Infliximab, Solution Yothetsera

Zamkati

• Machenjezo ofunikira
• Chenjezo la FDA:
  
• Machenjezo ena
• Kodi infliximab ndi chiyani?
• Chifukwa chimagwiritsidwa ntchito
• Momwe imagwirira ntchito
• Zotsatira za infliximab
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Infliximab imatha kulumikizana ndi mankhwala ena
• Machenjezo a infliximab
• Chenjezo la ziwengo
• Machenjezo kwa anthu omwe ali ndi matenda ena
• Machenjezo kwa magulu ena
• Momwe mungatengere infliximab
• Tengani monga mwalamulidwa
• Zofunikira pakulera infliximab
• Kuyenda
• Kuyesedwa kwachipatala ndikuwunika
• Chilolezo chisanachitike

Mfundo zazikulu za infliximab

1. Njira yothetsera jekeseni ya infliximab imapezeka ngati mankhwala osokoneza bongo. Sichipezeka mumtundu wa generic. Mayina a Brand: Remicade, Inflectra, Renflexis.
2. Infliximab imabwera mu njira yothetsera jekeseni kuti igwiritsidwe ntchito ngati kulowetsedwa mkati.
3. Njira yothetsera jekeseni ya infliximab imagwiritsidwa ntchito pochiza matenda a Crohn, ulcerative colitis, nyamakazi ya nyamakazi, ankylosing spondylitis, psoriatic nyamakazi, ndi plaque psoriasis.

Machenjezo ofunikira

Chenjezo la FDA:

• Mankhwalawa ali ndi machenjezo a bokosi lakuda. Awa ndi machenjezo ovuta kwambiri ochokera ku Food and Drug Administration (FDA). Chenjezo la bokosi lakuda limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.
• Kuopsa kwa chenjezo lalikulu la matenda: Infliximab ingachepetse mphamvu ya chitetezo cha mthupi lanu yolimbana ndi matenda. Anthu ena amatenga matenda opatsirana akamamwa mankhwalawa. Izi zingaphatikizepo chifuwa chachikulu (TB) kapena matenda ena obwera chifukwa cha bakiteriya, mavairasi, kapena bowa. Musatenge infliximab ngati muli ndi matenda aliwonse osalankhula ndi dokotala poyamba. Dokotala wanu akhoza kukuyang'anirani ngati muli ndi matenda asanakwane, nthawi, komanso mutalandira chithandizo chanu ndi infliximab. Dokotala wanu amathanso kukuyesani TB musanayambe infliximab.
• Kuopsa kwa chenjezo la khansa: Mankhwalawa amachulukitsa chiopsezo cha lymphoma, khansa ya pachibelekero, ndi mitundu ina ya khansa. Anthu ochepera zaka 18, anyamata achichepere, komanso omwe ali ndi matenda a Crohn's kapena ulcerative colitis atha kutenga khansa. Lankhulani ndi dokotala wanu ngati mwakhala ndi khansa yamtundu uliwonse. Dokotala wanu angafunikire kusintha mankhwala anu.

Machenjezo ena

• Chenjezo kuwonongeka kwa chiwindi: Infliximab itha kuvulaza chiwindi chanu. Uzani dokotala wanu ngati muli ndi zizindikiro za kuwonongeka kwa chiwindi, monga:
  • chikasu cha khungu lako kapena kuyera kwa maso ako
  • mkodzo wamtundu wakuda
  • kupweteka kumanja kwa gawo m'mimba mwanu
  • malungo
  • kutopa kwambiri
• Kuopsa kwa chizindikiro cha Lupus: Lupus ndi matenda omwe amakhudza chitetezo cha mthupi lanu. Zizindikiro zimatha kuphatikizira kupweteka pachifuwa komwe sikutha, kupuma movutikira, kupweteka kwamalumikizidwe, komanso zotupa m'masaya mwanu kapena mikono yomwe imakulirakulira padzuwa. Inu adokotala mutha kusankha kusiya infliximab mukakhala ndi izi.
• Chenjezo la katemera: Musalandire katemera wamoyo mukamamwa infliximab. Dikirani miyezi itatu mutasiya infliximab kuti mulandire katemera wamoyo. Zitsanzo za katemera wamoyo ndi katemera wa chimfine cha mphuno, chikuku, matsagwidi, ndi katemera wa rubella, ndi katemera wa nkhuku kapena shingles. Katemera wamoyo sangakutetezeni ku matendawa mukamamwa mankhwalawa. Ngati simunakwanitse zaka 18, onetsetsani kuti katemera onse ali mgulu asanayambe infliximab.
• Aakulu zochita pambuyo kulowetsedwa chenjezo. Zochitika zazikulu zomwe zimakhudza mtima wanu, mayimbidwe amtima, komanso mitsempha yamagazi zimatha kuchitika mkati mwa maola 24 kuyambira kulowetsedwa kwa mankhwalawa. Izi zimatha kuphatikizanso matenda amtima, omwe amatha kupha. Ngati muli ndi zizindikilo monga chizungulire, kupweteka pachifuwa, kapena kupweteka kwamphindi mkati mwa maola 24 mutakulowetsani, itanani dokotala wanu nthawi yomweyo.

Kodi infliximab ndi chiyani?

Infliximab ndi mankhwala omwe mumalandira. Ipezeka ngati yankho la jakisoni.

Infliximab imapezeka ngati mankhwala osokoneza bongo a Remicade, Inflectra, ndi Renflexis. (Inflectra ndi Renflexis ndi biosimilars. *) Infliximab sichipezeka mu generic version.

Infliximab itha kuphatikizidwa ndi methotrexate mukamagwiritsa ntchito kuchiza nyamakazi.

* Biosimilar ndi mtundu wa mankhwala a biologic. Biologics amapangidwa kuchokera ku gwero lazinthu, monga maselo amoyo. Biosimilar ndi ofanana ndi dzina lodziwika bwino la mankhwala a biologic, koma siili yeniyeni. (Mankhwala achibadwa, kumbali inayo, ndi mankhwala enieni opangidwa ndi mankhwala. Mankhwala ambiri amapangidwa ndi mankhwala.)

Biosimilar atha kulembedwa kuti athetse zina kapena zonse zomwe mankhwala amtundu wa mankhwala amamuchitira, ndipo akuyembekezeredwa kukhala ndi zovuta zomwezo kwa wodwala. Poterepa, Inflectra ndi Renflexis ndi mitundu yofanana ya Remicade.

Chifukwa chimagwiritsidwa ntchito

Infliximab imagwiritsidwa ntchito pochiza:

• Matenda a Crohn (pomwe simunayankhe mankhwala ena)
• ulcerative colitis (pamene simunayankhe mankhwala ena)
• nyamakazi (yogwiritsidwa ntchito ndi methotrexate)
• ankylosing spondylitis
• nyamakazi ya psoriatic
• psoriasis yayitali komanso yayikulu (yogwiritsidwa ntchito mukafunika kuthandizira thupi lanu lonse kapena mankhwala ena siabwino kwa inu)

Momwe imagwirira ntchito

Mankhwalawa amagwira ntchito poletsa zomwe zimachitika m'thupi lanu lotchedwa tumor necrosis factor-alpha (TNF-alpha). TNF-alpha imapangidwa ndi chitetezo cha mthupi lanu. Anthu omwe ali ndi zikhalidwe zina ali ndi TNF-alpha yochulukirapo. Izi zitha kupangitsa chitetezo chamthupi kuthana ndi ziwalo zathanzi. Infliximab ikhoza kuletsa kuwonongeka kochititsidwa ndi TNF-alpha yochulukirapo.

Zotsatira za infliximab

Njira yothetsera jekeseni ya infliximab siyimayambitsa kugona, koma imatha kuyambitsa zovuta zina.

Zotsatira zofala kwambiri

Zotsatira zoyipa zomwe zimatha kuchitika ndi infliximab ndi monga:

• matenda opuma, monga matenda a sinus ndi zilonda zapakhosi
• kupweteka mutu
• kukhosomola
• kupweteka m'mimba

Zotsatira zofewa zimatha kutha masiku angapo kapena milungu ingapo. Lankhulani ndi dokotala kapena wamankhwala ngati ali ovuta kwambiri kapena samapita.

Zotsatira zoyipa

Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala. Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Mtima kulephera. Zizindikiro zimaphatikizapo:
  • kuvuta kupuma
  • kutupa kwa akakolo kapena mapazi anu
  • kufulumira kunenepa
• Mavuto amwazi. Zizindikiro zimaphatikizapo:
  • kuvulaza kapena kutuluka magazi mosavuta
  • malungo omwe samachoka
  • akuwoneka otuwa kwambiri
• Mavuto amanjenje amanjenje. Zizindikiro zimaphatikizapo:
  • masomphenya amasintha
  • kufooka kwa mikono kapena miyendo yanu
  • dzanzi kapena kumva kulasalasa thupi lako
  • kugwidwa
• Thupi lawo siligwirizana / kulowetsedwa zochita. Zitha kuchitika mpaka patadutsa maola awiri kulowetsedwa kwa infliximab. Zizindikiro zimaphatikizapo:
  • zotupa pakhungu
  • kuyabwa
  • ming'oma
  • kutupa kwa nkhope, milomo, kapena lilime
  • malungo kapena kuzizira
  • mavuto kupuma
  • kupweteka pachifuwa
  • kuthamanga kwa magazi kapena kuthamanga kwa magazi (chizungulire kapena kukomoka)
• Kuchedwa kuchepa kwa zomwe zimachitika. Zizindikiro zimaphatikizapo:
  • kupweteka kwa minofu kapena molumikizana
  • malungo
  • zidzolo
  • mutu
  • chikhure
  • kutupa kwa nkhope kapena manja
  • zovuta kumeza
• Psoriasis. Zizindikiro zimaphatikizapo:
  • ofiira, okhala ndi zigamba kapena zotumphukira pakhungu
• Matenda. Zizindikiro zimaphatikizapo:
  • malungo kapena kuzizira
  • chifuwa
  • chikhure
  • kupweteka kapena kuvuta kudutsa mkodzo
  • kumva kutopa kwambiri
  • khungu lofunda, lofiira, kapena lopweteka

Chodzikanira: Cholinga chathu ndikukupatsani chidziwitso chofunikira kwambiri komanso chaposachedwa. Komabe, chifukwa mankhwala amakhudza munthu aliyense mosiyanasiyana, sitingatsimikizire kuti izi zimaphatikizaponso zovuta zonse zomwe zingachitike. Izi sizilowa m'malo mwa upangiri wa zamankhwala. Nthawi zonse muzikambirana mavuto omwe angakhalepo ndi othandizira azaumoyo omwe amadziwa mbiri yanu yazachipatala.

Infliximab imatha kulumikizana ndi mankhwala ena

Njira yothetsera jekeseni ya infliximab imatha kulumikizana ndi mankhwala, zitsamba, kapena mavitamini omwe mwina mumamwa. Wopereka chithandizo chamankhwala adzayang'ana momwe mungachitire ndi mankhwala omwe alipo. Nthawi zonse onetsetsani kuti mumauza dokotala za mankhwala onse, zitsamba, kapena mavitamini omwe mukumwa.

Chodzikanira: Cholinga chathu ndikukupatsani chidziwitso chofunikira kwambiri komanso chaposachedwa. Komabe, chifukwa mankhwala amagwirira ntchito mosiyanasiyana mwa munthu aliyense, sitingatsimikizire kuti izi zikuphatikizira kulumikizana kulikonse kotheka. Izi sizilowa m'malo mwa upangiri wa zamankhwala. Nthawi zonse lankhulani ndi omwe amakuthandizani zaumoyo pazomwe mungachite ndi mankhwala onse, mavitamini, zitsamba ndi zowonjezera, komanso mankhwala owonjezera omwe mumamwa.

Machenjezo a infliximab

Mankhwalawa amabwera ndi machenjezo angapo.

Chenjezo la ziwengo

Infliximab imatha kuyambitsa vuto lalikulu. Izi zitha kuchitika mukamalandira chithandizo kapena mpaka maola awiri mutadwala. Zizindikiro zimaphatikizapo:

• ming'oma (ofiira, otukulidwa, zigamba za khungu)
• kuvuta kupuma
• kupweteka pachifuwa
• kuthamanga kwa magazi kapena kuthamanga kwa magazi. Zizindikiro za kuthamanga kwa magazi ndi monga:
  • chizungulire
  • kumva kukomoka
  • kuvuta kupuma
  • malungo ndi kuzizira

Nthawi zina infliximab imatha kuyambitsa kuchepa kwa zomwe zimachitika. Zomwe zimachitika zitha kuchitika masiku atatu kapena 12 mutalandira jakisoni wanu. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi zakuchedwa kuyanjana:

• malungo
• zidzolo
• mutu
• chikhure
• kupweteka kwa minofu kapena molumikizana
• kutupa kwa nkhope ndi manja anu
• vuto kumeza

Machenjezo kwa anthu omwe ali ndi matenda ena

Kwa anthu omwe ali ndi matenda: Uzani dokotala wanu ngati muli ndi matenda amtundu uliwonse, ngakhale atakhala ochepa, monga kudula kotseguka kapena zilonda zomwe zimawoneka kuti zili ndi kachilombo. Thupi lanu limakhala ndi nthawi yovuta kwambiri yolimbana ndi matendawa mukamamwa infliximab.

Kwa anthu omwe ali ndi chifuwa chachikulu (TB): Infliximab imakhudza chitetezo chanu chamthupi ndipo itha kukupangitsani kuti musakhale ndi TB. Dokotala wanu akhoza kukuyesani TB musanayambe kumwa mankhwala.

Kwa anthu omwe ali ndi hepatitis B: Ngati muli ndi kachilombo ka hepatitis B, kamatha kugwira ntchito mukamagwiritsa ntchito infliximab. Ngati kachilomboka kadzayambiranso kugwira ntchito, muyenera kusiya kumwa mankhwalawa ndikuchiza matendawa. Dokotala wanu akhoza kuyesa magazi musanayambe kulandira chithandizo, mukamalandira chithandizo, komanso kwa miyezi ingapo mutalandira chithandizo ndi infliximab.

Kwa anthu omwe ali ndi mavuto amwazi: Infliximab imatha kukhudza ma cell anu amwazi. Uzani dokotala wanu mavuto aliwonse omwe muli nawo ndi magazi anu musanayambe kumwa infliximab.

Kwa anthu omwe ali ndi mavuto amanjenje: Infliximab imatha kukulitsa mavuto amanjenje. Gwiritsani ntchito mosamala ngati muli ndi multiple sclerosis kapena matenda a Guillain-Barre.

Kwa anthu omwe ali ndi vuto la mtima: Mankhwalawa atha kukulitsa mtima. Itanani dokotala wanu nthawi yomweyo ngati mukumane ndi vuto lakukula kwa mtima. Zizindikiro zimaphatikizaponso kupuma movutikira, kutupa kwa akakolo kapena mapazi anu, komanso kunenepa mwadzidzidzi. Muyenera kusiya kumwa infliximab ngati mtima wanu walephera.

Machenjezo kwa magulu ena

Kwa amayi apakati: Infliximab ndi mankhwala a gulu B. Izi zikutanthauza zinthu ziwiri:

1. Kafukufuku wamankhwala anyama yapakati sanawonetse chiopsezo kwa mwana wosabadwayo.
2. Palibe maphunziro okwanira omwe apangidwa kwa amayi apakati omwe angawonetse ngati mankhwalawa ali pachiwopsezo kwa mwana wosabadwayo.

Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kutenga pakati. Infliximab iyenera kugwiritsidwa ntchito panthawi yapakati pokhapokha phindu lomwe lingakhalepo likutsimikizira kuwopsa kwa mwana wosabadwayo.

Itanani dokotala wanu mukakhala ndi pakati mukamamwa mankhwalawa.

Kwa amayi omwe akuyamwitsa: Sizikudziwika ngati mankhwalawa amapitilira mkaka wa m'mawere. Ngati infliximab imaperekedwa kwa mwana wanu kudzera mkaka wa m'mawere, zitha kuyambitsa mavuto akulu.

Inu ndi dokotala mungafunike kusankha ngati mungatenge infliximab kapena kuyamwitsa.

Kwa okalamba: Mutha kukhala pachiwopsezo chachikulu chotenga matendawa mukamamwa infliximab ngati muli ndi zaka zopitilira 65.

Kwa ana: Infliximab sinawonetsedwe kuti ndi yotetezeka komanso yothandiza ku matenda a Crohn kapena ulcerative colitis mwa anthu ochepera zaka 6.

Chitetezo ndi mphamvu ya infliximab pazinthu zina sizinakhazikitsidwe kwa anthu ochepera zaka 18.

Momwe mungatengere infliximab

Dokotala wanu adzakupatsani mlingo woyenera kwa inu malinga ndi momwe mulili komanso kulemera kwanu. Thanzi lanu lonse lingakhudze kuchuluka kwanu. Uzani dokotala wanu zaumoyo womwe muli nawo dokotala wanu kapena namwino asanakupatseni mankhwalawa. Mudzapatsidwa infliximab kudzera mu singano yoyikidwa mumtsempha (IV kapena kulowetsedwa m'mitsempha) m'manja mwanu.

Mudzalandira mlingo wanu wachiwiri pakatha milungu iwiri mutamwa mankhwala oyamba. Mlingo ukhoza kufalikira kwambiri pambuyo pake.

Chodzikanira: Cholinga chathu ndikukupatsani chidziwitso chofunikira kwambiri komanso chaposachedwa. Komabe, chifukwa mankhwala osokoneza bongo amakhudza munthu aliyense mosiyanasiyana, sitingatsimikizire kuti mndandandawu umaphatikizira miyezo yonse yotheka. Izi sizilowa m'malo mwa upangiri wa zamankhwala. Nthawi zonse lankhulani ndi dokotala kapena wamankhwala za mlingo woyenera kwa inu.

Tengani monga mwalamulidwa

Infliximab imagwiritsidwa ntchito pochiza kwa nthawi yayitali. Zimabwera ndi zoopsa zazikulu ngati simukuzitenga monga mwalamulo.

Ngati simutenga konse: Ngati simutenga infliximab, matenda anu sangasinthe ndipo amatha kukulirakulira.

Mukaleka kuzitenga: Mkhalidwe wanu ukhoza kukulirakulira mukasiya kugwiritsa ntchito infliximab.

Ngati mutenga zochuluka kwambiri: Ndi omwe akuyenera kulandira chithandizo chamankhwala okha omwe ayenera kukonzekera mankhwalawo ndi kukupatsani. Kumwa mankhwala ochuluka kwambiri sikungatheke. Komabe, onetsetsani kuti mukambirana za dokotala wanu paulendo uliwonse.

Zomwe muyenera kuchita mukaphonya mlingo: Ndikofunika kuti musaphonye mlingo wanu. Itanani dokotala wanu ngati mukulephera kusunga nthawi yanu.

Momwe mungadziwire ngati mankhwalawa akugwira ntchito: Zizindikiro zanu ziyenera kukhala bwino. Kwa matenda a Crohn's and ulcerative colitis, mutha kukhala ndi zizindikiro zochepa. Kwa nyamakazi, mutha kuyendayenda ndikuchita ntchito mosavuta.

Zofunikira pakulera infliximab

Kumbukirani izi ngati dokotala akukulemberani infliximab.

Kuyenda

Kuyenda kungakhudze dongosolo lanu la dosing. Infliximab imaperekedwa ndi othandizira azaumoyo kuchipatala kapena malo azachipatala. Ngati mukufuna kukayenda, lankhulani ndi adotolo zamayendedwe anu ndikuwona ngati zingakhudze kuchuluka kwanu.

Kuyesedwa kwachipatala ndikuwunika

Musanamwe mankhwala komanso musanamwe mankhwalawa, adokotala amatha kuyesa mayeso kuti awone thanzi lanu. Mayesowa atha kuphatikiza:

• Mayeso a chifuwa chachikulu (TB): Dokotala wanu angakuyeseni TB musanayambe infliximab ndikukuyang'anitsani ngati muli ndi matendawa.
• Kuyesedwa kwa kachilombo ka Hepatitis B: Dokotala wanu akhoza kuyesa magazi kuti akuyang'anireni kachilombo ka hepatitis B musanayambe kulandira chithandizo komanso mukalandira infliximab. Ngati muli ndi kachilombo ka hepatitis B, dokotala wanu adzakuyesani magazi mukamalandira chithandizo komanso kwa miyezi ingapo mutalandira mankhwala.
• Mayesero ena: Mayesowa atha kuphatikiza:
  • kuyezetsa magazi kuti aone ngati ali ndi matenda
  • kuyesa kwa chiwindi

Chilolezo chisanachitike

Makampani ambiri a inshuwaransi amafuna chilolezo choyambirira cha mankhwalawa. Izi zikutanthauza kuti dokotala wanu adzafunika kuvomerezedwa ndi kampani yanu ya inshuwaransi kampani yanu ya inshuwaransi isanakulipireni mankhwalawo.

Chodzikanira: Healthaline yayesetsa kwambiri kuti zidziwitso zonse zikhale zolondola, zokwanira, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina.Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.