Kugwiritsa ntchito Imuran Kuchiza Ulcerative Colitis (UC)

Zamkati

• Momwe Imuran amagwirira ntchito
• Mlingo
• Zotsatira zoyipa za Imuran
• Zowonjezera zowopsa zamitundu ina ya khansa
• Kuchulukitsa matenda
• Matupi awo sagwirizana
• Pancreatitis
• Machenjezo ndi kuyanjana
• Lankhulani ndi dokotala wanu

Kumvetsetsa ulcerative colitis (UC)

Ulcerative colitis (UC) ndimatenda amthupi okha. Zimapangitsa kuti chitetezo chamthupi chanu chiwononge ziwalo za thupi lanu. Ngati muli ndi UC, chitetezo chanu cha mthupi chimayambitsa kutupa ndi zilonda m'kati mwa khola lanu.

UC imatha kugwira ntchito nthawi zina komanso kusachita zambiri kwa ena. Mukamagwira ntchito kwambiri, mumakhala ndi zizindikiro zambiri. Nthawi izi zimadziwika kuti flare-ups.

Pofuna kupewa kuphulika, mutha kuyesa kuchepetsa kuchuluka kwa ma fiber muzakudya zanu kapena kupewa zakudya zina zomwe ndizonunkhira kwambiri. Komabe, anthu ambiri omwe ali ndi UC amafunikiranso thandizo la mankhwala.

Imuran ndi mankhwala akumwa omwe angakuthandizeni kuthana ndi zizindikilo zolimbitsa thupi za UC, kuphatikiza kukokana m'mimba ndi kupweteka, kutsegula m'mimba, ndi chopondapo chamagazi.

Momwe Imuran amagwirira ntchito

Malinga ndi upangiri wapachipatala waposachedwa, chithandizo chomwe mungakonde kuti muchepetse anthu omwe ali ndi UC yozama kwambiri ndi awa:

• corticosteroids
• anti-tumor necrosis factor (anti-TNF) mankhwala ndi mankhwala a biologic adalimumab, golimumab, kapena infliximab
• vedolizumab, mankhwala ena a biologic
• tofacitinib, mankhwala akumwa

Madokotala nthawi zambiri amapereka Imuran kwa anthu omwe ayesa mankhwala ena, monga corticosteroids ndi aminosalicylates, omwe sanathandize kuthetsa zizindikilo zawo.

Imuran ndi dzina lodziwika bwino la mankhwala achilengedwe azathioprine. Ili m'gulu la mankhwala otchedwa immunosuppressants. Zimagwira ntchito pochepetsa chitetezo cha mthupi lanu.

Izi zidza:

• kuchepetsa kutupa
• sungani zizindikiro zanu
• chepetsani mwayi wanu wazomwe mungachite

Imuran itha kugwiritsidwa ntchito limodzi ndi infliximab (Remicade, Inflectra) kuti ipangitse chikhululukiro kapena paokha kuti asunge chikhululukiro. Komabe, izi ndizogwiritsa ntchito pa Imuran.

Kugwiritsa ntchito mankhwala osokoneza bongo kumatanthauza mankhwala omwe amavomerezedwa ndi FDA pacholinga chimodzi amagwiritsidwa ntchito pazinthu zina zomwe sizinavomerezedwe. Komabe, dokotala amatha kugwiritsabe ntchito mankhwalawa pazifukwa izi. Izi ndichifukwa choti a FDA amayang'anira kuyesa ndi kuvomereza mankhwala, koma osati momwe madotolo amagwiritsira ntchito mankhwala pochizira odwala awo. Chifukwa chake, adotolo amatha kukupatsani mankhwala ngakhale akuganiza kuti ndi bwino kuti musamalire.

Zitha kutenga miyezi isanu ndi umodzi kuti Imuran ayambe kuthetsa matenda anu. Imuran imatha kuchepetsa kuwonongeka kwa kutupa komwe kumatha kuyambitsa kupita kuchipatala ndikufunika kochitidwa opaleshoni.

Zikuwonetsedwanso kuchepetsa kufunika kwa ma corticosteroids omwe amagwiritsidwa ntchito nthawi zambiri pochiza UC. Izi zitha kukhala zopindulitsa, chifukwa ma corticosteroids amatha kuyambitsa mavuto ena akagwiritsidwa ntchito kwakanthawi.

Mlingo

Kwa anthu omwe ali ndi UC, mlingo wa azathioprine ndi 1.5-2.5 milligrams pa kilogalamu ya kulemera kwa thupi (mg / kg). Imuran imangopezeka ngati piritsi la 50-mg.

Zotsatira zoyipa za Imuran

Imuran amathanso kuyambitsa zovuta zoyipa. Mukamazitenga, ndibwino kuti mukawone dokotala wanu nthawi zambiri momwe angakuuzireni. Mwanjira imeneyi, amatha kukuyang'anirani kuti muwone zoyipa.

Zotsatira zoyipa za Imuran zitha kuphatikizira kunyansidwa ndi kusanza. Zotsatira zoyipa kwambiri za mankhwalawa ndi awa:

Zowonjezera zowopsa zamitundu ina ya khansa

Kugwiritsa ntchito Imuran kwa nthawi yayitali kumakulitsa chiopsezo cha khansa yapakhungu ndi lymphoma. Lymphoma ndi khansa yomwe imakhudza ma chitetezo chamthupi.

Kuchulukitsa matenda

Imuran amachepetsa ntchito ya chitetezo cha mthupi lanu. Izi zikutanthauza kuti chitetezo cha mthupi chanu sichingagwire ntchito yolimbana ndi matenda. Zotsatira zake, mitundu yotsatira yamatenda ndi zotsatira zoyipa:

• mafangasi
• bakiteriya
• kachilombo
• protozoal

Ngakhale ndizofala, matenda amatha kukhala owopsa.

Matupi awo sagwirizana

Zizindikiro zakusavomerezeka nthawi zambiri zimachitika m'masabata ochepa oyamba akuchipatala. Zikuphatikizapo:

• nseru
• kusanza
• kutsegula m'mimba
• zidzolo
• malungo
• kutopa
• kupweteka kwa minofu
• chizungulire

Ngati muli ndi izi, funsani dokotala nthawi yomweyo.

Pancreatitis

Pancreatitis, kapena kutupa kwa kapamba, ndizovuta zomwe Imuran amachita. Ngati muli ndi zizindikiro monga kupweteka m'mimba, kusanza, kapena malo ogulitsira mafuta, itanani dokotala wanu nthawi yomweyo.

Machenjezo ndi kuyanjana

Imuran atha kucheza ndi mankhwala awa:

• aminosalicylates, monga mesalamine (Canasa, Lialda, Pentasa), omwe nthawi zambiri amapatsidwa kwa anthu omwe ali ndi UC ochepera pang'ono
• magazi owonda warfarin (Coumadin, Jantoven)
• angiotensin-converting enzyme (ACE) inhibitors, omwe amagwiritsidwa ntchito pochizira kuthamanga kwa magazi
• allpurinol (Zyloprim) ndi febuxostat (Uloric), yomwe ingagwiritsidwe ntchito pazinthu monga gout
• ribavirin, mankhwala a hepatitis C.
• co-trimoxazole (Bactrim), maantibayotiki

Ngati mukumwa imodzi mwa mankhwalawa, dokotala wanu atha kusiya kugwiritsa ntchito musanayambe Imuran.

Akhozanso kukulimbikitsani kuchuluka kwa Imuran kwa inu komwe kuli kocheperako poyerekeza ndi kuchuluka kwa Imuran. Mlingo wocheperako ungathandize kuchepetsa kuyanjana kwa mankhwala.

Lankhulani ndi dokotala wanu

Dokotala wanu anganene kuti Imuran ngati mankhwala monga aminosalicylates ndi corticosteroids sanagwire ntchito kuti athetse vuto lanu la UC. Zingakuthandizeni kuchepetsa kuwonongeka komanso kukuthandizani kuthana ndi matenda anu.

Imuran amabwera ndi chiopsezo cha zotsatirapo zoyipa, kuphatikizapo chiopsezo chowonjezeka cha khansa ndi matenda. Komabe, kutenga Imuran kungakuthandizeninso kupewa mavuto omwe amabwera chifukwa chogwiritsa ntchito corticosteroid nthawi yayitali.

Lankhulani ndi dokotala wanu kuti mudziwe ngati Imuran ndi chisankho chabwino kwa inu.