Zatsopano ndi Zotani za PPMS? Upangiri Wothandizira

Zamkati

• Kafukufuku wamankhwala ochokera ku NINDS
• Mankhwala ochiritsira
• Gene kusintha
• Malangizo okonzanso
• Thandizo lakuthupi ndi kafukufuku pa masewera olimbitsa thupi
• Zatsopano pantchito yothandizira
• Mayesero azachipatala a PPMS
• Tsogolo la chithandizo cha PPMS

Zowonjezera mu Multiple Sclerosis Treatment

Primary progressive multiple sclerosis (PPMS) ilibe mankhwala, koma pali njira zambiri zothanirana ndi vutoli. Chithandizo chimayang'ana pakuchepetsa zizindikilo ndikuchepetsa kuthekera kwa kulumala kwamuyaya.

Dokotala wanu ayenera kukhala gwero lanu loyamba pochiza PPMS. Amatha kukupatsani upangiri woyang'anira momwe angayang'anire kukula kwa matendawa.

Komabe, mungakhalebe ndi chidwi chofufuza zowonjezera zothandizira mankhwala a PPMS. Phunzirani za mwayi pano.

Kafukufuku wamankhwala ochokera ku NINDS

National Institute of Neurological Disorders and Stroke (NINDS) imachita kafukufuku wopitilira mitundu yonse ya multiple sclerosis (MS).

NINDS ndi nthambi ya National Institutes of Health (NIH), ndipo imathandizidwa ndi ndalama zaboma. NINDS pakadali pano ikufufuza zamankhwala omwe amatha kusintha myelin ndi majini omwe atha kulepheretsa kuyambika kwa PPMS.

Mankhwala ochiritsira

Mu 2017, ocrelizumab (Ocrevus) adavomerezedwa ndi Food and Drug Administration (FDA) kuti amuthandize PPMS ndikubwezeretsanso MS (RRMS). Mankhwala ojambulidwa ndi mankhwala oyamba komanso okhawo a PPMS pamsika.

Malinga ndi NINDS, mankhwala ena omwe akupanga chitukuko amawonetsanso lonjezo. Mankhwalawa amatha kugwira ntchito poletsa maselo a myelin kuti asatenthe ndikusanduka zilonda. Amatha kuteteza maselo a myelin kapena kuwathandiza kuwakonza pambuyo poti awopsa.

Mankhwala amlomo cladribine (Mavenclad) ndi amodzi mwa zitsanzo.

Mankhwala ena omwe akufufuzidwa atha kupititsa patsogolo kukula kwa ma oligodendrocyte. Oligodendrocyte ndimaselo amtundu waubongo omwe angathandize pakupanga maselo atsopano a myelin.

Gene kusintha

Chifukwa chenicheni cha PPMS - ndi MS chonse - sichidziwika. Gawo lachibadwa limaganiziridwa kuti limathandizira kukulitsa matenda. Ochita kafukufuku akupitiliza kuphunzira za majini mu PPMS.

NINDS imanena za majini omwe angapangitse kuti MS ikhale pachiwopsezo monga "majini omwe atengeke." Bungweli likuyang'ana mankhwala omwe amatha kusintha majiniwa MS isanatuluke.

Malangizo okonzanso

National Multiple Sclerosis Society ndi bungwe lina lomwe limapereka zosintha pazachipatala.

Mosiyana ndi NINDS, Sosaite ndi bungwe lopanda phindu. Ntchito yawo ndikufalitsa za MS komanso kusonkhetsa ndalama zothandizira kafukufuku wamankhwala.

Monga gawo la ntchito yake yothandizira oleza mtima, Sosaite imasinthiratu zomwe zili patsamba lake. Chifukwa zosankha mankhwala ndizochepa, mutha kupeza zothandizira anthu pakukonzanso zopindulitsa. Apa akufotokoza:

• chithandizo chamankhwala
• chithandizo pantchito
• kukonzanso kuzindikira
• mankhwala othandizira (pantchito)
• matenda olankhula

Njira zochiritsira zakuthupi ndi zantchito ndizofala kwambiri pakukonzanso mu PPMS. Zotsatirazi ndi zina mwazinthu zatsopano zomwe zikukhudzana ndi mankhwala awiriwa.

Thandizo lakuthupi ndi kafukufuku pa masewera olimbitsa thupi

Thandizo lakuthupi (PT) limagwiritsidwa ntchito ngati njira yokhazikitsira mu PPMS. Zolinga za PT zimatha kusiyanasiyana kutengera kukula kwa zizindikilo zanu. Amagwiritsidwa ntchito makamaka ku:

• thandizani anthu omwe ali ndi PPMS kuchita ntchito za tsiku ndi tsiku
• kulimbikitsa ufulu
• sinthani chitetezo - mwachitsanzo, kuphunzitsa njira zoyeserera zomwe zitha kuchepetsa ngozi zakugwa
• kuchepetsa mwayi wolumala
• perekani chilimbikitso chamalingaliro
• kudziwa kufunikira kwa zida zothandizira kunyumba
• kusintha moyo wonse

Dokotala wanu angakulimbikitseni kulandira chithandizo chamankhwala mukangomupeza koyambirira. Kuchita mosamala za chithandizo chamankhwala ndikofunikira - musayembekezere mpaka zizindikilo zanu zitakula.

Kuchita masewera olimbitsa thupi ndi gawo lofunikira la PT. Zimathandizira kukonza mayendedwe anu, mphamvu, komanso mayendedwe anu kuti mukhalebe odziyimira panokha.

Ofufuza akupitilizabe kuyang'ana za maubwino ochita masewera olimbitsa thupi mu mitundu yonse ya MS. Malinga ndi National Multiple Sclerosis Society, masewera olimbitsa thupi sanalimbikitsidwe mpaka pakati pa zaka za m'ma 1990. Apa ndipomwe chiphunzitso chakuti kuchita masewera olimbitsa thupi sichinali chabwino kwa MS pamapeto pake chidasinthidwa.

Katswiri wanu wathanzi angakulimbikitseni kuchita masewera olimbitsa thupi omwe mungathe kuchita - mosatekeseka - pakati pa nthawi yoikidwiratu kuti mukhale ndi zizolowezi komanso kuti mukhale ndi mphamvu.

Zatsopano pantchito yothandizira

Chithandizo chantchito chikudziwikanso kuti ndichothandiza mu chithandizo cha PPMS. Itha kukhala yothandiza pakudziyang'anira pawokha komanso kuntchito, komanso itha kuthandizira:

• zosangalatsa
• zosangalatsa
• kucheza
• kudzipereka
• kasamalidwe ka nyumba

OT nthawi zambiri imadziwika kuti ndi yofanana ndi PT. Ngakhale mankhwalawa amathandizana, onse ali ndi udindo pazithandizo zosiyanasiyana za PPMS.

PT imatha kuthandizira mphamvu zanu zonse komanso kuyenda kwanu, ndipo OT imatha kuthandizira pazinthu zomwe zimakhudza ufulu wanu, monga kusamba ndi kuvala nokha. Ndikulimbikitsidwa kuti anthu omwe ali ndi PPMS afunefune kuwunika kwa PT ndi OT komanso chithandizo chotsatira.

Mayesero azachipatala a PPMS

Muthanso kuwerenga zamankhwala omwe akutuluka komanso akutuluka a PPMS ku ClinicalTrials.gov. Ili ndiye nthambi ina ya NIH. Ntchito yawo ndikupereka "nkhokwe ya maphunziro azachipatala omwe ali payekha komanso pagulu omwe amachitika padziko lonse lapansi."

Lowani "PPMS" mu gawo la "Chikhalidwe kapena matenda". Mupeza maphunziro ambiri okangalika komanso omaliza okhudzana ndi mankhwala ndi zina zomwe zingakhudze matendawa.

Kuphatikiza apo, mungaganizire nawo kutenga nawo mbali pachipatala. Uku ndikudzipereka kwakukulu. Kuti muwonetsetse kuti muli otetezeka, muyenera kukambirana zamankhwala ndi dokotala poyamba.

Tsogolo la chithandizo cha PPMS

Palibe mankhwala a PPMS, ndipo zosankha zamankhwala ndizochepa. Kafukufuku akuchitikabe kuti mufufuze mankhwala osokoneza bongo kupatula ocrelizumab omwe angathandize kuwongolera zizindikilo zomwe zikupita patsogolo.

Kuphatikiza pakulankhula ndi dokotala wanu pafupipafupi, gwiritsani ntchito izi kuti mudziwe zamtundu waposachedwa pakufufuza kwa PPMS. Ntchito zambiri zikuchitika kuti mumvetse bwino PPMS ndikuwathandiza anthu moyenera.