Kodi JAK2 Gene ndi Chiyani?

Zamkati

• Chidule
• Chibadwa ndi matenda
• Ntchito yabwinobwino ya JAK2
• JAK2 ndi matenda amwazi
• Kafukufuku wa JAK2

Chidule

Mavitamini a JAK2 akhala akugwiritsidwa ntchito posachedwapa pochiza myelofibrosis (MF). Imodzi mwamankhwala atsopano komanso odalirika kwambiri a MF ndi mankhwala omwe amaimitsa kapena kubweza momwe enzyme ya JAK2 imagwirira ntchito. Izi zimathandiza kuchepetsa matendawa.

Pitilizani kuwerenga kuti muphunzire za enzyme ya JAK2, komanso momwe imagwirizirana ndi jini la JAK2.

Chibadwa ndi matenda

Kuti mumvetsetse bwino mtundu wa JAK2 ndi enzyme, ndizothandiza kukhala ndi chidziwitso choyambirira cha momwe majini ndi michere imagwirira ntchito limodzi mthupi lathu.

Ma jini athu ndi malangizo kapena mapulani kuti matupi athu agwire ntchito. Tili ndi malangizo awa mkati mwa selo iliyonse yamthupi lathu. Amauza maselo athu momwe angapangire mapuloteni, omwe amapanganso michere.

Ma enzyme ndi mapuloteni amatumiza mauthenga mbali zina za thupi kuti achite ntchito zina, monga kuthandiza kugaya chakudya, kulimbikitsa kukula kwa maselo, kapena kuteteza thupi lathu ku matenda.

Maselo athu akamakula ndikugawana, majini athu m'maselo amatha kusintha. Selo limadutsa kusintha komweko kupita ku selo iliyonse yomwe imapanga. Jini ikasintha, zimatha kupanga mapulani kukhala ovuta kuwerenga.

Nthawi zina, kusinthaku kumapangitsa kulakwitsa kosakhoza kuwerengedwa kotero kuti khungu silimatha kupanga mapuloteni aliwonse. Nthawi zina, kusinthaku kumapangitsa kuti puloteni igwire ntchito nthawi yochulukirapo kapena kuti izikhala yoyatsidwa nthawi zonse. Kusintha kusokoneza mapuloteni ndi enzyme, kumatha kuyambitsa matenda m'thupi.

Ntchito yabwinobwino ya JAK2

Jeni ya JAK2 imapatsa ma cell malangizo kuti apange mapuloteni a JAK2, omwe amalimbikitsa kukula kwa maselo. Mtundu wa JAK2 ndi enzyme ndizofunikira kwambiri pakuwongolera kukula ndi kupanga kwa maselo.

Ndizofunikira makamaka pakukula ndi kupanga maselo amwazi. Enzyme ya JAK2 imagwira ntchito molimbika m'maselo am'mafupa athu. Amadziwikanso kuti maselo am'magazi a hematopoietic, maselowa ali ndi udindo wopanga maselo atsopano a magazi.

JAK2 ndi matenda amwazi

Zosintha zomwe zimapezeka mwa anthu omwe ali ndi MF zimapangitsa kuti ma enzyme a JAK2 azikhala otseguka nthawi zonse. Izi zikutanthauza kuti ma enzyme a JAK2 amagwirabe ntchito nthawi zonse, zomwe zimabweretsa kuchuluka kwa maselo otchedwa megakaryocyte.

Ma megakaryocyte awa amauza maselo ena kuti atulutse collagen. Zotsatira zake, zilonda zofiira zimayamba kukhazikika m'mafupa - chizindikiro chodziwitsira cha MF.

Zosintha mu JAK2 zimalumikizananso ndi zovuta zina zamagazi. Nthawi zambiri, zosinthazi zimalumikizidwa ndi vuto lotchedwa polycythemia vera (PV). Mu PV, kusintha kwa JAK2 kumayambitsa kupangika kwama cell am'magazi.

Pafupifupi 10 mpaka 15 peresenti ya anthu omwe ali ndi PV apitiliza kukulitsa MF. Ofufuza sakudziwa chomwe chimapangitsa anthu ena omwe ali ndi kusintha kwa JAK2 kupanga MF pomwe ena amakhala ndi PV m'malo mwake.

Kafukufuku wa JAK2

Chifukwa kusintha kwa JAK2 kwapezeka mwa anthu opitilira theka omwe ali ndi MF, ndipo anthu opitilira 90 peresenti omwe ali ndi PV, akhala akukambirana zambiri.

Pali mankhwala amodzi okha ovomerezedwa ndi FDA, otchedwa ruxolitinib (Jakafi), omwe amagwira ntchito ndi ma enzyme a JAK2. Mankhwalawa amagwira ntchito ngati JAK inhibitor, kutanthauza kuti imachedwetsa ntchito ya JAK2.

Ntchito ya enzyme ikayamba kuchepa, ma enzyme samayatsidwa nthawi zonse. Izi zimabweretsa kuchepa kwa megakaryocyte ndi collagen, zomwe zimachedwetsa khungu la MF.

Mankhwala a ruxolitinib amathandizanso pakupanga maselo amwazi. Imachita izi pochepetsa ntchito ya JAK2 m'maselo am'magazi am'magazi. Izi zimapangitsa kukhala kothandiza mu PV ndi MF.

Pakadali pano pali mayesero ambiri azachipatala omwe amayang'ana kwambiri ma JAK inhibitors ena.Ofufuza akugwiritsanso ntchito momwe angagwiritsire ntchito jini ndi enzyme kuti akhulupirire kuti apeza chithandizo chabwino kapena chithandizo cha MF.