Zithandizo za psoriasis: mafuta ndi mapiritsi

Zamkati

• Mankhwala apakhungu (mafuta odzola)
• 1. Ma Corticoids
• 2. Calcipotriol
• 3. Zodzitetezera ndi zotulutsa
• Njira zothandiza piritsi (mapiritsi)
• 1. Acitretin
• 2. Methotrexate
• 3. Cyclosporine
• 4. Tizilombo toyambitsa matenda

Psoriasis ndi matenda osachiritsika komanso osachiritsika, komabe, ndizotheka kuthetsa zizindikilo ndikuwonjezera kukhululukidwa kwa matendawa kwakanthawi kochepa ndi chithandizo choyenera.

Chithandizo cha psoriasis chimadalira mtundu, malo komanso kukula kwa zotupazo, ndipo zitha kuchitidwa ndi mafuta kapena mafuta opaka ndi corticosteroids ndi retinoids kapena mankhwala am'kamwa, monga cyclosporine, methotrexate kapena acitretin, mwachitsanzo, pamalangizo a dokotala.

Kuphatikiza pa chithandizo chamankhwala, ndikofunikanso kusungunula khungu tsiku lililonse, makamaka zigawo zomwe zakhudzidwa, komanso kupewa zinthu zopweteka kwambiri zomwe zimayambitsa kukwiya pakhungu komanso kuwuma kwambiri.

Zina mwa mankhwala omwe nthawi zambiri amapatsidwa ndi dokotala kuti azitha psoriasis ndi awa:

Mankhwala apakhungu (mafuta odzola)

1. Ma Corticoids

Matenda a corticosteroids ndi othandiza kuthana ndi zodandaula, makamaka ngati matendawa amangokhala kudera laling'ono, ndipo amatha kulumikizidwa ndi mankhwala a calcipotriol ndi systemic.

Zitsanzo zina za topical corticosteroids zomwe zimagwiritsidwa ntchito pochiza psoriasis ndi clobetasol cream kapena 0.05% capillary solution ndi dexamethasone cream 0.1%, mwachitsanzo.

Yemwe sayenera kugwiritsa ntchito: anthu omwe ali ndi hypersensitivity kuzipangizo, omwe ali ndi zotupa pakhungu zomwe zimayambitsidwa ndi mavairasi, bowa kapena mabakiteriya, anthu omwe ali ndi rosacea kapena dermatitis yosalamulira.

Zotsatira zoyipa: kuyabwa, kupweteka ndi kutentha pakhungu.

2. Calcipotriol

Calcipotriol ndi analogue ya vitamini D, yomwe imapezeka pa 0,005% pochiza psoriasis, chifukwa imathandizira kuchepetsa mapangidwe a psoriatic plaque. Nthawi zambiri, calcipotriol imagwiritsidwa ntchito limodzi ndi corticosteroid.

Yemwe sayenera kugwiritsa ntchito: anthu hypersensitivity ku zigawo zikuluzikulu ndi hyperkalaemia.

Zotsatira zoyipa: khungu kuyabwa, zidzolo, kumva kulasalasa, keratosis, kuyabwa, erythema ndi kukhudzana dermatitis.

3. Zodzitetezera ndi zotulutsa

Mafuta odzola ndi mafuta opaka mafuta ayenera kugwiritsidwa ntchito tsiku lililonse, makamaka ngati chithandizo chamankhwala atagwiritsidwa ntchito ndi corticosteroids, yomwe imathandiza kupewa kubwereranso kwa anthu omwe ali ndi psoriasis wofatsa.

Mafuta awa ndi mafuta onunkhira ayenera kukhala ndi urea m'magawo omwe amatha kusiyanasiyana pakati pa 5% mpaka 20% ndi / kapena salicylic acid pakati pa 3% ndi 6%, kutengera mtundu wa khungu ndi kuchuluka kwa sikelo.

Njira zothandiza piritsi (mapiritsi)

1. Acitretin

Acitretin ndi retinoid yomwe nthawi zambiri imawonetsedwa kuti imathandizira mitundu yayikulu ya psoriasis pakafunika kupewa kupewa kuponderezedwa ndi magazi ndipo imapezeka mu 10 mg kapena 25 mg.

Yemwe sayenera kugwiritsa ntchito: anthu omwe ali ndi hypersensitivity kuzipangizo, amayi apakati ndi amayi omwe akufuna kukhala ndi pakati pazaka zikubwerazi, amayi omwe akuyamwitsa komanso anthu omwe ali ndi chiwindi kapena impso zolephera

Zotsatira zoyipa: kupweteka kwa mutu, kuuma ndi kutupa kwa nembanemba wam'mimba, mkamwa mouma, ludzu, thrush, matenda am'mimba, cheilitis, kuyabwa, kutayika kwa tsitsi, kuphulika mthupi lonse, kupweteka kwa minofu, kuchuluka kwama cholesterol m'magazi ndi triglycerides ndi edema wamba.

2. Methotrexate

Methotrexate imasonyezedwa pochiza psoriasis yoopsa, chifukwa imachepetsa kuchuluka ndi kutupa kwa khungu. Izi zimapezeka m'mapiritsi a 2.5 mg kapena ma 50 amp / 2mL ampoules.

Yemwe sayenera kugwiritsa ntchito: anthu omwe ali ndi hypersensitivity ku zigawozo, amayi apakati ndi omwe akuyamwa, anthu omwe ali ndi matenda enaake, matenda a ethyl, chiwindi, chiwindi, kufooka kwa chiwindi, matenda akulu, immunodeficiency syndromes, aplasia kapena spinal hypoplasia, thrombocytopenia kapena kuchepa kwa magazi m'thupi komanso pachimake pachimake pamimba.

Zotsatira zoyipa: kupweteka kwa mutu, kuuma kwa khosi, kusanza, malungo, khungu lofiira, kuchuluka kwa uric acid, kuchepetsa kuchuluka kwa umuna mwa amuna, thrush, kutupa kwa lilime ndi nkhama, kutsegula m'mimba, kuchepa kwa magazi oyera ndi kuchuluka kwa ma platelet, kulephera kwa impso ndi pharyngitis.

3. Cyclosporine

Cyclosporine ndi mankhwala opatsirana pogonana omwe amawonetsedwa kuti amachiza psoriasis yayikulu, ndipo sayenera kupitirira zaka ziwiri.

Yemwe sayenera kugwiritsa ntchito: anthu omwe ali ndi hypersensitivity ku zigawo zikuluzikulu, matenda oopsa kwambiri, osakhazikika komanso osalamulirika ndi mankhwala osokoneza bongo, matenda opatsirana komanso khansa.

Zotsatira zoyipa: matenda a impso, matenda oopsa komanso kufooketsa chitetezo cha mthupi.

4. Tizilombo toyambitsa matenda

M'zaka zaposachedwa, chidwi chofuna kupanga zinthu zamoyo zomwe zimakhala ndi ma immunosuppressive omwe amasankha kuposa cyclosporine chawonjezeka pofuna kukonza mbiri ya mankhwala a psoriasis.

Zitsanzo zina zamagetsi zomwe zapangidwa posachedwapa zochizira psoriasis ndi izi:

• Adalimumab;
• Etanercept;
• Infliximab;
• Ustecinumab;
• Mphotho.

Gulu latsopanoli la mankhwala limakhala ndi mapuloteni kapena ma monoclonal antibodies opangidwa ndi zamoyo, pogwiritsa ntchito recombinant biotechnology, yomwe yawonetsa kusintha kwa zotupa ndikuchepetsa kuwonjezera kwawo.

Yemwe sayenera kugwiritsa ntchito: anthu omwe ali ndi hypersensitivity ku zigawo zikuluzikulu, omwe ali ndi vuto la mtima, osachotsa matenda, mbiri yaposachedwa ya neoplasia, matenda opatsirana, kugwiritsa ntchito katemera wokhala ndi moyo komanso katemera wa pakati.

Zotsatira zoyipa: zochita za jakisoni, matenda, chifuwa chachikulu, khungu, zotupa, matenda opatsirana, kupweteka mutu, chizungulire, kutsegula m'mimba, kuyabwa, kupweteka kwa minofu ndi kutopa.