Kuyezetsa kwa CPK: ndichifukwa chiyani ndikusinthidwa
Zamkati
Creatinophosphokinase, yomwe imadziwika ndi dzina loti CPK kapena CK, ndi enzyme yomwe imagwira ntchito makamaka pamatumba am'mimba, ubongo ndi mtima, ndipo mayeso ake amafunsidwa kuti afufuze kuwonongeka kwa ziwalozi.
Dokotala amatha kuyitanitsa mayesowa munthu akafika kuchipatala akudandaula za kupweteka pachifuwa kapena kuti awone ngati ali ndi stroke kapena matenda aliwonse omwe amakhudza minofu.
Malingaliro owonetsera
Malingaliro owunikira a creatine phosphokinase (CPK) ndi 32 ndi 294 U / L za amuna ndipo 33 mpaka 211 U / L azimayi koma zimatha kusiyanasiyana kutengera labotale komwe mayeso amachitikira.
Ndi chiyani
Kuyesa kwa creatinophosphokinase (CPK) ndikothandiza kuthandiza kuzindikira matenda monga matenda amtima, impso kapena mapapo kulephera, pakati pa ena. Enzyme imeneyi imagawika m'magulu atatu malinga ndi komwe imapezeka:
- CPK 1 kapena BB: Amapezeka m'mapapu ndi ubongo, makamaka;
- CPK 2 kapena MB: Imapezeka muminyewa yamtima chifukwa chake itha kugwiritsidwa ntchito ngati chikhomo cha infarction, mwachitsanzo;
- CPK 3 kapena MM: Imapezeka munyama zam'mimba ndipo imayimira 95% ya zolengedwa zonse za phosphokinases (BB ndi MB).
Mlingo wa mtundu uliwonse wa CK umachitika ndi njira zosiyanasiyana za ma labotale malingana ndi momwe zimakhalira komanso malinga ndi zomwe akuchipatala akuwonetsa. Mlingo wa CPK ukafunsidwa kuti uunike infarction, mwachitsanzo, CK MB imayesedwa kuphatikiza pazizindikiro zina zamtima, monga myoglobin ndi troponin, makamaka.
Mtengo wa CK MB wofanana kapena wochepera 5 ng / mL umawerengedwa kuti ndi wabwinobwino ndipo nthawi zambiri ndende yake imadzetsa matenda amtima. Mulingo wa CK MB nthawi zambiri umachulukitsa 3 mpaka 5 maola pambuyo pa infarction, imafika pachimake mpaka maola 24 ndipo mtengowo umabwerera mwakale pakati pa 48 mpaka 72 maola pambuyo pa infarction. Ngakhale amawoneka ngati chikhomo chabwino cha mtima, muyeso wa CK MB wokhudzana ndi infarction uyenera kuchitidwa limodzi ndi troponin, makamaka chifukwa ma troponin amabwereranso mwakale pafupifupi masiku 10 pambuyo pa infarction, makamaka, makamaka. Onani chomwe mayeso a troponin ndi ake.
Zomwe CPK zapamwamba komanso zotsika zikutanthauza
Kuchulukitsa kwa enzyme ya creatinophosphokinase kungasonyeze:
| Mkulu CPK | CPK Yotsika | |
| CPK BB | Infarction, stroke, chotupa chaubongo, khunyu, kulephera kwamapapo | -- |
| CPK MB | Kutupa kwamtima, kuvulala pachifuwa, kugwedezeka kwamagetsi, ngati mtima wanu usokonezeka, kuchita opaleshoni ya mtima | -- |
| MM CPK | Kuphwanya kuvulala, kulimbitsa thupi kwambiri, kulepheretsa thupi kwa nthawi yayitali, kugwiritsa ntchito mankhwala osokoneza bongo, kutupa mthupi, kusokonekera kwa minofu, pambuyo pa electromyography | Kutaya minofu, cachexia ndi kuperewera kwa zakudya m'thupi |
| CPK YONSE | Kumwa mopitirira muyeso zakumwa zoledzeretsa, chifukwa chogwiritsa ntchito mankhwala monga amphotericin B, clofibrate, ethanol, carbenoxolone, halothane ndi succinylcholine omwe amaperekedwa limodzi, ndikupaka poizoni ndi barbiturates | -- |
Kuchita dosing ya CPK, kusala kudya sikofunikira, ndipo dokotala sangakuyamikireni kapena mwina, komabe ndikofunikira kupewa kuchita zolimbitsa thupi zolimbitsa thupi kwa masiku osachepera 2 musanayese mayeso, chifukwa enzyme iyi imatha kukwezedwa pambuyo pochita masewera olimbitsa thupi chifukwa pakupanga kwake ndi minofu, kuphatikiza kuyimitsidwa kwa mankhwala, monga Amphotericin B ndi Clofibrate, mwachitsanzo, chifukwa amatha kusokoneza zotsatira zoyeserera.
Ngati mayeso akufunsidwa kuti apeze matenda amtima, tikulimbikitsidwa kuti ubale wapakati pa CPK MB ndi CPK uyesedwe pogwiritsa ntchito njira zotsatirazi: 100% x (CK MB / CK yathunthu). Ngati zotsatira za ubalewu ndizoposa 6%, zikuwonetsa kuvulala kwa minofu yamtima, koma ngati ndi yochepera 6%, ndichizindikiro chovulala pamfupa, ndipo adotolo ayenera kufufuza chifukwa chake.
Chosangalatsa
Momwe mungayesere mayeso kuti mutsimikizire khungu khungu
