Nicotinamide Riboside: Ubwino, Zotsatira zoyipa ndi Mlingo

Zamkati

• Kodi Nicotinamide Riboside ndi Chiyani?
• Zopindulitsa
• Kutembenuzidwa Mosavuta Kukhala NAD +
• Amayambitsa ma enzyme omwe angalimbikitse ukalamba wathanzi
• Angathandize Kuteteza Maselo Aubongo
• Matenda Ochepetsa Matenda a Mtima
• Zopindulitsa Zina
• Zowopsa Zomwe Zingachitike ndi Zotsatira Zake
• Mlingo ndi Malangizo
• Mfundo Yofunika Kwambiri

Chaka chilichonse, aku America amawononga ndalama mabiliyoni ambiri pazinthu zotsutsana ndi ukalamba.

Ngakhale mankhwala ambiri olimbana ndi ukalamba amayesa kusinthira zizindikiro zakukalamba pakhungu lanu, nicotinamide riboside - yomwe imadziwikanso kuti niagen - imafuna kuthana ndi zizindikiro zakukalamba zomwe zili mkati mwa thupi lanu.

M'thupi lanu, nicotinamide riboside imasandulika NAD +, molekyulu yothandizira yomwe imakhalapo mkati mwa maselo anu onse ndipo imathandizira mbali zambiri za ukalamba wathanzi.

Nkhaniyi ikufotokoza zonse zomwe muyenera kudziwa za nicotinamide riboside, kuphatikiza maubwino ake, zoyipa zake ndi kuchuluka kwake.

Kodi Nicotinamide Riboside ndi Chiyani?

Nicotinamide riboside, kapena niagen, ndi mitundu ina ya vitamini B3, yotchedwanso niacin.

Monga mitundu ina ya vitamini B3, nicotinamide riboside imasinthidwa ndi thupi lanu kukhala nicotinamide adenine dinucleotide (NAD +), coenzyme kapena molekyulu yothandizira.

NAD + imagwira ntchito ngati mafuta pazinthu zofunikira kwambiri zamoyo, monga (,):

• Kusintha chakudya kukhala mphamvu
• Kukonza DNA yowonongeka
• Kulimbitsa chitetezo cha ma cell
• Kukhazikitsa wotchi yamkati yamthupi lanu kapena chizungulire cha circadian

Komabe, kuchuluka kwa NAD + m'thupi lanu mwachilengedwe kumagwa ndi zaka ().

Magulu otsika a NAD + adalumikizidwa ndi zovuta zathanzi monga ukalamba ndi matenda osachiritsika, monga matenda ashuga, matenda amtima, matenda a Alzheimer's komanso kutayika kwamaso ().

Chosangalatsa ndichakuti, kafukufuku wazinyama wapeza kuti kukweza milingo ya NAD + kumatha kuthandizira kusintha zizindikilo za ukalamba ndikuchepetsa chiopsezo cha matenda ambiri okhalitsa (,,).

Zowonjezera za Nicotinamide riboside - monga niagen - zayamba kutchuka chifukwa zimawoneka ngati zothandiza kwambiri pakukweza milingo ya NAD + ().

Nicotinamide riboside imapezekanso motsatira mkaka wa ng'ombe, yisiti ndi mowa ().

Nicotinamide riboside, kapena niagen, ndi mtundu wina wa vitamini B3. Amalimbikitsidwa ngati mankhwala odana ndi ukalamba chifukwa amalimbikitsa thupi lanu NAD +, lomwe limakhala ngati mafuta pazinthu zazikuluzikulu zachilengedwe.

Zopindulitsa

Chifukwa kafukufuku wambiri pa nicotinamide riboside ndi NAD + amachokera ku maphunziro a nyama, palibe zomveka bwino zomwe zingapangidwe pazothandiza kwa anthu.

Izi zati, Nazi zina mwaubwino wa nicotinamide riboside.

Kutembenuzidwa Mosavuta Kukhala NAD +

NAD + ndi coenzyme, kapena molekyulu yothandizira, yomwe imatenga nawo gawo pazambiri zachilengedwe.

Ngakhale ndizofunikira kuti munthu akhale ndi thanzi labwino, kafukufuku akuwonetsa kuti milingo ya NAD + ikupitilira kuchepa ndi ukalamba. Magawo otsika a NAD + amalumikizidwa ndi ukalamba wosauka komanso matenda osiyanasiyana owopsa (,).

Njira imodzi yokwezera milingo ya NAD + ndikugwiritsa ntchito oyambira a NAD + - zomangira za NAD + - monga nicotinamide riboside.

Kafukufuku wazinyama akuwonetsa kuti nicotinamide riboside imakweza milingo yamagazi NAD + mpaka nthawi 2.7. Kuphatikiza apo, imagwiritsidwa ntchito mosavuta ndi thupi lanu kuposa ena amtsogolo a NAD + ().

Amayambitsa ma enzyme omwe angalimbikitse ukalamba wathanzi

Nicotinamide riboside imathandizira kukulitsa milingo ya NAD + mthupi lanu.

Poyankha, NAD + imayambitsa ma enzyme ena omwe amalimbikitsa ukalamba wathanzi.

Gulu limodzi ndi ma sirtuin, omwe amawoneka kuti amasintha moyo wamoyo komanso thanzi la nyama. Kafukufuku akuwonetsa kuti ma sirtiins amatha kukonza DNA yowonongeka, kuwonjezera kupsinjika, kuchepetsa kutupa komanso kupereka maubwino ena omwe amalimbikitsa ukalamba wathanzi (,,).

Sirtuins nawonso ali ndi udindo pantchito yopititsa patsogolo kuletsa kwa kalori ().

Gulu lina ndi Poly (ADP-Ribose) polymerases (PARPs), omwe amakonza DNA yowonongeka. Kafukufuku amalumikiza zochitika zapamwamba za PARP ndikuchepetsa kuwonongeka kwa DNA komanso moyo wautali (,).

Angathandize Kuteteza Maselo Aubongo

NAD + imathandiza kwambiri kuti maselo a ubongo wanu azikula bwino.

M'maselo aubongo, NAD + imathandizira kuwongolera kupanga kwa PGC-1-alpha, puloteni yomwe imawoneka ngati ikuthandiza kuteteza maselo motsutsana ndi kupsinjika kwa oxidative komanso kusokonekera kwa mitochondrial function ().

Ofufuzawo amakhulupirira kuti kupsinjika kwa oxidative komanso kuchepa kwa ntchito ya mitochondrial kumalumikizidwa ndi zovuta zokhudzana ndi ukalamba monga matenda a Alzheimer's and Parkinson's (,,).

Mu mbewa zomwe zili ndi matenda a Alzheimer's, nicotinamide riboside idakweza milingo ya ubongo NAD + ndi PGC-1-alpha yopanga mpaka 70% ndi 50%, motsatana. Pakutha phunziroli, mbewa zimachita bwino kwambiri pantchito zokumbukira ().

Pakafukufuku wa chubu, nicotinamide riboside idakweza milingo ya NAD + ndipo idasintha magwiridwe antchito a mitochondrial m'maselo otengedwa kuchokera kwa wodwala matenda a Parkinson ().

Komabe, sizikudziwikabe kuti ndizothandiza bwanji kukweza milingo ya NAD + mwa anthu omwe ali ndi vuto laubongo okhudzana ndi ukalamba. Maphunziro owonjezera aanthu amafunikira.

Matenda Ochepetsa Matenda a Mtima

Ukalamba ndi chiopsezo chachikulu cha matenda amtima, chomwe chimayambitsa imfa ().

Zitha kupangitsa kuti mitsempha yamagazi monga aorta yanu ikhale yolimba, yolimba komanso yosasintha.

Kusintha koteroko kumakweza kuthamanga kwa magazi ndikupangitsa mtima wanu kugwira ntchito molimbika.

Mwa nyama, kulera NAD + kunathandiza kusintha kusintha kwaukalamba pamitsempha ().

Mwa anthu, nicotinamide riboside idakweza milingo ya NAD +, idathandizira kuchepetsa kuuma kwa aorta ndikutsitsa kuthamanga kwa magazi kwa akulu omwe ali pachiwopsezo cha kuthamanga kwa magazi (22).

Izi zati, kufufuza kwina kwa anthu kumafunikira.

Zopindulitsa Zina

Kuphatikiza apo, nicotinamide riboside itha kuperekanso maubwino ena angapo:

• Mulole thandizo kuwonda: Nicotinamide riboside idathandizira kufulumizitsa kagayidwe ka mbewa. Komabe, sizikudziwika ngati zingakhudze momwemonso mwa anthu komanso momwe zotsatirazi zilili zamphamvu ().
• Mutha kuchepetsa chiopsezo cha khansa: Mulingo wapamwamba wa NAD + umathandizira kuteteza kuwonongeka kwa DNA komanso kupsinjika kwa oxidative, komwe kumalumikizidwa ndi chitukuko cha khansa (,).
• Zitha kuthandizira kuthana ndi ma jet: NAD + imathandizira kuwongolera nthawi yamkati yamthupi lanu, chifukwa chake kutenga niagen kumatha kuthandizira kuthana ndi jet lag kapena zovuta zina za circadian pokhazikitsanso wotchi yamkati ya thupi lanu ().
• Limbikitsani ukalamba wathanzi: Kukweza milingo ya NAD + kudathandizira kukonza minofu, mphamvu ndi kupirira mbewa zakale (,).

Nicotinamide riboside imathandizira kuchuluka kwa NAD +, komwe kumalumikizidwa ndi zabwino zomwe zingachitike pokhudzana ndi ukalamba, thanzi laubongo, chiwopsezo cha matenda amtima ndi zina zambiri.

Zowopsa Zomwe Zingachitike ndi Zotsatira Zake

Nicotinamide riboside ndiyotetezeka ndi zovuta zochepa - ngati zilipo.

M'maphunziro aumunthu, kutenga 1,000-2,000 mg patsiku sikunakhale ndi zotsatirapo zoyipa (,).

Komabe, maphunziro ambiri aanthu ndi achidule ndipo amakhala ndi ochepa omwe amatenga nawo mbali. Kuti mumve bwino za chitetezo chake, maphunziro aumunthu olimba amafunikira.

Anthu ena anena zoyipa zochepa, monga kunyoza, kutopa, kupweteka mutu, kutsegula m'mimba, kusapeza m'mimba komanso kudzimbidwa ().

Zinyama, kutenga 300 mg pa kg ya kulemera kwa thupi (136 mg pa paundi) tsiku lililonse masiku 90 sikunakhale ndi zotsatirapo zoipa ().

Kuphatikiza apo, mosiyana ndi mavitamini B3 (niacin) othandizira, nicotinamide riboside sayenera kuyambitsa nkhope kumaso ().

Nicotinamide riboside imawoneka ngati yotetezeka ndi zovuta zina zochepa. Komabe, zotsatira zake kwakanthawi kwa anthu sizidziwikabe.

Mlingo ndi Malangizo

Nicotinamide riboside imapezeka piritsi kapena kapisozi ndipo imadziwika kuti niagen.

Amapezeka m'masitolo osankhika azakudya, pa Amazon kapena kudzera kwa ogulitsa pa intaneti.

Mankhwala a Niagen amakhala ndi nicotinamide riboside yokha, koma opanga ena amawaphatikiza ndi zinthu zina monga Pterostilbene, yomwe ndi polyphenol - antioxidant yomwe imafanana ndi resveratrol ().

Mitundu yambiri yama niagen imalimbikitsa kumwa 250-300 mg patsiku, ofanana ndi makapisozi 1-2 patsiku kutengera mtundu.

Ambiri opanga ma niagen amalimbikitsa kutenga 250-300 mg wa nicotinamide riboside patsiku.

Mfundo Yofunika Kwambiri

Nicotinamide riboside ndi mtundu wina wa vitamini B3 wokhala ndi zovuta zochepa. Amakonda kugulitsidwa ngati chinthu chotsutsa ukalamba.

Thupi lanu limasandulika kukhala NAD +, yomwe imayatsa maselo anu onse. Ngakhale milingo ya NAD + imagwera mwachilengedwe ndi ukalamba, kuwonjezera ma NAD + kumatha kusintha zizindikilo zingapo zakukalamba.

Komabe, kafukufuku wambiri pa nicotinamide riboside ndi NAD + ali munyama. Maphunziro owonjezera apamwamba kwambiri amafunika asanavomerezedwe ngati chithandizo.