Matenda a Calcinosis Cutis

Zamkati

• Mitundu ya calcinosis cutis
• Zizindikiro za calcinosis cutis
• Zimayambitsa calcinosis cutis
• Kuwerengera kwa Dystrophic
• Kuwerengera kwamatenda
• Kuwerengera kwa Idiopathic
• Kuwerengera kwa Iatrogenic
• Matenda a calciphylaxis
• Pamodzi ndi scleroderma
• Matenda a calcinosis cutis
• Chithandizo cha calcinosis cutis
• Mankhwala osokoneza bongo
• Opaleshoni
• Mankhwala ena
• Chiyembekezo cha calcinosis cutis

Chidule

Calcinosis cutis ndikudzikundikira kwama calcium mumiyala pakhungu lanu. Malo osungira calcium ndi mabampu ovuta omwe samasungunuka. Maonekedwe ndi kukula kwa zilondazo zimasiyana.

Izi ndizosowa zomwe zimayambitsa zifukwa zosiyanasiyana. Izi zimachokera ku matenda ndi kuvulala kwa matenda amachitidwe monga impso kulephera.

Nthawi zambiri calcinosis cutis ilibe zisonyezo. Koma nthawi zina, zimakhala zopweteka kwambiri. Mankhwala alipo, kuphatikizapo opaleshoni, koma zotupa za calcium zimatha kubwereranso.

Mitundu ya calcinosis cutis

Pali magawo asanu a calcinosis cutis:

• Kuwerengera kwa Dystrophic. Uwu ndiye mtundu wofala kwambiri wa calcinosis. Zimachitika pomwe khungu lawonongeka kapena latupa. Sizimaphatikizapo milingo yachilendo ya calcium kapena phosphorous m'thupi.
• Kuwerengera kwamatenda. Izi zimachitika mwa anthu omwe ma calcium ndi phosphorous amakhala okwera modabwitsa.
• Kuwerengera kwa Idiopathic. Mtundu uwu wa calcinosis cutis ulibe chifukwa chowonekera. Nthawi zambiri zimachitika mdera limodzi lokha.
• Kuwerengera kwa Iatrogenic. Mtundu uwu wa calcinosis cutis umachokera kuchipatala kapena kuchipatala, nthawi zambiri mwangozi. Mwachitsanzo, akhanda atha kubadwa amatha kuwerengedwa ndi iatrogenic pachidendene, chifukwa cha zidendene kuti atenge magazi.
• Matenda a calciphylaxis. Mtundu wosowa komanso wowopsa wa calcinosis cutis nthawi zambiri umachitika mwa anthu omwe ali ndi impso kulephera, alandiridwa impso, kapena ali ndi dialysis. Zimakhudza mitsempha ya khungu pakhungu kapena mafuta osanjikiza.Magulu a calcium ndi phosphate mthupi siachilendo.

Zizindikiro za calcinosis cutis

Maonekedwe ndi malo a calcinosis cutis zimadalira chomwe chimayambitsa. Zilondazo nthawi zambiri zimakhala zovuta, zoyera zachikasu pakhungu. Amayamba pang'onopang'ono komanso amasiyana kukula.

Zilondazo sizingakhale ndi zisonyezo, kapena zitha kukhala zowopsa, zopweteka, kapena zotulutsa zoyera. Nthawi zambiri, chotupacho chitha kupha moyo.

Pano pali malo omwe zilondazo zimawonekera m'magulu onse a calcinosis cutis:

• Kuwerengera kwa Dystrophic. Ziphuphu zimachitika m'malo owonongeka kwa minofu. Madera omwe amapezeka ndizakutsogolo, zigongono, zala, ndi mawondo. Ndi lupus, zotupazo zimapezeka pamanja ndi pamapazi, matako, komanso pansi pa zotupa za lupus.
• Kuwerengera kwamatenda. Ziphuphu zimapezeka mozungulira molumikizana mafupa: mawondo, zigongono, kapena mapewa. Amathanso kupanga ziwalo zamkati, monga mapapo, impso, mitsempha yamagazi, kapena m'mimba. Zilonda zam'mimbazi zimatha kuchepetsa kuyenda kwa khungu.
• Kuwerengera kwa Idiopathic. Izi nthawi zambiri zimakhudza gawo limodzi lokha la thupi. Zitha kuchitika pamalumikizidwe akulu, chikopa, mutu, mabere, mbolo, kumaliseche, kapena manja ndi mapazi. Mwa ana akhoza kukhala pankhope. Zilondazo zimatha kutuluka zoyera.
• Kuwerengera kwa Iatrogenic. Chotupacho chimapezeka pamalo azachipatala kapena othandizira omwe amapyoza khungu.
• Matenda a calciphylaxis. Zilonda za khungu nthawi zambiri zimakhala pamapazi kapena thunthu, makamaka malo amafuta monga mabere, matako, ndi m'mimba. Zilondazo zimakhala zowoneka bwino komanso zopweteka. Amatha kukhala zilonda zosapola, kapena amatha kudwala chilonda. Zilondazo zitha kutsagana ndi zizindikilo zina, monga kutopa ndi kufooka.

Zimayambitsa calcinosis cutis

Calcinosis cutis ndiyosowa koma imayambitsa zifukwa zingapo, kutengera mtundu:

Kuwerengera kwa Dystrophic

Kawirikawiri, kuwonongeka kwa minofu kumabweretsa mapuloteni a phosphate omwe amatulutsidwa ndi maselo akufa omwe amawerengetsa, ndikupanga mchere wa calcium. Kuwonongeka kwa minofu kumatha kubwera kuchokera:

• matenda
• zotupa
• ziphuphu
• Matenda othandizira monga lupus, systemic sclerosis, kapena dermatomyositis

Kuwerengera kwamatenda

Calcium phosphate ya thupi ikakhala yayikulu modabwitsa, imatulutsa mchere wa calcium womwe umapanga tinthu tating'onoting'ono pakhungu. Zomwe zimayambitsa kuchepa kwa calcium ndi phosphate ndi:

• Kulephera kwa impso (chifukwa chofala kwambiri)
• vitamini D wambiri
• hyperparathyroidism (khungu lokulitsa la parathyroid limatulutsa timadzi ta chithokomiro)
• sarcoidosis (magulu am'magazi otupa amapangidwa m'mapapu, ma lymph node, khungu, ndi ziwalo zina za thupi)
• mkaka-alkali syndrome (calcium yochuluka kwambiri kuchokera ku zakudya kapena maantacid)
• matenda a mafupa, monga matenda a Paget

Kuwerengera kwa Idiopathic

Mosiyana ndi mitundu iwiri yoyambirira ya calcinosis cutis, idiopathic calcification imachitika popanda kuwonongeka kwa minofu ndipo mulibe calcium kapena phosphorus yosazolowereka. Idiopathic amatanthauza "palibe chifukwa chodziwika." Pali mitundu itatu:

• maqhubu apabanja, omwe nthawi zambiri amawoneka achichepere kapena ana athanzi
• mitsempha ya subepidermal, yomwe imawonekera pansi pa khungu
• mitsempha pamatumbo

Kuwerengera kwa Iatrogenic

Zomwe zimayambitsa kuwerengera kwa iatrogenic ndi njira zamankhwala zomwe mwangozi zimayambitsa madipoziti amchere wa calcium. Makina a izi sakudziwika. Zina mwa njira zomwe zikukhudzidwa ndi izi:

• makonzedwe a mayankho okhala ndi calcium ndi phosphate
• Kuyanjana kwakanthawi kokhala ndi calcium calcium chloride electrode phala pa electroencephalograph kapena electromyograph
• intravenous calcium gluconate, calcium chloride, ndi para-aminosalicylic acid pochiza TB
• chidendene chimamangirira ana obadwa kumene

Matenda a calciphylaxis

Chifukwa cha calciphylaxis sichidziwika bwinobwino. Ndizochepa kwambiri, ngakhale zina mwazinthu zomwe zimagwirizanitsidwa ndizofala:

• aakulu impso kulephera
• kunenepa kwambiri
• matenda ashuga
• hyperparathyroidism

Pamodzi ndi scleroderma

Calcinosis cutis nthawi zambiri imachitika limodzi ndi systemic sclerosis (scleroderma). Amapezeka makamaka munthawi yochepa ya matendawa, omwe amadziwika kuti limited cutaneous systemic sclerosis (CREST).

Ena mwa iwo omwe ali ndi matenda a CREST adzalandira calcinosis cutis pambuyo pake.

Zilondazo nthawi zambiri zimawoneka mozungulira zala ndi m'zigongono ndipo zimatha kutseguka ndikutuluka zoyera zakuda.

Matenda a calcinosis cutis

Kudziwa mtundu wa calcinosis cutis omwe muli nawo ndikofunikira posankha chithandizo choyenera. Dokotala wanu amakupimitsani ndikutenga mbiri yanu yazachipatala ndikukufunsani mafunso okhudzana ndi zizindikilo zanu.

Dokotala atha kuyitanitsa mayeso angapo a labotale kuti adziwe chomwe chimayambitsa calcinosis cutis yanu:

• kuyezetsa magazi kuti muwone ngati calcium yanu ndi phosphate ndiyokwera modabwitsa, kufunafuna zizindikiritso za lupus ndi zotupa zomwe zingachitike, ndikuwononga kuchuluka kwa parathyroid ndi vitamini D
• mayesero amadzimadzi kuti athetse mavuto a impso
• X-ray, CT scan, kapena bone scans (scintigraphy) kuti muwone kuchuluka kwake
• biopsy ya zotupa
• mayeso ena apadera kuti aone ngati ali ndi dermatomyositis (matenda otupa) ndi matenda amkaka-alkali

Ukadaulo watsopano womwe ukupangidwira kuti athandizire kuzindikira ndiwowoneka bwino kwambiri. Njira yodziwitsa matenda imeneyi imagwiritsa ntchito kuwunikira kwa Fourier infrared (FT-IR) kapena kuwunika kochititsa chidwi kwa Raman. Imazindikiritsa mwachangu zomwe zimapangidwa ndi zilonda za calcinosis cutis. Ikhozanso kuneneratu kukula kwa matendawa.

Chithandizo cha calcinosis cutis

Chithandizo cha calcinosis cutis chimadalira matenda oyambitsa kapena chifukwa.

Mankhwala osokoneza bongo

Mankhwala osiyanasiyana amatha kuyesedwa kuti athetse zilondazo, koma kupambana kwawo kwakhala kowala.

Kwa zilonda zazing'ono, mankhwala omwe akuphatikizapo:

• warfarin
• alireza
• mtsempha wamagazi immunoglobulin (IVIG)

Kwa zilonda zokulirapo, mankhwala omwe akuphatikizapo:

• alireza
• ziphuphu
• chiweb
• zotayidwa hydroxide

Kafukufuku wa 2003 adanenanso kuti mankhwala ocheperako a minocycline anali othandiza kuthana ndi zowawa komanso zotupa kwa anthu omwe ali ndi matenda a CREST. Matenda a sodium thiosulfate amathanso kukhala othandiza.

Opaleshoni

Ngati zotupa zanu ndizopweteka, kutenga kachilomboka nthawi zambiri, kapena kusokoneza magwiridwe antchito anu, adokotala angakupatseni opaleshoni. Koma zilondazo zimatha kubwereranso pambuyo pochitidwa opaleshoni. Ndikulimbikitsidwa kuti opareshoni iyambike ndi gawo laling'ono la chotupa.

Mankhwala ena

Chithandizo chatsopano chofunsidwa ndi hematopoietic stem cell transplantation (HSCT), yomwe imalowa m'malo mwa maselo opangira magazi a munthu. Izi zakhala zikugwiritsidwa ntchito pochiza matenda ena amthupi okha.

Mankhwala a Laser ndi mantha wave lithotripsy (mankhwala a ultrasound omwe amathandizira kuphwanya miyala ya impso) nawonso ndi mankhwala.

Chiyembekezo cha calcinosis cutis

Maganizo a calcinosis cutis amatengera matenda kapena chifukwa, komanso kuopsa kwa zotupa zanu. Chithandizo chamakono chingathandize, ndipo njira zatsopano zamankhwala zikupangidwira. Lankhulani ndi dokotala wanu za momwe mungachepetsere matenda anu ndikuchotsa muzu wa vutoli.