Zovuta za Myelofibrosis ndi Njira Zochepetsera Ngozi Zanu

Zamkati

• Kukula kwa nthata
• Zotupa (zopanda kukula) m'matumba ena amthupi lanu
• Matenda oopsa a Portal
• Kuwerengera kwapamwamba
• Kupweteka kwa mafupa ndi mafupa
• Gout
• Kuchepa kwa magazi m'thupi
• Khansa ya m'magazi (AML)
• Kuchiza zovuta za MF
• Kuchepetsa chiopsezo chanu cha zovuta za MF
• Kutenga

Myelofibrosis (MF) ndi khansa yayikulu yamagazi pomwe minofu yotupa m'mafupa imachedwetsa kupanga maselo athanzi lamagazi. Kuchepa kwamaselo amwazi kumayambitsa zisonyezo ndi zovuta zambiri za MF, monga kutopa, mabala osavuta, malungo, ndi mafupa kapena mafupa.

Anthu ambiri samakumana ndi zizindikiro zilizonse kumayambiriro kwa matendawa. Matendawa akamakula, zizindikilo ndi zovuta zina zomwe zimafanana ndi kuchuluka kwama cell amwazi zimatha kuwonekera.

Ndikofunika kugwira ntchito ndi dokotala kuti muthandize MF, makamaka mukangoyamba kukumana ndi zizindikilo. Chithandizo chingathandize kuchepetsa chiopsezo cha zovuta ndikuwonjezera kupulumuka.

Pano pali kuyang'anitsitsa zovuta zomwe zingakhalepo za MF ndi momwe mungachepetsere chiopsezo chanu.

Kukula kwa nthata

Nthenda yanu imathandiza kulimbana ndi matenda ndikutulutsa maselo akale kapena owonongeka. Imasunganso maselo ofiira am'magazi omwe amathandiza magazi kuundana.

Mukakhala ndi MF, mafupa anu sangathe kupanga maselo okwanira am'magazi chifukwa chazipsera. Maselo amwazi amapangidwa kunja kwa mafupa m'mbali zina za thupi lanu, monga nthenda yanu.

Izi zimatchedwa extramedullary hematopoiesis. Nthata nthawi zina zimakhala zazikulu modabwitsa chifukwa zimagwira ntchito molimbika kupanga maselowa.

Nthata yowonjezera (splenomegaly) imatha kuyambitsa zizindikilo zosasangalatsa. Zitha kupweteketsa m'mimba zikakankhira ziwalo zina ndikukupangitsani kukhala okhuta ngakhale simunadye kwambiri.

Zotupa (zopanda kukula) m'matumba ena amthupi lanu

Maselo a magazi akatulutsidwa kunja kwa mafupa, zotupa zopanda khansa zamaselo amwazi nthawi zina zimapanga mbali zina za thupi.

Zotupa izi zimatha kuyambitsa magazi mkati mwanu m'mimba. Izi zitha kukupangitsa kutsokomola kapena kulavulira magazi. Zotupa zimathanso kupondereza msana wanu kapena zimayambitsa kugwa.

Matenda oopsa a Portal

Magazi amayenda kuchokera ku ndulu kupita pachiwindi kudzera mumitsempha yotsegula. Kuwonjezeka kwa magazi kupita kukulira kwa nthata mu MF kumayambitsa kuthamanga kwa magazi m'mitsempha yapanyumba.

Kuwonjezeka kwa kuthamanga kwa magazi nthawi zina kumakakamiza magazi ochulukirapo m'mimba ndi m'mimba. Izi zitha kuphulika mitsempha yaying'ono ndikupangitsa magazi. Za anthu omwe ali ndi MF amakumana ndi izi.

Kuwerengera kwapamwamba

Ma platelet m'magazi amathandiza magazi anu kuphimba pambuyo povulala. Kuwerengera kwa ma Platelet kumatha kutsika kwambiri pomwe MF ikupita. Manambala ochepa amatchedwa thrombocytopenia.

Popanda mapulateleti okwanira, magazi anu sangathe kuundana bwino. Izi zitha kukupangitsani kutuluka magazi mosavuta.

Kupweteka kwa mafupa ndi mafupa

MF ikhoza kuumitsa mafupa anu. Zikhozanso kuchititsa kutupa m'magulu olumikizana ndi mafupa. Izi zimabweretsa kupweteka kwa mafupa ndi mafupa.

Gout

MF imapangitsa kuti thupi lipange uric acid wochulukirapo kuposa wabwinobwino. Ngati uric acid imalira, nthawi zina imakhazikika m'malo olumikizirana mafupa. Izi zimatchedwa gout. Gout imatha kupangitsa kutupa ndi kupweteka kwamafundo.

Kuchepa kwa magazi m'thupi

Maselo ofiira ofiira omwe amadziwika kuti kuchepa magazi m'thupi ndi chizindikiro chodziwika bwino cha MF. Nthawi zina kuchepa kwa magazi kumakhala kwakukulu ndipo kumayambitsa kufooka, kufinya, ndi zizindikilo zina.

Khansa ya m'magazi (AML)

Kwa anthu pafupifupi 15 mpaka 20 peresenti, MF ikupita ku khansa yoopsa kwambiri yotchedwa acute myeloid leukemia (AML). AML ndi khansa yomwe ikupita patsogolo kwambiri m'magazi ndi m'mafupa.

Kuchiza zovuta za MF

Dokotala wanu akhoza kukupatsani mankhwala osiyanasiyana kuti athane ndi zovuta za MF. Izi zikuphatikiza:

• JAK inhibitors, kuphatikiza ruxolitinib (Jakafi) ndi fedratinib (Inrebic)
• Mankhwala osokoneza bongo, monga thalidomide (Thalomid), lenalidomide (Revlimid), interferon, ndi pomalidomide (Pomalyst)
• corticosteroids, monga prednisone
• Kuchotsa opaleshoni ya ndulu (splenectomy)
• mankhwala a androgen
• mankhwala a chemotherapy, monga hydroxyurea

Kuchepetsa chiopsezo chanu cha zovuta za MF

Ndikofunikira kuti mugwire ntchito ndi dokotala kuti muyang'anire MF. Kuwunika pafupipafupi ndikofunikira pakuchepetsa chiopsezo chanu cha MF. Dokotala wanu akhoza kukupemphani kuti mubwere kuwerengera magazi ndi kuyezetsa thupi kamodzi kapena kawiri pachaka kapena kangapo kamodzi pa sabata.

Ngati pakadali pano mulibe zisonyezo komanso MF yemwe ali pachiwopsezo chochepa, palibe umboni kuti mudzapindula ndi machitidwe am'mbuyomu. Dokotala wanu akhoza kudikirira kuti ayambe kulandira chithandizo mpaka matenda anu atakula.

Ngati muli ndi zizindikiro kapena MF wapakati- kapena woopsa pachiwopsezo, dokotala wanu akhoza kukupatsani chithandizo.

JAK inhibitors ruxolitinib ndi fedratinib akuwunikira njira zosazolowereka zomwe zimayambitsidwa ndi kusintha kwamtundu wa MF wamba. Mankhwalawa awonetsedwa kuti amachepetsa kwambiri kukula kwa ndulu ndikuthana ndi zofooka zina kuphatikiza mafupa ndi mafupa. Kafukufuku atha kuchepetsa chiopsezo cha zovuta ndikuwonjezera kupulumuka.

Kuika mafuta m'mafupa ndiwo mankhwala okhawo omwe angachiritse MF. Zimaphatikizapo kulandira kulowetsedwa kwa maselo amtundu kuchokera kwa wopereka wathanzi, omwe amalowa m'malo mwa maselo olakwika omwe amachititsa zizindikiro za MF.

Njirayi imakhala ndi zoopsa zazikulu komanso zowopsa pamoyo. Nthawi zambiri zimangolimbikitsidwa kwa achinyamata popanda zovuta zina zomwe zidalipo kale.

Mankhwala atsopano a MF akupangidwa nthawi zonse. Yesetsani kukhala ndi kafukufuku waposachedwa ku MF, ndikufunsani dokotala ngati mungaganizire zolembetsa zamankhwala.

Kutenga

Myelofibrosis ndi khansa yosawerengeka komwe kumapangitsa kuti mafupa anu asatulutse maselo amwazi wathanzi okwanira. Ngati muli ndi MF wapakati kapena woopsa kwambiri, mankhwala angapo amatha kuthana ndi zizindikilo, kuchepetsa mavuto omwe amakumana nawo, komanso kuthekera kokulitsa moyo.

Mayesero ambiri omwe akupitilira akupitiliza kufufuza mankhwala atsopano. Lumikizanani ndi dokotala wanu ndikukambirana za mankhwala omwe angakhale oyenera kwa inu.