Mankhwala a RA: DMARDs ndi TNF-Alpha Inhibitors

Zamkati

• Chiyambi
• DMARD: Zofunikira pakuchiza koyambirira
• DMARD okhala ndi mankhwala othetsa ululu
• Corticosteroids
• Ma NSAID owerengera
• NSAID zamankhwala
• DMARDs ndi matenda
• TNF-alpha zoletsa
• Lankhulani ndi dokotala wanu
• Funso:
• Yankho:

Chiyambi

Matenda a nyamakazi (RA) ndimatenda amthupi okhaokha. Zimapangitsa kuti chitetezo chamthupi chanu chiwononge ziwalo zathanzi m'magulu anu, zomwe zimayambitsa kupweteka, kutupa, ndi kuuma. Mosiyana ndi nyamakazi ya m'mafupa, yomwe imayamba chifukwa chovala ndikumakalamba mukamakula, RA imatha kukhudza aliyense wazaka zilizonse. Palibe amene amadziwa bwino zomwe zimayambitsa.

RA ilibe mankhwala, koma mankhwala angathandize kuthetsa zizindikilo. Mankhwalawa amaphatikizapo mankhwala odana ndi kutupa, corticosteroids, ndi mankhwala omwe amalepheretsa chitetezo cha mthupi. Zina mwa mankhwala othandiza kwambiri ndi matenda osintha mankhwala a rheumatic (DMARDs), omwe akuphatikizapo TNF-alpha inhibitors.

DMARD: Zofunikira pakuchiza koyambirira

Ma DMARD ndi mankhwala omwe ma rheumatologists nthawi zambiri amalamula atangopeza RA. Zowonongeka zonse zophatikizika kuchokera ku RA zimachitika mzaka ziwiri zoyambirira, chifukwa chake mankhwalawa amatha kusintha kwambiri nthawi yamatenda.

Ma DMARD amagwira ntchito pochepetsa chitetezo chamthupi. Izi zimachepetsa kuukira kwa RA pamafundo anu kuti muchepetse kuwonongeka konse.

Zitsanzo za ma DMARD ndi awa:

• methotrexate (Otrexup)
• hydroxychloroquine (Plaquenil)
• leflunomide (Arava)

DMARD okhala ndi mankhwala othetsa ululu

Chovuta chachikulu chogwiritsa ntchito ma DMARD ndikuti amachedwa kuchita. Zitha kutenga miyezi ingapo kumva kupweteka kulikonse kuchokera ku DMARD. Pachifukwa ichi, ma rheumatologists nthawi zambiri amapereka mankhwala opha ululu monga corticosteroids kapena nonsteroidal anti-inflammatory drugs (NSAIDs) kuti atenge nthawi yomweyo. Mankhwalawa amatha kuthandizira kuchepetsa ululu mukadikirira kuti DMARD ichitike.

Zitsanzo za ma corticosteroids kapena ma NSAID omwe atha kugwiritsidwa ntchito ndi ma DMARD ndi awa:

Corticosteroids

• prednisone (Rayos)
• methylprednisolone (Depo-Medrol)
• triamcinolone (Aristospan)

Ma NSAID owerengera

• aspirin
• ibuprofen
• naproxen sodium

NSAID zamankhwala

• nabumetone
• alirazamalik (Alirazamalik)
• piroxicam (Feldene)

DMARDs ndi matenda

Ma DMARD amakhudza chitetezo chanu chonse chamthupi. Izi zikutanthauza kuti amakuikani pachiwopsezo chachikulu chotenga matenda.

Matenda omwe RA ali nawo ndi awa:

• matenda akhungu
• matenda opatsirana apamwamba
• chibayo
• matenda opatsirana mumkodzo

Pofuna kupewa matenda, muyenera kukhala aukhondo, kuphatikiza kusamba m'manja nthawi zambiri komanso kusamba tsiku lililonse kapena tsiku lililonse. Muyeneranso kukhala kutali ndi anthu omwe akudwala.

TNF-alpha zoletsa

Tumor necrosis factor alpha, kapena TNF alpha, ndichinthu chomwe chimapezeka mwachilengedwe mthupi lanu. Mu RA, chitetezo cha mthupi chomwe chimagunda malumikizowo chimapanga ma alpha a TNF apamwamba. Mulingo wapamwambawu umapweteka komanso kutupa. Ngakhale zinthu zina zingapo zimawonjezera kuwonongeka kwa RA m'malo olumikizana mafupa, TNF alpha ndimasewera akulu pantchitoyi.

Chifukwa alfine ya TNF ndi vuto lalikulu mu RA, TNF-alpha inhibitors ndiimodzi mwamitundu yofunikira kwambiri ya DMARD pamsika pompano.

Pali mitundu isanu ya TNF-alpha inhibitors:

• adalimumab (Humira)
• etanercept (Enbrel)
• chitsimikizo cha pegol (Cimzia)
• golimumab (Simponi)
• infliximab (Kutulutsa)

Mankhwalawa amatchedwanso TNF-alpha blockers chifukwa amaletsa ntchito za TNF alpha. Amachepetsa ma alpha a TNF mthupi lanu kuti athandizire kuchepa kwa RA. Amayambanso kugwira ntchito mwachangu kuposa ma DMARD ena. Atha kuyamba kugwira ntchito mkati mwa milungu iwiri mpaka mwezi.

Lankhulani ndi dokotala wanu

Anthu ambiri omwe ali ndi RA amayankha bwino ku TNF-alpha inhibitors ndi ma DMARD ena, koma kwa anthu ena, izi sizingagwire ntchito konse. Ngati sakugwirira ntchito, uzani katswiri wanu wamankhwala. Angathe kupereka TNF-alpha inhibitor yosiyana ngati gawo lina, kapena atha kupereka mtundu wina wa DMARD palimodzi.

Onetsetsani kuti mwasintha rheumatologist wanu momwe mumamvera komanso momwe mukuganizira kuti mankhwala anu akugwira ntchito. Pamodzi, inu ndi dokotala mutha kupeza njira yothandizira RA yomwe ingakuthandizeni.

Funso:

Kodi zakudya zanga zingakhudze RA yanga?

Yankho:

Inde. Pali zakudya zambiri zomwe zingathandize kuchepetsa kutupa m'thupi lanu. Ngati mukufuna kuyesa kusintha zakudya kuti muchepetse zizindikiro za RA, yambani kudya zakudya zambiri zomwe zili ndi omega-3 fatty acids, antioxidants, ndi fiber, monga mtedza, nsomba, zipatso, masamba, ndi tiyi wobiriwira. Njira imodzi yabwino yobweretsera zakudya izi tsiku lililonse ndikutsata zakudya za ku Mediterranean. Kuti mumve zambiri pazakudya izi ndi zakudya zina zomwe zingathandize kuchepetsa zizindikiro za RA, onani zakudya zotsutsana ndi zotupa za RA.