Kodi Therapy Phage Ndi Chiyani?

Zamkati

• Njira yosiyana yolimbana ndi mabakiteriya
• Momwe mankhwala a phage amagwirira ntchito
• Therapy ya Phage motsutsana ndi maantibayotiki
• 1. Maantibayotiki amalimbana ndi mabakiteriya amtundu umodzi
• 2. Maantibayotiki amatha kuyambitsa "superbugs"
• Phindu limathandizira
• Phage chithandizo
• Ntchito ya Phage ku United States
• Makampani azakudya
• Zinthu zomwe zingapindule ndi mankhwala a phage
• Kutenga

Njira yosiyana yolimbana ndi mabakiteriya

Mankhwala a Phage (PT) amatchedwanso bacteriophage therapy. Amagwiritsa ntchito mavairasi kuthana ndi matenda a bakiteriya. Ma virus a bakiteriya amatchedwa phages kapena bacteriophages. Amangowononga mabakiteriya; mapaji alibe vuto kwa anthu, nyama, ndi zomera.

Bacteriophages ndi adani achilengedwe a mabakiteriya. Mawu oti bacteriophage amatanthauza "wakudya mabakiteriya." Amapezeka m'nthaka, zimbudzi, m'madzi, ndi m'malo ena mabakiteriya amakhala. Mavairasiwa amathandiza kuti mabakiteriya akule bwino.

Thandizo la Phage likhoza kumveka latsopano, koma lakhala likugwiritsidwa ntchito kwazaka zambiri. Komabe, mankhwalawa sadziwika bwino. Kafukufuku wochuluka amafunika pa bacteriophages. Chithandizo ichi cha mabakiteriya oyambitsa matenda atha kukhala njira yothandiza m'malo mwa maantibayotiki.

Momwe mankhwala a phage amagwirira ntchito

Bacteriophages amapha mabakiteriya powapangitsa kuti aphulike kapena kuyatsa. Izi zimachitika kachilomboka kakamangirira mabakiteriya. Tizilombo toyambitsa matenda timayambitsa mabakiteriya mwa kubayira majini ake (DNA kapena RNA).

Vuto la phage limadzikopera (limaberekana) mkati mwa mabakiteriya. Izi zitha kupanga ma virus atsopano mu bacteria iliyonse. Pomaliza, kachilomboka kamatsegula mabakiteriya, ndikutulutsa ma bacteriophage atsopano.

Bacteriophages amatha kuchulukana ndikukula mkati mwa bakiteriya.Mabakiteriya onse akadzasungunuka (atamwalira), amasiya kuchulukana. Monga mavairasi ena, mapages amatha kugona (moziziritsa) mpaka mabakiteriya ambiri atayamba kuwonekera.

Therapy ya Phage motsutsana ndi maantibayotiki

Maantibayotiki amatchedwanso anti-bakiteriya. Ndiwo njira yodziwika kwambiri yothandizira matenda opatsirana ndi mabakiteriya. Maantibayotiki ndi mankhwala kapena mankhwala omwe amawononga mabakiteriya mthupi lanu.

Maantibayotiki amapulumutsa miyoyo ndikutchinjiriza matenda kuti asafalikire. Komabe, atha kubweretsa mavuto awiri akulu:

1. Maantibayotiki amalimbana ndi mabakiteriya amtundu umodzi

Izi zikutanthauza kuti amatha kupha mabakiteriya oyipa komanso abwino mthupi lanu. Thupi lanu limafunikira mitundu ina ya mabakiteriya kuti ikuthandizeni kugaya chakudya, kupanga zakudya zina, komanso kukhala ndi thanzi labwino.

Mabakiteriya abwino amathandizanso kuyimitsa matenda ena a bakiteriya, mavairasi, ndi mafangasi kuti asakule mthupi lanu. Ichi ndichifukwa chake maantibayotiki amatha kuyambitsa zovuta monga:

• kukhumudwa m'mimba
• nseru ndi kusanza
• kuphwanya
• Kutupa ndi gassiness
• kutsegula m'mimba
• matenda a yisiti

2. Maantibayotiki amatha kuyambitsa "superbugs"

Izi zikutanthauza kuti m'malo moima, mabakiteriya ena amalimbana ndi mankhwala kapena mankhwala. Kukana kumachitika mabakiteriya amasintha kapena kusintha kuti akhale olimba kuposa maantibayotiki.

Amatha kufalitsa "mphamvu zazikuluzikulu" izi kwa mabakiteriya ena. Izi zitha kuyambitsa matenda owopsa omwe sangachiritsidwe. Mabakiteriya osachiritsika amatha kupha.

Gwiritsani ntchito maantibayotiki moyenera kuti muteteze mabakiteriya omwe sagonjetsedwa. Mwachitsanzo:

• Gwiritsani ntchito maantibayotiki pamagulu abacteria. Maantibayotiki sachiza matenda opatsirana ngati ma chimfine, chifuwa, ndi bronchitis.
• Musagwiritse ntchito maantibayotiki ngati simukuwafuna.
• Musakakamize dokotala wanu kuti akupatseni inu kapena mwana wanu maantibayotiki.
• Tengani maantibayotiki onse monga momwe amafunira.
• Malizitsani mlingo wonse wa maantibayotiki, ngakhale mutakhala bwino.
• Musamwe maantibayotiki omwe atha ntchito.
• Ponyani maantibayotiki omwe atha ntchito kapena omwe sanagwiritsidwe ntchito.

Phindu limathandizira

Ubwino wothandizila kuthana ndi zovuta za maantibayotiki.

Monga momwe pali mitundu yambiri ya mabakiteriya, pali mitundu ingapo yama bacteriophages. Koma mtundu uliwonse wa phage umangolimbana ndi bakiteriya winawake. Sichidzatengera mitundu ina ya mabakiteriya.

Izi zikutanthauza kuti phage itha kugwiritsidwa ntchito kuthana ndi mabakiteriya oyambitsa matenda. Mwachitsanzo, strep bacteriophage imangopha mabakiteriya omwe amayambitsa matenda am'mero.

Kafukufuku wa 2011 adalemba zina mwa ma bacteriophages:

• Phages imagwira ntchito motsutsana ndi mabakiteriya onse ochiritsika komanso opha maantibayotiki.
• Angagwiritsidwe ntchito payekha kapena ndi maantibayotiki ndi mankhwala ena.
• Phages amachulukitsa ndikuwonjezekera palokha pa nthawi ya chithandizo (pamafunika mlingo umodzi wokha).
• Amangosokoneza pang'ono mabakiteriya "abwino" mthupi.
• Phages ndi achilengedwe komanso osavuta kupeza.
• Sizowopsa (poizoni) mthupi.
• Sali owopsa kwa nyama, zomera, komanso chilengedwe.

Phage chithandizo

Ma bacteriophage sanagwiritsidwebe ntchito pano. Mankhwalawa amafunikira kafukufuku wambiri kuti adziwe momwe zimagwirira ntchito. Sizikudziwika ngati mapaji atha kuvulaza anthu kapena nyama m'njira zosagwirizana ndikuwongolera poyizoni.

Kuphatikiza apo, sizikudziwika ngati mankhwala a phage atha kuyambitsa mabakiteriya kukhala olimba kuposa bacteriophage, zomwe zimayambitsa kukana kwa phage.

Kuipa kwa mankhwala a phage ndi awa:

• Phages pakadali pano ndi kovuta kukonzekera kuti igwiritsidwe ntchito mwa anthu ndi nyama.
• Sidziwika kuti ndi mlingo kapena kuchuluka kwa mapaji omwe ayenera kugwiritsidwa ntchito.
• Sidziwika kuti mankhwalawa amatha kutenga nthawi yayitali bwanji kuti agwire ntchito.
• Kungakhale kovuta kupeza phage yeniyeni yofunikira kuchiza matenda.
• Phages imatha kuyambitsa chitetezo cha mthupi kutengeka kapena kuyambitsa kusamvana.
• Mitundu ina ya mapaji siyigwiranso ntchito ngati mitundu ina yochizira matenda a bakiteriya.
• Mwina sipangakhale mitundu yokwanira yothanirana matenda onse a bakiteriya.
• Ziphuphu zina zimatha kupangitsa kuti mabakiteriya akhale olimba.

Ntchito ya Phage ku United States

Mankhwala a Phage sanavomerezedwebe kwa anthu ku United States kapena ku Europe. Pakhala pali kuyesa kwa phage koyeserera kamodzi kokha.

Chifukwa chimodzi cha izi ndi chakuti maantibayotiki amapezeka mosavuta ndipo amaonedwa kuti ndi otetezeka kugwiritsa ntchito. Pali kafukufuku wopitilira wa momwe mungagwiritsire ntchito bacteriophages mwa anthu ndi nyama. Chitetezo cha mankhwala a phage chimafunikanso kafukufuku wina.

Makampani azakudya

Mankhwala a Phage akugwiritsidwanso ntchito m'makampani azakudya, komabe. US Food and Drug Administration (FDA) yavomereza zosakaniza zina za phage kuti zithandize kuletsa mabakiteriya kukula m'zakudya. Mankhwalawa amatha kuteteza mabakiteriya omwe angayambitse poizoni, monga:

• Salmonella
• Listeria
• E. coli
• Mycobacterium chifuwa chachikulu
• Msika
• Pseudomonas

Ma phages amawonjezeredwa pazakudya zina zopangidwa kuti zithandizire kupewa bakiteriya kukula.

Ntchito ina yothandizira phage yomwe ikuyesedwa imaphatikizapo kuwonjezera ma bacteriophages pazinthu zotsukira kuti ziwononge mabakiteriya pamtunda. Izi zitha kukhala zopindulitsa muzipatala, malo odyera, ndi malo ena.

Zinthu zomwe zingapindule ndi mankhwala a phage

Thandizo la Phage lingakhale lofunikira kwambiri pochiza matenda omwe samayankha maantibayotiki. Mwachitsanzo, itha kugwiritsidwa ntchito motsutsana ndi wamphamvu Staphylococcus(staph) matenda a bakiteriya otchedwa MRSA.

Pakhala pali milandu yopambana yogwiritsa ntchito mankhwala a phage. Nkhani imodzi yopambana yotereyi idakhudza bambo wazaka 68 ku San Diego, California, yemwe adalandira mtundu wina wa mabakiteriya omwe amalimbana nawo Acinetobacter baumannii.

Pambuyo pa miyezi yopitilira itatu akuyesera maantibayotiki, madokotala ake adatha kuletsa matendawa ndi ma bacteriophages.

Kutenga

Mankhwala a Phage siachilendo, koma kugwiritsa ntchito kwake mwa anthu ndi nyama nawonso sikunafufuzidwe bwino. Kafukufuku wapano komanso milandu yabwino ingatanthauze kuti zitha kukhala zofala. Popeza mankhwala a phage amawerengedwa kuti ndi otetezeka komanso ovomerezeka kuti agwiritsidwe ntchito pamakampani azakudya, izi zitha kukhala posachedwa.

Mankhwala a Phage ndi "maantibayotiki" achilengedwe ndipo atha kukhala njira yabwino yothandizira. Zitha kupindulitsanso ntchito zina monga mankhwala ophera tizilombo ndi chipatala. Kafukufuku wochuluka amafunika musanavomereze kugwiritsa ntchito anthu.