Darzalex (daratumumab)

Zamkati

• Kodi Darzalex ndi chiyani?
• Momwe imagwiritsidwira ntchito
• Kuchita bwino
• Darzalex generic
• Zotsatira za Darzalex
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Mtengo wa Darzalex
• Thandizo lazachuma komanso inshuwaransi
• Mlingo wa Darzalex
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa myeloma yambiri
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Darzalex ya myeloma yambiri
• Kuchita bwino
• Darzalex pazinthu zina
• Kugwiritsa ntchito Darzalex ndi mankhwala ena a myeloma angapo
• Njira zina ku Darzalex
• Darzalex vs. Empliciti
• Pafupi
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Darzalex motsutsana ndi Kyprolis
• Pafupi
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Momwe Darzalex imagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Darzalex ndi mowa
• Kuyanjana kwa Darzalex
• Darzalex ndi mayeso a labotale
• Momwe Darzalex amaperekedwera
• Nthawi yoti mutenge
• Kutenga Darzalex ndi chakudya
• Darzalex ndi mimba
• Darzalex yokhala ndi lenalidomide kapena pomalidomide
• Darzalex ndi kulera
• Darzalex yokhala ndi lenalidomide kapena pomalidomide
• Darzalex ndi kuyamwitsa
• Darzalex yokhala ndi lenalidomide kapena pomalidomide
• Mafunso wamba okhudza Darzalex
• Kodi ndichifukwa chiyani ndiyenera kumwa ma steroids ndi mankhwala ena ndikadaliranso za Darzalex infusions?
• Kodi ndizitha kuyendetsa pagalimoto nditachoka ku Darzalex?
• Kodi ndingagwiritse ntchito Darzalex ngati ndakhala ndi shingles?
• Kodi Darzalex imachiza myeloma yambiri?
• Zodzitetezera ku Darzalex
• Zambiri zamaluso za Darzalex
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Kodi Darzalex ndi chiyani?

Darzalex ndi mankhwala odziwika ndi dzina lodziwika bwino. Amagwiritsidwa ntchito pochiza myeloma yambiri, yomwe ndi mtundu wa khansa yomwe imakhudza maselo ena oyera am'magazi otchedwa ma plasma.

Darzalex ili ndi daratumumab. Uwu ndi mtundu wa mankhwala otchedwa monoclonal antibody.

Darzalex si chemotherapy. Ndi mtundu wa mankhwala omwe amalimbana nawo ndipo nthawi zina amatchedwa immunotherapy. Izi zikutanthauza kuti Darzalex yapangidwa kuti igwire ntchito ndi chitetezo cha mthupi lanu (chitetezo cha thupi lanu kumatenda).

Wothandizira zaumoyo adzakupatsani Darzalex ngati kulowetsedwa kwa intravenous (IV) muofesi yanu kapena kuchipatala. Kulowetsedwa kwa IV ndi jakisoni mumitsempha yanu yomwe imaperekedwa kwakanthawi.

Momwe imagwiritsidwira ntchito

Darzalex itha kuperekedwa nokha kapena ndi mankhwala ena. Food and Drug Administration (FDA) yavomereza kuti Darzalex igwiritsidwe ntchito:

• Mwa achikulire omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell transplant, maselo anu enieni amagwiritsidwa ntchito.) Izi:
  • Darzalex itha kugwiritsidwa ntchito ndi mankhwala lenalidomide (Revlimid) ndi dexamethasone.
  • Darzalex itha kugwiritsidwanso ntchito ndi mankhwala a bortezomib (Velcade), melphalan, ndi prednisone.
• Mwa akulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera. Poterepa, Darzalex imagwiritsidwa ntchito ndi lenalidomide ndi dexamethasone.
• Kwa achikulire omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma. Poterepa, Darzalex imagwiritsidwa ntchito ndi bortezomib ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo lenalidomide ndi proteasome inhibitor, womwe ndi mtundu wa mankhwala. Poterepa, Darzalex imagwiritsidwa ntchito ndi mankhwala pomalidomide (Pomalyst) ndi dexamethasone.
• Mwa achikulire omwe alandila mankhwala atatu kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo proteasome inhibitor ndi mankhwala opatsirana pogonana. Poterepa, Darzalex imagwiritsidwa ntchito paokha.
• Kwa achikulire omwe ayesapo mankhwala a proteasome inhibitor ndi mankhwala opewetsa chitetezo mthupi, koma palibe mankhwala omwe adagwira ma myeloma angapo. Poterepa, Darzalex imagwiritsidwa ntchito paokha.

Kuchita bwino

Kafukufuku wazachipatala zisanu ndi chimodzi adayang'ana momwe Darzalex imagwirira ntchito pochiza matenda a myeloma, okha komanso kuphatikiza mankhwala ena olimbana ndi khansa.Maphunzirowa amatchedwa MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, ndi SIRIUS. Kafukufukuyu adawonetsa kuti chithandizo cha ma myeloma angapo anali othandiza ngati Darzalex idawonjezeredwa pamankhwala wamba a khansa kuposa ngati mankhwalawa amaperekedwa okha. Kuti mumve zambiri zantchito, onani gawo la "Darzalex for multiple myeloma" pansipa.

Darzalex generic

Darzalex imapezeka kokha ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Darzalex ili ndi chinthu chimodzi chogwiritsira ntchito mankhwala: daratumumab.

Zotsatira za Darzalex

Darzalex imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukamamwa Darzalex. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri paza zotsatira zoyipa za Darzalex, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zoyipa za Darzalex zitha kuphatikiza:

• kumva kutopa
• kufooka kapena kusowa mphamvu
• mitsempha ya minofu (zopindika)
• nseru kapena kusanza
• kupweteka m'mimba kuphatikiza kutsegula m'mimba kapena kudzimbidwa
• kuchepa kudya
• kuvuta kugona
• malungo
• kuzizira
• kupuma pang'ono kapena kutsokomola
• matenda apamwamba opuma, monga chimfine
• bronchitis, mtundu wa matenda am'mapapo
• kupweteka kwa thupi
• kulumikizana kapena kupweteka kwakumbuyo
• chizungulire

Ngati mavuto omwe mukukumana nawo akuwoneka ovuta kwambiri kapena osatha, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Darzalex sizachilendo, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Kulowetsedwa anachita, mtundu wa thupi lawo siligwirizana. Zizindikiro zimatha kuphatikiza:
  • kuvuta kupuma
  • kukhazikika pakhosi
  • kumverera mopepuka kapena wamisala chifukwa chotsika magazi
  • kukhosomola kapena kupuma
  • yothamanga kapena mphuno yothinana
  • nseru kapena kusanza
  • kuzizira
  • malungo
  • mutu
  • kuyabwa
• Chibayo, mtundu wa matenda am'mapapo. Zizindikiro zimatha kuphatikiza:
  • kukhosomola koipa (ntchofu)
  • malungo ndi kuzizira
  • kupuma movutikira
  • kupweteka pachifuwa
• Hepatitis B, ngati mudakhalapo kale. Zizindikiro zimatha kuphatikiza:
  • kutopa kukulira
  • chikasu cha khungu lako kapena gawo loyera la maso ako
• Peripheral sensory neuropathy (kuwonongeka kwa mitsempha komwe kumayambitsa kuyabwa, kufooka, kapena kupweteka). Zizindikiro zimatha kuphatikiza:
  • dzanzi kapena kumva kulasalasa
  • ululu woyaka
  • kukhudzidwa
  • kufooka m'manja kapena m'mapazi anu
• Zotumphukira edema (kutupa kwa manja ndi mapazi). Zizindikiro zimatha kuphatikiza:
  • kutupa kwa mikono kapena miyendo
  • khungu lotambasula
  • khungu lomwe limang'ambika (maenje) mukapanikizika kwa masekondi ochepa

Zotsatira zoyipa zina, zofotokozedwa mwatsatanetsatane pansipa mu "Zotsatira zoyipa," ndi izi:

• thupi lawo siligwirizana
• thrombocytopenia, mulingo wochepa wa maselo othandiza magazi kuundana, omwe ndi mtundu wa maselo amwazi omwe amathandiza magazi kuundana
• neutropenia, mulingo wochepa wa ma neutrophil, omwe ndi mtundu wama cell oyera omwe amathandiza kulimbana ndi matenda
• shingles (herpes zoster matenda)

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa. Nayi tsatanetsatane wazovuta zomwe mankhwalawa angayambitse.

Matupi awo sagwirizana

Mofanana ndi mankhwala ambiri, anthu ena amatha kudwala matendawa atatenga Darzalex. Sizikudziwika kuti anthu omwe amagwiritsa ntchito Darzalex amakhala ndi vuto lotani. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• Kutupa pakhungu kapena ming'oma (kuyabwa pakhungu lanu)
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)
• malungo

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro za kuyanjana kwambiri ndi izi:

• kutupa pansi pa khungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma

Itanani dokotala wanu nthawi yomweyo ngati muli ndi vuto lalikulu ku Darzalex. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Kulowetsedwa

Darzalex amapatsidwa kulowetsedwa kwa intravenous (IV) muofesi yanu kapena kuchipatala. Ichi ndi jakisoni mumtsempha wanu womwe umaperekedwa kwakanthawi. Mofanana ndi mankhwala ambiri omwe amaperekedwa ngati kulowetsedwa kwa IV, mutha kulowetsedwa mukalandira Darzalex. (Kulowetsedwa kwa kulowetsedwa ndi mtundu wa zovuta zomwe zimachitika.)

Pakati pa maphunziro azachipatala, kulowetsedwa kwa infusion kunachitika pafupifupi theka la anthu omwe amathandizidwa ndi kulowetsedwa kwa Darzalex. Nthawi zambiri, zimachitika pakulowetsedwa koyamba ndipo zimakhala zofatsa pang'ono. Anthu ambiri omwe adalandira Darzalex adachitapo kanthu pakadutsa maola 4 kuchokera kumapeto kwa kulowetsedwa. Kulowetsedwa m'malo mwake sikungachitike ndi chithandizo chamtsogolo. M'maphunzirowa, anthu omwe adalandira mankhwala ena kupatula Darzalex sanapatsidwe mankhwalawo ngati infusions.

Ngati muli ndi kulowetsedwa komwe kumakhala kofatsa kapena kopepuka, dokotala wanu akhoza kuyimitsa kulowetsedwa kwanu kuti athetse vutoli. Amatha kuyambiranso kulowetsedwa pang'onopang'ono (kuthamanga) kuti mupeze mankhwalawo pang'onopang'ono. Ngati kulowetsedwa kwanu kuli koopsa kapena anaphylactic (kuopseza moyo), dokotala akhoza kusiya mankhwala ndi Darzalex ndikuyamba chithandizo chamankhwala mwadzidzidzi.

Pofuna kuchepetsa mwayi wololedwa, dokotala wanu adzakupatsani mankhwala osakaniza. Maola atatu kapena atatu isanachitike kulowetsedwa kwa Darzalex, mudzalandira:

• corticosteroid (kuchepetsa kutupa)
• antipyretic (kupewa kapena kuchepetsa kutentha thupi)
• antihistamine (kupewa kapena kuchepetsa zizindikiritso)

Muthanso kulandira tsiku limodzi la corticosteroid mutalowetsedwa kuti musachedwe kuchitapo kanthu. Koma ngati mukumwa kale steroid monga dexamethasone kapena prednisone, mwina simufunikira kuwonjezera kwa steroid.

Ngati muli ndi vuto lalikulu ku Darzalex mutachoka ku ofesi ya dokotala kapena kulowetsedwa, pitani kuchipatala nthawi yomweyo. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Matenda am'magazi

Darzalex itha kuyambitsa thrombocytopenia, yomwe ndi kutsika kwa mulingo wamagazi anu. (Awa ndi mtundu wa selo yamagazi yomwe imathandizira magazi kuundana.) Zizindikiro zake zimatha kukhala ndikulakwitsa ndi kutuluka magazi.

M'maphunziro azachipatala, pafupifupi 48% mpaka 90% ya anthu omwe adatenga Darzalex kapena Darzalex ndi mankhwala angapo a myeloma anali ndi thrombocytopenia. Poyerekeza, 58% mpaka 88% ya anthu omwe anali ndi mankhwala wamba anali ndi thrombocytopenia.

Darzalex amathanso kuyambitsa neutropenia. Uku ndikuchepa kwa ma neutrophil, omwe ndi mtundu wama cell oyera omwe amathandiza kulimbana ndi matenda. Zizindikiro zimatha kuphatikizira malungo komanso matenda.

M'maphunziro azachipatala, pafupifupi 58% mpaka 95% ya anthu omwe adatenga Darzalex kapena Darzalex limodzi ndi mankhwala wamba a myeloma anali ndi neutropenia. Poyerekeza, 40% mpaka 87% ya anthu omwe anali ndi mankhwala wamba anali ndi neutropenia.

Mukamalandira chithandizo cha Darzalex, dokotala wanu amayang'ana pafupipafupi kuchuluka kwanu kwa magazi ndi magazi. Adzakuwunikiraninso pamavuto aliwonse, magazi, kapena matenda aliwonse. Ngati mukukhala ndi zizindikilo kapena zizindikilozi, uzani dokotala wanu.

Ziphuphu

Pamene mukutenga Darzalex, mutha kukhala ndi matenda otchedwa shingles (herpes zoster). Izi ndichifukwa choti kukhala ndi myeloma yambiri ndikulandila chithandizo chambiri cha myeloma kumatha kukulitsa chiopsezo chotenga matenda.

Mukapeza ma shingles, mutha kukhala ndi:

• ululu woyaka
• kumva kulira
• kuyabwa
• zidzolo ndi matuza mbali imodzi yokha ya thupi lanu

Kachilombo komweko kamene kamagwedeza ma shingles kangayambitsenso nkhuku. Ngati mwakhala mukukhalapo kale, kachilomboka sikamachoka m'thupi mutachira. M'malo mwake, kachilomboka "kamangogona" m'mitsempha yanu.

Palibe amene akudziwa chifukwa chake, koma kachilomboka kakhoza kuyambiranso kapena "kudzuka" ndi zoyambitsa zina monga chitetezo chamthupi chofooka. (Chitetezo chanu cha mthupi ndi chitetezo chamthupi lanu kumatenda.)

Mankhwala a khansa kapena khansa amatha kufooketsa chitetezo cha mthupi lanu ndikukhazikitsanso kachilombo ka herpes zoster. Ikadzuka, imadzionetsa ngati yolimba m'malo mwa nthomba.

M'maphunziro azachipatala, ma shingles adanenedwa mwa 3% mwa anthu omwe amathandizidwa ndi Darzalex yokha. Poyerekeza, ma shingles adachitika mwa 2% mpaka 5% ya anthu omwe adatenga Darzalex ndi mankhwala enanso a khansa.

Ngati mwakhala mukukhalapo ndi chikuku kapena zipilala m'mbuyomu ndipo mukumwa Darzalex, dokotala wanu akhoza kukupatsani mankhwala ochepetsa ma virus. Mtundu uwu wa mankhwala ungathandize kupewa ma shingles kuti asakule mthupi lanu. Muyenera kumwa mankhwalawa musanathe sabata limodzi mutalandira Darzalex. Kenako mupitiliza kumwa kwa miyezi itatu mukamaliza mankhwala ndi Darzalex.

Chibayo

Kutenga Darzalex kungapangitse kuti mukhale ndi matenda am'mapapo otchedwa chibayo. Izi ndichifukwa choti ngati muli ndi myeloma yambiri, mumatha kutenga matenda kuposa anthu athanzi.

M'maphunziro azachipatala, 11% mpaka 26% ya anthu omwe adatenga Darzalex adadwala chibayo. Izi zikuyerekeza ndi 6% mpaka 14% ya anthu omwe adatenga placebo (palibe chithandizo).

Chibayo chinali matenda ofala kwambiri. Mpaka 4% ya anthu pamaphunziro onse a Darzalex amayenera kusiya kumwa mankhwalawa chifukwa cha chibayo. Imfa ya chibayo inali yosowa kwambiri. Koma ngati imfa idachitikadi, idachitika chifukwa cha chibayo ndi sepsis (poyankha koopsa pangozi ku matenda).

Zizindikiro za chibayo zitha kuphatikiza:

• kukhosomola koipa (ntchofu)
• malungo ndi kuzizira
• kupuma movutikira
• kupweteka pachifuwa

Mukakhala ndi zizindikiro za chibayo, uzani dokotala wanu. Amatha kuyimitsa mankhwala anu a Darzalex kuti athetse chibayo. M'maphunziro azachipatala, pafupifupi 1% mpaka 4% ya anthu omwe adatenga Darzalex kapena chithandizo chamankhwala wamba cha khansa amayenera kusiya mankhwala awo chifukwa cha chibayo chachikulu.

Mtengo wa Darzalex

Monga mankhwala onse, mtengo wa Darzalex umasiyana. Kuti mupeze mitengo yamtundu wa Darzalex mdera lanu, onani WellRx.com. Mtengo womwe mumapeza pa WellRx.com ndiomwe mungalipire popanda inshuwaransi. Mtengo weniweni womwe mudzalipira uzidalira inshuwaransi yanu komanso mankhwala omwe mumagwiritsa ntchito.

Ndondomeko yanu ya inshuwaransi ingafune kuti mupeze chilolezo musanavomereze za Darzalex. Izi zikutanthauza kuti dokotala wanu adzafunika kutumiza pempho ku kampani yanu ya inshuwaransi kuwafunsa kuti aphimbe mankhwalawa. Kampani ya inshuwaransi iunikanso pempholi ndikudziwitsani inu ndi dokotala ngati pulani yanu ipanga Darzalex.

Ngati simukudziwa ngati mukufuna kupeza chilolezo cha Darzalex, lemberani ku inshuwaransi yanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Darzalex, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Janssen Biotech, Inc., wopanga Darzalex, amapereka pulogalamu yotchedwa Janssen CarePath. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 844-553-2792 kapena pitani patsamba lino.

Mlingo wa Darzalex

Mlingo wa Darzalex womwe dokotala akukupatsani umadalira pazinthu zingapo. Izi zikuphatikiza:

• ngati matenda anu atulukira kumene kapena mwalandira mankhwala amodzi kapena angapo am'mbuyomu a myeloma
• mankhwala ena aliwonse omwe mukulandira limodzi ndi Darzalex kuti muchiritse myeloma yambiri
• matenda ena omwe mungakhale nawo
• zovuta zilizonse zomwe sizimatha

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu. Kuti mupindule kwambiri ndi chithandizochi, ndikofunikira kupita kumisonkhano yanu yonse osadumpha masiku aliwonse.

Mitundu ya mankhwala ndi mphamvu

Darzalex imabwera ngati yankho (kusakaniza kwamadzi) komwe mudzalandire ngati jakisoni. Yankho likhoza kukhala lopanda utoto wachikaso. Darzalex imapezeka m'mizere iwiri:

• 100 mg / 5 mL mu botolo limodzi
• 400 mg / 20 mL mu botolo limodzi

Wothandizira zaumoyo asakaniza gawo la Darzalex ndi 0.9% sodium chloride (mtundu wamadzi amchere). Kenako akupatsani mankhwalawa kudzera mu singano yomwe imayikidwa mumthambo wanu. Izi zimatchedwa kulowetsedwa m'mitsempha (IV).

Nthawi zambiri, dokotala wanu amakupatsani muyeso woyenera koma motsika (kuthamanga) kwa kulowetsedwa. Popita nthawi, amasintha kulowetsedwa pamlingo woyenera kwa inu. Izi zimatengera momwe muliri ndi kulowetsedwa kulikonse.

Kulowetsedwa kwanu koyamba kwa Darzalex kumatha kutenga pafupifupi maola 7. Izi ndichifukwa choti dokotala wanu amalowetsa (kukupatsani) mankhwala anu pang'onopang'ono mumitsempha yanu. M'tsogolomu, infusions imatha pafupifupi 3 mpaka 5 maola chifukwa mudzalandira mankhwala mwachangu. Wopereka chithandizo chamankhwala nthawi zonse amakhala akukuyang'anirani mukamakulowetsani.

Mlingo wa myeloma yambiri

Darzalex imaperekedwa yokha kapena ndi mitundu ina ya mankhwala a khansa kwa achikulire omwe ali ndi myeloma angapo. Ndondomeko ya chithandizo ndi kutalika kudzadalira ngati mwapezeka kumene kapena mwalandira mankhwala am'mbuyomu. Darzalex sanaphunzirepo ana.

Mlingo woyenera wa Darzalex ndi mamiligalamu / kilogalamu 16 (mg / kg) a kulemera kwenikweni kwa thupi ngati kulowetsedwa kwa IV. Mwachitsanzo, mayi wa mapaundi 110 amalemera pafupifupi 50 kg. Izi zikutanthauza kuti mlingo wake wa Darzalex ukhoza kukhala 50 kg wochulukitsidwa ndi 16 mg / kg, womwe ndi 800 mg.

Akuluakulu omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika

Maselo anu enieni amagwiritsidwa ntchito. Njira imodzi yothandizira ndi Darzalex yokhala ndi lenalidomide (Revlimid) ndi dexamethasone. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 8: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi itatu)
• Masabata 9 mpaka 24: Mlingo umodzi pamasabata awiri (pamiyeso isanu ndi itatu)
• Sabata 25 kupita mtsogolo: Mlingo umodzi pakatha milungu inayi

Njira ina yothandizira ndi Darzalex yokhala ndi bortezomib (Velcade), melphalan, ndi prednisone. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 6: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi umodzi)
• Masabata 7 mpaka 54: Mlingo umodzi pamasabata atatu (pamlingo wokwana 16)
• Sabata 55 mtsogolo: Mlingo umodzi pakatha milungu inayi

Akuluakulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera

Mudzalandira Darzalex ndi lenalidomide ndi dexamethasone. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 8: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi itatu)
• Masabata 9 mpaka 24: Mlingo umodzi pamasabata awiri (pamiyeso isanu ndi itatu)
• Sabata 25 kupita mtsogolo: Mlingo umodzi pakatha milungu inayi

Akuluakulu omwe adalandira chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma

Mudzalandira Darzalex ndi bortezomib ndi dexamethasone. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 9: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi inayi)
• Masabata 10 mpaka 24: Mlingo umodzi pamasabata atatu (pamiyeso isanu)
• Sabata 25 kupita mtsogolo: Mlingo umodzi pakatha milungu inayi

Akuluakulu omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma, kuphatikizapo lenalidomide ndi proteasome inhibitor

Mudzalandira Darzalex ndi pomalidomide (Pomalyst) ndi dexamethasone. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 8: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi itatu)
• Masabata 9 mpaka 24: Mlingo umodzi pamasabata awiri (pamiyeso isanu ndi itatu)
• Sabata 25 kupita mtsogolo: Mlingo umodzi pakatha milungu inayi

Akuluakulu omwe adalandira mankhwala atatu kapena angapo am'mbuyomu a myeloma, kuphatikiza proteasome inhibitor ndi mankhwala opatsirana pogonana, kapena sanayankhe mankhwala a proteasome inhibitor komanso mankhwala opatsirana pogonana.

Mudzalandira kokha Darzalex. Ndondomeko ya mlingo woyenera ndi:

• Masabata 1 mpaka 8: Mlingo umodzi sabata iliyonse (pamiyeso isanu ndi itatu)
• Masabata 9 mpaka 24: Mlingo umodzi pamasabata awiri (pamiyeso isanu ndi itatu)
• Sabata 25 kupita mtsogolo: Mlingo umodzi pakatha milungu inayi

Pofuna kuchepetsa mwayi wololedwa, dokotala wanu adzakupatsani mankhwala osakaniza. Maola atatu kapena atatu isanachitike kulowetsedwa kwa Darzalex, mudzalandira:

• corticosteroid (kuchepetsa kutupa)
• antipyretic (kupewa kapena kuchepetsa kutentha thupi)
• antihistamine (kupewa kapena kuchepetsa zizindikilo za thupi).

Muthanso kulandira tsiku limodzi la corticosteroid mutalowetsedwa kuti musachedwe kuchitapo kanthu. Koma ngati mukumwa kale steroid monga dexamethasone kapena prednisone, mwina simufunikira kuwonjezera kwa steroid.

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya nthawi yokumana ndi kulowetsedwa kwa Darzalex, pitani kuchipatala nthawi yomweyo kuti musinthe. Adzasintha dongosolo lanu la dosing kuti atsimikizire kuti mulandira chithandizo choyenera munthawi yoyenera.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

M'maphunziro azachipatala, nthawi yayitali yomwe Darzalex idayamba kugwira ntchito inali mwezi umodzi.

Komabe, mutha kupatsidwa mankhwala kwa nthawi yayitali. Izi zimadalira momwe thupi lanu limayankhira Darzalex komanso ngati myeloma yanu yambiri ikuyamba kukulira.

Kutalika kwa chithandizo kudzadaliranso ngati myeloma yanu ingapezeke kapena ngati mwalandira mankhwala m'mbuyomu.

Darzalex ya myeloma yambiri

Food and Drug Administration (FDA) yavomereza Darzalex yothandizira matenda angapo a myeloma.

Uwu ndi mtundu wa khansa yomwe imakhudza maselo ena oyera am'magazi am'magazi am'magazi. Maselo a plasma amapanga gawo la chitetezo chanu ndipo amathandiza kulimbana ndi matenda m'thupi lanu. M'magazi angapo a myeloma, maselo am'magazi amasintha kukhala ma cell angapo a myeloma. Maselo angapo a myeloma akamakula ndikufalikira, amatha kutulutsa maselo athanzi ndikuwononga mafupa owazungulira.

Darzalex imavomerezedwa kuti igwiritsidwe ntchito:

• Mwa achikulire omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell transplant, maselo anu enieni amagwiritsidwa ntchito.) Izi:
  • Darzalex itha kugwiritsidwa ntchito ndi mankhwala lenalidomide (Revlimid) ndi dexamethasone.
  • Darzalex itha kugwiritsidwanso ntchito ndi mankhwala a bortezomib (Velcade), melphalan, ndi prednisone.
• Mwa akulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera. Poterepa, Darzalex imagwiritsidwa ntchito ndi lenalidomide ndi dexamethasone.
• Kwa achikulire omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma. Poterepa, Darzalex imagwiritsidwa ntchito ndi bortezomib ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo lenalidomide ndi proteasome inhibitor, womwe ndi mtundu wa mankhwala. Poterepa, Darzalex imagwiritsidwa ntchito ndi mankhwala pomalidomide (Pomalyst) ndi dexamethasone.
• Mwa achikulire omwe alandila mankhwala atatu kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo proteasome inhibitor ndi mankhwala opatsirana pogonana. Poterepa, Darzalex imagwiritsidwa ntchito paokha.
• Mwa achikulire omwe ayesapo proteasome inhibitor ndi mankhwala opewera chitetezo mthupi koma palibe mankhwala omwe adagwira ma myeloma angapo. Poterepa, Darzalex imagwiritsidwa ntchito paokha.

Kuchita bwino

Kafukufuku wazachipatala zisanu ndi chimodzi adayang'ana momwe Darzalex imagwirira ntchito pochiza matenda a myeloma okha komanso kuphatikiza mankhwala ena olimbana ndi khansa. Maphunzirowa amatchedwa MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, ndi SIRIUS. Kafukufukuyu adawonetsa kuti mankhwala anali othandiza kwambiri ngati Darzalex idawonjezeredwa pamankhwala wamba a khansa kuposa ngati mankhwalawa amaperekedwa okha.

Kafukufuku wa MAIA

Kafukufuku wa MAIA adayang'ana anthu omwe atulukira kumene kuti ali ndi myeloma angapo omwe samatha kulandira mawonekedwe am'magazi am'magazi. Anthu amalandila mankhwala wamba a khansa ya lenalidomide (Revlimid) ndi dexamethasone ya mankhwala otsika kapena mankhwala omwewo kuphatikiza Darzalex. Poyerekeza ndi gulu wamba la mankhwala, gulu la Darzalex linali ndi chiopsezo chotsika 44% cha myeloma yawo yambiri yomwe imakulira kapena kufa.

Kwa miyezi 42 ya kafukufukuyu, myeloma yambiri sinakule kwambiri mwa anthu omwe amatenga Darzalex limodzi ndi mankhwala wamba. Kwa anthu omwe adalandira chithandizo chamankhwala wamba, zidatenga pafupifupi miyezi 31.9 kuti myeloma yawo yambiri iyambe kukulirakulira. Kuyankha kwathunthu kunali 47.6% ya anthu omwe amathandizidwa ndi Darzalex ndi 24.9% kwa iwo omwe adalandira chithandizo chofananira. (Kuyankha kwathunthu kumatanthauza kuti khansa yonse yatha ndipo palibe zisonyezo zamatenda m'mayeso a labu, X-ray, kapena mayeso azachipatala.)

Kafukufuku wa ALCYONE

Kafukufuku wa ALCYONE adayang'ana anthu omwe apezeka ndi matenda a myeloma angapo omwe samatha kupatsidwa ma cell opangira autologous. Anthuwa adalandira chithandizo chamankhwala cha khansa ya bortezomib (Velcade), melphalan, ndi prednisone kapena mankhwalawo kuphatikiza Darzalex. Poyerekeza ndi gulu la mankhwala wamba, gulu la Darzalex linali ndi chiopsezo chotsika 50% cha myeloma yawo yambiri yomwe imakulira kapena kufa.

Mwa anthu omwe adalandira chithandizo cha Darzalex, 42.6% adayankha kwathunthu. Izi zidafanizidwa ndi 24.4% ya anthu omwe amalandila chithandizo chofananira.

Kafukufuku wa POLLUX

Kafukufuku wa POLLUX adayang'ana anthu omwe ali ndi myeloma angapo omwe adalandirapo chithandizo chimodzi. Anthuwo amamwa mankhwala wamba a lenalidomide ndi dexamethasone kapena mankhwala omwewo kuphatikiza Darzalex. Zotsatira zinawonetsa kuti pafupifupi 91.3% ya anthu adayankha kuchipatala ndi Darzalex poyerekeza ndi anthu pafupifupi 74.6% omwe amalandira chithandizo chofananira.

Poyerekeza ndi gulu lachipatala, gulu lomwe limathandizidwa ndi Darzalex linali ndi chiopsezo chochepa cha 63% cha myeloma yawo yambiri. Pambuyo pa miyezi 13.5, 19% ya gulu la Darzalex adawona kuti myeloma yawo ikukulirakulira kapena amwalira. Izi zidafanizidwa ndi 41% yamankhwala ochiritsira.

Kafukufuku wa CASTOR

Kafukufuku wa CASTOR adayang'ananso anthu omwe ali ndi myeloma angapo omwe adalandilapo chithandizo chimodzi m'mbuyomu. Anthuwo adalandira chithandizo chofananira cha bortezomib ndi dexamethasone kapena mankhwala omwewo kuphatikiza Darzalex. Zotsatira zake zinali zofanana ndi za kafukufuku wa POLLUX. Pafupifupi 73.9% ya anthu adayankha kuchipatala ndi Darzalex poyerekeza ndi pafupifupi 59.9% ya anthu omwe amalandila chithandizo chofananira.

Poyerekeza ndi chithandizo chamankhwala, mankhwala a Darzalex adalumikizidwa ndi chiopsezo chotsika 61% cha myeloma yochulukirapo kapena kufa. Anthu omwe adatenga Darzalex adathanso kukhala okhululukidwa kwakanthawi. (Kukhululukidwa kumatanthauza kuti kuchuluka kwa kufalikira kwa khansa kudachepa.)

Kafukufuku wa EQUULEUS

Kafukufuku wa EQUULEUS adayang'ana anthu 103 omwe ali ndi myeloma angapo omwe adalandilidwapo kanayi chifukwa cha myeloma yawo yambiri. Anthuwa anali atalandira kale mitundu iwiri yamankhwala: proteasome inhibitor komanso mankhwala osokoneza bongo. Aliyense mu phunziroli adalandira mankhwala ofanana a pomalidomide (Pomalyst) ndi dexamethasone kuphatikiza Darzalex. Cholinga chachikulu cha phunziroli chinali kuwona kuchuluka kwa anthu omwe amalandila chithandizo.

Ponseponse, mankhwalawa adayamba kugwira ntchito pafupifupi mwezi umodzi mwa anthu ambiri. Mankhwalawa adagwira pafupifupi miyezi 13.6. Zizindikiro zingapo za myeloma zidachepetsedwa ndi 90% kapena kuposa mwa anthu 42%. Anthu ena adasiyanso khansa kumapeto kwa kafukufukuyu.

Kafukufuku wa SIRIUS

Kafukufuku wa SIRIUS adayang'ana anthu 106 omwe ali ndi myeloma angapo omwe adadwala kwambiri ndipo adalandira pafupifupi mankhwala asanu m'mbuyomu. Anthu onse omwe anali mu kafukufukuyu adapatsidwa Darzalex yokha. Cholinga chachikulu cha phunziroli chinali kuwona kuchuluka kwa anthu omwe amalandila chithandizo.

Ponseponse, anthu 31 omwe adalandira Darzalex adakhala ndi matenda angapo a myeloma. Pafupifupi anthu 64.8% omwe adatenga Darzalex mu kafukufukuyu adapulumuka kwa miyezi yosachepera 12.

Pofuna kuchepetsa mwayi wokhala ndi kulowetsedwa, anthu m'maphunziro onsewa adapatsidwa mankhwala osakaniza. Ola limodzi kapena atatu asanafike kulowetsedwa kulikonse kwa Darzalex, adalandira:

• corticosteroid (kuchepetsa kutupa)
• antipyretic (kupewa kapena kuchepetsa kutentha thupi)
• antihistamine (kupewa kapena kuchepetsa zizindikiritso)

Atha kulandiranso tsiku limodzi la corticosteroid atalowetsedwa kuti apewe kuchitapo kanthu mochedwa. Koma ngati anthu anali atatenga kale steroid monga dexamethasone kapena prednisone, mwina sanafunikire kuwonjezera kwa steroid.

Darzalex pazinthu zina

Kuphatikiza pa myeloma yambiri, Darzalex ikuwerengedwa ngati chithandizo cha immunoglobulin light chain amyloidosis.

Darzalex ya immunoglobulin light chain amyloidosis (pansi pa kuphunzira)

Chingwe chowunikira cha immunoglobulin amyloidosis (AL) ndichikhalidwe chomwe mapuloteni ena omwe amatchedwa maunyolo amtundu amamangirira m'thupi lanu mthupi lanu lonse. Nthawi zambiri, mtima wanu, impso, ndulu, ndi chiwindi zimakhudzidwa. Mapuloteni akumanga amatha kuwononga ndikupangitsa ziwalozi kulephera.

Darzalex sivomerezedwa ndi FDA kuti ichiritse AL. Komabe, pali kafukufuku wochepa wogwiritsa ntchito Darzalex off-label kuti athetse vutoli. (Kugwiritsa ntchito kopanda chizindikiro ndi pamene mankhwala omwe amavomerezedwa kuti athetse vuto limodzi amagwiritsidwa ntchito pochiza matenda ena.)

Pakafukufuku wina, Darzalex idaperekedwa kwa anthu omwe ali ndi AL omwe, pafupifupi, adalandira mankhwala atatu osiyanasiyana omwe sagwira ntchito. Darzalex adatulutsa yankho pafupifupi lathunthu kapena lathunthu mwa anthu 76% omwe adamwa mankhwalawa. (Kuyankha kwathunthu kumatanthauza kuti matenda onse atha ndipo palibe zisonyezo zamatenda m'mayeso a labu, X-ray, mayeso azachipatala.) Anthuwa anali ndi zovuta zina monga zomwe zimayembekezereka kwa anthu omwe adatenga Darzalex kuchiza matenda a myeloma angapo. Nthawi zina, Darzalex anali othandiza pochiza AL ndikukweza miyoyo ya anthu omwe amamwa mankhwalawa.

Kafukufuku wowonjezera amafunikira kuti atsimikizire kuti Darzalex imagwira ntchito bwino komanso yotetezeka ikagwiritsidwa ntchito kwa anthu omwe ali ndi AL. Mpaka nthawiyo, ofufuza atha kugwiritsa ntchito Darzalex kwa anthu omwe ali ndi AL omwe alibe chisankho choyambirira, chithandizo chovomerezeka ndi FDA chotsalira.

Kugwiritsa ntchito Darzalex ndi mankhwala ena a myeloma angapo

Darzalex imaperekedwa yokha kapena ndi mitundu ina ya chithandizo cha khansa kwa achikulire omwe ali ndi myeloma yambiri. Ndondomeko ya chithandizo ndi kutalika kudzadalira ngati mwapezeka kumene kapena mwalandira mankhwala am'mbuyomu.

Darzalex imavomerezedwa kuti igwiritsidwe ntchito limodzi ndi:

• lenalidomide (Revlimid) ndi dexamethasone mwa achikulire omwe ali ndi myeloma yatsopano omwe sangalandire autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell kumuika, maselo anu enieni amagwiritsidwa ntchito.)
• lenalidomide ndi dexamethasone mwa akulu omwe adalandira chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera.
• bortezomib (Velcade), melphalan, ndi prednisone mwa achikulire omwe ali ndi myeloma yatsopano yomwe sangalandire autologous stem cell kumuika.
• bortezomib ndi dexamethasone mwa akulu omwe adalandira mankhwala amodzi kapena angapo am'mbuyomu a myeloma.
• pomalidomide (Pomalyst) ndi dexamethasone mwa akulu omwe adalandirapo mankhwala awiri kapena angapo am'mbuyomu a myeloma. Mankhwalawa ayenera kuti anali ndi lenalidomide komanso proteasome inhibitor.

Kafukufuku wazachipatala zisanu ndi chimodzi adayang'ana momwe Darzalex imagwirira ntchito pochiza matenda a myeloma, okha komanso kuphatikiza mankhwala ena olimbana ndi khansa. Maphunzirowa amatchedwa MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, ndi SIRIUS. Kafukufukuyu adawonetsa kuti chithandizo cha ma myeloma angapo anali othandiza ngati Darzalex idawonjezeredwa pamankhwala wamba a khansa kuposa ngati mankhwalawa amaperekedwa okha. Kuti mumve zambiri zamaphunziro awa, chonde onani gawo la "Darzalex for multiple myeloma" pamwambapa.

Njira zina ku Darzalex

Mankhwala ena alipo omwe angachiritse myeloma angapo. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina ya Darzalex, lankhulani ndi dokotala kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

M'munsimu muli mndandanda wa mankhwala omwe akulimbikitsidwa ndi National Comprehensive Cancer Network malangizo othandizira kuchiza matenda a myeloma.

• Mankhwala a Chemotherapy, monga:
  • bendamustine (Bendeka kapena Treanda)
  • cisplatin
  • cyclophosphamide (Cytoxan)
  • doxorubicin (Doxil)
  • etoposide (Etopophos)
  • nyimbo (Alkeran)
• Proteasome inhibitors, monga:
  • bortezomib (Velcade)
  • carfilzomib (Kyprolis)
  • ixazomib (Ninlaro)
• Ma antibodies a monoclonal, monga:
  • elotuzumab (Empliciti)
• Histone deacetylase inhibitors, monga:
  • panobinostat (Farydak)
• Ma Immunomodulators, monga:
  • lenalidomide (Wowonjezera)
  • pomalidomide (Pomalyst)
  • thalidomide (Thalomid)
• Corticosteroids, monga:
  • dexamethasone (Decadron)

Zindikirani: Zina mwa mankhwala omwe atchulidwa pano atha kugwiritsidwa ntchito ngati mankhwala kuti athetse ma myeloma angapo.

Darzalex vs. Empliciti

Mutha kudabwa momwe Darzalex ikufananirana ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa tikuwona momwe Darzalex ndi Empliciti alili ofanana komanso osiyana.

Pafupi

Darzalex ili ndi daratumumab, pomwe Empliciti ili ndi elotuzumab. Darzalex ndi Empliciti onse ali mgulu la mankhwala otchedwa monoclonal antibodies. (Gulu la mankhwala ndi gulu la mankhwala omwe amagwiranso ntchito chimodzimodzi.) Onse a Darzalex ndi Empliciti amawerengedwa kuti ndi chithandizo chamankhwala angapo a myeloma.

Ntchito

Food and Drug Administration (FDA) yavomereza onse Darzalex ndi Empliciti kuti athetse ma myeloma angapo.

Darzalex imavomerezedwa kuti igwiritsidwe ntchito:

• Mwa achikulire omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell transplant, maselo anu enieni amagwiritsidwa ntchito.) Izi:
  • Darzalex itha kugwiritsidwa ntchito ndi mankhwala lenalidomide (Revlimid) ndi dexamethasone.
  • Darzalex itha kugwiritsidwanso ntchito ndi mankhwala a bortezomib (Velcade), melphalan, ndi prednisone.
• Mwa akulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera. Poterepa, Darzalex imagwiritsidwa ntchito ndi lenalidomide ndi dexamethasone.
• Kwa achikulire omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma. Poterepa, Darzalex imagwiritsidwa ntchito ndi bortezomib ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo lenalidomide ndi proteasome inhibitor, womwe ndi mtundu wa mankhwala. Poterepa, Darzalex imagwiritsidwa ntchito ndi mankhwala pomalidomide (Pomalyst) ndi dexamethasone.
• Mwa achikulire omwe alandila mankhwala atatu kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo proteasome inhibitor ndi mankhwala opatsirana pogonana. Poterepa, Darzalex imagwiritsidwa ntchito paokha.
• Mwa achikulire omwe ayesapo proteasome inhibitor ndi mankhwala opewera chitetezo mthupi koma palibe mankhwala omwe adagwira ma myeloma angapo. Poterepa, Darzalex imagwiritsidwa ntchito paokha.

Empliciti imavomerezedwa kuti igwiritsidwe ntchito:

• Akuluakulu omwe adalandira chithandizo chimodzi kapena zitatu m'mbuyomu chifukwa cha myeloma angapo. Empliciti imagwiritsidwa ntchito ndi lenalidomide (Revlimid) ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala osachepera awiri am'mbuyomu omwe amaphatikizapo lenalidomide ndi proteasome inhibitor. Empliciti imagwiritsidwa ntchito ndi pomalidomide (Pomalyst) ndi dexamethasone.

Nthawi zambiri, Empliciti imaperekedwa ngati myeloma yanu yambiri yabwerera pambuyo pa chithandizo china.

Mafomu azamankhwala ndi makonzedwe

Darzalex ndi Empliciti onse amaperekedwa ngati kulowetsedwa mu mtsempha (IV). Iyi ndi jakisoni yemwe amalowetsedwa pang'onopang'ono pakapita nthawi kudzera mu singano yomwe imayikidwa mumtsempha wanu.

Za Darzalex

Darzalex imabwera ngati yankho (kusakaniza kwamadzi) komwe mudzalandire ngati jakisoni. Yankho likhoza kukhala lopanda utoto wachikasu. Mankhwalawa amapezeka m'mitundu iwiri:

• 100 mg / 5 mL mu botolo limodzi
• 400 mg / 20 mL mu botolo limodzi

Pofuna kuchepetsa mwayi wololedwa, dokotala wanu adzakupatsani mankhwala osakaniza. Maola atatu kapena atatu isanachitike kulowetsedwa kwa Darzalex, mudzalandira:

• corticosteroid yochepetsa kutupa
• antipyretic yoletsa kapena kuchepetsa kutentha thupi
• antihistamine yoletsa kapena kuchepetsa zizindikilo za thupi

Muthanso kulandira tsiku limodzi la corticosteroid mutalowetsedwa kuti musachedwe kuchitapo kanthu. Koma ngati mukumwa kale steroid monga dexamethasone kapena prednisone, mwina simufunikira kuwonjezera kwa steroid.

Kwa Empliciti

Empliciti imabwera ngati yoyera mpaka ufa woyera. Wothandizira zaumoyo adzasakaniza izi ndi yankho kuti akupatseni ngati jekeseni. Empliciti imapezeka ndi mphamvu ziwiri:

• 300 mg mu botolo limodzi
• 400 mg mu botolo limodzi

Pofuna kuchepetsa mwayi wololedwa, dokotala wanu adzakupatsani mankhwala osakaniza. Pafupifupi mphindi 45 mpaka 90 isanachitike kulowetsedwa kwa Empliciti, mudzalandira:

• acetaminophen kupewa kapena kuchepetsa kutentha thupi
• diphenhydramine (Benadryl) kupewa kapena kuchepetsa zizindikilo za thupi
• ranitidine kupewa kapena kuchepetsa zizindikiro za thupi lawo siligwirizana
• dexamethasone kuchepetsa kutupa

Zotsatira zoyipa ndi zoopsa

Darzalex ndi Empliciti zonsezi zili ndi mankhwala omwe amagwira ntchito chimodzimodzi. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Darzalex, ndi Empliciti, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Darzalex:
  • kufooka
  • kupweteka kwa thupi kapena kupweteka kwamalumikizidwe
  • nseru
  • kuvuta kugona
  • bronchitis, mtundu wa matenda am'mapapo
  • chizungulire
• Zitha kuchitika ndi Empliciti:
  • shuga wambiri magazi
  • kupweteka kwamikono kapena miyendo yanu * *
• Zitha kuchitika ndi Darzalex ndi Empliciti:
  • kumva kutopa kapena kusowa mphamvu
  • kupweteka m'mimba kuphatikiza kutsegula m'mimba kapena kudzimbidwa
  • kuchepa kudya
  • malungo
  • kuzizira
  • kupuma pang'ono kapena kutsokomola
  • matenda opuma apamwamba monga chimfine
  • mitsempha ya minofu (zopindika)
  • kusanza
  • zotumphukira edema, komwe ndikutupa kwa manja ndi mapazi

** Pamene Empliciti imagwiritsidwa ntchito ndi lenalidomide kuphatikiza dexamethasone

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Darzalex, ndi Empliciti, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Darzalex:
  • thrombocytopenia, mulingo wochepa wa maselo othandiza magazi kuundana, omwe ndi mtundu wa maselo amwazi omwe amathandiza magazi kuundana
  • neutropenia, mulingo wochepa wa ma neutrophil, omwe ndi mtundu wama cell oyera omwe amathandiza kulimbana ndi matenda
  • shingles (herpes zoster matenda)
• Zitha kuchitika ndi Empliciti:
  • Khansa yatsopano
  • mavuto a chiwindi
• Zitha kuchitika ndi Darzalex ndi Empliciti:
  • kulowetsedwa zochita
  • chibayo, mtundu wa matenda am'mapapo
  • zotumphukira zamaganizidwe am'mitsempha, mtundu wa kuwonongeka kwa mitsempha komwe kumayambitsa kuyabwa, kufooka, kapena kupweteka

Kuchita bwino

Darzalex ndi Empliciti ali ndi ntchito zosiyanasiyana zovomerezeka ndi FDA, koma zonse zimagwiritsidwa ntchito pochiza myeloma angapo mwa akulu.

Mankhwalawa sanayerekezeredwe mwachindunji m'maphunziro azachipatala (otchedwa mutu ndi mutu). Komabe, kuwunikiridwa kwamaphunziro 13 azachipatala a Darzalex ndi Empliciti adapeza kuti mankhwala onsewa anali othandiza pochedwetsa kupitilira (kukulira) kwa myeloma yambiri.

Kwa anthu omwe myeloma angapo abwerera kapena akupitilizabe kukula ngakhale atalandira chithandizo chamankhwala chambiri, malangizo a National Comprehensive Cancer Network amalimbikitsa Darzalex poyamba. Ngati Darzalex sichigwira ntchito, chithandizo ndi Empliciti ndi njira ina.

Mtengo

Darzalex ndi Empliciti onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa WellRx.com, Darzalex nthawi zambiri imakhala yotsika mtengo kuposa Empliciti. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso komwe muli.

Darzalex motsutsana ndi Kyprolis

Monga Empliciti (pamwambapa), mankhwala a Kyprolis amagwiritsanso ntchito ofanana ndi a Darzalex. Tiyeni tiwone momwe Darzalex ndi Kyprolis alili ofanana komanso osiyana.

Pafupi

Darzalex ili ndi daratumumab, pomwe Kyprolis ili ndi carfilzomib. Mankhwala onsewa amawerengedwa kuti ndi chithandizo chamankhwala angapo a myeloma. Komabe, mankhwalawa ali m'magulu osiyanasiyana azamankhwala. (Gulu la mankhwala ndi gulu la mankhwala omwe amagwiranso ntchito chimodzimodzi.) Darzalex ndi mtundu wa mankhwala otchedwa antioclonal antibody. Kyprolis ndi mtundu wa mankhwala otchedwa proteasome inhibitor.

Ntchito

Food and Drug Administration (FDA) yavomereza kuti Darzalex igwiritsidwe ntchito:

• Mwa achikulire omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell transplant, maselo anu enieni amagwiritsidwa ntchito.) Izi:
  • Darzalex itha kugwiritsidwa ntchito ndi mankhwala lenalidomide (Revlimid) ndi dexamethasone.
  • Darzalex itha kugwiritsidwanso ntchito ndi mankhwala a bortezomib (Velcade), melphalan, ndi prednisone.
• Mwa akulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera. Poterepa, Darzalex imagwiritsidwa ntchito ndi lenalidomide ndi dexamethasone.
• Kwa achikulire omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma. Poterepa, Darzalex imagwiritsidwa ntchito ndi bortezomib ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo lenalidomide ndi proteasome inhibitor, womwe ndi mtundu wa mankhwala. Poterepa, Darzalex imagwiritsidwa ntchito ndi mankhwala pomalidomide (Pomalyst) ndi dexamethasone.
• Mwa achikulire omwe alandila mankhwala atatu kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo proteasome inhibitor ndi mankhwala opatsirana pogonana. Poterepa, Darzalex imagwiritsidwa ntchito paokha.
• Mwa achikulire omwe ayesapo proteasome inhibitor ndi mankhwala opewera chitetezo mthupi koma palibe mankhwala omwe adagwira ma myeloma angapo. Poterepa, Darzalex imagwiritsidwa ntchito paokha.

Kyprolis ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito:

• Akuluakulu omwe adalandira chithandizo chimodzi kapena zitatu m'mbuyomu chifukwa cha myeloma angapo. Kyprolis imagwiritsidwa ntchito ndi dexamethasone kapena lenalidomide ndi dexamethasone.
• Akuluakulu omwe adalandira mankhwala amodzi kapena angapo am'mbuyomu chifukwa cha myeloma angapo. Kyprolis imagwiritsidwa ntchito paokha.

Mafomu azamankhwala ndi makonzedwe

Onse Darzalex ndi Kyprolis amaperekedwa ngati kulowetsedwa mu mtsempha (IV). Iyi ndi jakisoni yemwe amalowetsedwa pang'onopang'ono pakapita nthawi kudzera mu singano yomwe imayikidwa mumtsempha wanu.

Za Darzalex

Darzalex imabwera ngati yankho (kusakaniza kwamadzi) komwe mudzalandire ngati jakisoni. Yankho likhoza kukhala lopanda utoto wachikasu. Mankhwalawa amapezeka m'mitundu iwiri:

• 100 mg / 5 mL mu botolo limodzi
• 400 mg / 20 mL mu botolo limodzi

Kuti muchepetse mwayi wolowetsedwa, dokotala wanu akupatsaninso. mankhwala osokoneza bongo. Maola atatu kapena atatu isanachitike kulowetsedwa kwa Darzalex, mudzalandira:

• corticosteroid yochepetsa kutupa
• antipyretic yoletsa kapena kuchepetsa kutentha thupi
• antihistamine yoletsa kapena kuchepetsa zizindikilo za thupi

Muthanso kulandira tsiku limodzi la corticosteroid mutalowetsedwa kuti musachedwe kuchitapo kanthu. Koma ngati mukumwa kale steroid monga dexamethasone kapena prednisone, mwina simufunikira kuwonjezera kwa steroid.

Za Kyprolis

Kyprolis amabwera mu keke kapena mawonekedwe a ufa mumtsuko umodzi. Zimabwera ndi mphamvu zitatu: 10 mg, 30 mg, ndi 60 mg.

Pofuna kuchepetsa mwayi wokhala ndi kulowetsedwa, dokotala wanu adzakupatsani steroid. Mudzalandira steroid mphindi 30 mpaka maola 4 musanalowetsedwe Kyprolis. Koma ngati mukumwa kale steroid monga dexamethasone, dokotala wanu safunika kukupatsirani mlingo wowonjezera.

Zotsatira zoyipa ndi zoopsa

Darzalex ndi Kyprolis zitha kuyambitsa zovuta zomwezo. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Darzalex, ndi Kyprolis, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Darzalex:
  • kufooka kapena kusowa mphamvu
  • bronchitis, mtundu wa matenda am'mapapo
  • kupweteka kwa thupi kapena kupweteka kwamalumikizidwe
• Zitha kuchitika ndi Kyprolis:
  • kuchuluka kwama cell ofiira ofiira
  • kuchuluka kwama cell oyera
  • kuvuta kupuma
  • kuchepa kwa potaziyamu
• Zitha kuchitika ndi Darzalex ndi Kyprolis:
  • mitsempha ya minofu (zopindika)
  • kuvuta kugona
  • kumva kutopa
  • kupweteka m'mimba kuphatikiza kutsegula m'mimba kapena kudzimbidwa
  • malungo
  • kuzizira
  • kupuma movutikira
  • chifuwa
  • matenda apamwamba opuma, monga chimfine
  • nseru kapena kusanza
  • kuchepa kudya
  • zotumphukira edema, komwe ndikutupa kwa manja ndi mapazi
  • chizungulire

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Darzalex, ndi Kyprolis, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Darzalex:
  • neutropenia, mulingo wochepa wa ma neutrophils, womwe ndi mtundu wa maselo oyera amwazi omwe amathandiza kulimbana ndi matenda
  • shingles (herpes zoster matenda)
  • zotumphukira zamaganizidwe am'mitsempha, mtundu wa kuwonongeka kwa mitsempha komwe kumayambitsa kuyabwa, kufooka, kapena kupweteka
• Zitha kuchitika ndi Kyprolis:
  • kuwonongeka kwa mapapo monga kutuluka magazi, kuundana kwa magazi, kutupa, kapena matenda m'mapapu
  • kuwonongeka kwa mtima kapena kulephera kwa mtima
  • mavuto a chiwindi, monga kuchuluka kwa kuchuluka kwa mapuloteni a chiwindi kapena kulephera kwa chiwindi
  • impso kulephera
  • chotupa chotchedwa tumor lysis syndrome, momwe ma cell a khansa amafera mwachangu ndipo zomwe zimapezeka zimatsikira m'magazi anu
  • matenda obwerera m'mbuyo osinthasintha, matenda amitsempha muubongo
  • kuthamanga kwa magazi
  • kuthamanga kwa magazi m'mapapo, komwe kumathamanga kwambiri m'mapapu
  • kuundana kwamagazi
  • mavuto akulu otuluka magazi monga kutuluka magazi m'mimba, m'mapapo, kapena muubongo
• Zitha kuchitika ndi Darzalex ndi Kyprolis:
  • kulowetsedwa zochita
  • thrombocytopenia, mulingo wochepa wa maselo othandiza magazi kuundana, womwe ndi mtundu wa maselo amwazi omwe amathandiza magazi kuundana
  • chibayo, mtundu wa matenda am'mapapo

Kuchita bwino

Darzalex ndi Kyprolis ali ndi ntchito zosiyanasiyana zovomerezeka ndi FDA, koma zonsezi zimagwiritsidwa ntchito pochiza myeloma yambiri.

Kugwiritsa ntchito Darzalex ndi Kyprolis kwa ma myeloma angapo sikunafanane mwachindunji pamaphunziro azachipatala. Komabe, kafukufuku wapeza kuti Darzalex ndi Kyprolis ndizothandiza kuthana ndi myeloma yambiri.

Ofufuza tsopano akuphunzira kugwiritsa ntchito mankhwala awiriwa pamodzi ndi dexamethasone pochiza khansa yamtunduwu. Zotsatirazi zawonetsa kuti anthu omwe anali atalandira kale matenda a myeloma angapo adayankha bwino pamankhwalawa kuphatikiza. Koma kuyesedwa kwina kumafunikira FDA isanavomereze kuphatikiza kwa mankhwala a Darzalex ndi Kyprolis a myeloma angapo.

Mtengo

Darzalex ndi Kyprolis onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa WellRx.com, Darzalex nthawi zambiri imakhala yotsika mtengo kuposa Kyprolis. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso komwe muli.

Momwe Darzalex imagwirira ntchito

Multiple myeloma ndi khansa yomwe imayambira mumtundu wama cell oyera omwe amatchedwa plasma cell. Maselo a plasma amapanga gawo la chitetezo chanu ndipo amathandiza kulimbana ndi matenda m'thupi lanu.

Nthawi zina kusintha mwadzidzidzi kwa majini anu, otchedwa kusintha, kumatha kusintha ma cell athanzi kukhala khansa. (Chibadwa ndi malangizo omwe amathandizira kuwongolera momwe ma cell anu amakulira komanso momwe amakhalira). Maselo am'magazi akasintha kukhala ma cell angapo a myeloma, amayamba kukula m'mafupa (mkatikati mwa mafupa anu). Maselo angapo a myeloma akamakula ndikufalikira, amatha kutulutsa maselo athanzi ndikuwononga mafupa owazungulira.

Darzalex ndi mankhwala opangidwa ndi anthu otchedwa monoclonal antibody. (Ma antibodies a monoclonal ndi mapuloteni m'thupi lanu. Amapangidwa kuti akwaniritse gawo linalake la khungu la khansa.)

Maselo am'magazi akasanduka ma cell angapo a myeloma, amakhala ndi puloteni yambiri yotchedwa CD38 pamtunda wawo. Mankhwala otchedwa monoclonal antibody Darzalex amagwira ntchito pophatikiza mapuloteni a CD38 pama cell angapo a myeloma. Pochita izi, Darzalex imapha kapena kuthandizira chitetezo chanu cha mthupi kuwononga ma cell angapo a myeloma.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

M'maphunziro azachipatala, nthawi yayitali yomwe Darzalex idayamba kugwira ntchito inali mwezi umodzi. Komabe, mutha kupatsidwa mankhwala kwa nthawi yayitali. Izi zimadalira momwe thupi lanu limayankhira ku Darzalex komanso ngati myeloma yanu yambiri ikuyamba kukulira. Kutalika kwa chithandizo kumadaliranso ngati myeloma yanu yambiri yapezeka kumene kapena ngati mudalandira kale mankhwala kale.

Darzalex ndi mowa

Palibe kuyanjana kulikonse komwe kumadziwika pakati pa Darzalex ndi mowa. Koma tikulimbikitsidwa kuti mupewe kumwa mowa mukamamwa Darzalex. Izi zimakhudzana ndi nthawi yayitali bwanji kuti munthu alandire mankhwalawo.

Darzalex imaperekedwa ngati kulowetsedwa m'mitsempha (IV). Ichi ndi jakisoni mumtsempha wanu womwe umaperekedwa kwakanthawi. Matenda a Darzalex amatha maola atatu mpaka 7. Chifukwa chake ndikofunikira kuti musakhale ndi hydrate musanalowe komanso mukamakulowetsani. Zakumwa zoledzeretsa zimatha kukupangitsani kusowa madzi m'thupi, chifukwa chake pewani mowa mukamamwa Darzalex.

Ngati muli ndi mafunso okhudzana ndi mowa komanso Darzalex, funsani dokotala wanu.

Kuyanjana kwa Darzalex

Musanatenge Darzalex, onetsetsani kuti mukuwuza adotolo ndi asayansi wanu zamankhwala onse, pa-counter ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Darzalex ndi mayeso a labotale

Kutenga Darzalex kungasinthe zotsatira za mayeso ena a labu.

Zolakwa zamtundu wamagazi

Ngati mukutenga Darzalex ndikuyesedwa magazi kuti mufanane ndi mtundu wamagazi anu, zotsatira zake sizingakhale zolondola. Zolakwitsa pamayesowa amatha miyezi isanu ndi umodzi mutatha kumwa Darzalex.

Darzalex imagwira ntchito pophatikiza puloteni ya CD38 pamwamba pama cell angapo a myeloma ndikuwononga mapuloteni. Nthawi zina maselo ofiira amathanso kukhala ndi mapuloteni a CD38. Darzalex imatha kudziphatika mwangozi ku puloteni ya CD38 pa khungu lofiira m'malo mwa ma cell angapo a myeloma. Izi zikachitika, zimasintha momwe selo yofiira yamagazi "imawonekera" poyesa magazi. Komabe, Darzalex sichidzakhudza mtundu wamagazi anu.

Pofuna kupewa zolakwika pakulemba magazi, dokotala wanu adzakuyesani mtundu wamagazi musanalandire mlingo woyamba wa Darzalex. Adzachita izi ngati mungafune kuikidwa magazi mtsogolo.

Momwe Darzalex amaperekedwera

Kuti mulandire kuchuluka kwanu kwa Darzalex, mupita kuofesi yanu kapena kuchipatala. Mankhwalawa amabwera ngati yankho (kusakaniza madzi). Wopereka chithandizo chamankhwala adzasakaniza Darzalex ndi 0.9% sodium chloride (mtundu wamadzi amchere). Kenako amakupatsani mankhwalawa pakapita nthawi kudzera mu singano yomwe imayikidwa mumthambo wanu. Izi zimatchedwa kulowetsedwa m'mitsempha (IV). Mutha kulandira Darzalex palokha kapena ndi mankhwala ena.

Dokotala wanu adzasankha kuchuluka kwa Darzalex yomwe angakupatseni malinga ndi kulemera kwanu komanso dongosolo lanu lamankhwala. Wopereka chithandizo chamankhwala nthawi zonse amakhala akukuyang'anirani nthawi yolowetsedwa.

Nthawi yoti mutenge

Dokotala wanu adzasankha nthawi pakati pa mlingo ndi mankhwala angati omwe mukufuna. Izi zidzatengera ngati mukumwa Darzalex nokha kapena ndi mankhwala ena. Funsani dokotala wanu kuti akulimbikitseni tsiku ndi nthawi yabwino kuti mutenge infusions malinga ndi zomwe mumachita tsiku ndi tsiku.

Kodi mumapeza Darzalex kangati ndipo kutalika kwa nthawi yolowetsedwa kumachepa pakapita nthawi. Kulowetsedwa kwanu koyamba kwa Darzalex kumatha kutenga pafupifupi maola 7. Izi ndichifukwa choti dokotala amakupatsani mankhwala pang'onopang'ono mumitsempha yanu. Kulowetsedwa mtsogolo kudzatenga nthawi yocheperako ndipo kumatha pafupifupi 3 mpaka 5 maola chifukwa mudzalandira mankhwala mwachangu.

Kutenga Darzalex ndi chakudya

Nthawi zolowetsedwa za Darzalex zimatha kuyambira 3 mpaka 7 maola, kutengera dongosolo lanu la mankhwala. Ndicho chifukwa chake ndibwino kubwera kukonzekera ndi zakudya zopatsa thanzi komanso zakumwa ngati zili bwino ndi dokotala wanu.

Darzalex ndi mimba

Darzalex sanaphunzirepo mwa amayi apakati kapena nyama. Koma Darzalex ndi antioclonal antibody, womwe ndi mtundu wa mankhwala omwe amalimbana ndi khansa. Ndipo ma antibodies a monoclonal amadziwika kuti amadutsa placenta. (The placenta ndi chiwalo chamkati mwanu chomwe chimapereka michere kuchokera mthupi lanu kupita kwa mwana wanu.)

Kutengera momwe Darzalex imagwirira ntchito, mankhwalawa amatha kuyambitsa kuchepa kwa mafupa mwa mwana wosabadwa. Zitha kuchepetsanso kuchuluka kwa magazi ndi maselo amthupi omwe mwana amene akukula amapanga.

Musanayambe kutenga Darzalex, onetsetsani kuti muuze dokotala ngati muli ndi pakati, atha kukhala ndi pakati, kapena kukonzekera kukhala ndi pakati.

Darzalex yokhala ndi lenalidomide kapena pomalidomide

Darzalex nthawi zina amatengedwa ndi mankhwala otchedwa lenalidomide (Revlimid) kapena pomalidomide (Pomalyst) ya myeloma yambiri. Lenalidomide ndi pomalidomide onse ali ndi chenjezo la mabokosi pazowopsa zakubadwa. Ngati ndinu mayi ndipo dokotala akukulemberani Darzalex ndi lenalidomide kapena pomalidomide, simuyenera kutenga pakati:

• osachepera masabata anayi musanayambe kumwa mankhwala
• pamene mukumwa mankhwala
• panthawi iliyonse yopuma
• kwa milungu yosachepera 4 mutasiya lenalidomide kapena pomalidomide

Ngati muli ndi mafunso okhudza kutenga Darzalex, lenalidomide, kapena pomalidomide muli ndi pakati, lankhulani ndi dokotala wanu.

Darzalex ndi kulera

Ngati pali mwayi woti mutha kutenga pakati, tikulimbikitsidwa kuti mugwiritse ntchito njira yolerera mukamamwa Darzalex. Muyenera kugwiritsa ntchito njira zakulera kwa miyezi itatu mukamaliza mankhwala a Darzalex. Izi ndichifukwa choti mankhwalawa amatha kukhala m'dongosolo lanu kwakanthawi kochepa mutasiya kumwa.

Ngati ndinu mwamuna ndipo mukugonana ndi mkazi, pali mwayi woyembekezera kuti ungachitike. Ganizirani kugwiritsa ntchito njira yoletsa kulera, monga kondomu, ngakhale mnzanu akugwiritsanso ntchito njira yolerera.

Darzalex yokhala ndi lenalidomide kapena pomalidomide

Nthawi zina, mutha kumwa Darzalex ndi mankhwala otchedwa lenalidomide (Revlimid) kapena pomalidomide (Pomalyst). Ngati ndinu mkazi ndipo mukumwa Darzalex ndi lenalidomide kapena pomalidomide, muyenera kuvomereza kugwiritsa ntchito njira ziwiri zakulera. Muyenera kuyamba kugwiritsa ntchito njira zakulera osachepera milungu 4 musanayambe mankhwala ndi mankhwalawa. Pitirizani kugwiritsa ntchito njira zakulera mukamamwa Darzalex ndi lenalidomide kapena pomalidomide, komanso panthawi iliyonse yopuma. Muyeneranso kupitiriza kugwiritsa ntchito njira zakulera kwa masabata osachepera 4 mutasiya kumwa lenalidomide kapena pomalidomide.

Lenalidomide ndi pomalidomide zimatha kulowa mumuna wamunthu. Chifukwa chake amuna onse ayenera kugwiritsa ntchito kondomu ya latex kapena yokumba pogonana ndi mayi yemwe angatenge mimba. Amuna akuyenera kugwiritsa ntchito njira yolerera imeneyi kwa nthawi yofanana yomwe bwenzi lawo limalera.

Ngati mukugonana ndipo inu kapena mnzanuyo mutha kutenga pakati, lankhulani ndi dokotala wanu. Amatha kukuthandizani kusankha zosowa zanu zakulera mukamagwiritsa ntchito Darzalex.

Darzalex ndi kuyamwitsa

Sizikudziwika ngati Darzalex itha kulowa mkaka wa m'mawere kapena momwe mankhwalawa angakhudzire mkaka wa m'mawere. Sikudziwikanso ngati Darzalex ingakhudze mwana woyamwitsa.

Darzalex yokhala ndi lenalidomide kapena pomalidomide

Nthawi zina, mutha kumwa Darzalex ndi mankhwala otchedwa lenalidomide (Revlimid) kapena pomalidomide (Pomalyst). Ngati ndinu mayi yemwe akuyamwitsa, simuyenera kugwiritsa ntchito lenalidomide kapena pomalidomide. Sizikudziwika ngati mankhwalawa amatha kulowa mkaka wa m'mawere ndikuvulaza mwana wanu.

Ngati mukufuna kuyamwitsa mwana wanu ndipo mukuganiza zotenga Darzalex, lankhulani ndi dokotala wanu. Amatha kukuwuzani zabwino ndi zoyipa zogwiritsa ntchito mankhwalawa mukamayamwitsa.

Mafunso wamba okhudza Darzalex

Nawa mayankho pamafunso omwe amafunsidwa zambiri za Darzalex.

Kodi ndichifukwa chiyani ndiyenera kumwa ma steroids ndi mankhwala ena ndikadaliranso za Darzalex infusions?

Mukalandira Darzalex, mutha kukhala osavomerezeka. Pofuna kupewa izi, dokotala wanu akhoza kukupatsani mankhwala otchedwa corticosteroids ndi mankhwala ena.

Wothandizira zaumoyo adzakupatsani Darzalex ngati kulowetsedwa kwa intravenous (IV) muofesi yanu kapena kuchipatala. Ichi ndi jakisoni mumtsempha wanu womwe umaperekedwa kwakanthawi. Ola limodzi kapena atatu pasanachitike kulowetsedwa kwa Darzalex, nthawi zambiri mumalandira mankhwala awa:

• corticosteroid (kuchepetsa kutupa)
• antipyretic (kupewa kapena kuchepetsa kutentha thupi)
• antihistamine (kupewa kapena kuchepetsa zizindikiritso)

Muthanso kulandira tsiku limodzi la corticosteroid mutalowetsedwa kuti musachedwe kuchitapo kanthu. Koma ngati mukumwa kale steroid monga dexamethasone kapena prednisone, mwina simufunikira kuwonjezera kwa steroid.

Ngati muli ndi mafunso okhudza mankhwala aliwonse omwe amaperekedwa ndi Darzalex infusions, funsani dokotala wanu.

Kodi ndizitha kuyendetsa pagalimoto nditachoka ku Darzalex?

Sizikulimbikitsidwa. Izi ndichifukwa choti sizachilendo kumva kutopa pambuyo polowetsedwa kapena ngakhale kulowetsedwa. (Onani "Zomwe zimayambitsa kulowetsedwa" mu gawo la "Zotsatira zoyipa" pamwambapa kuti mudziwe zambiri.) Kuti mukhale otetezeka, khalani ndi wachibale, bwenzi, kapena womusamalira kuti akutsogolereni kupita ndi kuchokera kumalo omwe mudalowetsedwa.

Samalani momwe mumamvera mukadzakumenyani ndikulemba zolemba zanu. Izi zitha kukuthandizani kusankha ngati mungadziyendetse, ngati mungafunike kutero.

Ngati simungapeze dalaivala, Janssen Biotech, Inc., wopanga Darzalex, atha kuthandiza. Mutha kuyankhula ndi wotsogolera wa Janssen CarePath za kupita ndi kubwera kuchokera kwa omwe adasankhidwa ndikulandila thandizo pamtengo woyendera. Kuti mudziwe zambiri, imbani 844-553-2792 kapena pitani patsamba la Darzalex.

Kodi ndingagwiritse ntchito Darzalex ngati ndakhala ndi shingles?

Inde, mutha kugwiritsa ntchito Darzalex ngati mwadwala matenda otchedwa shingles. Koma musanatenge Darzalex, ndikofunikira kuuza dokotala ngati mwakhalapo ndi ming'alu kapena nthomba. (Kachilombo komweko kamene kamayambitsa ma shingles kangayambitsenso nkhuku.)

Ngati mwakhala mukukhalapo kale, kachilomboka sikamachoka m'thupi mutachira. M'malo mwake, kachilomboka "kamangogona" m'mitsempha yanu.

Palibe amene akudziwa chifukwa chake, koma kachilomboka kakhoza kuyambiranso kapena "kudzuka" ndi zoyambitsa zina monga chitetezo chamthupi chofooka. (Chitetezo chanu cha mthupi ndi chitetezo chamthupi lanu kumatenda.)

Mankhwala a khansa monga Darzalex amatha kufooketsa chitetezo cha mthupi lanu ndikuyambiranso kachilomboka. Ikadzuka, imadzionetsa ngati yolimba m'malo mwa nthomba.

Chifukwa chake ngati mwakhala ndi ma shingles kapena nthomba, dokotala wanu amakupatsani mankhwala ochepetsa ma virus kuti ma shingles asadzayambenso mthupi lanu. Muyenera kumwa mankhwalawa musanathe sabata imodzi mutayamba kumwa Darzalex. Kenako mupitiliza kumwa ma antiviral kwa miyezi itatu mukamaliza mankhwala ndi Darzalex.

Ngati simukudziwa ngati mwakhalapo ndi minyewa kapena nthomba, lankhulani ndi dokotala wanu.

Kodi Darzalex imachiza myeloma yambiri?

Pakalipano, palibe mankhwala a myeloma angapo. Koma zomwe Darzalex angachite ndikusintha moyo wanu komanso kutalika kwa moyo, kutengera matenda anu. Dokotala wanu akhoza kukuwuzani zambiri.

Zodzitetezera ku Darzalex

Musanatenge Darzalex, kambiranani ndi dokotala za mbiri yanu. Darzalex mwina siyabwino kwa inu ngati mukudwala kapena zina zomwe zimakhudza thanzi lanu. Izi zikuphatikiza:

• Chiwindi B. Ngati mungakhale ndi hepatitis B kapena mudakhalapo m'mbuyomu, kutenga Darzalex kumatha kuyambitsa kuyambiranso. Musanayambe kumwa Darzalex, dokotala wanu adzakufufuzani ngati ali ndi matenda a chiwindi a hepatitis B. Adzakufunsaninso mukamaliza mankhwala anu. Zizindikiro za matenda otupa chiwindi a B zimaphatikizapo kutopa komwe kumakulirakulira, komanso khungu lanu loyera komanso maso anu oyera. Mukawona izi, uzani dokotala wanu.
• Ziphuphu. Pamene mukutenga Darzalex, mutha kukhala ndi matenda otchedwa shingles. Kachilombo komweko kamene kamagwedeza ma shingles kangayambitsenso nkhuku. Chifukwa chake ngati mudakhala ndi chikuku kapena ma shilles m'mbuyomu ndipo mukumwa Darzalex, dokotala wanu akhoza kukupatsani mankhwala ochepetsa ma virus. Mtundu uwu wa mankhwala ungathandize kupewa ma shingles kuti asakule mthupi lanu.
• Matenda osokoneza bongo (COPD). Ngati muli ndi vuto la kupuma lotchedwa chronic obstructive pulmonary disease (COPD), uzani dokotala musanayambe kumwa Darzalex. Angakupatseni inhaler kuti ikuthandizeni kupuma mosavuta komanso ma corticosteroids kuti muchepetse kutupa m'mapapu anu.
• Mimba. Darzalex sanaphunzirepo mwa amayi apakati. Koma ndi mtundu wa mankhwala omwe amatha kuwoloka nsengwa. (Placenta ndi chiwalo chomwe chili mkati mwanu chomwe chimapereka zakudya kuchokera m'thupi lanu kupita kwa mwana wanu.) Kuti mumve zambiri, chonde onani gawo la "Darzalex ndi pakati" pamwambapa.
• Kuyamwitsa. Sizikudziwika ngati ndibwino kuyamwa mkaka mukamamwa Darzalex. Kuti mumve zambiri, onani gawo la "Darzalex ndi yoyamwitsa" pamwambapa.

Uzani wothandizira zaumoyo wanu ngati mungakhale ndi izi mukamalandira chithandizo cha Darzalex kapena mukalandira chithandizo chake.

Zindikirani: Kuti mumve zambiri paza zotsatira zoyipa za Darzalex, onani gawo la "Darzalex Side Effects" pamwambapa.

Zambiri zamaluso za Darzalex

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Food and Drug Administration (FDA) yavomereza ndikuwonetsa Darzalex kuti igwiritsidwe ntchito:

• Mwa achikulire omwe ali ndi myeloma angapo omwe sangathenso kulandira omwe sangathe kulandira autologous stem cell kumuika. (Pogwiritsa ntchito autologous stem cell transplant, maselo anu enieni amagwiritsidwa ntchito.) Izi:
  • Darzalex itha kugwiritsidwa ntchito ndi mankhwala lenalidomide (Revlimid) ndi dexamethasone.
  • Darzalex itha kugwiritsidwanso ntchito ndi mankhwala a bortezomib (Velcade), melphalan, ndi prednisone.
• Mwa akulu omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zomwe sizinagwire bwino kapena omwe myeloma angapo abwerera. Poterepa, Darzalex imagwiritsidwa ntchito ndi lenalidomide ndi dexamethasone.
• Kwa achikulire omwe alandila chithandizo chimodzi kapena zingapo zam'mbuyomu zamankhwala a myeloma. Poterepa, Darzalex imagwiritsidwa ntchito ndi bortezomib ndi dexamethasone.
• Mwa achikulire omwe adalandira mankhwala awiri kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo lenalidomide ndi proteasome inhibitor, womwe ndi mtundu wa mankhwala. Poterepa, Darzalex imagwiritsidwa ntchito ndi mankhwala pomalidomide (Pomalyst) ndi dexamethasone.
• Mwa achikulire omwe alandila mankhwala atatu kapena angapo am'mbuyomu a myeloma omwe amaphatikizapo proteasome inhibitor ndi mankhwala opatsirana pogonana. Poterepa, Darzalex imagwiritsidwa ntchito paokha.
• Mwa achikulire omwe ayesapo proteasome inhibitor ndi mankhwala opewera chitetezo mthupi koma palibe mankhwala omwe adagwira ma myeloma angapo. Poterepa, Darzalex imagwiritsidwa ntchito paokha.

Njira yogwirira ntchito

Darzalex ndi antioclonal antibody ndipo imalepheretsa kapena kuwononga chotupacho kukula kwa maselo angapo a myeloma. Maselo am'magazi akasanduka ma cell angapo a myeloma, amakhala ndi mapuloteni ambiri otchedwa CD38. Darzalex imayang'ana ndikudziphatika ku mapuloteni a CD38. Kudzera mwa zoteteza mthupi komanso molunjika pachitupa, Darzalex imalepheretsa kukula kwama cell angapo a myeloma ndikuyamba njira ya apoptosis (cell death).

Pharmacokinetics ndi metabolism

Palibe kusiyana kwakadwala pama pharmacokinetics a Darzalex ngati monotherapy kapena ngati mankhwala ophatikizika omwe adawonedwa kutengera anthu ena.

Kutsatira kulowetsedwa kwa mlingo woyenera wa Darzalex wokha kapena ngati mankhwala osakanikirana, kuchuluka kwa magazi a Darzalex kudakwera pafupifupi katatu kumapeto kwa mlingo wa sabata poyerekeza ndi mlingo woyamba.

Kuwaza mlingo woyamba wa Darzalex kudapangitsa kuti magazi azikhala ochepa kuposa momwe munthu amalandirira mlingo woyamba. Komabe, nsonga zofananira ndi zokometsera zamagazi zimawoneka ndikuwonedweratu atalandira gawo lachiwiri logawanika sabata 1, tsiku 2 la chithandizo.

Darzalex atangopatsidwa yekha, kuchuluka kwa magazi mosasunthika (boma lokhazikika) kudafikiridwa pafupifupi miyezi isanu ndi iwiri (4) ndikulowetsedwa kwama 21). Pakhazikike, Darzalex amatanthauza kuchuluka kwakachulukidwe kochulukirapo kwamagazi anali 1.6.

Kufalitsa:

• monotherapy: 4.7 ± 1.3 L
• mankhwala ophatikizana: 4.4 ± 1.5 L

Kuchotsa theka la moyo wa monotherapy ndi mankhwala osakaniza anali masiku 18 ± 9. Chilolezo cha Darzalex chatsika ndi kuchuluka kwa mlingo komanso ndi ma dosing angapo. Kutulutsa kumayerekezeredwa kukhala 171.4 ± 95.3 mL / tsiku. Pamene kulemera kwa thupi kumakulirakulira, kuchuluka kwa magawidwe ndi kuchuluka kwa momwe Darzalex adachotsedwa mthupi kumakulirakulira

Zotsutsana

Darzalex imatsutsana ndi odwala omwe ali ndi mbiri yovuta kwambiri ya anaphylactic ku daratumumab kapena chilichonse chothandizidwa ndi mankhwalawa. Matenda owopsa a neutropenia, thrombocytopenia, kapena kulowetsedwa chifukwa chamankhwala angafune kuti Darzalex iimitsidwe kapena kuyimitsidwa kotheratu.

Yosungirako

Darzalex iyenera kusungidwa mufiriji pa 36 ° F mpaka 46 ° F (2 ° C mpaka 8 ° C).

Osagwedeza kapena kuzizira Darzalex. Mankhwalawa ayenera kutetezedwa ku kuwala. Darzalex mulibe zotetezera zilizonse.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.