Tecfidera (dimethyl fumarate)

Zamkati

• Tecfidera ndi chiyani?
• Tecfidera dzina lenileni
• Zotsatira za Tecfidera
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• PML
• Kuthamanga
• Lymphopenia
• Zotsatira za chiwindi
• Kwambiri matupi awo sagwirizana anachita
• Chitupa
• Kutaya tsitsi
• Kulemera / kuwonda
• Kutopa
• Kupweteka m'mimba
• Kutsekula m'mimba
• Mphamvu pa umuna kapena chonde chamwamuna
• Mutu
• Kuyabwa
• Matenda okhumudwa
• Ziphuphu
• Khansa
• Nseru
• Kudzimbidwa
• Kuphulika
• Kusowa tulo
• Kulalata
• Ululu wophatikizana
• Pakamwa pouma
• Zotsatira pamaso
• Zizindikiro ngati chimfine
• Zotsatira zoyipa zazitali
• Tecfidera amagwiritsa ntchito
• Tecfidera ya MS
• Tecfidera wa psoriasis
• Njira zina ku Tecfidera
• Tecfidera vs. mankhwala ena
• Tecfidera vs. Aubagio
• Tecfidera vs. Copaxone
• Tecfidera vs. Ocrevus
• Tecfidera vs. Tysabri
• Tecfidera vs.Gilenya
• Tecfidera vs. interferon (Avonex, Rebif)
• Tecfidera vs. Protandim
• Mlingo wa Tecfidera
• Mlingo wa multiple sclerosis
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Momwe mungatengere Tecfidera
• Kusunga nthawi
• Kutenga Tecfidera ndi chakudya
• Kodi Tecfidera ingaphwanyidwe?
• Mimba ndi Tecfidera
• Kuyamwitsa ndi Tecfidera
• Momwe Tecfidera imagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Tecfidera ndi mowa
• Kuyanjana kwa Tecfidera
• Tecfidera ndi ocrelizumab (Ocrevus)
• Tecfidera ndi ibuprofen
• Tecfidera ndi aspirin
• Mafunso wamba onena za Tecfidera
• Nchifukwa chiyani Tecfidera imayambitsa kuthamanga?
• Kodi mungapewe bwanji kutuluka kuchokera ku Tecfidera?
• Kodi Tecfidera imakutopetsani?
• Kodi Tecfidera ndi immunosuppressant?
• Kodi ndiyenera kuda nkhawa zakudziwika ndi dzuwa ndikamamwa Tecfidera?
• Kodi Tecfidera ndi yothandiza motani?
• Chifukwa chiyani ndimakhala ndi mayendedwe osiyanasiyana sabata latha?
• Kodi ndiyenera kukayezetsa magazi ndili pa Tecfidera?
• Kuchuluka kwa Tecfidera
• Zizindikiro zambiri za bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Machenjezo a Tecfidera
• Kutha kwa Tecfidera
• Zambiri zamaluso za Tecfidera
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako
• Kulemba zambiri

Tecfidera ndi chiyani?

Tecfidera (dimethyl fumarate) ndi mankhwala olembedwa ndi dzina lodziwika. Amagwiritsidwa ntchito pochiza mitundu yobwereranso ya multiple sclerosis (MS).

Tecfidera amadziwika kuti ndi njira yosinthira matenda ku MS. Amachepetsa chiopsezo choti MS ayambiranso mpaka 49 peresenti pazaka ziwiri. Zimachepetsanso chiopsezo chokhala ndi chilema chowonjezeka chakuthupi pafupifupi 38%.

Tecfidera imabwera ngati kapisozi wotulutsa pakamwa wachedwa. Amapezeka mu mphamvu ziwiri: makapisozi a 120-mg ndi makapisozi a 240-mg.

Tecfidera dzina lenileni

Tecfidera ndi dzina la mankhwala osokoneza bongo. Sikupezeka pakadali pano ngati mankhwala achibadwa.

Tecfidera ili ndi mankhwala a dimethyl fumarate.

Zotsatira za Tecfidera

Tecfidera imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zovuta zina zomwe zingachitike mukamamwa Tecfidera. Mndandandawu sungaphatikizepo zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Tecfidera, kapena maupangiri amomwe mungachitire ndi zovuta zomwe zingachitike, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Tecfidera ndi monga:

• kutentha (kufiira kwa nkhope ndi khosi)
• kukhumudwa m'mimba
• kupweteka m'mimba
• kutsegula m'mimba
• nseru
• kusanza
• khungu loyabwa
• zidzolo

Zotsatirazi zimatha kuchepa kapena kutha pakangotha ​​milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala. Zotsatira zoyipa zingaphatikizepo izi:

• kuthamanga kwambiri
• kupita patsogolo kwa leukoencephalopathy (PML)
• kuchepa kwa maselo oyera a magazi (lymphopenia)
• kuwonongeka kwa chiwindi
• kwambiri thupi lawo siligwirizana

Onani pansipa kuti mumve zambiri pazovuta zilizonse zoyipa.

PML

Progressive multifocal leukoencephalopathy (PML) ndi matenda owopsa aubongo omwe amayamba chifukwa cha kachilombo ka JC. Nthawi zambiri zimangochitika mwa anthu omwe chitetezo chamthupi chawo sichikugwira bwino ntchito. Nthawi zambiri, PML yachitika mwa anthu omwe ali ndi MS omwe amatenga Tecfidera. Pazochitikazi, anthu omwe adayamba PML adachepetsanso magulu oyera amwazi.

Pofuna kupewa PML, dokotala wanu amayesa magazi nthawi zonse mukamalandira chithandizo kuti muwone kuchuluka kwama cell oyera. Ngati magulu anu atsika kwambiri, dokotala wanu angakulimbikitseni kuti musiye kumwa Tecfidera.

Dokotala wanu adzakuyang'anirani ngati muli ndi vuto la PML mukamamwa mankhwalawa. Zizindikiro zimaphatikizapo:

• kufooka mbali imodzi ya thupi lanu
• mavuto a masomphenya
• chibwibwi
• mavuto okumbukira
• chisokonezo

Ngati muli ndi zizindikirozi mukamamwa Tecfidera, itanani dokotala wanu nthawi yomweyo. Dokotala wanu angayese mayeso kuti muwone ngati muli ndi PML, ndipo atha kuyimitsa chithandizo chanu ndi Tecfidera.

Kuthamanga

Flushing (reddening kumaso kwanu kapena m'khosi) ndizomwe zimachitika chifukwa cha Tecfidera. Zimachitika mpaka 40 peresenti ya anthu omwe amamwa mankhwalawa. Zotsatira zamadzimadzi zimachitika mukangoyamba kumwa Tecfidera, kenako ndikusintha kapena kutha kwathunthu milungu ingapo.

Nthaŵi zambiri, kuthamanga kumakhala kovuta kwambiri ndipo zizindikiro zimaphatikizapo:

• kumverera kwa kutentha pakhungu
• khungu lofiira
• kuyabwa
• kumva kutentha

Kwa ena, zizindikilo zakutsuka zimatha kukhala zazikulu komanso zosapilira. Pafupifupi 3 peresenti ya anthu omwe amatenga Tecfidera amatha kusiya mankhwalawa chifukwa chothamanga kwambiri.

Kutenga Tecfidera ndi chakudya kungathandize kuchepetsa kuthamanga. Kutenga aspirin mphindi 30 musanatenge Tecfidera kungathandizenso.

Lymphopenia

Tecfidera imatha kuyambitsa lymphopenia, kuchepa kwa maselo oyera amwazi omwe amatchedwa ma lymphocyte. Lymphopenia imatha kuwonjezera chiopsezo chotenga matenda. Zizindikiro za lymphopenia zitha kuphatikizira:

• malungo
• ma lymph node owonjezera
• mafupa opweteka

Dokotala wanu adzayezetsa magazi asanafike komanso mukamamwa mankhwala ndi Tecfidera. Ngati kuchuluka kwanu kwa ma lymphocyte kumakhala kotsika kwambiri, dokotala wanu angakuuzeni kuti musiye kumwa Tecfidera kwakanthawi kokhazikika, kapena kwamuyaya.

Zotsatira za chiwindi

Tecfidera imatha kuyambitsa chiwindi. Itha kukulitsa michere yambiri ya chiwindi yomwe imayesedwa ndi kuyezetsa magazi. Kuwonjezeka kumeneku kumachitika m'miyezi isanu ndi umodzi yoyambirira yamankhwala.

Kwa anthu ambiri, kuwonjezeka kumeneku sikubweretsa mavuto. Koma kwa anthu ochepa, amatha kukhala owopsa ndikuwonetsa kuwonongeka kwa chiwindi. Zizindikiro za kuwonongeka kwa chiwindi zingaphatikizepo:

• kutopa
• kusowa chilakolako
• chikasu cha khungu lako kapena kuyera kwa maso ako

Musanalandire chithandizo chonse ndi Tecfidera, dokotala wanu amayesa magazi kuti muwone momwe chiwindi chanu chikuyendera. Ngati michere ya chiwindi yanu ichulukirachulukira, dokotala akhoza kukulepheretsani kumwa mankhwalawa.

Kwambiri matupi awo sagwirizana anachita

Kusintha kwakukulu, kuphatikizapo anaphylaxis, kumatha kuchitika kwa anthu ena omwe amatenga Tecfidera. Izi zitha kuchitika nthawi iliyonse mukamalandira chithandizo. Zizindikiro zosavomerezeka zitha kuphatikizira:

• kuvuta kupuma
• zotupa pakhungu kapena ming'oma
• kutupa kwa milomo yanu, lilime, mmero

Ngati simukugwirizana nazo, pitani kuchipatala nthawi yomweyo. Ngati matenda anu akukulira, itanani 911 kapena pitani kuchipinda chadzidzidzi chapafupi.

Ngati mudakumana ndi vuto linalake m'mbuyomu, mwina simungathenso kuyilandira. Kugwiritsanso ntchito mankhwalawa kumatha kupha. Ngati mudachitapo kanthu ndi mankhwalawa kale, lankhulani ndi dokotala musanamwe mankhwalawa.

Chitupa

Pafupifupi 8 peresenti ya anthu omwe amatenga Tecfidera amatupa khungu pang'ono atatenga Tecfidera kwa masiku angapo. Kuthamanga kumatha kuchoka ndikupitiliza kugwiritsidwa ntchito. Ngati sichichoka kapena chikhala chosokoneza, lankhulani ndi dokotala wanu.

Ziphuphu zikawoneka mwadzidzidzi mutamwa mankhwalawo, zimatha kukhala zosavomerezeka. Ngati mukuvutikanso kupuma kapena kutupa kwa milomo kapena lilime lanu, izi zitha kukhala zoyipa za anaphylactic. Ngati mukuganiza kuti mukuvutika ndi mankhwalawa, imbani 911.

Kutaya tsitsi

Kutayika kwa tsitsi si zotsatira zoyipa zomwe zachitika m'maphunziro a Tecfidera. Komabe, anthu ena omwe amatenga Tecfidera adataya tsitsi.

Mu lipoti lina, mayi yemwe adayamba kumwa Tecfidera adayamba kumeta tsitsi atamwa mankhwalawo kwa miyezi iwiri kapena itatu. Tsitsi lake linachepa atapitiliza kumwa mankhwalawo kwa miyezi iwiri, ndipo tsitsi lake linayambanso kukula.

Kulemera / kuwonda

Kulemera kwa thupi kapena kuchepa kwa thupi sizotsatira zoyipa zomwe zachitika m'maphunziro a Tecfidera. Komabe, anthu ena omwe amamwa mankhwalawa adayamba kunenepa. Ena adachepetsa thupi atatenga Tecfidera. Sizikudziwika ngati Tecfidera ndiyomwe imapangitsa kuti muchepetse kapena muchepetse.

Kutopa

Anthu omwe amatenga Tecfidera amatha kutopa. Pakafukufuku wina, kutopa kudachitika mwa 17 peresenti ya anthu omwe adatenga. Izi zimatha kuchepa kapena kuchokapo ndikupitiliza kugwiritsa ntchito mankhwalawa.

Kupweteka m'mimba

Pafupifupi 18 peresenti ya anthu omwe amatenga Tecfidera ali ndi ululu m'mimba. Izi zimakhala zofala kwambiri mwezi woyamba wamankhwala ndipo nthawi zambiri zimachepa kapena zimatha ndikumagwiritsabe ntchito mankhwalawa.

Kutsekula m'mimba

Pafupifupi 14 peresenti ya anthu omwe amatenga Tecfidera amatsekula m'mimba. Izi zimakhala zofala kwambiri mwezi woyamba wamankhwala ndipo nthawi zambiri zimachepa kapena zimatha ndikumagwiritsabe ntchito.

Mphamvu pa umuna kapena chonde chamwamuna

Kafukufuku waumunthu sanawunikire momwe Tecfidera imakhudzira umuna kapena chonde cha abambo. M'maphunziro azinyama, Tecfidera sizinakhudze chonde, koma kafukufuku wazinyama nthawi zonse samaneneratu zomwe zidzachitike mwa anthu.

Mutu

Anthu ena omwe amatenga Tecfidera amakhala ndi mutu. Komabe, sizikudziwika ngati Tecfidera ndiye woyambitsa. Pakafukufuku wina, 16 peresenti ya anthu omwe adatenga Tecfidera adadwala mutu, koma mutu umachitika kawirikawiri mwa anthu omwe amamwa mapiritsi a placebo.

Kuyabwa

Pafupifupi 8 peresenti ya anthu omwe amatenga Tecfidera amakhala ndi khungu loyabwa. Izi zimatha kupitilira kugwiritsa ntchito mankhwalawa. Ngati sichitha kapena ngati chingakuvutitseni, lankhulani ndi dokotala wanu.

Matenda okhumudwa

Anthu ena omwe amatenga Tecfidera amakhala ndi nkhawa. Komabe, sizikudziwika ngati Tecfidera ndiye woyambitsa. Kafukufuku wina, 8 peresenti ya anthu omwe adatenga Tecfidera anali ndi nkhawa, koma izi zimachitika kawirikawiri mwa anthu omwe amamwa mapiritsi a placebo.

Ngati muli ndi zizindikiro zakukhumudwa zomwe zimakuvutitsani, lankhulani ndi dokotala wanu za njira zokuthandizani kuti mukhale osangalala.

Ziphuphu

M'maphunziro azachipatala, Tecfidera sanawonjezere chiwopsezo cha ma shingles. Komabe, pali lipoti la ma shingles mwa mayi yemwe ali ndi multiple sclerosis yemwe adatenga Tecfidera.

Khansa

M'maphunziro azachipatala, Tecfidera sanawonjezere ngozi za khansa.M'malo mwake, ofufuza ena akufufuza ngati Tecfidera ingathandize kupewa kapena kuchiza khansa ina.

Nseru

Pafupifupi 12 peresenti ya anthu omwe amatenga Tecfidera amakhala ndi nseru. Izi zimatha kupitilira kugwiritsa ntchito mankhwalawa. Ngati sichitha kapena ngati chingakuvutitseni, lankhulani ndi dokotala wanu.

Kudzimbidwa

Kudzimbidwa sikunatchulidwepo m'maphunziro azachipatala a Tecfidera. Komabe, anthu omwe amatenga Tecfidera nthawi zina amatha kudzimbidwa. Sizikudziwika ngati izi ndi zotsatira zoyipa za Tecfidera.

Kuphulika

Kuphulika sikunatchulidwe m'maphunziro azachipatala a Tecfidera. Komabe, anthu omwe amatenga Tecfidera nthawi zina amatuluka. Sizikudziwika ngati izi ndi zotsatira zoyipa za Tecfidera.

Kusowa tulo

Kusowa tulo (kuvutika kugona kapena kugona) sikunachitike m'maphunziro azachipatala a Tecfidera. Komabe, anthu omwe amatenga Tecfidera nthawi zina amakhala ndi tulo. Sizikudziwika ngati izi ndi zotsatira zoyipa za mankhwalawa.

Kulalata

M'maphunziro azachipatala, Tecfidera sinawonjezere ngozi yakulakwitsa. Komabe, anthu ambiri omwe ali ndi MS amati nthawi zambiri amakhala ndi zipsera. Zomwe izi sizikudziwika. Malingaliro ochepa alembedwa pansipa.

• Pamene MS ikupita, kukhalabe olimba komanso kulumikizana kumatha kukhala kovuta kwambiri. Izi zitha kupangitsa kugundana ndi zinthu kapena kugwa, zonsezi zomwe zingayambitse kuvulaza.
• Munthu yemwe ali ndi MS yemwe amatenga Tecfidera amathanso kumwa aspirin kuti ateteze kuthamanga. Aspirin amatha kukulitsa mabala.
• Anthu omwe atenga ma steroids atha kukhala ndi khungu locheperako, lomwe lingawapangitse kuvulaza mosavuta. Chifukwa chake anthu omwe ali ndi MS omwe ali ndi mbiri yogwiritsa ntchito steroid atha kuvulazidwa kwambiri.

Ngati muli ndi nkhawa zovulaza mukamamwa Tecfidera, lankhulani ndi dokotala wanu. Dokotala wanu amatha kuyesa magazi kuti awone zifukwa zina.

Ululu wophatikizana

Kupweteka pamodzi kungachitike mwa anthu omwe amatenga Tecfidera. Pakafukufuku wina, anthu 12 pa 100 alionse omwe adatenga Tecfidera anali ndi ululu wophatikizana. Lipoti lina lidalongosola anthu atatu omwe anali ndi ululu wolumikizana pang'ono kapena waminyewa atayamba Tecfidera.

Izi zimatha kuchepa kapena kuchokapo ndikupitiliza kugwiritsa ntchito mankhwalawa. Kupweteka pamodzi kungathandizenso Tecfidera itayimitsidwa.

Pakamwa pouma

Mlomo wouma sunatchulidwe m'maphunziro azachipatala a Tecfidera. Komabe, anthu omwe amatenga Tecfidera nthawi zina amakhala ndi pakamwa pouma. Sizikudziwika ngati izi ndi zotsatira zoyipa za Tecfidera.

Zotsatira pamaso

Zotsatira zokhudzana ndi diso sizinaperekedwe m'maphunziro azachipatala a Tecfidera. Komabe, anthu ena omwe amamwa mankhwalawa anena kuti akhala ndi zizindikiro monga:

• maso owuma
• kugwedeza diso
• kusawona bwino

Sizikudziwika ngati zotsatirazi zamaso zimayambitsidwa ndi mankhwalawa kapena ndi chinthu china. Ngati muli ndi zotsatirazi ndipo sizipita kapena zimakhala zovuta, lankhulani ndi dokotala wanu.

Zizindikiro ngati chimfine

Chimfine kapena zizindikiro ngati chimfine zachitika m'maphunziro a anthu omwe amatenga Tecfidera. Pakafukufuku wina, anthu 6 pa anthu 100 alionse omwe adamwa mankhwalawa adakumana ndi zotsatirazi, koma zotsatirazi zimachitika kawirikawiri mwa anthu omwe amamwa mapiritsi a placebo.

Zotsatira zoyipa zazitali

Kafukufuku wowunika zomwe Tecfidera adachita adatenga zaka ziwiri mpaka zisanu ndi chimodzi. Kafukufuku wina wazaka zisanu ndi chimodzi, zovuta zoyipa kwambiri zinali:

• Kubwereranso kwa MS
• zilonda zapakhosi kapena mphuno
• kuchapa
• matenda opuma
• matenda opatsirana mumkodzo
• mutu
• kutsegula m'mimba
• kutopa
• kupweteka m'mimba
• kupweteka kumbuyo, mikono, kapena miyendo

Ngati mukumwa Tecfidera ndikukhala ndi zovuta zomwe sizimatha kapena kukhala zovuta kapena zosokoneza, lankhulani ndi dokotala wanu. Angakupatseni njira zochepetsera kapena kuthetsa zotsatirapo zake, kapena angakuuzeni kuti musiye kumwa mankhwalawo.

Tecfidera amagwiritsa ntchito

Tecfidera imavomerezedwa ndi Food and Drug Administration (FDA) pochiza multiple sclerosis (MS).

Tecfidera ya MS

Tecfidera imavomerezedwa pochiza mitundu yobwerezabwereza ya MS, mitundu yodziwika kwambiri ya MS. Mwa mitundu iyi, kuukira kwakukulira kapena zizindikilo zatsopano zimachitika (kubwereranso), kutsatiridwa ndi kuchira pang'ono kapena kokwanira (chikhululukiro).

Tecfidera imachepetsa chiopsezo chobwereranso kwa MS mpaka 49 peresenti pazaka ziwiri. Zimachepetsanso chiopsezo chokhala ndi chilema chowonjezeka chakuthupi pafupifupi 38%.

Tecfidera wa psoriasis

Tecfidera imagwiritsidwa ntchito polemba mankhwala a psoriasis. Kugwiritsa ntchito mankhwala osokoneza bongo ndi pamene mankhwala amavomerezedwa kuti athetse vuto limodzi koma amagwiritsidwa ntchito pochiza matenda ena.

Pakafukufuku wamankhwala, pafupifupi 33% ya anthu omwe amamwa Tecfidera anali ndi zikwangwani zomveka bwino kapena zomveka bwino pakatha milungu 16. Pafupifupi 38 peresenti ya anthu omwe amamwa mankhwalawa adakwanitsa kusintha 75% mu index of plaque mwamphamvu ndi dera lomwe lakhudzidwa.

Njira zina ku Tecfidera

Mankhwala angapo amapezeka kuti athetse mitundu yobwerezabwereza ya multiple sclerosis (MS). Zitsanzo za mankhwalawa ndi awa:

• interferon beta-1a (Avonex, Rebif)
• interferon beta-1b (Betaseron)
• glatiramer nthochi (Copaxone, Glatopa)
• IV immunoglobulin (Bivigam, Gammagard, ena)
• ma monoclonal antibodies monga:
• alemtuzumab (Lemtrada)
• natalizumab (Tysabri)
• rituximab (Rituxan)
• ocrelizumab (Ocrevus)
• fingolimod (Gilenya)
• teriflunomide (Aubagio)

Chidziwitso: Ena mwa mankhwala omwe atchulidwa pano amagwiritsidwa ntchito ngati malembo kuti athetse mitundu yobwereranso ya MS.

Tecfidera vs. mankhwala ena

Mutha kudabwa momwe Tecfidera amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. M'munsimu pali kufananizira pakati pa Tecfidera ndi mankhwala angapo.

Tecfidera vs. Aubagio

Tecfidera ndi Aubagio (teriflunomide) onse amadziwika ngati othandizira kusintha matenda. Zonsezi zimachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi Aubagio onse ndi ovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS).

Mitundu ya mankhwala osokoneza bongo

Tecfidera imabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse. Aubagio amabwera ngati piritsi lakamwa lomwe limatengedwa kamodzi tsiku lililonse.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi Aubagio ali ndi zovuta zina zofanana ndipo zina zimasiyana. M'munsimu muli zitsanzo za zotsatirazi.

* Aubagio adalemba machenjezo kuchokera ku FDA. Awa ndi chenjezo lamphamvu kwambiri lomwe a FDA amafuna. Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Tecfidera ndi Aubagio onse ndi othandiza pochiza MS. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, pakuwunika kumodzi, adafaniziridwa mosawonekera ndipo adapezeka ndi maubwino ofanana.

Mtengo

Tecfidera ndi Aubagio amapezeka ngati mankhwala osokoneza bongo. Mitundu ya mankhwalawa sikupezeka. Mitundu ya generic nthawi zambiri imakhala yotsika mtengo kuposa mankhwala omwe amadziwika nawo.

Tecfidera nthawi zambiri imawononga pang'ono kuposa Aubagio. Komabe, mtengo womwe mumalipira umadalira dongosolo lanu la inshuwaransi.

Tecfidera vs. Copaxone

Tecfidera ndi Copaxone (glatiramer acetate) onse amadziwika kuti ndi othandizira kusintha matenda. Zonsezi zimachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi Copaxone onse ndi ovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS).

Mitundu ya mankhwala osokoneza bongo

Ubwino umodzi wa Tecfidera ndikuti amatengedwa pakamwa. Zimabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse.

Copaxone iyenera kubayidwa. Imabwera ngati jakisoni wokha wokha wokhazikika. Itha kuperekedwa kunyumba kamodzi tsiku lililonse kapena katatu pa sabata.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi Copaxone ali ndi zovuta zina zomwe zimafanana. M'munsimu muli zitsanzo za zotsatirazi.

Kuchita bwino

Tecfidera ndi Copaxone onse ndi othandiza pochiza MS. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, malinga ndi kafukufuku wina, Tecfidera itha kukhala yothandiza kwambiri kuposa Copaxone popewa kubwereranso ndikuchepetsa kukulira.

Mtengo

Tecfidera imangopezeka ngati mankhwala omwe amadziwika ndi dzina. Copaxone imapezeka ngati dzina la mankhwala osokoneza bongo. Ikupezekanso mu mawonekedwe achibadwa otchedwa glatiramer acetate.

Mtundu wa Copaxone ndi wotsika mtengo kwambiri kuposa Tecfidera. Copaxone ndi Tecfidera dzina lake limatengera chimodzimodzi. Ndalama zomwe mumalipira zimadalira inshuwaransi yanu.

Tecfidera vs. Ocrevus

Tecfidera ndi Ocrevus (ocrelizumab) onse amadziwika ngati othandizira kusintha matenda. Zonsezi zimachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi Ocrevus onse ndi ovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS). Ocrevus amavomerezedwanso pochiza mitundu yopita patsogolo ya MS.

Mitundu ya mankhwala osokoneza bongo

Ubwino wa Tecfidera ndikuti amatha kumwa pakamwa. Zimabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse.

Ocrevus ayenera kubayidwa pogwiritsa ntchito kulowetsedwa kwamitsempha (IV). Iyenera kuperekedwa kuchipatala kapena kuchipatala. Pambuyo pa Mlingo woyamba woyamba, Ocrevus amapatsidwa miyezi isanu ndi umodzi iliyonse.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi Ocrevus ali ndi zovuta zina zofanana ndipo zina zimasiyana. M'munsimu muli zitsanzo za zotsatirazi.

Kuchita bwino

Onse awiri Tecfidera ndi Ocrevus ndi othandiza pochiza MS, koma sizikudziwika ngati wina akugwira ntchito bwino kuposa winayo. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala.

Mtengo

Tecfidera ndi Ocrevus amapezeka ngati mankhwala odziwika ndi dzina. Sizimapezeka m'mafomu achibadwa, omwe angakhale otsika mtengo kuposa mankhwala osokoneza bongo.

Ocrevus atha kukhala otsika mtengo kuposa Tecfidera. Ndalama zomwe mumalipira zimadalira inshuwaransi yanu.

Tecfidera vs. Tysabri

Tecfidera ndi Tysabri (natalizumab) onse amadziwika ngati othandizira kusintha matenda. Mankhwala onsewa amachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi Tysabri onse ndi ovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS). Tysabri imavomerezedwanso pochiza matenda a Crohn.

Mitundu ya mankhwala osokoneza bongo

Ubwino umodzi wa Tecfidera ndikuti amatengedwa pakamwa. Tecfidera imabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse.

Tysabri iyenera kuperekedwa ngati kulowetsedwa kwamitsempha (IV) komwe kumaperekedwa kuchipatala kapena kuchipatala. Amapatsidwa kamodzi pamwezi.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi Tysabri ali ndi zovuta zina zofanana ndipo zina zimasiyana. M'munsimu muli zitsanzo za zotsatirazi.

* Mankhwala onsewa adalumikizidwa ndi progressive multifocal leukoencephalopathy (PML), koma ndi Tysabri yekha yemwe ali ndi chenjezo lofananira lochokera ku FDA. Ili ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Tecfidera ndi Tysabri onse ndi othandiza pochiza MS. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, malinga ndi kafukufuku wina, Tysabri itha kukhala yothandiza kwambiri kuposa Tecfidera yopewa kuyambiranso.

Ndikofunika kuzindikira kuti chifukwa cha chiwopsezo cha PML, Tysabri nthawi zambiri samakhala mankhwala osankhika oyamba a MS.

Mtengo

Tecfidera ndi Tysabri amapezeka ngati mankhwala osokoneza bongo. Mitundu ya mankhwalawa sikupezeka. Zodzoladzola zimakhala zotsika mtengo poyerekeza ndi mankhwala omwe amadziwika ndi dzina.

Tecfidera nthawi zambiri imawononga zambiri kuposa Tysabri. Ndalama zomwe mumalipira zimadalira inshuwaransi yanu.

Tecfidera vs.Gilenya

Tecfidera ndi Gilenya (fingolimod) onse amagawidwa ngati njira zosinthira matenda. Zonsezi zimachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi Gilenya onse ndi ovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS).

Mitundu ya mankhwala osokoneza bongo

Tecfidera imabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse. Gilenya amabwera ngati kapisozi wamlomo yemwe amatengedwa kamodzi tsiku lililonse.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi Gilenya ali ndi zovuta zina zofanana ndipo zina zimasiyana. M'munsimu muli zitsanzo za zotsatirazi.

Kuchita bwino

Tecfidera ndi Gilenya onse ndi othandiza pochiza MS. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, malinga ndi kafukufuku wina, Tecfidera ndi Gilenya amagwira ntchito mofananamo popewa kuyambiranso.

Mtengo

Tecfidera ndi Gilenya amapezeka ngati mankhwala osokoneza bongo. Mitundu ya mankhwalawa sikupezeka. Zodzoladzola zimakhala zotsika mtengo poyerekeza ndi mankhwala omwe amadziwika ndi dzina.

Tecfidera ndi Gilenya nthawi zambiri amawononga ndalama zofanana. Ndalama zomwe mumalipira zimadalira inshuwaransi yanu.

Tecfidera vs. interferon (Avonex, Rebif)

Tecfidera ndi interferon (Avonex, Rebif) onse amadziwika kuti ndi othandizira kusintha matenda. Zonsezi zimachepetsa mphamvu zina m'thupi, koma zimagwira ntchito m'njira zosiyanasiyana.

Ntchito

Tecfidera ndi interferon (Avonex, Rebif) ndi aliyense wovomerezeka ndi FDA pochiza mitundu yobwereranso ya multiple sclerosis (MS).

Mitundu ya mankhwala osokoneza bongo

Ubwino umodzi wa Tecfidera ndikuti amatengedwa pakamwa. Tecfidera imabwera ngati kapilisi wamlomo wachedwa kutulutsidwa yemwe amatengedwa kawiri tsiku lililonse.

Avonex ndi Rebif ndi mayina awiri osiyana a interferon beta-1a. Mitundu yonseyi iyenera kubayidwa. Rebif amabwera ngati jakisoni wocheperako womwe umaperekedwa pansi pa khungu katatu pamlungu. Avonex amabwera ngati jakisoni wamitsempha womwe umaperekedwa mu minofu kamodzi sabata iliyonse. Onsewa amadzipatsa okha kunyumba.

Zotsatira zoyipa ndi zoopsa

Tecfidera ndi interferon zimakhala ndi zovuta zina zomwe zimafanana. M'munsimu muli zitsanzo za zotsatirazi.

Kuchita bwino

Tecfidera ndi interferon onse ndi othandiza pochiza MS. Kuchita bwino kwa mankhwalawa sikunafanane mwachindunji m'maphunziro azachipatala. Komabe, malinga ndi kafukufuku wina, Tecfidera itha kukhala yothandiza kwambiri kuposa interferon popewa kubwereranso ndikuchepetsa kukulira.

Mtengo

Tecfidera ndi interferon (Rebif, Avonex) amapezeka pokhapokha ngati mankhwala osokoneza bongo. Mitundu ya mankhwalawa sikupezeka. Zodzoladzola zimakhala zotsika mtengo poyerekeza ndi mankhwala amtundu.

Tecfidera ndi interferon nthawi zambiri zimawononga chimodzimodzi. Ndalama zomwe mumalipira zimadalira inshuwaransi yanu.

Tecfidera vs. Protandim

Tecfidera ndi mankhwala ovomerezeka ndi FDA ochiritsira mitundu yobwereranso ya multiple sclerosis (MS). Kafukufuku wowerengeka wazachipatala awonetsa kuti zitha kuteteza MS kubwerera mmbuyo ndikuchedwa kukulira kulumala.

Protandim ndizowonjezera zakudya zomwe zimakhala ndi zinthu zingapo, kuphatikizapo:

• nthula yamkaka
• ashwagandha
• tiyi wobiriwira
• mfuti
• bacopa

Ena amati Protandim imagwira ntchito ngati Tecfidera. Protandim nthawi zina amatchedwa "Tecfidera wachilengedwe."

Komabe, Protandim sanaphunzirepopo za anthu omwe ali ndi MS. Chifukwa chake, palibe kafukufuku wodalirika wazachipatala yemwe amagwira ntchito.

Chidziwitso: Ngati dokotala wakulemberani Tecfidera, musasinthe ndi Protandim. Ngati mukufuna kudziwa njira zina zamankhwala, kambiranani ndi dokotala wanu.

Mlingo wa Tecfidera

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mlingo wa multiple sclerosis

Tecfidera ikayamba, mlingowo ndi 120 mg kawiri patsiku masiku asanu ndi awiri oyamba. Pambuyo sabata yoyamba iyi, mlingowo wawonjezeka mpaka 240 mg kawiri tsiku lililonse. Uwu ndiye mulingo wokonzanso kwakanthawi.

Kwa anthu omwe ali ndi zovuta zoyipa kuchokera ku Tecfidera, kuchuluka kwakukonzekera kumatha kutsika kwakanthawi mpaka 120 mg kawiri tsiku lililonse. Mlingo wokwanira wa 240 mg kawiri tsiku lililonse uyenera kuyambidwanso mkati mwa milungu inayi.

Ndingatani ngati ndaphonya mlingo?

Mukaphonya mlingo, imwani mukamakumbukira. Ngati ili pafupi nthawi ya mlingo wanu wotsatira, ingotengani mlingo umodziwo. Musayese kugwira mwakumwa miyezo iwiri nthawi imodzi.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Inde, mankhwalawa amayenera kumwa nthawi yayitali.

Momwe mungatengere Tecfidera

Tengani Tecfidera ndendende molingana ndi malangizo a dokotala wanu.

Kusunga nthawi

Tecfidera amatengedwa kawiri tsiku lililonse. Nthawi zambiri amatengedwa ndi chakudya cham'mawa komanso chakudya chamadzulo.

Kutenga Tecfidera ndi chakudya

Tecfidera iyenera kutengedwa ndi chakudya. Izi zitha kuthandiza kuchepetsa zotsatira zoyipa. Kutuluka kumathanso kuchepa potenga 325 mg wa aspirin mphindi 30 musanamwe Tecfidera.

Kodi Tecfidera ingaphwanyidwe?

Tecfidera sayenera kuphwanyidwa, kapena kutsegulidwa ndikuwaza pa chakudya. Makapisozi a Tecfidera ayenera kumezedwa kwathunthu.

Mimba ndi Tecfidera

Kafukufuku wazinyama akuwonetsa kuti Tecfidera itha kukhala yowopsa kwa mwana wosabadwa ndipo sangakhale otetezeka kutenga nthawi yapakati. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Kafukufuku sanawunikire zotsatira za Tecfidera pokhudzana ndi pakati kapena zolakwika zobadwa mwa anthu.

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, lankhulani ndi dokotala wanu ngati mungatenge Tecfidera.

Mukakhala ndi pakati mukatenga Tecfidera, mutha kutenga nawo gawo mu Tecfidera Pregnancy Registry. Kalata yolembetsera imathandizira kudziwa momwe mankhwala ena amakhudzira kutenga pakati. Ngati mukufuna kulowa nawo kaundula, funsani dokotala wanu, imbani foni ku 866-810-1462, kapena pitani patsamba la registry.

Kuyamwitsa ndi Tecfidera

Sipanakhale maphunziro okwanira owonetsa ngati Tecfidera imapezeka mkaka wa m'mawere.

Akatswiri ena amalimbikitsa kupewa kuyamwitsa mukamamwa mankhwalawa. Komabe, ena satero. Ngati mukumwa Tecfidera ndipo mukufuna kuyamwitsa mwana wanu, lankhulani ndi dokotala wanu za zomwe zingakhale zovuta komanso zopindulitsa.

Momwe Tecfidera imagwirira ntchito

Multiple sclerosis (MS) ndimatenda amthupi okha. Ndi matenda amtunduwu, chitetezo chamthupi, chomwe chimalimbana ndi matenda, chimalakwitsa maselo athanzi kwa omwe akuwaukira adani ndikuwamenya. Izi zitha kuyambitsa kutupa kosatha.

Ndi MS, kutupa kotereku kumaganiziridwa kuti kumawononga mitsempha, kuphatikiza kuwonongedwa komwe kumayambitsa matenda ambiri a MS. Kupsinjika kwa okosijeni (OS) kumaganiziridwanso kuti kumawononga izi. OS ndi kusalinganika kwa mamolekyulu ena mthupi lanu.

Tecfidera imaganiziridwa kuti imathandizira kuchiza MS poyambitsa thupi kupanga puloteni yotchedwa Nrf2. Puloteni iyi imaganiziridwa kuti ithandizanso kupezanso mawonekedwe amthupi. Izi zimathandizanso kuchepetsa kuwonongeka komwe kumachitika chifukwa cha kutupa ndi OS.

Kuphatikiza apo, Tecfidera amasintha zina mwazomwe chitetezo chamthupi chimagwira kuti muchepetse mayankho ena otupa. Zitha kupewanso thupi kuyambitsa ma cell amthupi ena. Izi zitha kuthandizanso kuchepetsa zizindikilo za MS.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Tecfidera iyamba kugwira ntchito mthupi lanu nthawi yomweyo, koma zimatha kutenga milungu ingapo kuti ifike pochita zonse.

Pomwe ikugwira ntchito, mwina simungazindikire kusintha kwakukulu pazizindikiro zanu. Izi ndichifukwa choti cholinga chake ndi kupewa kupewa kubwereranso.

Tecfidera ndi mowa

Tecfidera sagwirizana ndi mowa. Komabe, mowa umatha kukulitsa zovuta zina za Tecfidera, monga:

• kutsegula m'mimba
• nseru
• kuchapa

Pewani kumwa mowa kwambiri mukamamwa Tecfidera.

Kuyanjana kwa Tecfidera

Tecfidera itha kuyanjana ndi mankhwala ena. M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Tecfidera. Mndandandawu sungakhale ndi mankhwala onse omwe angayanjane ndi Tecfidera.

Kuyanjana kosiyanasiyana kwa mankhwala kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, ena amatha kusokoneza momwe mankhwala amagwirira ntchito, pomwe ena amatha kuyambitsa zovuta zina.

Musanatenge Tecfidera, onetsetsani kuti muwauze adotolo ndi asayansi wanu zamankhwala onse, pa-counter ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Tecfidera ndi ocrelizumab (Ocrevus)

Kutenga Tecfidera ndi ocrelizumab kumachulukitsa chiopsezo chodzitetezera kumatenda ndipo zimayambitsa matenda akulu. Chitetezo cha chitetezo cha mthupi ndi pomwe chitetezo chamthupi chimafooka.

Tecfidera ndi ibuprofen

Palibe kulumikizana komwe kumadziwika pakati pa ibuprofen ndi Tecfidera.

Tecfidera ndi aspirin

Palibe kulumikizana komwe kumadziwika pakati pa aspirin ndi Tecfidera. Aspirin amagwiritsidwa ntchito kwambiri mphindi 30 asanamwe Tecfidera kuti ateteze kuthamanga.

Mafunso wamba onena za Tecfidera

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Tecfidera.

Nchifukwa chiyani Tecfidera imayambitsa kuthamanga?

Sizikudziwika bwinobwino chifukwa chomwe Tecfidera imayambitsa kutsuka. Komabe, zikuyenera kuti zimakhudzana ndi kukulitsa (kukulira) kwa mitsempha yamagazi kumaso komwe kumayambira.

Kodi mungapewe bwanji kutuluka kuchokera ku Tecfidera?

Simungalepheretse kutuluka konse chifukwa cha Tecfidera, koma pali zinthu ziwiri zomwe mungachite kuti muchepetse:

• Tengani Tecfidera ndi chakudya.
• Tengani aspirin 325 mg mphindi 30 musanamwe Tecfidera.

Ngati izi sizikuthandizani ndipo mukuvutikabe, lankhulani ndi dokotala wanu.

Kodi Tecfidera imakutopetsani?

Anthu ena omwe amatenga Tecfidera amati akumva kutopa. Komabe, kumva kutopa kapena kugona sizotsatira zoyipa zomwe zapezeka m'maphunziro azachipatala a Tecfidera.

Kodi Tecfidera ndi immunosuppressant?

Tecfidera imakhudza chitetezo chamthupi. Amachepetsa chitetezo china chamthupi kuti chichepetse mayankho otupa. Zingathenso kuchepetsa kuyambitsa kwa maselo ena amthupi.

Komabe, Tecfidera samakonda kugawidwa ngati immunosuppressant. Nthawi zina amatchedwa immunomodulator, zomwe zikutanthauza kuti zimakhudza zina mwa chitetezo chamthupi.

Kodi ndiyenera kuda nkhawa zakudziwika ndi dzuwa ndikamamwa Tecfidera?

Tecfidera sizimapangitsa khungu lanu kukhala lowona dzuwa ngati mankhwala enaake. Komabe, ngati mukukumana ndi madzi kuchokera ku Tecfidera, kuwonekera padzuwa kumatha kukulitsa kumverera kwakanthawi.

Kodi Tecfidera ndi yothandiza motani?

Tecfidera yapezeka kuti ichepetsa MS kuyambiranso mpaka 49 peresenti pazaka ziwiri. Zapezeka kuti zachepetsa chiopsezo chokhala ndi chilema chowonjezeka chakuthupi pafupifupi 38 peresenti.

Chifukwa chiyani ndimakhala ndi mayendedwe osiyanasiyana sabata latha?

Zimakhala zachizolowezi kuti mankhwala amayambitsidwa pamlingo wotsika kenako nkuwonjezeka pambuyo pake. Izi zimalola thupi lanu kupanga mulingo wochepa momwe umasinthira mankhwala.

Kwa Tecfidera, mumayamba ndi mlingo wochepa wa 120 mg kawiri tsiku lililonse m'masiku asanu ndi awiri oyamba. Pambuyo pake, mlingowo umakulitsidwa mpaka 240 mg kawiri tsiku lililonse, ndipo uwu ndi mulingo womwe mungakhalebe. Komabe, ngati muli ndi zovuta zambiri pamlingo wambiri, dokotala wanu akhoza kuchepetsa mlingo wanu kwakanthawi.

Kodi ndiyenera kukayezetsa magazi ndili pa Tecfidera?

Inde. Musanayambe kumwa Tecfidera, dokotala wanu adzayezetsa magazi kuti muwone kuchuluka kwa maselo amwazi wamagazi ndi chiwindi chanu. Mayeserowa atha kubwerezedwa mukamamwa mankhwalawa. Kwa chaka choyamba cha chithandizo, mayeserowa amachitika pafupifupi miyezi isanu ndi umodzi iliyonse.

Kuchuluka kwa Tecfidera

Kumwa mankhwalawa mopitirira muyeso kungapangitse kuti mukhale ndi zovuta zina.

Zizindikiro zambiri za bongo

Zizindikiro za bongo zingaphatikizepo:

• kutsegula m'mimba
• nseru
• kuchapa
• kusanza
• zidzolo
• kukhumudwa m'mimba
• mutu

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu kapena funsani malangizo kuchokera ku American Association of Poison Control Center ku 800-222-1222 kapena kudzera pa chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Machenjezo a Tecfidera

Musanatenge Tecfidera, lankhulani ndi dokotala wanu zamatenda aliwonse omwe muli nawo. Tecfidera sangakhale yoyenera kwa inu ngati mukudwala. Izi ndi monga:

• Kuponderezedwa kwa chitetezo cha mthupi: Ngati chitetezo chamthupi chanu chitaponderezedwa, Tecfidera itha kukulitsa vuto ili. Izi zimatha kuwonjezera chiopsezo cha matenda opatsirana.
• Matenda a chiwindi: Tecfidera imatha kuwononga chiwindi. Ngati muli ndi matenda a chiwindi, atha kukulitsa vuto lanu.

Kutha kwa Tecfidera

Tecfidera akatulutsidwa ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pazolemba zomwe zili m'botolo. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe mankhwalawa adaperekedwa.

Cholinga cha masiku otha ntchitowa ndikutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito. Komabe, kafukufuku wa FDA adawonetsa kuti mankhwala ambiri atha kukhala abwino kupitilira tsiku lomaliza lomwe lalembedwa m'botolo.

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mankhwalawo amasungidwira. Tecfidera iyenera kusungidwa kutentha kwa chidebe choyambirira ndikutetezedwa ku kuwala.

Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Zambiri zamaluso za Tecfidera

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Njira yogwirira ntchito

Machitidwe a Tecfidera ndi ovuta komanso osamvetsetseka. Imagwira ntchito ya multiple sclerosis (MS) kudzera ku anti-inflammatory effects ndi antioxidant zotsatira. Kutupa ndi kupsinjika kwa oxidative kumaganiziridwa kuti ndi njira zofunika kwambiri kwa odwala omwe ali ndi MS.

Tecfidera imapangitsa kuti nyukiliya 1 factor (erythroid-derived 2) -monga 2 (Nrf2) antioxidant pathway, yomwe imateteza ku kuwonongeka kwa okosijeni mkatikati mwa manjenje ndikuchepetsa kufooka kwa mitsempha.

Tecfidera imalepheretsanso njira zingapo zodzitetezera zokhudzana ndi zolandilira, zomwe zimachepetsa kutulutsa kwa cytokine. Tecfidera imachepetsanso kutsegula kwa ma T-cell amthupi.

Pharmacokinetics ndi metabolism

Pambuyo poyang'anira pakamwa Tecfidera, imagwiritsidwa ntchito mwachangu ndi magawo ena ku metabolite yake yogwira, monomethyl fumarate (MMF). Chifukwa chake, dimethyl fumarate siyiyeneratu mu plasma.

Nthawi yolekezera kwambiri pa MMF (Tmax) ndi maola 2-2.5.

Kutulutsa mpweya wa carbon dioxide kumapangitsa kuti 60% ya mankhwalawo ichotsedwe. Kuchotsa amphongo ndi chimbudzi ndi njira zazing'ono.

Hafu ya moyo wa MMF ndi pafupifupi ola limodzi.

Zotsutsana

Tecfidera imatsutsana ndi odwala omwe ali ndi hypersensitivity ku dimethyl fumarate kapena chilichonse chowonjezera.

Yosungirako

Tecfidera iyenera kusungidwa kutentha, 59 ° F mpaka 86 ° F (15 ° C mpaka 30 ° C). Iyenera kusungidwa mu chidebe choyambirira ndikutetezedwa ku kuwala.

Kulemba zambiri

Tecfidera yodzaza ndi chidziwitso chitha kupezeka Pano.

Chodzikanira: MedicalNewsToday yachita zonse zotheka kuti zitsimikizire kuti zidziwitso zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.