Omwe Amatsutsa Matenda a Matenda a Crohn

Zamkati

• Azathioprine
• Zamgululi
• Methotrexate
• Zinthu zofunika kuziganizira

Chidule

Palibe mankhwala a matenda a Crohn, chifukwa chake kupumula kwa zizindikiro kumabwera ngati chikhululukiro. Pali mankhwala osiyanasiyana omwe angathandize kuchepetsa zizindikiro zanu. Ma immunomodulators ndi mankhwala omwe amasintha chitetezo chamthupi.

Kwa munthu yemwe ali ndi Crohn's, izi zitha kuthandiza kuchepetsa kutupa komwe kumayambitsa zisonyezo zambiri.

Ma immunomodulators amaphatikiza mankhwala omwe ali ma immunosuppressants ndi ma immunostimulants. Ma immunosuppressants amalepheretsa chitetezo chamthupi, koma kuponderezedwa kwa chitetezo kumathanso kuyika thupi pachiwopsezo chachikulu cha matenda ena.

Ma immunostimulants amachulukitsa kapena "amalimbikitsa" chitetezo chamthupi, chomwe chimalimbikitsa thupi kuyamba kulimbana ndi matenda.

Pali mitundu yosiyanasiyana yama immunomodulators, iliyonse imagulitsidwa pansi pa dzina lake. Azathioprine, mercaptopurine, ndi methotrexate ndi mitundu itatu yayikulu.

Azathioprine

Azathioprine nthawi zambiri amagwiritsidwa ntchito mwa anthu omwe amalandila ziwalo zina kuti thupi lisakane chiwalo chatsopanocho poletsa chitetezo chamthupi. Amagwiritsidwanso ntchito pochiza nyamakazi ya nyamakazi, yomwe ndi mkhalidwe womwe thupi la munthu limagunda malo awo.

Ngakhale azathioprine sanawonetsedwe kuti ndi othandiza pochepetsa zizindikiro za Crohn zazifupi kapena kukwaniritsa chikhululukiro, zitha kuchepetsa kufunikira kwa chithandizo cha steroid. Kafukufuku akuwonetsa kuti azathioprine imathandiza kuti anthu azikhululukidwa pokhapokha ngati matenda a Crohn ayamba.

Pachifukwa ichi, American College of Gastroenterology imathandizira kugwiritsa ntchito azathioprine kwa anthu omwe akukhululukidwa kapena omwe ali ndi zizindikilo ngakhale akugwiritsa ntchito ma steroids.

Palinso zovuta zina, koma zoyipa, zoyipa za azathioprine. Mankhwalawa amachititsa kuti thupi lanu lipange maselo oyera oyera ochepa. Izi zitha kubweretsa mavuto chifukwa ma cell oyera amalimbana ndi matenda.

Anthu omwe amatenga azathioprine amathanso kutupa kapamba kapena chiopsezo chachikulu chokhala ndi lymphoma.

Chifukwa cha zotsatirazi, azathioprine nthawi zambiri imangolembedwa pamatenda owopsa a Crohn's. Muyenera kuganizira zoopsa zonse musanatenge azathioprine. Muthanso kuyesedwa kuti mulibe vuto la TPMT, lomwe lingakhudze chitetezo chanu chamthupi.

Zamgululi

Mercaptopurine, yotchedwanso 6-MP, imadziwika kuti imaletsa ma cell a khansa kukula. Mankhwalawa amagwiritsidwa ntchito nthawi zambiri pochiza khansa ya m'magazi. Mwa anthu omwe ali ndi Crohn's, mercaptopurine itha kuthandizira kukhalabe ndi chikhululukiro.

Mercaptopurine imatha kuchepetsa kupanga maselo oyera ndi ofiira. Dokotala wanu angafunike kuyesa magazi nthawi zonse kuti awonetsetse kuti palibe chowononga mafupa anu. Muthanso kuyesedwa kuti mulibe vuto la TPMT, lomwe lingakhudze chitetezo chanu chamthupi.

Zotsatira zina za mercaptopurine zitha kukhala:

• zilonda mkamwa
• malungo
• chikhure
• magazi mkodzo kapena chopondapo

Muyenera kuganizira zovuta zonse musanamwe mankhwala.

Methotrexate

Methotrexate imatchinga kagayidwe kakang'ono ka cell, kamene kamapangitsa kuti maselo afe. Izi zapangitsa kuti agwiritse ntchito matenda a Crohn, khansa, komanso psoriasis.

American College of Gastroenterology imathandizira kugwiritsa ntchito methotrexate kuchiza zizindikiro za matenda a Crohn mwa anthu omwe amadalira ma steroids. Methotrexate imathandizanso kuti anthu omwe ali ndi Crohn's akhululukidwe.

Komabe, methotrexate imakhala ndi zovuta zina zomwe zimaphatikizapo chiwopsezo cha chiwindi kapena mafupa ndipo, nthawi zambiri, kawopsedwe ka m'mapapo. Amuna kapena akazi omwe akuyesera kutenga pakati sayenera kugwiritsa ntchito mankhwalawa. Zotsatira zoyipa zochepa ndizo:

• mutu
• Kusinza
• zotupa pakhungu
• nseru ndi kusanza
• kutayika tsitsi

Zinthu zofunika kuziganizira

Ma immunomodulators amatha kuthandiza kuthana ndi zizindikilo zokhudzana ndi matenda a Crohn, koma zimasokoneza thupi lanu kuthana ndi matenda. Mukamamwa ma immunomodulators, samalani zizindikiro zilizonse za matenda, monga kutentha thupi kapena kuzizira.

Mukakhala ndi zizindikilozi, funsani dokotala nthawi yomweyo.

Nthawi iliyonse yomwe mumamwa ma immunomodulators, onetsetsani kuti dokotala akuyesa magazi anu pafupipafupi kuti awone ngati mafupa anu ndi ziwalo zanu zawonongeka.

Ma immunomodulators ena akhoza kukhala abwino kumwa mukamakhala ndi pakati, koma muyenera kukambirana zaubwino ndi zoyipa zoyambira mankhwala atsopano ndi dokotala. Muyenera kulankhula ndi dokotala ngati muli ndi pakati kapena, kaya ndinu mwamuna kapena mkazi, mutha kukhala ndi pakati.