr-abl1
5. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC: American Association for Clinical Chemistry; c2001–2018. Khansa ya m'magazi [yasinthidwa 2018 Jan 18; yatchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/conditions/leukemia
6. Khansa ya m'magazi ndi Lymphoma Society [Internet]. Rye Brook (NY): Khansa ya m'magazi ndi Lymphoma Society; c2015. Matenda a Myeloid Leukemia [otchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: http://www.lls.org/leukemia/chronic-myeloid-leukemia
7. Chipatala cha Mayo [Intaneti]. Mayo Foundation for Medical Education and Research; c1998–2018. Kufufuza kwa m'mafupa ndi chikhumbo: Mwachidule; 2018 Jan 12 [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Chipatala cha Mayo [Intaneti]. Mayo Foundation for Medical Education and Research; c1998–2018. Matenda myelogenous khansa ya magazi: mwachidule; 2016 Meyi 26 [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.mayoclinic.org/diseases-conditions/chronic-myelogenous-leukemia/symptoms-causes/syc-20352417
9. Chipatala cha Mayo: Mayo Medical Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995–2018. Chidziwitso cha Mayeso: BADX: BCR / ABL1, Qualitative, Diagnostic Assay: Clinical and Interpretive [cited 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89006
10. Merck Manual Consumer Version [Intaneti]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Kufufuza kwa Bone Marrow [kutchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
11. Merck Manual Consumer Version [Intaneti]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Matenda a m'magazi [otchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://www.merckmanuals.com/home/blood-disorders/leukemias/chronic-myelogenous-leukemia
12. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Chithandizo cha Matenda Oopsa a Myelogenous Leukemia (PDQ®) -Patient Version [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq
13. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Njira Zochizira Khansa [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
14. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. NCI Dictionary Yamatenda a Khansa: BCR-ABL fusion gene [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene
15. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. NCI Dictionary Wamasamba a Khansa: BCR-ABL maphatikizidwe mapuloteni [otchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-protein
16. National Cancer Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. NCI Dictionary Yokhudza Khansa: jini [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
17. National Heart, Lung, ndi Blood Institute [Internet]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Mayeso Amwazi [otchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.nhlbi.nih.gov/health-topics/blood-tests
18. NIH National Human Genome Research Institute [Intaneti]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Chromosome Zovuta; 2016 Jan 6 [yotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.genome.gov/11508982
19. NIH U.S. National Library of Medicine: Genetics Home Reference [Internet]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Mtundu wa ABL1; 2018 Jul 31 [wotchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://ghr.nlm.nih.gov/gene/ABL1#conditions
20. Oncolink [Intaneti]. Philadelphia: Matrasti aku University of Pennsylvania; c2018. Zonse Zokhudza Matenda Aakulu Aakulu A m'magazi (ONSE) [zosinthidwa 2018 Jan 22; yatchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.oncolink.org/cancers/leukemia/leukemia-acute-lymphocytic-leukemia-all/all-about-adult-acute-lymphocytic-leukemia-all
21. Oncolink [Intaneti]. Philadelphia: Matrasti aku University of Pennsylvania; c2018. All About Chronic Myeloid Leukemia (CML) [yasinthidwa 2017 Oct 11; yatchulidwa 2018 Aug 1]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.oncolink.org/cancers/leukemia/chronic-myelogenous-leukemia-cml/all-about-chronic-myeloid-leukemia-cml

Zomwe zili patsamba lino siziyenera kugwiritsidwa ntchito m'malo mwa chithandizo chamankhwala kapena upangiri. Lumikizanani ndi othandizira azaumoyo ngati muli ndi mafunso okhudzana ndi thanzi lanu.