Idiopathic Autoimmune Hemolytic Anemia

Zamkati

• Ndani ali pachiwopsezo?
• Zizindikiro za idiopathic AIHA
• Kuzindikira idiopathic AIHA
• Njira zochiritsira IAIHA
• Steroids
• Opaleshoni
• Mankhwala osokoneza bongo
• Kuwona kwakanthawi

Kodi idiopathic autoimmune hemolytic anemia ndi chiyani?

Idiopathic autoimmune hemolytic anemia ndi mtundu wa autoimmune hemolytic anemia. Autoimmune hemolytic anemia (AIHA) ndi gulu la matenda osowa koma owopsa amwazi. Zimachitika thupi likawononga maselo ofiira mwachangu kwambiri kuposa momwe amapangira. Matenda amaonedwa kuti ndi amisili pomwe zomwe zimayambitsa sizikudziwika.

Matenda omwe amadzimadzimitsa okha amadzaukira thupi lokha. Chitetezo chanu cha mthupi chimapanga ma antibodies kuti athandize owukira akunja monga mabakiteriya ndi ma virus. Pankhani yamavuto amthupi mwako, thupi lako limapanga molakwika ma antibodies omwe amalimbana ndi thupi lomwe. Ku AIHA, thupi lanu limapanga ma antibodies omwe amawononga maselo ofiira.

Idiopathic AIHA ikhoza kukhala pangozi chifukwa chobwera mwadzidzidzi. Amafuna chithandizo chamankhwala mwachangu komanso kuchipatala.

Ndani ali pachiwopsezo?

Pafupifupi milandu yonse ya AIHA ndi idiopathic. AIHA imatha kuchitika nthawi iliyonse pamoyo ndipo imatha kukula mwadzidzidzi kapena pang'onopang'ono. Zimakhudza kwambiri azimayi.

Ngati AIHA si idiopathic, ndichifukwa chakuti idayambitsidwa ndi matenda oyambitsa kapena mankhwala. Komabe, idiopathic AIHA ilibe zifukwa zoonekeratu. Anthu omwe ali ndi idiopathic AIHA atha kumangokhala ndi zotsatira zachilendo zoyesera magazi ndipo alibe zisonyezo.

Zizindikiro za idiopathic AIHA

Mutha kumva kufooka komanso kupuma pang'ono ngati mungayambe mwadzidzidzi idiopathic AIHA. Nthawi zina, vutoli limakhala lachilendo ndipo limayamba pakapita nthawi, kotero zizindikirazo sizowonekera kwenikweni. Pazochitika zonsezi, zizindikiro zimatha kukhala chimodzi kapena zingapo zotsatirazi:

• kufooka kowonjezereka
• kupuma movutikira
• kugunda kwamtima mwachangu
• khungu loyera kapena lachikaso
• kupweteka kwa minofu
• nseru
• kusanza
• mkodzo wamtundu wakuda
• mutu
• kusapeza m'mimba
• kuphulika
• kutsegula m'mimba

Kuzindikira idiopathic AIHA

Dokotala wanu amalankhula nanu zambiri za zizindikilo zanu ngati akuganiza kuti muli ndi AIHA. Ayenera kukudziwani kuti muli ndi AIHA ndikuletsa mankhwala kapena zovuta zina monga zomwe zingayambitse AIHA asanakupeze ndi mtundu wa idiopathic.

Choyamba, dokotala wanu adzakufunsani za mbiri yanu yazachipatala. Zikuwoneka kuti adzakulowetsani kuchipatala kuti mukayesedwe mwachangu ndikuwunika ngati zizindikiro zanu zili zazikulu. Zitsanzo zazinthu zazikulu ndizophatikizira khungu kapena mkodzo kapena kuchepa kwa magazi m'thupi. Amatha kukutumizirani kwa katswiri wamagazi, kapena hematologist.

Muyenera kukhala ndi mndandanda wamagazi wambiri kuti mutsimikizire AIHA. Mayeso ena amayesa kuchuluka kwa maselo ofiira a thupi. Ngati muli ndi AIHA, kuchuluka kwanu kwama cell ofiira kumakhala kotsika. Mayesero ena amayang'ana zinthu zina m'magazi. Kuyesedwa kwa magazi komwe kumawulula kuchuluka kolakwika kwa mwana wakhanda mpaka maselo ofiira ofiira atha kuwonetsa AIHA. Maselo ofiira ofiira ambiri akuwonetsa kuti thupi limayesetsa kubwezera maselo ofiira omwe akuwonongeka mwachangu kwambiri.

Zotsatira zina zoyesera magazi zimaphatikizira mulingo woposa wabwinobwino wa bilirubin komanso kuchepa kwa protein yotchedwa haptoglobin. Bilirubin ndi chinthu chachilengedwe chobwera chifukwa cha kuwonongeka kwa maselo ofiira amwazi. Maguluwa amakula kwambiri pamene maselo ofiira ambiri awonongedwa. Kuyezetsa magazi kwa haptoglobin kumatha kukhala kothandiza kwambiri pakuzindikira AIHA. Pamodzi ndi kuyezetsa magazi kwina, zimawulula kuti mapuloteni akuwonongedwa limodzi ndi maselo ofiira ofiira okhwima.

Nthawi zina, zotsatira za labu zoyeserera magazi izi sizingakhale zokwanira kuti mupeze AIHA, chifukwa chake dokotala angafunike kuyesa zina. Mayesero ena, kuphatikiza mayeso achindunji komanso osadziwika a Coombs, amatha kuzindikira ma antibodies owonjezeka m'magazi. Kuthira urinal komanso kusonkhetsa mkodzo kwa maola 24 zitha kuwonetsa zovuta mumkodzo, monga kuchuluka kwa mapuloteni.

Njira zochiritsira IAIHA

Anthu omwe akuganiziridwa kuti adayamba mwadzidzidzi AIHA nthawi zambiri amapititsidwa kuchipatala chifukwa chovuta. Matenda atha kubwera nthawi zambiri osafotokozedwa. Ndizotheka kuti vutoli lipite popanda chithandizo.

Dokotala wanu amayang'anitsitsa kuchuluka kwa magazi m'magazi anu ngati muli ndi matenda ashuga. Matenda ashuga ndi omwe amawopsa kwambiri chifukwa cha chithandizo chamankhwala.

Steroids

Chithandizo cha mzere woyamba nthawi zambiri chimakhala ma steroids monga prednisone. Amatha kuthandiza kukonza kuwerengera kwama cell ofiira. Dokotala wanu amayang'anitsitsa mosamala kuti aone ngati ma steroids akugwira ntchito. Mkhalidwe wanu ukayamba kukhululukidwa, dokotala wanu amayesa kukuchotsani ku steroids pang'onopang'ono. Anthu omwe ali ndi AIHA omwe amalandira mankhwala a steroid angafunike zowonjezera panthawi ya chithandizo. Izi zingaphatikizepo:

• ziphuphu
• vitamini D
• kashiamu
• kupatsidwa folic acid

Opaleshoni

Dokotala wanu angakuuzeni kuchotsa kwa ndulu ngati ma steroids samagwira ntchito kwathunthu. Kuchotsa ndulu kumatha kusintha kuwonongeka kwa maselo ofiira. Kuchita opaleshoniyi kumadziwika kuti splenectomy. Anthu omwe amakhala ndi splenectomy amakhala ndi chikhululukiro pang'ono kapena kwathunthu kuchokera ku AIHA, ndipo anthu omwe ali ndi mtundu wa idiopathic amakonda kukhala ndi zotsatira zabwino kwambiri.

Mankhwala osokoneza bongo

Njira zina zamankhwala ndimankhwala osokoneza bongo, monga azathioprine ndi cyclophosphamide. Izi zitha kukhala mankhwala othandiza kwa anthu omwe sakwanitsa kuyankha mankhwala ndi ma steroids kapena omwe sioyenera kuchitidwa opaleshoni.

Nthawi zina, mankhwala a rituximab amatha kusankhidwa kuposa mankhwala omwe amaletsa chitetezo chamthupi. Rituximab ndi antibody yemwe amamenya mwachindunji mapuloteni ena omwe amapezeka m'maselo ena amthupi.

Kuwona kwakanthawi

Kungakhale kovuta kupeza matendawa mwachangu ngati izi sizikudziwika chifukwa chake. Chithandizo nthawi zina chimachedwa panthawiyi. Idiopathic AIHA imatha kupha ngati singachiritsidwe.

Idiopathic AIHA mwa ana amakhala osakhalitsa. Vutoli nthawi zambiri limakhala lachilendo kwa achikulire, ndipo limatha kudzilimbitsa kapena kudzisintha lokha popanda kufotokozera. AIHA imachiritsidwa kwambiri kwa akulu komanso ana. Anthu ambiri amachira kwathunthu.