Chilombo (tildrakizumab-asmn)

Zamkati

• Ilumya ndi chiyani?
• Kuvomerezeka ndi FDA
• Ilumya generic
• Mtengo wa Ilumya
• Thandizo lazachuma komanso inshuwaransi
• Ilumya amagwiritsa ntchito
• Ilumya wa psoriasis yolembera
• Ntchito zomwe sizivomerezedwa
• Mlingo wa Ilumya
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa plaque psoriasis
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Zotsatira za Ilumya
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zochita jekeseni patsamba
• Kutsekula m'mimba
• Kuchulukitsa chiwopsezo cha matenda
• Chitetezo cha mthupi kwa Ilumya
• Njira Zina ku Ilumya
• Ilumya vs. Tremfya
• Pafupi
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Ilumya vs. mankhwala ena
• Ilumya vs. Cosentyx
• Ilumya vs. Humira
• Ilumya vs. Enbrel
• Ilumya vs. methotrexate
• Ilumya amagwiritsira ntchito mankhwala ena
• Ilumya ndi mowa
• Kuyanjana kwa Ilumya
• Ilumya ndi katemera wamoyo
• Momwe mungatenge Ilumya
• Musanayambe mankhwala a Ilumya
• Kusunga nthawi
• Momwe Ilumya amagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Ilumya ndi mimba
• Ilumya ndi kuyamwitsa
• Mafunso wamba za Ilumya
• Kodi Ilumya amachiza psoriasis?
• Nthawi zonse ndimagwiritsa ntchito mafuta a psoriasis yanga. Chifukwa chiyani ndiyenera kuyamba kulandira jakisoni?
• Kodi ndiyenera kutenga Ilumya nthawi yayitali bwanji?
• Kodi mankhwala osokoneza bongo ndi ati?
• Kodi Ilumya amagwiritsidwa ntchito pochiza nyamakazi ya psoriatic?
• Chifukwa chiyani ndikufunika kuyezetsa TB ndisanayambe kumwa mankhwala ndi Ilumya?
• Kodi ndingatani kuti ndipewe matendawa ndikamamwa Ilumya?
• Machenjezo a Ilumya
• Zambiri zamaluso kwa Ilumya
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Katemera
• Kukonzekera
• Yosungirako

Ilumya ndi chiyani?

Ilumya (tildrakizumab-asmn) ndi mankhwala omwe amagwiritsidwa ntchito pochizira psoriasis yolemera kwambiri. Amapatsidwa kwa achikulire omwe ali oyenera kulandira chithandizo chamagetsi (mankhwala operekedwa ndi jakisoni kapena kumwa pakamwa) kapena phototherapy (mankhwala ochepa).

Ilumya ndi mtundu wa mankhwala otchedwa monoclonal antibody. A monoclonal antibody ndi mapuloteni apadera a chitetezo cha mthupi omwe amapangidwa mu labu. Mapuloteniwa amayang'ana mbali zina za chitetezo cha mthupi lanu. Ndiwo mtundu wa mankhwala a biologic (mankhwala opangidwa kuchokera kuzinthu zamoyo m'malo mwa mankhwala).

Ilumya amabwera mu syringe imodzi yokhayokha. Wothandizira zaumoyo kuofesi ya dokotala amakupatsani jakisoni pansi pa khungu lanu (jakisoni wamagetsi).

Pambuyo pa mayeza awiri oyamba, omwe amapatsidwa milungu inayi kupatukana, Ilumya amapatsidwa milungu 12 iliyonse.

M'maphunziro azachipatala, pakati pa 55% ndi 58% ya anthu omwe adalandira Ilumya anali ndi zochepa kapena kuchotsa psoriasis pambuyo pa masabata 12. Oposa awiri mwa atatu mwa anthu omwe anali ndi zotsatirazi adawasunga pamasabata a 64.

Kuvomerezeka ndi FDA

Ilumya adavomerezedwa ndi Food and Drug Administration (FDA) mu Marichi 2018.

Ilumya generic

Ilumya imangopezeka ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Ilumya ili ndi mankhwalawa tildrakizumab, omwe amatchedwanso tildrakizumab-asmn.

Mtengo wa Ilumya

Monga mankhwala onse, mtengo wa Ilumya umasiyana.

Mtengo wanu weniweni umatengera inshuwaransi yanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Ilumya, thandizo lilipo.

Sun Pharma Global FZE, yemwe amapanga Ilumya, apereka pulogalamu yotchedwa Ilumya Support Lighting the Way. Kuti mumve zambiri, imbani 855-4ILUMYA (855-445-8692) kapena pitani patsamba la Ilumya.

Ilumya amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Ilumya kuti athetse mavuto ena. Ilumya itha kugwiritsidwanso ntchito polemba zina pazinthu zina.

Ilumya wa psoriasis yolembera

Ilumya ndivomerezedwa ndi FDA kuti azitha kugwiritsa ntchito psoriasis yolimbitsa thupi mwa akulu omwe ali oyenera kulandira mankhwala kapena phototherapy. Njira yothandizira ndi mankhwala omwe amatengedwa pakamwa kapena kudzera mu jakisoni ndipo amagwira ntchito mthupi lonse. Phototherapy (mankhwala opepuka) ndi chithandizo chomwe chimakhudza kuwonetsa khungu lomwe lakhudzidwa ndi kuwala kwachilengedwe kapena kopanga kwa ultraviolet.

Anthu omwe ali oyenera kulandira chithandizo chamagetsi kapena phototherapy ndi omwe:

• khalani ndi chikwangwani cha psoriasis chochepa kwambiri, kapena
• ayesapo mankhwala apakhungu koma apeza kuti mankhwalawa samalamulira zizindikiro zawo za psoriasis

Malinga ndi National Psoriasis Foundation, plaque psoriasis imawerengedwa kuti ndiyabwino kwambiri ngati zikwangwani zimaphimba kuposa 3 peresenti yamthupi lanu. Poyerekeza, dzanja lanu lonse limapanga pafupifupi 1 peresenti ya thupi lanu.

Ngati muli ndi zikwangwani m'malo ovuta, monga manja anu, mapazi, nkhope, kapena ziwalo zoberekera, psoriasis yanu imawonekeranso kuti ndiyabwino.

Ntchito zomwe sizivomerezedwa

Ilumya itha kugwiritsidwa ntchito ngati chizindikiro pazochitika zina. Kugwiritsa ntchito mankhwala osokoneza bongo ndi pamene mankhwala omwe amavomerezedwa kuti athetse vuto limodzi amalembedwa kuti athetse vuto lina.

Matenda a Psoriatic

Ilumya sivomerezeka kuti athetse vuto la nyamakazi ya psoriatic, koma atha kulembedwa kuti sangachoke pamtunduwu. Matenda a Psoriatic amaphatikizapo zizindikiro za psoriasis pakhungu komanso zilonda, zotupa.

Phunziro limodzi laling'ono lazachipatala, Ilumya sanasinthe kwambiri zipsinjo zamatenda am'mimba kapena zowawa zikagwiritsidwa ntchito masabata a 16, poyerekeza ndi placebo (palibe chithandizo).

Komabe, maphunziro owonjezera akuchitika kuti aone ngati Ilumya ndi othandiza pochizira nyamakazi ya psoriatic. Kafukufuku wina wanthawi yayitali akuchitikabe.

Ankylosing spondylitis

Ilumya sivomerezeka kuchiza ankylosing spondylitis (nyamakazi yomwe imakhudza msana wanu). Komabe, pali kafukufuku wamankhwala wopitilira kuti awone ngati zili zothandiza pamkhalidwe uwu.

Mlingo wa Ilumya

Zotsatira izi zikufotokozera mulingo wabwinobwino wa Ilumya. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Ilumya amabwera mu syringe imodzi yokhayokha. Sirinji iliyonse imakhala ndi 100 mg ya tildrakizumab mu 1 mL yankho.

Ilumya amaperekedwa ngati jakisoni pansi pa khungu lanu (subcutaneous).

Mlingo wa plaque psoriasis

Mlingo woyenera wa Ilumya wa plaque psoriasis ndi jakisoni mmodzi wa 100-mg subcutaneous.

Mudzalandira jakisoni woyamba ndi wachiwiri patadutsa milungu inayi. Pambuyo pa mlingo wachiwiri, mudzalandira mankhwala ena onse milungu 12 iliyonse. Wothandizira zaumoyo kuofesi ya dokotala amakupatsani jakisoni aliyense.

Ndingatani ngati ndaphonya mlingo?

Ngati muiwala kupita ku ofesi ya dokotala kuti mukamwe mankhwala, imbani foni kuti musinthe nthawi yomwe mwasankhidwa posachedwa. Pambuyo pake, pitilizani ndandanda yovomerezeka.

Mwachitsanzo, ngati mwalandira kale magawo awiri oyamba, mutha kukonzekera mlingo wotsatirawo kwa masabata 12 mutadzipangira mankhwala.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Izi zitengera ngati inu ndi adokotala mukuwona kuti Ilumya ndiotetezeka komanso othandiza pochiza psoriasis yanu. Ngati mutero, mutha kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kuti muwongolere zizindikiro zanu za psoriasis.

Zotsatira za Ilumya

Ilumya amatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukamamwa Ilumya. Mndandandawu sungaphatikizepo zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike ndi Ilumya kapena maupangiri amomwe mungachitire ndi zovuta zina, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Ilumya zitha kuphatikiza:

• matenda opatsirana apamwamba
• jakisoni malo zochita
• kutsegula m'mimba

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Ilumya sizodziwika, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa zimaphatikizaponso zovuta za Ilumya. Zizindikiro zake ndi izi:

• zotupa pakhungu
• kuyabwa
• kutupa kwa pakhosi, pakamwa, kapena lilime, zomwe zingayambitse kupuma
• angioedema (kutupa pansi pa khungu lanu, makamaka m'maziso anu, milomo, manja, kapena mapazi)

Zochita jekeseni patsamba

M'maphunziro azachipatala, mayankho a malo obayira jekeseni anachitika mwa 3 peresenti ya anthu omwe adalandira Ilumya. Zizindikiro patsamba la jakisoni zitha kuphatikiza:

• kufiira
• khungu loyabwa
• kupweteka pamalo opangira jekeseni
• kuvulaza
• kutupa
• kutupa
• magazi

Zochita patsamba la jakisoni nthawi zambiri sizikhala zazikulu ndipo ziyenera kutha patangopita masiku ochepa. Ngati ali ovuta kapena osapita, lankhulani ndi dokotala wanu.

Kutsekula m'mimba

Kutsekula m'mimba kunachitika mwa 2 peresenti ya anthu omwe adalandira Ilumya m'maphunziro azachipatala. Izi zimatha kuchoka ndikupitiliza kugwiritsa ntchito mankhwalawa. Ngati kutsekula m'mimba kuli koopsa kapena kumatenga nthawi yayitali kuposa masiku angapo, lankhulani ndi dokotala wanu.

Kuchulukitsa chiwopsezo cha matenda

M'maphunziro azachipatala, 23 peresenti ya anthu omwe adalandira Ilumya adadwala. Ndikofunika kudziwa, komabe, kuti matenda omwewo adachitikanso mwa anthu omwe adalandira malowa (palibe chithandizo).

Matenda omwe amapezeka kwambiri mwa anthu omwe amatenga Ilumya anali matenda opuma apamwamba, monga chimfine. Anthu 14 pa anthu 100 alionse omwe anali kuphunzira anali ndi matenda opuma. Komabe, pafupifupi matenda onsewa anali ochepa kapena osakhala ovuta. Osachepera 0,3 peresenti ya matendawa amawoneka kuti ndi ovuta.

Ilumya amachulukitsa chiopsezo chotenga kachirombo chifukwa amachepetsa magwiridwe antchito amthupi lanu. Chitetezo chanu cha mthupi ndi chitetezo cha thupi lanu kumatenda.

Musanayambe kumwa mankhwala ndi Ilumya, dokotala wanu adzakuyang'anirani ngati muli ndi matenda, kuphatikizapo chifuwa chachikulu (TB). Ngati muli ndi mbiri ya chifuwa cha TB kapena muli ndi TB yogwira, muyenera kulandira chithandizo cha vutoli musanayambe kumwa Ilumya.

Munthawi yonse yamankhwala anu a Ilumya, ndikofunikira kulumikizana ndi adotolo nthawi yomweyo ngati muli ndi zizindikiro za TB. Izi zimaphatikizapo kutentha thupi, kupweteka kwa minofu, kuonda, kutsokomola, kapena magazi m'matumbo anu.

Chitetezo cha mthupi kwa Ilumya

M'maphunziro azachipatala, anthu ochepera 7 peresenti ya omwe amatenga Ilumya adachitapo kanthu momwe chitetezo chamthupi chawo chimapanga ma antibodies a Ilumya.

Ma antibodies ndi mapuloteni omwe amalimbana ndi zinthu zakunja mthupi lanu ngati zowononga. Thupi limatha kupanga ma antibodies pachinthu chilichonse chakunja, kuphatikiza ma monoclonal antibody monga Ilumya.

Ngati thupi lanu limapanga ma antibodies a Ilumya, ndizotheka kuti mankhwalawo sangathenso kuthandizira psoriasis yanu. Ndikofunika kuzindikira, komabe, kuti Ilumya adachepetsedwa mwa 3% yokha mwa anthu omwe adalandira.

Njira Zina ku Ilumya

Mankhwala ena alipo omwe angachiritse plaque psoriasis pang'ono. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Ilumya, lankhulani ndi dokotala wanu kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochizira psoriasis yolemera kwambiri ndi monga:

• methotrexate (Otrexup, Rasuvo, Trexall)
• adalimumab (Humira)
• etanercept (Enbrel)
• secukinumab (Cosentyx)
• ustekinumab (Stelara)
• guselkumab (Tremfya)

Ilumya vs. Tremfya

Mutha kudabwa momwe Ilumya amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. Apa tikuwona momwe Ilumya ndi Tremfya alili ofanana komanso osiyana.

Pafupi

Ilumya ili ndi tildrakizumab, womwe ndi mtundu wa mankhwala otchedwa antioclonal antibody. Tildrakizumab imaletsa (kutseka) ntchito ya protein yotchedwa interleukin-23 (IL-23) molekyulu. Mu plaque psoriasis, molekyulu iyi imakhudzidwa ndi khungu lomwe limapangidwira lomwe limatsogolera kuzipilala.

Tremfya ndi anti-monoclonal antibody yomwe imalepheretsa zochitika za IL-23. Lili ndi mankhwala guselkumab.

Ilumya ndi Tremfya onse ndi mankhwala a biologic omwe amachepetsa kutupa ndikuthandizira kupewa zolembera mwa anthu omwe ali ndi psoriasis. Biologics ndi mankhwala omwe amapangidwa kuchokera kuzinthu zamoyo osati mankhwala.

Ntchito

Ilumya ndi Tremfya onse ndi ovomerezeka ndi FDA kuti azitha kupopera psoriasis yolimbitsa thupi mwa akulu omwe ali oyenera kulandira mankhwala kapena phototherapy.

Mankhwala amtundu uliwonse amakhala ndi mankhwala otengedwa pakamwa kapena kudzera mu jakisoni wogwira ntchito mthupi lonse. Phototherapy imaphatikizapo kuwonetsa khungu lomwe lakhudzidwa ndi kuwala kwachilengedwe kapena kopanga kwa ultraviolet.

Mitundu yamankhwala iyi imagwiritsidwa ntchito poika psoriasis yolemera kwambiri kapena kwa anthu omwe samayankha mankhwala omwe ali apakhungu (ogwiritsidwa ntchito pakhungu).

Mafomu azamankhwala ndi makonzedwe

Ilumya amabwera mu jakisoni woyamwa umodzi wokhala ndi 100 mg ya tildrakizumab. Ilumya amaperekedwa ngati jakisoni pansi pa khungu (subcutaneous) kuofesi ya adotolo. Majekeseni awiri oyamba amaperekedwa patadutsa milungu inayi. Pambuyo pa jakisoniyo, amalandira mankhwalawo milungu 12 iliyonse.

Monga Ilumya, Tremfya amabwera mu syringe imodzi yokhayo, koma imakhala ndi 100 mg ya guselkumab. Amaperekedwanso ngati jekeseni ya subcutaneous. Ndipo monga Ilumya, jakisoni awiri oyamba amaperekedwa patatha milungu inayi. Komabe, mankhwala onse pambuyo pake amaperekedwa milungu isanu ndi itatu iliyonse.

Tremfya itha kuperekedwa kuofesi ya dokotala wanu, kapena kudzipangira jakisoni kunyumba mukalandira maphunziro oyenera kuchokera kwa omwe amakuthandizani.

Zotsatira zoyipa ndi zoopsa

Ilumya ndi Tremfya ali ndi zovuta zina zofanana ndipo zina zosiyana. Zitsanzo zalembedwa pansipa.

Kuchita bwino

Ilumya ndi Tremfya sanayerekezeredwe m'maphunziro azachipatala, koma onsewa ndi othandiza pochizira psoriasis yolimbitsa thupi.

Kuyerekeza kosazungulira kwa mankhwala a plaque psoriasis kunapeza kuti Tremfya itha kukhala yothandiza kwambiri pakusintha zizindikilo kuposa Ilumya. Phunziroli, anthu omwe adatenga Tremfya anali ndi mwayi 12.4 wowonjezera kuti akhale ndi kusintha kwa 75%, poyerekeza ndi anthu omwe adatenga placebo (palibe chithandizo).

Pakafukufuku womwewo, anthu omwe adatenga Ilumya anali ndi mwayi wokwanira maulendo 11 kukhala ndi zotsatira zofananira ndi placebo.

Mtengo

Ilumya ndi Tremfya onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Ilumya ndi Tremfya nthawi zambiri amawononga ndalama zofanana. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Ilumya vs. mankhwala ena

Kuphatikiza pa Tremfya, palinso mankhwala ena angapo omwe amagwiritsidwa ntchito pochizira plaque psoriasis. M'munsimu pali kufananizira pakati pa Ilumya ndi ena mwa mankhwalawa.

Ilumya vs. Cosentyx

Ilumya ili ndi tildrakizumab, womwe ndi mtundu wa mankhwala otchedwa antioclonal antibody. Tildrakizumab imaletsa (kutseka) ntchito ya protein yotchedwa interleukin-23 (IL-23) molekyulu. Mu plaque psoriasis, molekyulu iyi imakhudzidwa ndi khungu lomwe limapangidwira lomwe limatsogolera kuzipilala.

Cosentyx imakhalanso ndi antioclonal antibody. Lili ndi mankhwala osokoneza bongo secukinumab ndikuletsa interleukin-17A (IL-17A). Monga IL-23, IL-17A imakhudzidwa ndikupanga khungu lamatenda omwe amatsogolera kuzipilala.

Ngakhale Ilumya ndi Cosentyx onse ndi mankhwala a biologic, amagwira ntchito mosiyanasiyana.

Biologics ndi mankhwala omwe amapangidwa kuchokera kuzinthu zamoyo osati mankhwala.

Ntchito

Ilumya ndi Cosentyx onse ndi ovomerezeka ndi FDA kuti azitha kulandira psoriasis yolimbitsa thupi mwa akulu omwe akufuna kulandira chithandizo cha mankhwala kapena phototherapy. Njira yothandizira ndi mankhwala omwe amatengedwa pakamwa kapena kudzera mu jakisoni ndipo amagwira ntchito mthupi lonse. Phototherapy imaphatikizapo kuwonetsa khungu lomwe lakhudzidwa ndi kuwala kwa ultraviolet.

Cosentyx imavomerezedwanso ndi FDA kuti ichiritse psoriatic arthritis (psoriasis yokhala ndi nyamakazi yolumikizana) ndi ankylosing spondylitis (nyamakazi mumsana).

Mafomu azamankhwala ndi makonzedwe

Ilumya ndi Cosentyx onse amaperekedwa ngati jakisoni pansi pa khungu (subcutaneous).

Ilumya amaperekedwa ku ofesi ya dokotala ndi wothandizira zaumoyo. Majekeseni awiri oyamba amaperekedwa patadutsa milungu inayi. Pambuyo pa jakisoni awiriwa, mankhwalawa amaperekedwa milungu 12 iliyonse. Mlingo uliwonse ndi 100 mg.

Mlingo woyamba wa Cosentyx nthawi zambiri umaperekedwa kuofesi ya dokotala. Pambuyo pake, mankhwalawa amatha kubayidwa jekeseni kunyumba ataphunzitsidwa bwino ndi wothandizira zaumoyo.

Kwa Cosentyx, jakisoni awiri a 150 mg (okwanira 300 mg pa mlingo) amaperekedwa sabata iliyonse kwa milungu isanu. Pambuyo pake, jakisoni mmodzi amaperekedwa mwezi uliwonse. Iliyonse ya mankhwalawa ndi 300 mg, ngakhale anthu ena amangofunikira 150 mg pa mlingo.

Zotsatira zoyipa ndi zoopsa

Ilumya ndi Cosentyx ali ndi zovuta zina zofanana ndipo zina ndizosiyana. Zitsanzo za zovuta zamankhwala onsewa zalembedwa pansipa.

Kuchita bwino

Ilumya ndi Cosentyx sanafananidwe m'maphunziro azachipatala, koma onsewa ndi othandiza pochizira psoriasis yolimbitsa thupi.

Kuyerekeza kosazungulira kwa mankhwala a plaque psoriasis kunapeza kuti Cosentyx itha kukhala yothandiza kwambiri kuposa Ilumya pakukonza zisonyezo. Pakafukufukuyu, anthu omwe adatenga 300 mg ya Cosentyx anali ndi mwayi 17.5 wowonjezera kuti akhale ndi kusintha kwa 75% poyerekeza ndi anthu omwe adatenga placebo (palibe chithandizo).

Pakafukufuku womwewo, anthu omwe adatenga Ilumya anali ndi mwayi wokwanira maulendo 11 kukhala ndi zotsatira zofananira, poyerekeza ndi placebo.

Mtengo

Ilumya ndi Cosentyx onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Ilumya ndi Cosentyx nthawi zambiri amawononga ndalama zofanana. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Ilumya vs. Humira

Ilumya ili ndi tildrakizumab, womwe ndi mtundu wa mankhwala otchedwa antioclonal antibody. Tildrakizumab imaletsa (kutseka) ntchito ya protein yotchedwa interleukin-23 (IL-23) molekyulu. Mu plaque psoriasis, molekyulu iyi imakhudzidwa ndi khungu lomwe limapangidwira lomwe limatsogolera kuzipilala.

Humira ali ndi mankhwala adalimumab. Komanso ndi antioclonal antibody ndipo imatchinga ntchito ya protein yotchedwa tumor necrosis factor-alpha (TNF-alpha). TNF-alpha ndi mthenga wamankhwala omwe amachititsa kuti khungu la khungu lizikula mwachangu mu plaque psoriasis.

Ngakhale Ilumya ndi Humira onse ndi mankhwala a biologic omwe amalepheretsa chitetezo cha mthupi, imagwira ntchito m'njira zosiyanasiyana. Biologics ndi mankhwala omwe amapangidwa kuchokera kuzinthu zamoyo osati mankhwala.

Ntchito

Ilumya ndi Humira onse ndi ovomerezeka ndi FDA kuti azitha kupopera psoriasis yolimbitsa thupi mwa akulu omwe akufuna kulandira mankhwala kapena phototherapy. Njira yothandizira ndi mankhwala omwe amatengedwa pakamwa kapena kudzera mu jakisoni ndipo amagwira ntchito m'thupi lonse. Phototherapy imaphatikizapo kuchiza khungu lomwe lakhudzidwa ndikuwonetsa kuwala kwa ultraviolet.

Humira ali ndi ntchito zingapo zovomerezeka ndi FDA, zina mwazinthu monga:

• nyamakazi
• nyamakazi ya psoriatic
• Matenda a Crohn
• ankylosing spondylitis
• anam`peza matenda am`matumbo

Mafomu azamankhwala ndi makonzedwe

Ilumya ndi Humira onse amapatsidwa ngati jakisoni pansi pa khungu (subcutaneous).

Ilumya amaperekedwa ku ofesi ya dokotala ndi wothandizira zaumoyo. Majakisoni awiri oyamba amaperekedwa patadutsa milungu inayi. Pambuyo pa jakisoni awiriwa, mankhwalawa amaperekedwa milungu 12 iliyonse. Mlingo uliwonse ndi 100 mg.

Humira amaperekedwanso ku ofesi ya dokotala, kapena ngati kudzipiritsa yekha kunyumba ataphunzira bwino kuchokera kwa wothandizira zaumoyo. Mlingo woyamba ndi 80 mg, wotsatira 40 mg mg sabata limodzi pambuyo pake. Pambuyo pake, mlingo wa 40-mg umaperekedwa milungu iwiri iliyonse.

Zotsatira zoyipa ndi zoopsa

Ilumya ndi Humira amagwira ntchito m'njira zosiyanasiyana koma amakhala ndi zovuta zina. Zitsanzo za zovuta zoyipa komanso zoyipa za mankhwala aliwonse alembedwa pansipa.

Humira adalemba machenjezo kuchokera ku FDA. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Machenjezo akuti Humira amachulukitsa chiopsezo chotenga matenda akulu ndi khansa zina.

Kuchita bwino

Ilumya ndi Humira sanafananidwe m'maphunziro azachipatala, koma onsewa ndi othandiza pochizira psoriasis yolimbitsa thupi.

Fanizo limodzi losawonekera lidapeza kuti Ilumya adagwiranso ntchito ngati Humira ngati mankhwala a plaque psoriasis. Phunziroli, anthu omwe amamwa mankhwala aliwonse amakhala ndi mwayi wokulirapo pakusintha chizindikiritso chawo kuposa anthu omwe adatenga placebo (palibe chithandizo).

Komabe, potengera kusanthula kwa mankhwala ena, kafukufukuyu adati mankhwala omwe amalimbana ndi IL-23, monga Ilumya, akuwoneka kuti ndi othandiza kwambiri pochotsa plaque psoriasis kuposa TNF-blockers, monga Humira. Maphunziro ena amafunikira.

Mtengo

Ilumya ndi Humira onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Komabe, pali mitundu ingapo ya adalimumab (mankhwala ku Humira) omwe amavomerezedwa kuchiza psoriasis. Ena mwa iwo ndi Hyrimoz, Cyltezo, ndi Amjevita. Mankhwala a biosimilar ndi ofanana ndi mankhwala a biologic omwe adakhazikitsidwa, koma sizofanana kwenikweni. Mankhwala osokoneza bongo amatha pafupifupi 30% kuposa mankhwala oyambawo.

Ilumya ndi Humira nthawi zambiri amawononga ndalama zofanana. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Ilumya vs. Enbrel

Ilumya ili ndi tildrakizumab, womwe ndi mtundu wa mankhwala otchedwa antioclonal antibody. Tildrakizumab imaletsa (kutseka) ntchito ya protein yotchedwa interleukin-23 (IL-23) molekyulu. Mu plaque psoriasis, molekyulu iyi imakhudzidwa ndi khungu lomwe limapangidwira lomwe limatsogolera kuzipilala.

Enbrel ndi anti-monoclonal antibody. Lili ndi mankhwala etanercept, omwe amalepheretsa ntchito ya protein yotchedwa tumor necrosis factor-alpha (TNF-alpha). TNF-alpha ndi mthenga wamankhwala omwe amachititsa kuti khungu la khungu lizikula mwachangu mu plaque psoriasis.

Ilumya ndi Enbrel onse ndi mankhwala a biologic omwe amachepetsa kupangika kwa zolembera, koma amatero m'njira zosiyanasiyana. Biologics ndi mankhwala omwe amapangidwa kuchokera kuzinthu zamoyo osati mankhwala.

Ntchito

Ilumya ndi Enbrel onse ndi ovomerezeka ndi FDA kuti azitha kulandira psoriasis yolimbitsa thupi kwa akulu omwe akufuna kulandira mankhwala kapena phototherapy. Njira yothandizira ndi mankhwala omwe amatengedwa pakamwa kapena kudzera mu jakisoni ndipo amagwira ntchito m'thupi lonse. Phototherapy imaphatikizapo kuchiza khungu lomwe lakhudzidwa ndikuwonetsa kuwala kwa ultraviolet.

Enbrel amavomerezedwanso kuti azitsatira zolembera za psoriasis zolimbitsa thupi kwa ana azaka 4 kapena kupitilira apo, komanso:

• nyamakazi
• polyarticular ana idiopathic nyamakazi
• nyamakazi ya psoriatic
• ankylosing spondylitis

Mafomu azamankhwala ndi makonzedwe

Ilumya ndi Enbrel onse amaperekedwa ngati jakisoni pansi pa khungu (subcutaneous).

Ilumya amabwera mu syringe imodzi yokhayokha. Amaperekedwa kuofesi ya adotolo ndi omwe amakuthandizani pa zaumoyo. Majekeseni awiri oyamba amaperekedwa patadutsa milungu inayi. Pambuyo pa jakisoni awiriwa, mankhwalawa amaperekedwa milungu 12 iliyonse. Jakisoni aliyense ndi 100 mg.

Enbrel amaperekedwanso ku ofesi ya dokotala kapena ngati kudzipiritsa jekeseni kunyumba pambuyo pophunzitsidwa bwino kuchokera kwa wothandizira zaumoyo. Kwa miyezi itatu yoyambirira, Enbrel amapatsidwa kawiri sabata iliyonse. Pambuyo pake, mlingo woyang'anira umaperekedwa kamodzi sabata iliyonse. Mlingo uliwonse ndi 50 mg.

Enbrel imapezeka m'njira zingapo, kuphatikiza jakisoni woyambira limodzi ndi autoinjector.

Zotsatira zoyipa ndi zoopsa

Ilumya ndi Enbrel amagwira ntchito m'njira zosiyanasiyana koma amakhala ndi zovuta zina zofanana. Zitsanzo za zovuta zoyipa komanso zoyipa za mankhwala aliwonse alembedwa pansipa.

Enbrel adalemba machenjezo kuchokera ku FDA. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Machenjezo akuti Enbrel amachulukitsa chiopsezo chotenga matenda akulu ndi khansa zina.

Kuchita bwino

Ilumya ndi Enbrel onse ndi othandiza kuthana ndi plaque psoriasis, koma Ilumya atha kukhala othandiza kwambiri pochepetsa zipsera.

Pakafukufuku wina wamankhwala, 61 peresenti ya anthu omwe adalandira Ilumya adakhala ndi kusintha kwakusachepera 75 peresenti. Mbali inayi, 48 peresenti ya anthu omwe adalandira Enbrel adachitanso chimodzimodzi.

Mtengo

Ilumya ndi Enbrel onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Enbrel ndiokwera mtengo pang'ono kuposa Ilumya. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Ilumya vs. methotrexate

Ilumya ili ndi tildrakizumab, womwe ndi mtundu wa mankhwala otchedwa antioclonal antibody. Tildrakizumab imaletsa (kutseka) ntchito ya protein yotchedwa interleukin-23 (IL-23) molekyulu. Molekyu imeneyi imakhudzidwa ndi khungu lomwe limapangidwira lomwe limatsogolera ku zolembera.

Methotrexate (Otrexup, Trexall, Rasuvo) ndi mtundu wa mankhwala otchedwa antimetabolite, kapena folic acid antagonist (blocker). Methotrexate imagwira ntchito poletsa ntchito ya enzyme yomwe imakhudza kukula kwa khungu pakapangidwe kake.

Ilumya ndi mankhwala a biologic, pomwe methotrexate ndi njira yodziwika bwino yothandizira.Mankhwala othandiza amatanthauza mankhwala omwe amatengedwa pakamwa kapena kudzera mu jakisoni ndipo amagwira ntchito mthupi lonse. Biologics ndi mankhwala omwe amapangidwa kuchokera kuzinthu zamoyo osati mankhwala.

Mankhwala onsewa amathandizira kukonza zizindikiro za psoriasis pochepetsa mapangidwe.

Ntchito

Ilumya ndi methotrexate onse ndi ovomerezeka ndi FDA kuti athetse chikwangwani chachikulu cha psoriasis. Ilumya imavomerezedwanso kuti imathandizira psoriasis yolimbitsa thupi. Methotrexate amayenera kugwiritsidwa ntchito pokhapokha ngati matenda a psoriasis a munthu ali owopsa kapena olumala ndipo samayankha mankhwala ena.

Methotrexate imavomerezedwanso kuti ithetse mitundu ina ya khansa ndi nyamakazi ya nyamakazi.

Mafomu azamankhwala ndi makonzedwe

Ilumya amaperekedwa ngati jakisoni pansi pa khungu (subcutaneous) kuofesi ya dokotala ndi wothandizira zaumoyo. Majekeseni awiri oyamba amaperekedwa patadutsa milungu inayi. Pambuyo pa jakisoniyo, amalandira mankhwalawo milungu 12 iliyonse. Jakisoni aliyense ndi 100 mg.

Methotrexate imabwera ngati piritsi yamlomo, yankho lamadzi, kapena jakisoni. Pofuna kuchiza plaque psoriasis, nthawi zambiri amatengedwa pakamwa. Itha kumwa ngati kamodzi kamodzi pa sabata, kapena ngati mitundu itatu ya mankhwala opatsidwa maola 12 kamodzi pa sabata.

Zotsatira zoyipa ndi zoopsa

Ilumya ndi methotrexate zimayambitsa zovuta zina zoyipa komanso zoyipa. Zotsatira zofala kwambiri komanso zoyipa zomwe zimawoneka mwa anthu omwe ali ndi psoriasis zalembedwa pansipa. Mndandandawu mulibe zovuta zonse zomwe zingachitike chifukwa cha mankhwalawa.

Methotrexate ili ndi machenjezo angapo ochokera ku FDA ofotokoza kuopsa kwa zovuta zoyipa zomwe zatchulidwa pamwambapa. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Ilumya ndi methotrexate sizinafananidwe mwachindunji m'maphunziro azachipatala, koma zonsezi ndizothandiza kuthana ndi plaque psoriasis.

Fanizo limodzi losawonekera lidapeza kuti Ilumya adagwiranso ntchito komanso methotrexate pakuthandizira zidziwitso za psoriasis. Komabe, methotrexate imatha kuyambitsa zovuta zoyipa poyerekeza ndi Ilumya.

Mtengo

Ilumya imangopezeka ngati mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya Ilumya. Methotrexate imapezeka ngati mankhwala wamba komanso mankhwala osokoneza bongo a Trexall, Otrexup, ndi Rasuvo. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Ilumya amawononga zambiri kuposa mitundu ya genotrox ndi maina a methotrexate. Mtengo weniweni womwe mumalipira pamtundu uliwonse wa mankhwala umadalira dongosolo lanu la inshuwaransi.

Ilumya amagwiritsira ntchito mankhwala ena

Ilumya ndi yothandiza pakhungu la psoriasis palokha, koma itha kugwiritsidwanso ntchito ndi mankhwala ena kuti mupindule nawo. Kugwiritsa ntchito njira zingapo pochizira psoriasis kumatha kuthandiza kuchotsa zikwangwani mwachangu ndikuchotsa zikwatu zambiri.

Mankhwala ophatikizana amathanso kuchepetsa kuchuluka kwa mankhwala a psoriasis, omwe amachepetsa chiopsezo chanu chazovuta. Kuphatikiza apo, kuphatikiza mankhwala kungachepetse chiopsezo chanu cholimbana ndi Ilumya (pomwe mankhwalawa sakugwiraninso ntchito).

Zitsanzo zamankhwala ena omwe angagwiritsidwe ntchito bwino ndi Ilumya ndi awa:

• topical corticosteroids, monga betamethasone
• mafuta ndi vitamini D (monga Dovonex ndi Vectical)
• methotrexate (Trexall, Otrexup, ndi Rasuvo)
• phototherapy (mankhwala opepuka)

Ilumya ndi mowa

Palibe mgwirizano wodziwika pakati pa mowa ndi Ilumya panthawiyi. Komabe, kutsegula m'mimba ndi zotsatira zoyipa za Ilumya kwa anthu ena. Kumwa mowa kumathandizanso kutsegula m'mimba. Chifukwa chake, kumwa mowa mukalandira chithandizo cha Ilumya kumatha kukulitsa chiopsezo chotere.

Mowa amathanso kupangitsa kuti mankhwala anu a Ilumya asamagwire bwino ntchito. Izi ndichifukwa chakumwa mowa kwa psoriasis komwe, komanso zomwe zingachitike pamomwe mungatsatire ndondomeko yanu yothandizira. Kumwa mowa kumatha:

• onjezerani kutupa komwe kumatha kubweretsa khungu pakhungu
• muchepetse mphamvu yachitetezo cha mthupi lanu yolimbana ndi matenda ndi mavuto akhungu
• kukupangitsani kuiwala kumwa mankhwala anu kapena kusiya kutsatira dongosolo lanu la mankhwala

Ngati mumamwa Ilumya ndipo mukuvutika kupeŵa zakumwa zoledzeretsa, kambiranani ndi adotolo za njira zopewera matenda ndikuthandizira mwayi wopatsidwa chithandizo ndi Ilumya.

Kuyanjana kwa Ilumya

Ilumya samalumikizana pang'ono ndi mankhwala. Izi ndichifukwa choti Ilumya ndi ma antibodies amtundu umodzi amathandizidwa, kapena kuthyoledwa, ndi thupi mwanjira ina kuposa mankhwala ambiri. (Ma antibodies a Monoclonal ndi mankhwala opangidwa ndi labu kuchokera kuma cell immune.)

Mankhwala ambiri, zitsamba, ndi zowonjezera zimapukusidwa ndi michere m'chiwindi chanu. Ilumya, mbali inayi, imapukusidwa mwanjira yofananira ndi maselo amthupi oteteza thupi komanso mapuloteni mthupi. Mwachidule, chathyoledwa mkati mwa maselo mthupi lanu lonse. Chifukwa Ilumya sathyoledwa m'chiwindi ndi mankhwala ena, nthawi zambiri sagwirizana nawo.

Ilumya ndi katemera wamoyo

Kulumikizana kofunikira kwa Ilumya ndi katemera wamoyo. Katemera wamoyo ayenera kupewedwa mukamalandira Ilumya.

Katemera wamoyo ali ndi mavairasi ang'onoang'ono ofooka. Chifukwa Ilumya amaletsa mayankho abwinobwino omenyera chitetezo cha mthupi, thupi lanu silingathe kulimbana ndi kachilomboka mu katemera wamoyo mukamamwa mankhwalawa.

Zitsanzo za katemera wamoyo zomwe muyenera kupewa mukalandira mankhwala a Ilumya ndi katemera wa:

• chikuku, chikuku, ndi rubella (MMR)
• nthomba
• yellow fever
• nthomba
• rotavirus

Musanayambe kumwa mankhwala ndi Ilumya, lankhulani ndi dokotala wanu ngati mungafunike katemera wina uliwonse. Inu ndi dokotala mungasankhe kuchedwetsa chithandizo ndi Ilumya mpaka mutalandira katemera wa mankhwala aliwonse omwe mungafune.

Momwe mungatenge Ilumya

Ilumya amaperekedwa ngati jakisoni pansi pa khungu (subcutaneous) ndi othandizira azaumoyo kuofesi ya dokotala. Imabayidwa m'mimba mwanu, ntchafu, kapena manja apamwamba. Majekeseni m'mimba mwanu ayenera kukhala osachepera mainchesi awiri kuchokera kumimba kwanu.

Ilumya sayenera kubayidwa m'malo opunduka, zotambasula, kapena mitsempha yamagazi. Sitiyeneranso kuperekedwera m'matumba, mikwingwirima, kapena m'malo ofiira kapena ofewa.

Musanayambe mankhwala a Ilumya

Chifukwa Ilumya amachepetsa chitetezo chamthupi anu, adotolo amakuyang'anitsani TB (TB) musanayambe kumwa mankhwala. Ngati muli ndi TB yogwira ntchito, mudzalandira chithandizo cha TB musanayambe Ilumya. Ndipo ngati mudakhala ndi TB m'mbuyomu, mungafunike kuthandizidwa musanayambe Ilumya.

Koma ngakhale mutakhala kuti mulibe zizindikiro za chifuwa chachikulu cha TB, mutha kukhala ndi TB yosagwira ntchito, yotchedwa TB Yobisika. Ngati muli ndi TB yobisika ndipo mutenga Ilumya, TB yanu imayamba kugwira ntchito. Ngati kuyezetsa kukuwonetsa kuti muli ndi TB yobisika, mungafunikire kulandira chithandizo cha TB musanamwe kapena mukamamwa mankhwala ndi Ilumya.

Kusunga nthawi

Jakisoni woyamba ndi wachiwiri wa Ilumya amapatsidwa milungu inayi kupatukana. Mukatha kumwa miyezo iwiri yoyambirira, mudzabwerera ku ofesi ya dokotala milungu ingapo ya 12 kuti mudzamwe mankhwala ena. Ngati mwaphonya nthawi kapena nthawi, pezani msonkhano wina posachedwa.

Momwe Ilumya amagwirira ntchito

Plaque psoriasis ndimatenda amthupi, omwe ndi omwe amachititsa kuti chitetezo chamthupi chiteteze kwambiri. Plaque psoriasis imayambitsa maselo oyera amwazi, omwe amathandiza thupi kulimbana ndi matenda, molakwika kumenyana ndi khungu lamunthu yemwe. Izi zimapangitsa kuti khungu limagawike mwachangu ndikukula.

Maselo apakhungu amapangidwa mwachangu kwambiri kotero kuti maselo achikulire alibe nthawi yoti agwe ndikupanga malo am'maselo atsopano. Kuchulukanso kwa maselo amtundu wa khungu kumayambitsa zotupa, zotupa, zopweteka pakhungu lotchedwa mabwe.

Ilumya ndi antioclonal antibody, womwe ndi mtundu wa mankhwala omwe amapangidwa kuchokera kuma cell a chitetezo mu labu. Ma antibodies a monoclonal amayang'ana mbali zina za chitetezo cha mthupi.

Ilumya amatseka chitetezo cha chitetezo cha mthupi chotchedwa interleukin-23 (IL-23). Ndi plaque psoriasis, IL-23 imayambitsa mankhwala omwe amachititsa kuti chitetezo cha mthupi chiwononge maselo a khungu. Poletsa IL-23, Ilumya amathandiza kuchepetsa kuchuluka kwa khungu ndi zikwangwani.

Chifukwa Ilumya amatseka zochitika za IL-23, amatchedwa interleukin inhibitor.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Ilumya ayamba kugwira ntchito mukangoyamba kuigwira. Komabe, zimatenga nthawi kuti mumange m'dongosolo lanu ndikugwira ntchito mokwanira, mwina pamatha milungu ingapo musanawone zotsatira.

M'maphunziro azachipatala, patatha sabata limodzi akuthandizidwa, ochepera 20 peresenti ya anthu omwe amatenga Ilumya adawona kusintha kwa zikwangwani. Komabe, patadutsa milungu 12, anthu opitilira theka omwe adalandira Ilumya adawona kusintha kwakukulu pamatenda awo a psoriasis. Chiwerengero cha anthu omwe ali ndi zizindikilo zowonjezereka chidakulirakulirabe kupitilira masabata 28 achipatala.

Ilumya ndi mimba

Sizikudziwika ngati Ilumya ndiotetezeka kugwiritsa ntchito nthawi yapakati. Kafukufuku wazinyama awonetsa chiopsezo kwa mwana wosabadwa Ilumya akapatsidwa kwa mayi wapakati. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike ndi anthu.

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, lankhulani ndi dokotala wanu za maubwino ndi zoopsa za mankhwala a Ilumya panthawi yapakati.

Ilumya ndi kuyamwitsa

Sidziwika ngati Ilumya amadutsa mkaka wa m'mawere. M'maphunziro azinyama, Ilumya adadutsa mkaka wa m'mawere, ndikuwonetsa kuti akuyamwitsa anawo mankhwalawo. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Ngati mukuganiza za mankhwala a Ilumya mukamayamwitsa, lankhulani ndi dokotala wanu za maubwino ndi zoopsa zake.

Mafunso wamba za Ilumya

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Ilumya.

Kodi Ilumya amachiza psoriasis?

Ayi, Ilumya samachiritsa psoriasis yolembera. Pakadali pano palibe mankhwala ochiritsira matendawa. Komabe, chithandizo ndi Ilumya chitha kuthandiza kukonza zizindikiro zanu za psoriasis.

Nthawi zonse ndimagwiritsa ntchito mafuta a psoriasis yanga. Chifukwa chiyani ndiyenera kuyamba kulandira jakisoni?

Dokotala wanu atha kukhala kuti wasankha kuti chithandizo chamagetsi chitha kuchita zambiri kuti muchepetse zizindikilo zanu kuposa mafuta anu. Mankhwala amachitidwe amaperekedwa ndi jakisoni kapena kumwa pakamwa ndikugwira ntchito mthupi lonse.

Mankhwala ochiritsira monga Ilumya amakhala othandiza kwambiri pakuthandizira zizindikiro za psoriasis kuposa mankhwala apakhungu (mankhwala omwe amagwiritsidwa ntchito pakhungu). Izi ndichifukwa choti amagwira ntchito kuchokera mkati mpaka kunja. Amalimbitsa chitetezo cha mthupi chokha, chomwe chimayambitsa ma psoriasis anu. Izi zitha kuthandiza kumveketsa komanso kupewa ma psoriasis plaques.

Mankhwala opatsirana, kumbali inayo, nthawi zambiri amachiritsa zikwangwani zitapangidwa.

Njira zochiritsira nthawi zina zimagwiritsidwa ntchito limodzi, kapena mmalo mwake, mankhwala am'mutu. Zitha kugwiritsidwa ntchito ngati:

• mankhwala apakhungu samakulitsa zipsinjo za psoriasis zokwanira, kapena
• Zikwangwani zimaphimba khungu lanu (makamaka 3 peresenti kapena kupitilira apo), zomwe zimapangitsa kuti mankhwala azitsamba asapindule. Izi zimawerengedwa kuti psoriasis yovuta.

Kodi ndiyenera kutenga Ilumya nthawi yayitali bwanji?

Mutha kutenga Ilumya nthawi yayitali ngati inu ndi adokotala mukuwona kuti Ilumya ndiwotetezeka komanso wothandiza kwa inu.

Kodi mankhwala osokoneza bongo ndi ati?

Mankhwala osokoneza bongo ndi mankhwala omwe amapangidwa kuchokera ku mapuloteni a anthu kapena nyama. Mankhwala a biologic omwe amagwiritsidwa ntchito pochiza matenda omwe amadzichotsera okha, monga plaque psoriasis, amagwira ntchito polumikizana ndi chitetezo chamthupi. Amachita izi m'njira zowunikira kuti achepetse kutupa ndi zizindikiritso zina za chitetezo chamthupi chambiri.

Chifukwa amalumikizana ndi maselo am'magazi komanso mapuloteni, ma biologics amalingaliridwa kuti ali ndi zovuta zochepa poyerekeza ndi mankhwala omwe amakhudza machitidwe amthupi ambiri, monga mankhwala ambiri.

Pogwiritsidwa ntchito pochizira psoriasis, mankhwala a biologic amagwiritsidwa ntchito kwambiri kwa anthu omwe ali ndi plaque psoriasis ochepa omwe samayankha mankhwala ena (monga topical therapy).

Kodi Ilumya amagwiritsidwa ntchito pochiza nyamakazi ya psoriatic?

Ilumya sivomerezedwa ndi FDA kuti athetse psoriatic nyamakazi, koma itha kugwiritsidwa ntchito ngati chizindikiro paichi.

Phunziro limodzi laling'ono lazachipatala, Ilumya sanasinthe kwambiri zisonyezo za nyamakazi ya psoriatic kapena kupweteka, koma maphunziro owonjezera akuchitidwa kuti aone ngati ali othandiza pamtunduwu. Kafukufuku wina wanthawi yayitali akuchitikabe.

Chifukwa chiyani ndikufunika kuyezetsa TB ndisanayambe kumwa mankhwala ndi Ilumya?

Dokotala wanu adzakuyesani ngati muli ndi chifuwa chachikulu kapena chobisika (TB) musanayambe kumwa mankhwala ndi Ilumya. Anthu omwe ali ndi TB yobisika sangadziwe kuti ali ndi kachilomboko chifukwa nthawi zambiri sipakhala zizindikiro. Kuyezetsa magazi ndiyo njira yokhayo yodziwira ngati munthu yemwe ali ndi TB yobisika ali ndi kachilombo.

Kuyezetsa TB musanalandire chithandizo ndi Ilumya ndikofunikira chifukwa Ilumya amachepetsa chitetezo chamthupi. Chitetezo cha mthupi chikafooka, sichitha kulimbana ndi matenda, ndipo TB yobisika imatha kugwira ntchito. Zizindikiro za chifuwa chachikulu chimaphatikizapo kutentha thupi, kutopa, kuonda, kutsokomola magazi, ndi kupweteka pachifuwa.

Ngati mwapezeka kuti muli ndi chifuwa chachikulu cha TB, mungafunike kulandira chithandizo cha TB musanayambe Ilumya.

Kodi ndingatani kuti ndipewe matendawa ndikamamwa Ilumya?

Chithandizo cha Ilumya chimafooketsa chitetezo chamthupi chanu ndikuwonjezera chiopsezo chotenga matenda. Zitsanzo za matendawa ndi monga chifuwa chachikulu, ming'alu, matenda a mafangasi, ndi matenda opuma.

Komabe, pali zinthu zingapo zomwe mungachite kuti muteteze matenda:

• Khalani ndi zatsopano pa katemera, kuphatikizapo fuluwenza (chimfine).
• Pewani kusuta.
• Sambani m'manja ndi sopo pafupipafupi.
• Tsatirani zakudya zabwino.
• Muzigona mokwanira.
• Pewani kukhala pafupi ndi anthu odwala, ngati zingatheke.

Machenjezo a Ilumya

Musanatenge Ilumya, lankhulani ndi dokotala wanu za mbiri yanu. Ilumya sangakhale woyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Mbiri yakukhudzidwa kwakukulu kwa Ilumya kapena zina zake. Ngati mudakumana ndi Ilumya m'mbuyomu, simuyenera kulandira chithandizo ndi mankhwalawa. Zomwe zimachitika kwambiri zimaphatikizira kutupa kwa nkhope kapena lilime komanso kupuma movutikira.
• Matenda opatsirana kapena mbiri ya matenda obwereza. Ilumya sayenera kuyambitsidwa ndi anthu omwe ali ndi kachilombo koyambitsa matendawa kapena mbiri ya matenda obwerezabwereza. Ngati mukudwala matendawa mukamamwa Ilumya, uzani dokotala wanu nthawi yomweyo. Adzakuwunikirani mosamala ndipo angaganize zosiya mankhwala anu a Ilumya mpaka matenda atachira.
• Chifuwa chachikulu. Ngati muli ndi TB yobisika kapena TB yogwira, mungafunike chithandizo cha TB musanayambe Ilumya. Simuyenera kuyambitsa Ilumya ngati muli ndi chifuwa chachikulu cha TB. (Ngati muli ndi TB yobisika, dokotala wanu atha kuyamba kumwa Ilumya mukamamwa mankhwala a TB.)

Zambiri zamaluso kwa Ilumya

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Njira yogwirira ntchito

Ilumya imakhala ndi antioclonal antibody tildrakizumab. Amamangirira p19 subunit ya interleukin-23 (IL-23) cytokine ndipo imalepheretsa kuti imangirike ku IL-23 receptor. Kuletsa zochitika za IL-23 kumalepheretsa kuyambitsa njira yothandizira ya T-helper cell 17 (Th17).

Pharmacokinetics ndi metabolism

Mtheradi bioavailability ndi 80% kutsatira jakisoni wa subcutaneous. Kuzindikira kwakukulu kumafikira masiku asanu ndi limodzi. Ndende zosakhazikika zimachitika pofika sabata la 16.

Ilumya imadzazidwa ndi ma peptide ang'onoang'ono ndi ma amino acid kudzera mu katabolism. Kuthetsa theka la moyo pafupifupi masiku 23.

Zotsutsana

Ilumya amatsutsana ndi odwala omwe ali ndi mbiri yokhudzidwa kwambiri ndi mankhwalawo kapena chilichonse mwa omwe amathandizira.

Katemera

Pewani katemera wamoyo mwa odwala omwe alandira Ilumya.

Kukonzekera

Odwala onse ayenera kuwunikidwa ngati ali ndi chifuwa chosachedwa kapena champhamvu asanagwiritsidwe ntchito ndi Ilumya. Osapereka Ilumya kwa odwala omwe ali ndi TB yogwira ntchito. Odwala omwe ali ndi TB yobisika ayenera kuyamba kumwa mankhwala a TB asanayambe kumwa mankhwala ndi Ilumya.

Yosungirako

Ilumya iyenera kusungidwa mufiriji pa 36⁰F mpaka 46⁰F (2⁰C mpaka 8⁰C). Sungani mu chidebe choyambirira kuti muteteze ku kuwala. Ilumya amatha kusungidwa kutentha mpaka 77 upF (25⁰C) - mpaka masiku 30. Mukasunga kutentha, musabwerere m'firiji. Osazizira kapena kugwedezeka. Lolani Ilumya akhale kutentha kwa mphindi 30 asanafike.

Chodzikanira: MedicalNewsToday yachita zonse zotheka kuti zitsimikizire kuti zidziwitso zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.