Chofunikira ndi thrombocythemia, zizindikiro, kuzindikira ndi momwe angachiritsire

Zamkati

• Zizindikiro zazikulu
• Kodi khansa ya thrombocythemia yofunikira?
• Momwe matendawa amapangidwira
• Chithandizo cha thrombocythemia yofunikira

Chofunikira kwambiri cha thrombocythemia, kapena TE, ndi matenda am'magazi omwe amadziwika ndi kuchuluka kwa magazi m'mwazi, zomwe zimawonjezera chiopsezo cha thrombosis ndi magazi.

Matendawa nthawi zambiri amakhala opanda ziwalo, amapezeka pokhapokha kuwerengetsa magazi kokhazikika. Komabe, matendawa amangotsimikiziridwa ndi adotolo atatha kupatula zina zomwe zingayambitse kuchuluka kwa ma platelet, monga kuchepa kwa magazi m'thupi, mwachitsanzo.

Chithandizochi chimachitidwa ndi mankhwala omwe amatha kuchepetsa kuchuluka kwa ma platelet m'magazi ndikuchepetsa chiopsezo cha thrombosis, ndipo ayenera kugwiritsidwa ntchito motsogozedwa ndi dokotala kapena hematologist.

Zizindikiro zazikulu

Chofunikira cha thrombocythemia nthawi zambiri chimakhala chopanda tanthauzo, chiziwoneka pokhapokha mutakhala ndi magazi athunthu, mwachitsanzo. Komabe, zimatha kubweretsa zizindikilo zina, zazikuluzikulu ndizo:

• Kutentha kwamapazi ndi manja;
• Splenomegaly, komwe ndikukulitsa kwa ndulu;
• Kupweteka pachifuwa;
• Kutuluka thukuta;
• Zofooka;
• Mutu;
• Khungu kwakanthawi, komwe kumatha kukhala pang'ono kapena kwathunthu;
• Kuchepetsa thupi.

Kuphatikiza apo, anthu omwe amapezeka ndi thrombocythemia ofunikira ali pachiwopsezo chachikulu cha thrombosis ndi magazi. Matendawa amapezeka kwambiri kwa anthu opitilira 60, koma amathanso kuchitika kwa anthu ochepera zaka 40.

Kodi khansa ya thrombocythemia yofunikira?

Chofunika kwambiri cha thrombocythemia si khansa, popeza kulibe kuchuluka kwa maselo owopsa, koma maselo abwinobwino, pamenepa, ma platelets, omwe amadziwika ndi thrombocytosis kapena thrombocytosis. Matendawa amakhalabe okhazikika kwa zaka pafupifupi 10 mpaka 20 ndipo ali ndi vuto lochepetsetsa la leukemic, ochepera 5%.

Momwe matendawa amapangidwira

Matendawa amapangidwa ndi dokotala kapena hematologist malinga ndi zizindikilo zomwe wodwalayo adapeza, kuwonjezera pazotsatira zoyesedwa ndi labotale. Ndikofunikanso kuthana ndi zifukwa zina zowonjezerera zamagulu, monga matenda otupa, myelodysplasia ndi kusowa kwachitsulo, mwachitsanzo. Dziwani zomwe zimayambitsa kukulitsa kwamaplatelet.

Kufufuza kwa labotale ya thrombocythemia yofunikira kumayambitsidwa poyesa kuwerengera kwa magazi, momwe kuwonjezeka kwa ma platelet kumawonedwa, pamtengo wopitilira 450,000 ma platelets / mm³ amwazi. Nthawi zambiri, kuchuluka kwa ma platelet kumabwerezedwa masiku osiyanasiyana kuti muwone ngati mtengowo ukuwonjezeka.

Ngati ma platelet amapitilizidwa, amayesa majini kuti awone ngati pali kusintha komwe kumatha kuwonetsa kufunikira kwa thrombocythemia, kusintha kwa JAK2 V617F, komwe kulipo mwa odwala oposa 50%. Ngati kupezeka kwa kusinthaku kwatsimikiziridwa, ndikofunikira kuthana ndi matenda ena owopsa ndikuyang'ana nkhokwe zachitsulo.

Nthawi zina, ma biopsy am'mafupa amatha kuchitidwa, momwe kuwonjezeka kwa ma megakaryocyte, omwe amatsogolera maselo am'magazi, amatha kuwonedwa.

Chithandizo cha thrombocythemia yofunikira

Chithandizo cha thrombocythemia chofunikira ndikuchepetsa chiopsezo cha thrombosis ndi kukha magazi, ndipo nthawi zambiri amalimbikitsidwa ndi adotolo kuti agwiritse ntchito mankhwala kuti achepetse kuchuluka kwa ma platelet m'magazi, monga Anagrelide ndi Hydroxyurea, mwachitsanzo.

Hydroxyurea ndi mankhwala omwe nthawi zambiri amalimbikitsidwa kwa anthu omwe amawoneka kuti ali pachiwopsezo chachikulu, ndiko kuti, omwe ali ndi zaka zopitilira 60, adakhalapo ndi vuto la thrombosis ndipo amakhala ndi kuchuluka kwa ma platelet pamwamba pa 1500000 / mm³ yamagazi. Komabe, mankhwalawa amakhala ndi zovuta zina, monga kuphulika kwa khungu, nseru ndi kusanza.

Chithandizo cha odwala omwe ali pachiwopsezo chochepa, omwe ali osakwana zaka 40, nthawi zambiri amachitidwa ndi acetylsalicylic acid malinga ndi malangizo a dokotala kapena hematologist.

Kuphatikiza apo, kuti muchepetse chiopsezo cha thrombosis ndikofunikira kupewa kupewa kusuta ndikuchiza matenda omwe angakhalepo, monga matenda oopsa, kunenepa kwambiri komanso matenda ashuga, chifukwa amachulukitsa chiopsezo cha thrombosis. Dziwani zoyenera kuchita popewa thrombosis.