Zomwe zimayambitsa matenda a Alzheimer's komanso momwe matendawa amapangidwira

Zamkati

• 1. Chibadwa
• 2. Kumanga mapuloteni muubongo
• 3. Kuchepetsa mu neurotransmitter acetylcholine
• 4. Zowopsa zachilengedwe
• 5. Kachilombo ka Herpes
• Momwe mungadziwire
• Kuyesa kwa Alzheimer's Rapid. Yesani mayeso kapena mupeze chiopsezo chanu chokhala ndi matendawa.
• Kuchiza kwa Alzheimer's

Matenda a Alzheimer's ndi mtundu wa matenda a dementia omwe amachititsa kuti ubongo wamaubongo uwonongeke pang'onopang'ono komanso kusokonezeka kwa magwiridwe antchito, monga kukumbukira, chidwi, chilankhulo, malingaliro, malingaliro, kulingalira ndi kuganiza. Kuti mumvetse zomwe zizindikirazo, yang'anani zikwangwani za matenda a Alzheimer's.

Pali zifukwa zina zomwe zimayesa kuwonetsa zomwe zimayambitsa matendawa, ndipo zimafotokozera zambiri zomwe zimayamba pakukula kwake, koma amadziwika kuti Alzheimer's imalumikizidwa ndikuphatikizira pazifukwa zingapo zomwe zimaphatikizapo ma genetics ndi zina zowopsa monga kukalamba ., kusagwira ntchito, kupwetekedwa mutu komanso kusuta, mwachitsanzo.

Chifukwa chachikulu chomwe chimayambitsa matenda a Alzheimer ndi:

1. Chibadwa

Zosintha zawonetsedwa m'mitundu ina, yomwe imakhudza magwiridwe antchito aubongo, monga APP, apoE, PSEN1 ndi majini a PSEN2, mwachitsanzo, omwe amawoneka kuti akukhudzana ndi zotupa m'mitsempha yomwe imayambitsa matenda a Alzheimer's, koma sichikudziwika bwinobwino chomwe chimatsimikizira kusintha.

Ngakhale izi zili choncho, ochepera theka la matendawa amakhala obadwa nawo, ndiye kuti, amaperekedwa ndi makolo kapena agogo aamuna, omwe ndi banja la Alzheimer's, lomwe limachitika mwa achinyamata, azaka 40 mpaka 50, okhala ndi zambiri mofulumira kwambiri. Anthu omwe akhudzidwa ndimatendawa a Alzheimer's ali ndi mwayi wa 50% wofalitsa matendawa kwa ana awo.

Mtundu wofala kwambiri, komabe, ndi Alzheimer's, womwe sugwirizana ndi banja ndipo umapezeka mwa anthu opitilira 60, komabe pali zovuta zina kuti mupeze chomwe chimayambitsa vutoli.

2. Kumanga mapuloteni muubongo

Zikuwoneka kuti anthu omwe ali ndi matenda a Alzheimer's ali ndi mapuloteni ambiri, omwe amatchedwa Beta-amyloid protein ndi Tau protein, omwe amayambitsa kutupa, kusokonekera komanso kuwonongeka kwa ma cell a neuronal, makamaka zigawo zaubongo zotchedwa hippocampus ndi kotekisi.

Zimadziwika kuti kusintha kumeneku kumakhudzidwa ndi majini omwe atchulidwa, komabe, sizinapezeke zomwe zimayambitsa kusungaku, kapena zomwe mungachite kuti mupewe, chifukwa chake, mankhwala a Alzheimer's sanakhalebe anapeza.

3. Kuchepetsa mu neurotransmitter acetylcholine

Acetylcholine ndi neurotransmitter yofunikira yotulutsidwa ndi ma neuron, yomwe ili ndi gawo lofunikira kwambiri pakufalitsa zomwe zimakhudza mitsempha muubongo ndikuilola kuti igwire bwino ntchito.

Amadziwika kuti, mu matenda a Alzheimer's, acetylcholine imachepa ndipo ma neuron omwe amawutulutsa amachepa, koma chifukwa chake sichikudziwika.Ngakhale izi, mankhwala omwe alipo pakadali pano ndikugwiritsa ntchito mankhwala a anticholinesterase, monga Donepezila, Galantamina ndi Rivastigmina, omwe amagwira ntchito kuti achulukitse kuchuluka kwa mankhwalawa, omwe, ngakhale osachiritsa, amachepetsa kukula kwa matenda amisala ndikuthandizira kusintha kwa matenda .

4. Zowopsa zachilengedwe

Ngakhale pali zoopsa chifukwa cha majini, Alzheimer's sporadic imadziwikiranso chifukwa cha mikhalidwe yomwe imakhudzidwa ndi zizolowezi zathu, zomwe zimayambitsa kutupa muubongo, monga:

• Okhazikika mopanda malire, yomwe imadziunjikira mthupi lathu chifukwa cha kusakwanira zakudya, kukhala ndi shuga, mafuta ndi zakudya zopangidwa, kuphatikiza zizolowezi monga kusuta, kusachita masewera olimbitsa thupi ndikukhala mopanikizika;
• Cholesterol wokwera kumawonjezera mwayi wokhala ndi Alzheimer's, chifukwa chake ndikofunikira kuti muchepetse matendawa ndi mankhwala a cholesterol, monga simvastatin ndi atorvastatin, kuphatikiza kukhala chifukwa china chosamalira chakudya ndikuchita zolimbitsa thupi nthawi zonse;
• Matenda a m'mimba, komwe ndi kuchuluka kwa mafuta mumitsuko yoyambitsidwa ndi mavuto monga kuthamanga kwa magazi, matenda ashuga, cholesterol komanso kusuta, kumatha kutsitsa magazi kupita kuubongo ndikuthandizira kukulitsa matendawa;
• Zaka zoposa zaka 60 ndizoopsa kwambiri pakukula kwa matendawa, chifukwa, ndi ukalamba, thupi silingathe kukonza kusintha komwe kungachitike m'maselo, zomwe zimawonjezera chiopsezo cha matenda;
• Kuvulala kwa ubongo, zomwe zimachitika pambuyo povulala pamutu, pangozi kapena masewera, mwachitsanzo, kapena chifukwa cha sitiroko, zimawonjezera mwayi wowonongedwa ndi neuron komanso kukula kwa Alzheimer's.
• Kuwonetsedwa pazitsulo zolemera, monga mercury ndi aluminiumpopeza ndi zinthu zapoizoni zomwe zimatha kudziunjikira ndikuwononga ziwalo zosiyanasiyana m'thupi, kuphatikiza ubongo.

Pazifukwa izi, njira yofunikira yopewa matenda a Alzheimer ndikukhala ndi moyo wathanzi, ndikusankha zakudya zokhala ndi ndiwo zamasamba, ndizinthu zochepa zopangira zinthu, kuphatikiza pakuchita masewera olimbitsa thupi. Onani malingaliro omwe muyenera kukhala nawo kuti mukhale ndi moyo wautali komanso wathanzi.

5. Kachilombo ka Herpes

Kafukufuku waposachedwa awonetsa kuti china chomwe chingayambitse matenda a Alzheimer's ndi kachilombo kamene kamayambitsa zilonda zozizira, HSV-1, yomwe imatha kulowa mthupi nthawi yaubwana ndikukhalabe mtulo m'mitsempha, kuyambitsidwa kokha panthawi yamavuto komanso kufooka kwa chitetezo cha mthupi .

Asayansi akuwonetsa kuti anthu omwe ali ndi jini la APOE4 komanso kachilombo ka HSV-1 atha kukhala ndi Alzheimer's. Kuphatikiza apo, ukalamba umakhala ndi kufooka kwa chitetezo chamthupi, chomwe chitha kuthandizira kubwera kwa kachilomboka muubongo, kumayambitsidwa munthawi yamavuto kapena kuchepa kwa chitetezo cha mthupi, ndikupangitsa kudzala kwa beta yachilendo -amyloid protein ndi tau, omwe amadziwika ndi Alzheimer's. Dziwani kuti sikuti aliyense amene ali ndi kachilombo ka HSV-1 adzadwala Alzheimer's.

Chifukwa cha kupezeka kwa ubale womwe ungakhalepo pakati pa kachilombo ka herpes ndikukula kwa matenda a Alzheimer's, ofufuza akhala akuyang'ana njira zamankhwala zomwe zingathandize kuchepetsa zizindikiro za Alzheimer's kapena kuchiritsa matendawa pogwiritsa ntchito mankhwala ochepetsa mphamvu ya kachilombo, monga Acyclovir, mwachitsanzo.

Momwe mungadziwire

Alzheimer's amakayikiridwa pakakhala zizindikiro zomwe zimawonetsa kufooka kwa kukumbukira, makamaka kukumbukira kwaposachedwa kwambiri, komwe kumakhudzana ndi kusintha kwamalingaliro ndi machitidwe, zomwe zimaipiraipira pakapita nthawi, monga:

• Kusokonezeka maganizo;
• Zovuta kuloweza pamtima kuti muphunzire zatsopano;
• Kubwereza mawu;
• Kuchepetsa mawu;
• Kukwiya;
• Nkhanza;
• Kuvuta kugona;
• Kutaya kwa kugwirizanitsa magalimoto;
• Mphwayi;
• Kukhazikika kwamikodzo ndi zimbudzi;
• Osazindikira anthu omwe mumawadziwa kapena abale;
• Kudalira zochitika za tsiku ndi tsiku, monga kupita kubafa, kusamba, kugwiritsa ntchito foni kapena kugula.

Pozindikira matenda a Alzheimer's ndikofunikira kuyesa mayeso amalingaliro monga kuyesedwa kwa Mini kwamisala, kapangidwe ka Clock, Kuyesa kwamatchulidwe ena ndi mayeso ena a Neuropsychological, opangidwa ndi neurologist kapena dokotala wa zamankhwala.

Muthanso kuyitanitsa mayeso monga ubongo wa MRI kuti muwone kusintha kwaubongo, komanso kuyezetsa magazi komanso magazi, zomwe zitha kuthana ndi matenda ena omwe amayambitsa kusakumbukira kukumbukira, monga hypothyroidism, kukhumudwa, kusowa kwa vitamini B12, hepatitis kapena HIV, mwachitsanzo.

Kuphatikiza apo, kuchuluka kwa mapuloteni a beta-amyloid ndi mapuloteni a Tau atha kutsimikizika pofufuza kusonkhanitsa kwa madzi amadzimadzi, koma, chifukwa ndiokwera mtengo, sikupezeka nthawi zonse.

Yesani mwachangu tsopano poyankha mafunso otsatirawa omwe angakuthandizeni kuzindikira chiwopsezo cha Alzheimer's (osachotsa kuyesa kwa dokotala wanu):

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Kuyesa kwa Alzheimer's Rapid. Yesani mayeso kapena mupeze chiopsezo chanu chokhala ndi matendawa.

Yambani mayeso Kodi kukumbukira kwanu kuli bwino?

• Ndimakumbukira bwino, ngakhale pali zoiwalika zazing'ono zomwe sizimasokoneza moyo wanga watsiku ndi tsiku.
• Nthawi zina ndimayiwala zinthu monga funso lomwe adandifunsa, ndimayiwala zomwe ndachita komanso komwe ndidasiya makiyi.
• Nthawi zambiri ndimayiwala zomwe ndimapita kukakhitchini, chipinda chochezera, kapena chipinda chogona komanso zomwe ndimachita.
• Sindikukumbukira zambiri zosavuta komanso zaposachedwa ngati dzina la munthu amene ndangokumana naye, ngakhale nditayesetsa.
• Ndizosatheka kukumbukira komwe ndili komanso anthu omwe andizungulira.

Kodi mukudziwa kuti ndi tsiku liti?

• Nthawi zambiri ndimatha kuzindikira anthu, malo ndikudziwa tsiku ili.
• Sindikukumbukira bwino kuti lero ndi liti ndipo ndimavutika posunga madeti.
• Sindikudziwa kuti ndi mwezi uti, koma ndimatha kuzindikira malo omwe ndimazolowera, koma ndikusokonezeka m'malo atsopano ndipo ndimatha kusochera.
• Sindikukumbukira kuti abale anga ndi ndani, komwe ndimakhala ndipo sindikukumbukira chilichonse chakale.
• Zomwe ndimadziwa ndi dzina langa, koma nthawi zina ndimakumbukira mayina a ana anga, zidzukulu kapena abale ena

Kodi mudakali okhoza kupanga zisankho?

• Ndimatha kuthana ndi mavuto amtsiku ndi tsiku ndikuthana ndi mavuto azachuma komanso zachuma.
• Ndimavutika kumvetsetsa zinthu zina monga chifukwa chake munthu akhoza kukhala wachisoni, mwachitsanzo.
• Ndikumva kukhala wopanda chitetezo pang'ono ndipo ndikuopa kupanga zisankho ndichifukwa chake ndimakonda ena andisankhira.
• Sindikumva kuti ndingathetse vuto lililonse ndipo lingaliro lokhalo lomwe ndikupanga ndi zomwe ndikufuna kudya.
• Sindingathe kupanga chisankho ndipo ndimangodalira thandizo la ena.

Kodi mudakali ndi moyo wokangalika kunja kwanyumba?

• Inde, ndimatha kugwira ntchito mwachizolowezi, ndimagula zinthu, ndimakhala ndi anthu ammudzi, tchalitchi komanso magulu ena azikhalidwe.
• Inde, koma ndikuyamba kuvutikira kuyendetsa galimoto koma ndimadzimva kukhala wotetezeka ndikudziwa momwe ndingathanirane ndi zovuta zadzidzidzi kapena zosakonzekera.
• Inde, koma sindingathe kukhala ndekha pamavuto ofunikira ndipo ndikufuna wina woti andiperekeze pazochita zanga kuti ndiwoneke ngati "wabwinobwino" kwa ena.
• Ayi, sindimachoka panyumba ndekha chifukwa ndilibe mphamvu ndipo ndimafunikira thandizo nthawi zonse.
• Ayi, sindingathe kuchoka panyumba ndekha ndipo ndikudwala kwambiri kuti ndingathe kutero.

Maluso anu ali bwanji kunyumba?

• Zabwino. Ndimakhalabe ndi ntchito zapakhomo, ndili ndi zosangalatsa komanso zokonda zanga.
• Sindikumvanso ngati ndikufuna kuchita chilichonse kunyumba, koma ngati akakamira, ndingayesere kuchitapo kanthu.
• Ndinasiyiratu ntchito zanga, komanso zosangalatsa zina.
• Zomwe ndikudziwa ndikusamba ndekha, kuvala ndikuwonera TV, ndipo sinditha kugwira ntchito zina zapakhomo.
• Sindingathe kuchita chilichonse pandekha ndipo ndikufuna thandizo pazonse.

Kodi ukhondo wanu uli bwanji?

• Ndimatha kudzisamalira ndekha, kuvala, kuchapa, kusamba komanso kusamba kubafa.
• Ndikuyamba kukhala ndi vuto kusamalira ukhondo wanga.
• Ndikufuna ena kuti andikumbutse kuti ndiyenera kupita kuchimbudzi, koma ndimatha kuthana ndi zosowa zanga ndekha.
• Ndikufuna kuthandizidwa kuvala ndikudziyeretsa ndipo nthawi zina ndimayang'ana pazovala zanga.
• Sindingachite chilichonse pandekha ndipo ndikufuna wina kuti azisamalira ukhondo wanga.

Kodi khalidwe lanu likusintha?

• Ndimakhala ndimakhalidwe abwino ndipo sindisintha umunthu wanga.
• Ndili ndi zosintha zazing'ono pamakhalidwe, umunthu komanso kuwongolera kwamaganizidwe.
• Makhalidwe anga akusintha pang'ono ndi pang'ono, ndisanakhale wochezeka ndipo tsopano ndine wokhumudwa.
• Amati ndasintha kwambiri ndipo sindilinso munthu yemweyo ndipo ndimapewa kale ndi anzanga akale, oyandikana nawo komanso abale akutali.
• Khalidwe langa lidasintha kwambiri ndipo ndidakhala munthu wovuta komanso wosasangalatsa.

Kodi mumatha kulankhulana bwino?

• Ndilibe vuto polankhula kapena kulemba.
• Ndikuyamba kukhala ndi zovuta kupeza mawu oyenera ndipo zimanditengera nthawi kuti ndimalize kulingalira kwanga.
• Zikukhala zovuta kupeza mawu oyenera ndipo ndakhala ndikulephera kutchula zinthu ndipo ndazindikira kuti ndili ndi mawu ochepa.
• Ndizovuta kwambiri kulumikizana, ndimavutika ndi mawu, kuti ndimvetsetse zomwe akunena kwa ine ndipo sindikudziwa kuwerenga kapena kulemba.
• Sindingathe kulankhulana, sindinena chilichonse, sindilemba ndipo sindimamvetsetsa zomwe akunena kwa ine.

Kodi mukumva bwanji?

• Mwachizolowezi, sindikuwona kusintha kulikonse pamalingaliro anga, chidwi changa kapena chidwi changa.
• Nthawi zina ndimakhala wokhumudwa, wamanjenje, wodandaula kapena wokhumudwa, koma wopanda nkhawa zazikulu m'moyo.
• Ndimakhala wachisoni, wamanjenje kapena wamantha tsiku lililonse ndipo izi zachulukirachulukira.
• Tsiku lililonse ndimakhala wokhumudwa, wamanjenje, wodandaula kapena wopanikizika ndipo ndiribe chidwi kapena chidwi chogwira ntchito iliyonse.
• Zachisoni, kukhumudwa, nkhawa komanso mantha ndi anzanga omwe ndimakhala nawo tsiku lililonse ndipo sindinathenso kukhala ndi chidwi ndi zinthu ndipo sindilimbikitsidwanso chilichonse.

Kodi mutha kuyang'ana ndikumvetsera?

• Ndili ndi chidwi chenicheni, kulingalira bwino komanso kulumikizana bwino ndi zonse zomwe zandizungulira.
• Ndikuyamba kukhala ndi nthawi yovuta kusamala ndi china chake ndipo ndimayamba kugona masana.
• Ndimavutika kusamala komanso sindisinkhasinkha kwenikweni, kotero ndimatha kuyang'anitsitsa pang'ono kapena kutseka maso kwakanthawi, ngakhale osagona.
• Ndimakhala tsiku lonse ndikugona, sindimayang'ana chilichonse ndipo ndikamayankhula ndimanena zinthu zosamveka bwino kapena zosagwirizana ndi mutu wankhani wokambirana.
• Sindingathe kumvetsera kalikonse ndipo sindine wolunjika.

M'mbuyomu Kenako

Kuchiza kwa Alzheimer's

Chithandizo cha Alzheimer's ndikuchepetsa zizindikilo za matendawa, komabe matendawa alibe mankhwala. Pochiritsira akuti kugwiritsa ntchito mankhwala, monga Donepezila, Galantamina, Rivastigmina kapena Memantina, kuphatikiza pazomwe zimachitika ndi physiotherapy, chithandizo chantchito ndi psychotherapy.

Dziwani zambiri za momwe amathandizira ndi matenda a Alzheimer's.