Biologics ndi PsA: Kodi Mungasankhe Bwanji?

Zamkati

• Kodi biologics ndi chiyani?
• Kodi biologics imagwiritsidwa ntchito bwanji pochiritsa PsA?
• Kodi ndingatani kuti ndithandizire PsA ndi biologic?
• TNF-alpha zoletsa
• IL-12, IL-23, ndi IL-17 zoletsa
• T-selo zoletsa
• JAK kinase inhibitor
• Kodi biologics ndiyotetezeka kwa aliyense amene ali ndi PsA?
• Kodi zotsatira zoyipa zakutenga biologic ndi ziti?
• Kutenga

Chidule

Matenda a Psoriatic, kapena PsA, amachititsa kutupa, kuuma, ndi kupweteka kwamagulu. Palibe mankhwala a PsA, koma kusintha kwa moyo ndi mankhwala kungathandize kuthana ndi zizindikilo.

Mankhwala omwe amagwiritsidwa ntchito nthawi zambiri ndimankhwala osokoneza bongo (NSAIDs), mankhwala osokoneza bongo (DMARDs), komanso biologics.

Biologics siatsopano, koma amapereka chithandizo chazotsogola tsopano kuposa kale. Maupangiri atsopano amalimbikitsa kuti mankhwalawa ndi imodzi mwazithandizo zoyambirira za PsA.

Kodi biologics ndi chiyani?

Mankhwala achikhalidwe amakhala ndi zinthu zopangira. Zimapangidwa ndi mankhwala omwe sapezeka m'chilengedwe.

Mankhwala omwe anthu amawadziwa komanso kuwakhulupirira amapangidwa m'malo opangira labotale kuchokera kuzinthu zosagwirizana ndi chilengedwe. Mwachitsanzo, aspirini, ankayeserera kutengera khungwa la msondodzi, koma tsopano limapangidwa ndi zinthu zopangidwa.

Komano zinthu zamoyo zimapangidwa ndi zinthu zamoyo. Asayansi amagwiritsa ntchito maselo athunthu, ma enzyme, ma antibodies, ndi zinthu zina kuti apange mankhwala omwe ali ndi ntchito inayake.

Mwayi kuti mwakhala mukuwonapo kale ukadaulo wazachipatala wopangidwa kuchokera kuzinthu zopezeka m'chilengedwe. Ngati munalandirapo katemera kapena kulandira magazi, mwalandira chithandizo chamankhwala chomwe chinapangidwa motengera zinthu zachilengedwe.

Chifukwa biologics imakhala yolunjika kwambiri ikamafufuza maselo, ndipo amatsanzira mamolekyulu omwe amapezeka mwachilengedwe mthupi, amakhala othandiza kwambiri. Amakhalanso ndi zovuta zochepa kuposa mankhwala opangidwa ndi mankhwala.

Kodi biologics imagwiritsidwa ntchito bwanji pochiritsa PsA?

Kutupa kumayambitsa kutupa, kuuma, ndi kupweteka kwamagulu komwe kumatanthauzira PsA. Biologics yomwe imagwiritsidwa ntchito pochiza PsA imalunjika m'njira zosiyanasiyana mthupi zomwe zimayambitsa kutupa. Izi ndizosiyana ndi mankhwala amwambo, omwe amalimbana ndi chitetezo chamthupi.

Kutengera ndi matenda anu a nyamakazi a psoriatic komanso mbiri yazachipatala, adotolo angavomereze chimodzi mwazinthu zamoyo kuti zithandizire.

Kodi ndingatani kuti ndithandizire PsA ndi biologic?

Pali njira zingapo zochiritsira PsA yanu ndi biologic. Mankhwalawa atha kuphatikizidwa ndi dokotala kutengera momwe amathandizira poyerekeza ndi chitetezo chamthupi.

TNF-alpha zoletsa

Tumor necrosis factor-alpha (TNF-alpha) ndi protein yomwe imayambitsa kutupa. Anthu omwe ali ndi PsA ali ndi TNF-alpha yochulukirapo pakhungu lawo kapena m'malo awo olumikizana.

Mankhwala asanuwa adapangidwa kuti aletse puloteni iyi:

• Cimzia (chitsimikizo cha pegol)
• Zowonjezera (etanercept)
• Humira (adalimumab)
• Remicade (infliximab)
• Simponi (golimumab)

Amagwira ntchito poletsa kukula kwamaselo akhungu komanso kutupa komwe kumatha kuwononga minofu yolumikizana.

IL-12, IL-23, ndi IL-17 zoletsa

Interleukin-12, interleukin-17, ndi interleukin-23 ndi mapuloteni osiyanasiyana omwe amakhudzana ndi kutupa. Ma biologics asanu omwe alipo pakadali pano asokoneza ntchitoyi kapena cholandilira chofananira cha mapuloteniwa.

Mankhwalawa adapangidwa kuti ateteze kutupa:

• Stelara (ustekinumab): IL-12/23
• Cosentyx (secukinumab): IL-17
• Taltz (ixekizumab): IL-17
• Siliq (brodalumab): IL-17
• Tremfya (guselkumab): IL-23

T-selo zoletsa

Mwa anthu omwe ali ndi nyamakazi, ma T-lymphocyte cell, kapena T-cell, amayatsidwa, zomwe zimatha kubweretsa kuchuluka kwa ma cellwa. Anthu ena omwe ali ndi nyamakazi amatha kukhala ndi ma T-cell ochulukirapo.

Awa ndi ma cell a chitetezo, omwe tonse timafunikira. Koma zochuluka, zimatulutsa mankhwala omwe amatsogolera kuwonongeka kwamagulu, kupweteka, ndi kutupa.

Orencia (abatacept) ndi mankhwala omwe amakhudza T-cell. Orencia sichichepetsa kuchuluka kwa ma T-cell, koma imayimitsa kutulutsa kwa mankhwala omwe amayambitsa zizindikilo poletsa T-cell activation.

JAK kinase inhibitor

Xeljanz (tofacitinib) ndi mankhwala ena omwe amavomerezedwa ku PsA. Ndi JAK kinase inhibitor, yomwe imanena za kamolekyulu yaying'ono yomwe imatseka njira yomwe imakhudzidwa ndikutupa kwamatenda amthupi.

Mankhwalawa sakhala biologic, koma dokotala akhoza kuyankhula nanu za izi. Nthawi zambiri amaphatikizidwa ndi ma biologics pokambirana za omwe akuwatsata kwambiri kuti azitha kudziteteza.

Kodi biologics ndiyotetezeka kwa aliyense amene ali ndi PsA?

Ma biologics amalimbikitsidwa kwa iwo omwe amakhala ndi PsA yochepa. Koma anthu ena sali ofuna biologics.

Izi ndichifukwa choti zotsatira za mankhwalawa zitha kuvulaza kuposa zabwino. Anthu omwe ali ndi chitetezo chamthupi chovuta kapena matenda opatsirana sayenera kutenga biologics ya PsA yawo. Mankhwalawa amapondereza chitetezo cha mthupi ndipo amatha kukhala osatetezeka ngati anu asokonekera kale mwanjira ina.

Mtengo komanso kutuluka mthumba kwama biologics amathanso kukhala chotchinga kwa anthu ena.

Kodi zotsatira zoyipa zakutenga biologic ndi ziti?

PsA biologic iliyonse ndiyosiyana. Chilichonse chimakhala ndi zotsatirapo zake. Komabe, palinso zofanana mgululi. Zotsatira zoyipa kwambiri pa biologics yonse ndi chiopsezo chowonjezeka cha matenda achilendo, kapena opindulitsa.

Ngati inu ndi dokotala mwasankha kuyesa mankhwalawa ndi biologic, mutha kukhala ndi zizindikilo ngati chimfine kapena matenda opumira. Popeza biologics imaperekedwa ndi jakisoni kapena IV, mutha kukhalanso osasangalala pomwe singano imakoka khungu lanu.

Biologics imatha kubweretsa zovuta zina, monga zovuta zamagazi kapena khansa. Pazifukwa izi, ndibwino kuti mukhale ndi ubale wolimba ndi dokotala wanu. Pamodzi, mutha kusankha ngati biologic ndiyo njira yoyenera yothandizira nyamakazi yanu ya psoriatic.

Kutenga

Biologics yakhazikitsa njira zochiritsira kwa omwe akukhala ndi PsA yochepa. Sikuti zonse ndi zatsopano, koma tsopano akuwerengedwa kuti ndi mankhwala oyamba a PsA.