Kutaya Tsitsi ndi Testosterone

Zamkati

• Mitundu yosiyanasiyana ya testosterone
• Mawonekedwe a dazi
• DHT: Mahomoni osowa tsitsi
• DHT ndi zina
• Ndi majini anu
• Zonama: Kutha ndi tsitsi
• Kutaya tsitsi kwa akazi
• Mankhwala ochotsera tsitsi

Zoluka zovuta

Chiyanjano pakati pa testosterone ndi kutayika tsitsi ndi kovuta. Chikhulupiriro chofala ndichakuti amuna amadazi amakhala ndi testosterone yambiri, koma kodi izi ndi zoona?

Dazi la amuna, kapena androgenic alopecia, limakhudza amuna pafupifupi 50 miliyoni ndi akazi 30 miliyoni ku United States, malinga ndi National Institutes of Health (NIH). Kutaya tsitsi kumachitika chifukwa chakuchepa kwa ma follicles amtsitsi komanso zomwe zimakhudza kukula. Tsitsi latsopano limakhala labwino kwambiri mpaka pomwe palibe tsitsi lomwe limatsalira konse ndipo ma follicles amakhala atagona. Tsitsi ili limayamba chifukwa cha mahomoni ndi majini ena.

Mitundu yosiyanasiyana ya testosterone

Testosterone imapezeka m'thupi lanu m'njira zosiyanasiyana. Pali testosterone "yaulere" yomwe simamangiriridwa ku mapuloteni mthupi lanu. Uwu ndiye mawonekedwe a testosterone omwe amapezeka kwambiri mthupi.

Testosterone imathanso kumangidwa ndi albumin, puloteni m'magazi. Testosterone yambiri imamangiriridwa ndi mapuloteni a globulin (SHBG) ogonana omwe amagonana ndipo sagwira ntchito. Ngati muli ndi vuto lochepa la SHBG, mutha kukhala ndi testosterone yaulere mumwazi wanu.

Dihydrotestosterone (DHT) imapangidwa kuchokera ku testosterone ndi enzyme. DHT ndi yamphamvu kasanu kuposa testosterone. DHT imagwiritsidwa ntchito makamaka ndi thupi mu prostate, khungu, ndi tsitsi.

Mawonekedwe a dazi

Dazi la amuna (MPB) lili ndi mawonekedwe osiyana. Tsitsi lakumbuyo limabwerera, makamaka m'mbali, ndikupanga mawonekedwe a M. Uku ndi dazi lakumaso. Korona wa mutu, womwe umadziwikanso kuti vertex, umakhalanso wadazi. Pamapeto pake madera awiriwa amalowa mu "U". MPB imatha kufikira ku tsitsi lachifuwa, lomwe limatha kuchepa mukamakalamba. Chodabwitsa, tsitsi m'malo osiyanasiyana mthupi limatha kuchita mosiyanasiyana pakusintha kwa mahomoni. Mwachitsanzo, kukula kwa tsitsi kumaso kumatha kusintha pamene madera ena amakhala dazi.

DHT: Mahomoni osowa tsitsi

Dihydrotestosterone (DHT) imapangidwa kuchokera ku testosterone ndi enzyme yotchedwa 5-alpha reductase. Zitha kupangidwanso kuchokera ku DHEA, mahomoni ofala kwambiri mwa akazi. DHT imapezeka pakhungu, tsitsi la tsitsi, ndi prostate. Zomwe DHT imachita komanso chidwi cha ma follicles a tsitsi ku DHT ndizomwe zimayambitsa tsitsi.

DHT imagwiranso ntchito ku prostate. Popanda DHT, prostate sikukula bwino. Ndi DHT yochulukirapo, bambo amatha kukhala ndi benign prostate hypertrophy, yemwenso amadziwika kuti prostate wokulitsa.

DHT ndi zina

Pali umboni wina wokhudza kulumikizana pakati pa dazi ndi khansa ya prostate ndi matenda ena. Harvard Medical School inanena kuti amuna omwe ali ndi dazi la vertex ali ndi chiopsezo chotenga khansa ya prostate kuwirikiza 1.5 poyerekeza ndi amuna opanda madazi. Kuopsa kwa matenda amitsempha yam'mimba ndikoposa 23 peresenti kuposa amuna omwe ali ndi mawanga a vertex. Kafukufuku akupitilirabe ngati pali kulumikizana pakati pa milingo ya DHT ndi matenda amadzimadzi, matenda ashuga, ndi matenda ena.

Ndi majini anu

Si kuchuluka kwa testosterone kapena DHT komwe kumayambitsa dazi; ndikumverera kwa ma follicles anu atsitsi. Kumvetsetsa kumeneko kumatsimikiziridwa ndi chibadwa. Jini ya AR imapanga cholandirira pamutu wa tsitsi womwe umalumikizana ndi testosterone ndi DHT. Ngati mapulogalamu anu ali ovuta kwambiri, amayamba mosavuta ndi DHT, ndipo kutaya tsitsi kumachitika mosavuta chifukwa chake. Ma jini ena amathanso kutenga nawo mbali.

Zaka, kupsinjika, ndi zinthu zina zimatha kukukhudzani ngati tsitsi lanu latayika. Koma majini amatenga gawo lalikulu, ndipo amuna omwe ali ndi abale achibale omwe ali ndi MPB ali pachiwopsezo chachikulu chotenga MPB iwonso.

Zonama: Kutha ndi tsitsi

Pali zikhulupiriro zambiri kunja uko zakumeta amuna. Chimodzi mwazinthuzi ndikuti amuna omwe ali ndi MPB amakhala achilengedwe komanso amakhala ndi testosterone. Izi sizili choncho ayi. Amuna omwe ali ndi MPB atha kukhala ndi testosterone yocheperako koma ma enzyme omwe amasintha testosterone kukhala DHT. Mosiyana, mutha kukhala ndi majini omwe amakupatsani ma follicles atsitsi omwe amakhudzidwa kwambiri ndi testosterone kapena DHT.

Kutaya tsitsi kwa akazi

Amayi amathanso kutaya tsitsi chifukwa cha androgenetic alopecia. Ngakhale azimayi ali ndi testosterone yotsika kwambiri kuposa momwe amuna amachitira, pali zokwanira zomwe zingayambitse tsitsi la androgenetic.

Amayi amakumana ndi mtundu wina wosowa tsitsi. Kupatulira kumachitika pamwamba pamutu pamtengo wa "mtengo wa Khrisimasi", koma tsitsi lakumbuyo silimatha. Kutayika kwa tsitsi lachikazi (FPHL) kumayambanso chifukwa cha zochita za DHT pamutu wa tsitsi.

Mankhwala ochotsera tsitsi

Njira zingapo zochizira MPB ndi FPHL zimaphatikizapo kusokoneza machitidwe a testosterone ndi DHT. Finasteride (Propecia) ndi mankhwala omwe amaletsa enzyme ya 5-alpha reductase yomwe imasintha testosterone kukhala DHT. Ndizowopsa kugwiritsa ntchito mwa amayi omwe angatenge mimba, ndipo pakhoza kukhala zovuta zakugonana za mankhwalawa kwa amuna ndi akazi.

Chinanso cha 5-alpha reductase inhibitor chotchedwa dutasteride (Avodart) chikuwonedwa ngati chithandizo cha MPB. Pakali pano ili pamsika wothandizidwa ndi prostate wokulitsidwa.

Njira zina zamankhwala zomwe sizikuphatikizapo testosterone kapena DHT ndizo:

• minoxidil (Rogaine)
• ketoconazole
• chithandizo cha laser
• Kuika tsitsi lopangira tsitsi