Matenda a Lambert-Eaton Myasthenic

Zamkati

• Kodi Zizindikiro Za Lambert-Eaton Myasthenic Syndrome Ndi Ziti?
• Nchiyani Chimayambitsa Lambert-Eaton Myasthenic Syndrome?
• Kuzindikira Lambert-Eaton Myasthenic Syndrome
• Kuchiza Lambert-Eaton Myasthenic Syndrome
• Kodi Chiyembekezo Chosakhalitsa Ndi Chiyani?

Kodi Lambert-Eaton Myasthenic Syndrome ndi chiyani?

Matenda a Lambert-Eaton myasthenic (LEMS) ndimatenda achilengedwe omwe amangokhalira kusuntha. Chitetezo cha mthupi lanu chimagunda minofu yomwe imabweretsa zovuta kuyenda komanso mavuto ena am'mimba.

Matendawa sangachiritsidwe, koma zizindikiro zimatha kuchepa kwakanthawi ngati muchita khama. Mutha kusamalira vutoli ndi mankhwala.

Kodi Zizindikiro Za Lambert-Eaton Myasthenic Syndrome Ndi Ziti?

Zizindikiro zoyambirira za LEMS ndikufooka kwamiyendo komanso kuyenda movutikira. Matendawa akamakula, mudzakumananso ndi izi:

• kufooka kwa minofu ya nkhope
• Zizindikiro zaminyewa zosadziwika
• kudzimbidwa
• pakamwa pouma
• kusowa mphamvu
• mavuto chikhodzodzo

Kufooka kwamiyendo kumakula bwino kwakanthawi mukamayesetsa. Mukamachita masewera olimbitsa thupi, acetylcholine imakula mokwanira kuti mphamvu ikhale yabwino kwakanthawi kochepa.

Pali zovuta zingapo zomwe zimakhudzana ndi LEMS. Izi zikuphatikiza:

• kuvuta kupuma ndi kumeza
• matenda
• kuvulala chifukwa chakugwa kapena mavuto pakugwirizana

Nchiyani Chimayambitsa Lambert-Eaton Myasthenic Syndrome?

Mu matenda omwe amadzichitira okhaokha, chitetezo cha mthupi lanu chimalakwitsa thupi lanu ngati chinthu chachilendo. Chitetezo chanu cha mthupi chimapanga ma antibodies omwe amaukira thupi lanu.

Mu LEMS, thupi lanu limagunda mathero omwe amayang'anira kuchuluka kwa acetylcholiney thupi lanu limatulutsidwa. Acetylcholine ndi neurotransmitter yomwe imayambitsa kupindika kwa minofu. Kupanikizika kwa minofu kumakupatsani mwayi wopanga mwakufuna kwanu monga kuyenda, kugwedeza zala zanu, ndi kugwedeza mapewa anu.

Makamaka, thupi lanu limagunda puloteni yotchedwa voltage gated calcium channel (VGCC). VGCC imafunika kuti amasulidwe acetylcholine. Simumatulutsa acetylcholine yokwanira VGCC ikaukiridwa, ndiye kuti minofu yanu siyitha kugwira bwino ntchito.

Matenda ambiri a LEMS amakhudzana ndi khansa ya m'mapapo. Ofufuzawo amakhulupirira kuti maselo a khansa amatulutsa puloteni ya VGCC. Izi zimapangitsa kuti chitetezo chamthupi chanu chikhale ndi ma antibodies olimbana ndi VGCC. Ma antibodies awa amalimbana ndi maselo a khansa komanso minofu. Aliyense atha kukhala ndi LEMS m'moyo wawo wonse, koma khansa yamapapo imatha kukulitsa chiopsezo chokhala ndi vutoli. Ngati pali mbiri ya matenda omwe amadzichitira okhaokha m'banja lanu, mutha kukhala pachiwopsezo chachikulu chotenga LEMS.

Kuzindikira Lambert-Eaton Myasthenic Syndrome

Kuti mupeze LEMS, dokotala wanu atenga mbiri yakale ndikuwunika. Dokotala wanu adzafunafuna:

• kuchepa kwa malingaliro
• kutayika kwa minofu
• kufooka kapena kusunthika komwe kumawongokera ndi zochitika

Dokotala wanu amatha kuyitanitsa mayeso angapo kuti atsimikizire vutoli. Kuyezetsa magazi kumayang'ana ma antibodies olimbana ndi VGCC (anti-VGCC antibodies). Electromyography (EMG) imayesa minofu yanu poona momwe amachitira ikakhudzidwa. Singano yaying'ono imayikidwa mu mnofu ndikulumikizidwa ndi mita. Mudzafunsidwa kuti mutenge minofu imeneyo, ndipo mita iwerenga momwe minofu yanu imayankhira bwino.

Chiyeso china chotheka ndi kuyesa kwa mitsempha yopangira ma velocity test (NCV). Pachiyeso ichi, dokotala wanu amaika maelekitirodi pamwamba pa khungu lanu kuphimba minofu yayikulu. Zigawozi zimapereka chizindikiritso chamagetsi chomwe chimalimbikitsa minyewa ndi minofu. Ntchito zomwe zimachokera m'mitsempha zimajambulidwa ndi maelekitirodi ena ndipo zimagwiritsidwa ntchito kuti mudziwe momwe mitsempha imathandizira mwachangu pakukondoweza.

Kuchiza Lambert-Eaton Myasthenic Syndrome

Matendawa sangachiritsidwe. Mudzagwira ntchito ndi dokotala wanu kuti muthane ndi zovuta zina, monga khansa yam'mapapo.

Dokotala wanu angakulimbikitseni kulandira mankhwala a immunoglobulin (IVIG). Pachifukwa ichi, dokotala wanu adzakupatsani mankhwala osagwirizana ndi omwe amateteza chitetezo cha mthupi. Chithandizo china chotheka ndi plasmapheresis. Magazi amachotsedwa mthupi, ndipo madzi am'magazi amasiyana. Ma antibodies amachotsedwa, ndipo plasma imabwezeretsedwanso m'thupi.

Mankhwala omwe amagwira ntchito ndi minofu yanu nthawi zina amatha kuthana ndi matenda. Izi zikuphatikizapo mestinon (pyridostigmine) ndi 3, 4 diaminopyridine (3, 4-DAP).

Mankhwalawa ndi ovuta kupeza, ndipo muyenera kukambirana ndi dokotala kuti mudziwe zambiri.

Kodi Chiyembekezo Chosakhalitsa Ndi Chiyani?

Zizindikiro zimatha kusintha pochiza zovuta zina, kupondereza chitetezo chamthupi, kapena kuchotsa ma antibodies m'magazi. Sikuti aliyense amamvera chithandizo. Gwiritsani ntchito ndi dokotala wanu kuti mupeze njira yoyenera yothandizira.