Chithandizo cha Cell Cell cha Matenda Owononga Matenda Opatsirana (COPD)

Zamkati

• Kumvetsetsa COPD
• Maselo opangira zida 101
• Zopindulitsa za COPD
• Kafukufuku wapano
• Mwa nyama
• Mwa anthu
• Tengera kwina

Kumvetsetsa COPD

Matenda osokoneza bongo (COPD) ndimatenda am'mapapo omwe amapangitsa kuti zikhale zovuta kupuma.

Malinga ndi American Lung Association, anthu opitilira 16.4 miliyoni ku United States apezeka ndi matendawa. Komabe, akuti anthu enanso 18 miliyoni atha kukhala ndi COPD ndipo sakudziwa.

Mitundu ikuluikulu ya COPD ndi bronchitis yanthawi yayitali komanso emphysema. Anthu ambiri omwe ali ndi COPD ali ndi kuphatikiza zonse ziwiri.

Pakadali pano palibe mankhwala a COPD. Pali chithandizo chamankhwala chokhacho chomwe chingakuthandizeni kukhala ndi moyo wabwino komanso kuti muchepetse kukula kwa matendawa. Komabe, pali kafukufuku wodalitsika yemwe akuwonetsa kuti ma stem stem angathandize kuthana ndi matenda am'mapapowa.

Maselo opangira zida 101

Maselo opatsirana ndi ofunikira m'thupi lililonse ndipo amagawana zinthu zitatu zazikuluzikulu:

• Amatha kudzikonza okha kudzera m'magulu am'magulu.
• Ngakhale kuti poyamba sadziwika, amatha kudzisiyanitsa okha ndikukhala ndi mawonekedwe amitundu yosiyanasiyana, monga momwe kufunikira kungakhalire.
• Amatha kuikidwa m'thupi lina, momwe adzapitilizabe kugawikana ndikubwereza.

Maselo opatsirana amatha kupezeka m'maselo aanthu azaka 4 mpaka 5 omwe amatchedwa blastocysts. Mazirawa nthawi zambiri amapezeka kuchokera ku mu m'galasi umuna. Maselo ena amakhalanso m'magulu osiyanasiyana amthupi, kuphatikizapo ubongo, magazi, ndi khungu.

Maselo opatsirana amakhala nthawi yayitali mthupi la munthu wamkulu ndipo sagawanika pokhapokha atayatsidwa ndi chochitika, monga matenda kapena kuvulala.

Komabe, monga maselo am'mimba a embryonic, amatha kupanga ziwalo za ziwalo zina ndi ziwalo za thupi. Zitha kugwiritsidwa ntchito kuchiritsa kapena kusinthanso, kapena kuyambiranso, minofu yowonongeka.

Maselo amtunduwu amatha kutulutsidwa mthupi ndikulekanitsidwa ndi ma cell ena. Kenako amabwezeretsedwanso m'thupi, pomwe amatha kuyamba kulimbikitsa machiritso m'deralo.

Zopindulitsa za COPD

COPD imapangitsa kusintha m'mapapu ndi mpweya chimodzi kapena zingapo:

• Matumba ampweya ndi njira zapaulendo zimatha kutambasula.
• Makoma azikwama zam'mlengalenga amawonongeka.
• Makoma a mayendedwe apandege amakula ndikutupa.
• Maulendowa amakhala okuta ntchofu.

Kusintha kumeneku kumachepetsa kuchuluka kwa mpweya wolowa ndikutuluka m'mapapu, kumapangitsa thupi mpweya wofunikira kwambiri ndikupangitsa kuti kupuma kukhale kovuta.

Maselo amadzimadzi amatha kupindulitsa anthu omwe ali ndi COPD ndi:

• kuchepetsa kutupa m'mayendedwe amlengalenga, zomwe zingathandize kupewa kuwonongeka kwina
• Kumanga minofu yatsopano yamapapu, yomwe ingalowe m'malo mwa minofu yowonongeka m'mapapu
• kulimbikitsa mapangidwe a capillaries atsopano, omwe ndi mitsempha yaying'ono m'mapapu; izi zitha kupangitsa kuti mapapo agwire bwino ntchito

Kafukufuku wapano

Food and Drug Administration (FDA) sanavomereze njira iliyonse yothandizira anthu omwe ali ndi COPD, ndipo mayesero azachipatala sanapitirire gawo lachiwiri.

Gawo II ndipamene ochita kafukufuku amayesa kudziwa ngati chithandizo chimagwira ntchito komanso zovuta zake. Mpaka gawo lachitatu pomwe mankhwala omwe akufunsidwawo amafanizidwa ndi mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda omwewo.

Mwa nyama

M'maphunziro am'mbuyomu okhudza zinyama, mtundu wa tsinde wotchedwa cell mesenchymal stem cell (MSC) kapena mesenchymal stromal cell udakhala wodalirika kwambiri. Ma MSC ndimaselo olumikizana omwe amatha kusintha kukhala mitundu ingapo yama cell, kuchokera kuma cell cell mpaka kwamafuta amafuta.

Malinga ndi kafukufuku wamabuku a 2018, makoswe ndi mbewa zomwe zimadulidwa ndi ma MSC nthawi zambiri zimakulira kukulitsidwa ndi kutukusira kwa mlengalenga. Kukulitsa kwa malo ampweya ndi zotsatira za COPD, komanso emphysema makamaka, kuwononga makoma am'mapapu am'mapapo.

Mwa anthu

Kuyesedwa kwamankhwala mwa anthu sikupangabe zotsatira zabwino zomwe zimawonedwa mwa nyama.

Ofufuza akuti izi zidachitika pazinthu zingapo. Mwachitsanzo:

• Kafukufuku wamankhwala am'mbuyomu adagwiritsa ntchito nyama zokhala ndi matenda ofatsa a COPD, pomwe mayesero azachipatala amayang'ana anthu omwe ali ndi COPD yochepa.
• Nyamazo zidalandira kuchuluka kwa ma MSC, kutengera kulemera kwa thupi lawo, kuposa anthu. Izi zikunenedwa, maphunziro azachipatala pazinthu zina akuwonetsa kuti kuchuluka kwa maselo am'magazi sikumabweretsa zotsatira zabwino.
• Panali zosagwirizana pamitundu ya ma MSC omwe amagwiritsidwa ntchito. Mwachitsanzo, kafukufuku wina adagwiritsa ntchito timatumba tating'onoting'ono kapena tating'onoting'ono pomwe ena amagwiritsa ntchito atsopano.

Ngakhale kulibe umboni wamphamvu wosonyeza kuti mankhwala am'magazi amatha kusintha thanzi la anthu omwe ali ndi COPD, palibenso umboni wamphamvu wosonyeza kuti kupatsira ma cell ndikosavomerezeka.

Kafukufuku akupitilira mbali iyi, ndikuyembekeza kuti mayesero azachipatala opangidwa mosamala kwambiri atulutsa zotsatira zosiyanasiyana.

Tengera kwina

Ochita kafukufuku akuganiza kuti maselo am'madzi tsiku lina atha kugwiritsidwa ntchito popanga mapapu atsopano, athanzi mwa anthu omwe ali ndi matenda am'mapapo osachiritsika. Zingatenge zaka zingapo kafukufuku asanayambe kuyesa mankhwala opatsirana mwa anthu omwe ali ndi COPD.

Komabe, ngati chithandizochi chitha kubala zipatso, anthu omwe ali ndi COPD sangafunikirenso kuchita maopaleshoni owawa komanso owopsa. Zitha kuperekanso njira yoti mupeze mankhwala a COPD.