Zulresso (brexanolone)

Zamkati

• Zulresso ndi chiyani?
• Kuchita bwino
• Kuvomerezeka ndi FDA
• Kodi Zulresso ndi chinthu cholamulidwa?
• Zulresso generic
• Mtengo wa Zulresso
• Thandizo lazachuma komanso inshuwaransi
• Zotsatira zoyipa za Zulresso
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Matupi awo sagwirizana
• Kukhazikika ndi kutaya chidziwitso
• Zulresso chifukwa cha kukhumudwa pambuyo pobereka
• Mlingo wa Zulresso
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa postpartum depression (PPD)
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Zulresso ndi mowa
• Kuyanjana kwa Zulresso
• Zulresso ndi mankhwala ena
• Zulresso ndi opioids
• Zulresso ndi mankhwala ena amantha
• Zulresso ndi mankhwala ena ogona
• Zulresso ndi antidepressants
• Njira Zina Zulresso
• Zulresso vs. Zoloft
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Kuchita bwino
• Mtengo
• Zulresso vs. Lexapro
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Kuchita bwino
• Mtengo
• Momwe Zulresso amaperekera
• Zulresso ikaperekedwa
• Kutenga Zulresso ndi chakudya
• Momwe Zulresso imagwirira ntchito
• Zokhudza PPD
• Momwe Zulresso ingathandizire
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Zulresso ndi mimba
• Zulresso ndi kuyamwitsa
• Mafunso wamba za Zulresso
• Kodi Zulresso imatha kuthana ndi mavuto amtundu wina kupatula kukhumudwa pambuyo pobereka?
• Chifukwa chiyani Zulresso imangopezeka pamalo ovomerezeka a REMS?
• Kodi ndifunikirabe kumwa mankhwala opatsirana pogwiritsira ntchito mankhwala a Zulresso?
• Kodi amuna angathenso kukhumudwa pambuyo pobereka? Ngati ndi choncho, kodi angagwiritse ntchito Zulresso?
• Kodi Zulresso ingachiritse matenda a postpartum psychosis?
• Kodi Zulresso ingathe kuthana ndi vuto lakubereka pambuyo pobereka kwa achinyamata?
• Zisamaliro za Zulresso
• Chenjezo la FDA: Kuchepetsa kwambiri komanso kutaya chidziwitso mwadzidzidzi
• Machenjezo ena
• Zambiri za Zulresso
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Kuzunza komanso kudalira
• Yosungirako

Zulresso ndi chiyani?

Zulresso ndi mankhwala omwe amadziwika kuti ndi achikulire omwe ali ndi vuto la postpartum depression (PPD). PPD ndi kukhumudwa komwe kumayamba patangotha ​​milungu ingapo kuchokera pobereka. Kwa ena, sizimayamba mpaka miyezi ingapo pambuyo pokhala ndi mwana.

Zulresso sichiritsa PPD, koma itha kuthandiza kuthana ndi zizindikiro za PPD. Izi zingaphatikizepo kumva chisoni kwambiri, kuda nkhawa, komanso kuthedwa nzeru. PPD ikhoza kukulepheretsani kusamalira mwana wanu, ndipo itha kukhala ndi zoyipa zazikulu kwa inu ndi banja lanu.

Zulresso ili ndi mankhwala a brexanolone. Amapatsidwa ngati kulowetsedwa m'mitsempha (IV), komwe kumalowa m'mitsempha yanu. Mudzalandira kulowetsedwa munthawi ya maola 60 (masiku 2.5). Mudzakhala kuchipatala chovomerezeka kwambiri mukalandira Zulresso. (Pakadali pano, sizikudziwika ngati chithandizo chopitilira chimodzi ndi Zulresso ndichabwino kapena chothandiza.)

Kuchita bwino

M'maphunziro azachipatala, Zulresso adachepetsa zizindikiro za PPD kuposa placebo (chithandizo chopanda mankhwala ogwiritsira ntchito). Kafukufukuyu adagwiritsa ntchito kuchepa kwachisokonezo chokhala ndi mfundo zazikulu za 52. Malinga ndi kafukufukuyu, PPD yapakati imapezeka kuti ili ndi mfundo 20 mpaka 25. PPD yowopsa imapezeka kuti ili ndi mfundo za 26 kapena kupitilira apo.

Kafukufuku wina adaphatikiza azimayi omwe ali ndi PPD yovuta. Pambuyo pa kulowetsedwa kwa Zulresso kwa maola 60, kuchuluka kwa kukhumudwa kwa azimayiwa kunawongoleredwa ndi 3.7 mpaka 5.5 mfundo zochulukirapo kuposa azimayi ambiri omwe amatenga malowa.

Pakafukufuku yemwe adaphatikiza azimayi omwe ali ndi PPD yochepa, Zulresso adakulitsa kukhumudwa ndi ma 2.5 mfundo zochulukirapo kuposa placebo pambuyo pomulowetsa maola 60.

Kuvomerezeka ndi FDA

Zulresso idavomerezedwa ndi Food and Drug Administration (FDA) mu Marichi 2019. Ndi mankhwala oyamba komanso okhawo omwe FDA idavomereza kuti athetse PPD. Komabe, sichinapezeke kuti mugwiritse ntchito (onani "Kodi Zulresso ndi chinthu cholamulidwa?" Pansipa).

Kodi Zulresso ndi chinthu cholamulidwa?

Inde, Zulresso ndi chinthu chowongoleredwa, zomwe zikutanthauza kuti kuyigwiritsa ntchito kumayang'aniridwa ndi boma. Chida chilichonse cholamulidwa chimapatsidwa ndandanda potengera momwe amagwiritsidwira ntchito, ngati chilipo, komanso momwe angagwiritsire ntchito molakwika. Zulresso amadziwika kuti ndi ndandanda ya 4 (IV).

Zulresso akuyembekezeka kupezeka kumapeto kwa June 2019.

Boma lakhazikitsa malamulo apadera amomwe gulu lililonse la mankhwala omwe angakonzedwe lingaperekedwere ndikugawidwa. Dokotala wanu komanso wamankhwala angakuuzeni zambiri za malamulowa.

Zulresso generic

Zulresso imapezeka kokha ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Zulresso ili ndi mankhwala othandizira brexanolone.

Mtengo wa Zulresso

Monga mankhwala onse, mtengo wa Zulresso umasiyana. Sage Therapeutics, wopanga Zulresso, akuti mu lipoti lawo la kotala kuti mtengo wamndandanda ndi $ 7,450 pachotengera chimodzi. Chithandizo chimafunikira avareji ya mabotolo a 4.5, chifukwa chake mtengo wonse ungakhale pafupifupi $ 34,000 musanachotsere. Mtengo weniweni womwe mudzalipira umadalira dongosolo lanu la inshuwaransi.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Zulresso, thandizo lili panjira. Sage Therapeutics, omwe amapanga Zulresso, alengeza kuti apereka mapulogalamu othandizira azimayi omwe akuyenerera.

Kuti mudziwe zambiri, lemberani Sage Therapeutics pa 617-299-8380. Muthanso kuyang'ana zidziwitso zosinthidwa patsamba la kampaniyo.

Zotsatira zoyipa za Zulresso

Zulresso imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatira uli ndi zovuta zina zomwe zingachitike mukamamwa Zulresso. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazovuta za Zulresso, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Zulresso zitha kuphatikiza:

• sedation (kugona, kuvuta kuganiza bwino, kusakhoza kuyendetsa kapena kugwiritsa ntchito makina olemera)
• chizungulire kapena chizungulire (kumverera ngati ukusuntha pomwe sunapite)
• kumverera ngati ukukomoka
• pakamwa pouma
• kutsuka khungu (kufiira komanso kutentha pakhungu lanu)

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Zulresso zitha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta pambuyo mutachoka kuchipatala komwe mudalandira mankhwala anu. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Kutaya chidziwitso. Zizindikiro zimatha kuphatikiza:
• Malingaliro odzipha mwa achinyamata (ochepera zaka 25). * Zizindikiro zimatha kuphatikiza:

* Izi zitha kuchitikanso mwa ana. Mankhwalawa savomerezedwa kuti agwiritsidwe ntchito kwa ana.

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa. Nazi zina mwazovuta zina zomwe mankhwalawa angayambitse.

Matupi awo sagwirizana

Mofanana ndi mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Zulresso. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro za kuyanjana kwambiri ndi izi:

• angioedema (kutupa pansi pa khungu lanu, makamaka m'maziso anu, milomo, manja, kapena mapazi)
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma

Itanani dokotala wanu nthawi yomweyo ngati mukudwala Zulresso mukachoka kuchipatala. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Kukhazikika ndi kutaya chidziwitso

Sedation ndizomwe zimachitika ndi Zulresso. Zizindikiro zimaphatikizapo kugona ndi kuvuta kuganiza bwino. Nthawi zina, kukhala pansi kumatha kukhala koopsa, kumabweretsa tulo tofa nato komanso kutaya chidziwitso.

M'maphunziro azachipatala, anthu 5% anali ndi sedation yayikulu yomwe imafuna kuyimitsidwa kwakanthawi kapena kusintha kwa chithandizo. Mwa anthu omwe amatenga placebo (mankhwala osagwiritsa ntchito mankhwala), palibe amene adachita chimodzimodzi.

Kutaya chidziwitso kumatanthauza kukomoka kapena kuwoneka ngati wagona. Panthawiyi, simungathe kuyankha phokoso kapena kukhudza. M'maphunziro azachipatala, 4% ya anthu omwe adatenga Zulresso adataya chidziwitso. Palibe aliyense mwa anthu omwe adatenga malowa anali ndi zotere.

Kwa munthu aliyense amene adataya chidziwitso m'maphunziro, chithandizo chidayimitsidwa. Aliyense mwa anthuwa adatsitsimuka mphindi 15 mpaka 60 atasiya kumwa mankhwalawo.

Mukalandira Zulresso, dokotala wanu adzakuyang'anirani kuti musadziwe kanthu. Amachita izi maola awiri aliwonse nthawi yosagona. (Mukutsatira ndandanda yogona yanthawi yakumwa.)

Onse sedation ofooka komanso kutaya chidziwitso kumatha kubweretsa kutsika kwa oxygen (hypoxia). Mukakhala pansi kapena kukomoka, kupuma kwanu kumatha kuchepa. Izi zikachitika, thupi lanu limalandira mpweya wochepa. Mpweya wochepa kwambiri m'maselo anu ndi minofu yanu imatha kuwononga ubongo wanu, chiwindi, ndi ziwalo zina.

Pachifukwa ichi, dokotala wanu amayang'anira kuchuluka kwa mpweya m'magazi anu panthawi yonse yomwe mumalandira.Mukataya chidziwitso kapena mulibe mpweya wokwanira m'magazi anu, dokotala wanu amasiya chithandizo cha Zulresso kwakanthawi. Akasankha kuyambiranso mankhwala a Zulresso, atha kugwiritsa ntchito mankhwala ochepa.

Chifukwa cha chiwopsezo chotaya chidziwitso, Zulresso imangoperekedwa ndi akatswiri azaumoyo omwe ali ovomerezeka kuti apereka mankhwalawa.

[Kupanga: Chonde ikani ma Pros-Cons Suides Prevention Widget]

Zulresso chifukwa cha kukhumudwa pambuyo pobereka

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Zulresso kuti athetse mavuto ena.

Zulresso ndivomerezedwa ndi FDA kuti athetse achikulire omwe ali ndi vuto la postpartum (PPD). Vutoli ndi vuto lalikulu lakukhumudwa komwe kumachitika patatha milungu ingapo mpaka miyezi ingapo kuchokera pobereka. Ndizowopsa kuposa "baby blues" azimayi ambiri omwe amakhala nawo atangobereka kumene. PPD yosachiritsidwa imatha kupangitsa mayi kulephera kusamalira mwana wake.

PPD ikhoza kuyambitsidwa ndi zinthu zingapo, kuphatikiza:

• kusintha kwa mahomoni anu
• kutopa (kusowa mphamvu)
• zakudya zopanda pake kapena zosasinthasintha
• Zosintha pamoyo wanu wamakhalidwe kapena akatswiri (monga kukhala kunyumba kuposa momwe mumakhalira)
• ndandanda yovuta kapena yokhazikika yogona
• kukhala osungulumwa

Zizindikiro zakubadwa kwachisoni zimatha:

• kutopa
• nkhawa
• kusinthasintha kwamphamvu
• kumverera ngati ndiwe "mayi woyipa"
• kuvuta kugona kapena kudya
• mantha a kudzipweteka nokha kapena ena
• malingaliro ofuna kudzipha kapena machitidwe

M'maphunziro azachipatala, Zulresso adachepetsa zizindikiro za PPD kuposa placebo (chithandizo chopanda mankhwala ogwiritsira ntchito). Kafukufukuyu adagwiritsa ntchito sikelo kuti adziwe momwe kukhumudwa kwa munthu aliyense kudaliri kale komanso atapatsidwa Zulresso. Mulingo wowerengera uli ndi mfundo zazikuluzikulu za ma 52, pomwe zochulukirapo zikusonyeza kukhumudwa kwakukulu. Malinga ndi kafukufukuyu, PPD yapakati imapezeka kuti ili ndi mfundo 20 mpaka 25. PPD yowopsa imapezeka kuti ili ndi mfundo za 26 kapena kupitilira apo.

Kafukufuku wina adaphatikiza azimayi omwe ali ndi PPD yovuta. Pambuyo pa kulowetsedwa kwa Zulresso kwa maola 60, kuchuluka kwa kukhumudwa kwa azimayiwa kunawongoleredwa ndi 3.7 mpaka 5.5 mfundo zochulukirapo kuposa azimayi ambiri omwe amatenga malowa. Pakafukufuku yemwe adaphatikiza azimayi omwe ali ndi PPD yochepa, Zulresso adakulitsa kukhumudwa ndi ma 2.5 mfundo zochulukirapo kuposa placebo pambuyo pomulowetsa maola 60.

Mlingo wa Zulresso

Mlingo wa Zulresso omwe dokotala amakupatsani umadalira momwe thupi lanu limayankhira Zulresso.

Dokotala wanu akuyambitsani pamlingo wochepa ndikuwonjezera kwa maola angapo. Adzazisintha pakapita nthawi kuti zifike kuchuluka komwe thupi lanu limapilira popanda zovuta zina. Mu maora angapo apitawo a chithandizocho, adzatsitsiranso mlingo.

Izi zikufotokozera za mankhwala omwe amagwiritsidwa ntchito kwambiri kapena olimbikitsidwa. Dokotala wanu adzazindikira mlingo woyenera kuti mukwaniritse zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Zulresso imabwera ngati yankho lomwe limaperekedwa ngati kulowetsedwa kwa mtsempha (IV), komwe kumalowa mumitsempha yanu. Mudzalandira kulowetsedwa munthawi ya maola 60 (masiku 2.5). Mudzakhala kuchipatala kuti mulowetsedwe.

Mlingo wa postpartum depression (PPD)

Dokotala wanu adzakuuzani mlingo wanu malinga ndi kulemera kwanu. Kilogalamu imodzi ndi pafupifupi mapaundi 2.2.

Mlingo woyenera wa Zulresso wa PPD ndi:

• Kuyamba kulowetsedwa kudzera ola 3: 30 mcg / kg pa ola limodzi
• Maola 4–23: 60 mcg / kg pa ola limodzi
• Maola 24–51: 90 mcg / kg pa ola limodzi
• Maola 52-55: 60 mcg / kg pa ola limodzi
• Maola 56-60: 30 mcg / kg pa ola limodzi

Ngati muli ndi zovuta zoyipa pakulowetsedwa, dokotala wanu amatha kusokoneza chithandizocho kapena kuchepetsa kuchuluka kwa Zulresso. Ayambiranso mankhwalawo kapena azisunga mulingo wake ngati angaone kuti ndizotetezeka kuti mupitilize kulandira Zulresso.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Zulresso sichiyenera kugwiritsidwa ntchito ngati chithandizo chanthawi yayitali. Mukalandira Zulresso, inu ndi dokotala wanu mutha kukambirana njira zodetsa nkhawa komanso zothandiza zomwe mungatenge nthawi yayitali ngati zingafunike.

Zulresso ndi mowa

Simuyenera kumwa mowa nthawi isanakwane kapena mukamamwa mankhwala a Zulresso. Mowa umatha kuonjezera chiopsezo cha kukhala pansi kwambiri (kugona, kuvuta kuganiza bwino) mukamwa ndi Zulresso. Ikhozanso kuwonjezera chiopsezo chotaya chidziwitso (osakhoza kuyankha kumveka kapena kukhudza).

Ngati mukuda nkhawa kuti mutha kupewa mowa nthawi yomwe mumalandira chithandizo, lankhulani ndi dokotala wanu. Muthanso kukambirana zakuti kumwa mowa ndikwabwino kwa inu mutalandira mankhwala.

Kuyanjana kwa Zulresso

Zulresso amatha kulumikizana ndi mankhwala ena angapo.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito. Kuyanjana kwina kumatha kukulitsa zovuta zina kapena kuwapangitsa kukhala owopsa.

Zulresso ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Zulresso. Mndandandawu mulibe mankhwala onse omwe angagwirizane ndi Zulresso.

Musanatenge Zulresso, lankhulani ndi dokotala komanso wamankhwala. Auzeni zamankhwala onse omwe mumalandira, pa-pakauntala, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Zulresso ndi opioids

Kutenga mankhwala opweteka monga ma opioid asanachitike kapena nthawi ya mankhwala a Zulresso kumatha kuwonjezera ngozi zoyipa. Kutenga Zulresso ndi ma opioid kumatha kuonjezera chiopsezo chokhala pansi (kugona, kuvuta kuganiza bwino, komanso kusayendetsa galimoto kapena kugwiritsa ntchito makina olemera). Ikhozanso kuwonjezera chiopsezo chotayika chidziwitso (osatha kuyankha kumveka kapena kukhudza).

Zitsanzo za ma opioid omwe angapangitse chiopsezo chokhala pansi ndi kutaya chidziwitso ngati atengedwa ndi Zulresso ndi awa:

• hydrocodone (Hysingla, Zohydro)
• oxycodone (Oxycontin, Roxicodone, Xtampza ER)
• codeine
• morphine (Kadian, MS Kupitiliza)
• fentanyl (Abstral, Actiq, Duragesic, ena)
• methadone (Dolophine, Methadose)

Mankhwala ambiri opweteka amakhala ndi ma opioid ndi mankhwala ena. Onetsetsani kuuza dokotala wanu za mankhwala onse omwe mumamwa. Ngati mukumwa mankhwala opweteka, angakulimbikitseni kuti musamamwe nthawi yomweyo komanso musanamwe mankhwala a Zulresso. Izi zithandizira kuchepetsa ngozi yakukhazikika pansi ndi kutaya chidziwitso.

Zulresso ndi mankhwala ena amantha

Kutenga Zulresso ndi benzodiazepines (mankhwala omwe amagwiritsidwa ntchito pochiza nkhawa) kumatha kuwonjezera ngozi zoyipa. Kutenga Zulresso ndi benzodiazepine kumatha kuonjezera chiopsezo chokhala pansi (kugona, kulephera kuganiza bwino, osatha kuyendetsa kapena kugwiritsa ntchito makina olemera). Ikhozanso kuwonjezera chiopsezo chanu chotaya chidziwitso (osakhoza kuyankha kumveka kapena kukhudza).

Zitsanzo za benzodiazepines zomwe zitha kuwonjezera chiopsezo chokhala pansi ndi kutaya chidziwitso chikatengedwa ndi Zulresso ndi monga:

• alprazolam (Xanax, Xanax XR)
• diazepam (Valium)
• Lorazepam (Ativan)
• temazepam (Kubwezeretsa)
• triazolam (Halcion)

Zulresso ndi mankhwala ena ogona

Kutenga Zulresso ndi mankhwala ena osagona tulo (kuvuta kugona) kumatha kuonjezera chiopsezo chokhala pansi. Zizindikiro zokhala pansi zimaphatikizapo kugona, kulephera kuganiza bwino, komanso kusayendetsa galimoto kapena kugwiritsa ntchito makina olemera. Zitha kuphatikizaponso kutaya chidziwitso (osakhoza kuyankha kumveka kapena kukhudza).

Zitsanzo za mankhwala osowa tulo omwe angawonjezere chiopsezo chokhala ndi nkhawa ngati atamwa ndi Zulresso ndi awa:

• Mpho Regalo (Lunesta)
• zaleplon (Sonata)
• zolpidem (Ambien, Ambien CR, Edluar, Intermezzo, Zolpimist)

Zulresso ndi antidepressants

Kutenga Zulresso ndi mankhwala ena opewetsa kupsinjika kumatha kuonjezera ngozi zoyipa, monga kutopa kwambiri (kugona, kuvuta kuganiza bwino, kusakwanitsa kuyendetsa kapena kugwiritsa ntchito makina olemera. Zitha kuchititsanso kuti munthu asadziwike (osakhoza kuyankha phokoso kapena kukhudza).

Zitsanzo za antidepressants zomwe zitha kuwonjezera chiopsezo chokhala pansi ndi kutaya chidziwitso ndi monga:

• fluoxetine (Prozac, Sarafem, Selfemra)
• mankhwala (Zoloft)
• citalopram (Celexa)
• escitalopram (Lexapro)
• paroxetine (Brisdelle, Paxil, Pexeva)
• venlafaxine (Effexor XR)
• duloxetine (Cymbalta)

Njira Zina Zulresso

Mankhwala ena omwe amagwiritsidwa ntchito pakukhumudwa amatha kuthandiza kuthana ndi vuto la postpartum (PPD). Mankhwala aliwonse omwe amagwiritsidwa ntchito moyenera amagwiritsidwa ntchito ngati mankhwala kuti athetse PPD. Kugwiritsa ntchito mankhwala osokoneza bongo ndi pamene mankhwala omwe amavomerezedwa kuti agwiritsidwe ntchito kamodzi amalembedwa kuti agwiritse ntchito kwina.

Ena mwa mankhwalawa akhoza kukhala abwino kwa inu kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Zulresso, lankhulani ndi dokotala wanu. Amatha kukuwuzani zamankhwala ena omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito polemba ma PPD ndi awa:

• fluoxetine (Prozac, Sarafem, Selfemra)
• paroxetine (Brisdelle, Paxil, Pexeva)
• mankhwala (Zoloft)
• nortriptyline (Pamelor)
• kutchfuneralhome
• bupropion (Wellbutrin SR, Wellbutrin XL, Zyban)
• esketamine (Spravato)

Zulresso vs. Zoloft

Mutha kudabwa momwe Zulresso amafanizira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. Apa tikuwona momwe Zulresso ndi Zoloft alili ofanana komanso osiyana.

Ntchito

Zulresso ndi Zoloft amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse mavuto osiyanasiyana.

Zulresso ndivomerezedwa ndi FDA kuti athetse vuto la postpartum (PPD) mwa akulu.

Zoloft ndivomerezedwa ndi FDA kuti athetse achikulire ndi izi:

• kusokonezeka kwakukulu
• mantha amantha
• post-traumatic stress disorder
• premenstrual dysphoric matenda
• matenda amisala

Zoloft imavomerezedwanso kuti ichiritse anthu azaka 6 kapena kupitilira apo omwe ali ndimatenda osokoneza bongo. Zoloft imagwiritsidwa ntchito polemba ma PPD.

Zulresso ili ndi mankhwala a brexanolone. Zoloft ili ndi sertraline ya mankhwala.

Mafomu azamankhwala ndi makonzedwe

Zulresso imabwera ngati yankho lomwe limaperekedwa ngati kulowetsedwa kwa intravenous (IV), komwe kumalowa mumitsempha yanu. Mudzalandira kulowetsedwa m'malo azachipatala kwa nthawi yopitilira maola 60 (masiku 2.5).

Zoloft imabwera ngati piritsi kapena yankho lomwe limatengedwa pakamwa. Zimatengedwa kamodzi patsiku.

Zotsatira zoyipa ndi zoopsa

Zulresso ndi Zoloft zili ndi mankhwala osiyanasiyana. Chifukwa chake, mankhwalawa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zomwe zimachitika ndi Zulresso komanso Zoloft.

• Zitha kuchitika ndi Zulresso:
  • sedation (kugona, kuvuta kuganiza bwino, kusakhoza kuyendetsa kapena kugwiritsa ntchito makina olemera)
  • chizungulire kapena chizungulire (kumverera ngati ukusuntha pomwe sunapite)
  • kumverera ngati ukukomoka
  • pakamwa pouma
  • kutsuka khungu (kufiira komanso kutentha pakhungu)
• Zitha kuchitika ndi Zoloft:
  • nseru
  • kutsekula m'mimba kapena ndowe zotayirira
  • kukhumudwa m'mimba
  • kusowa chilakolako
  • thukuta kwambiri
  • kunjenjemera (kuyenda kosalamulirika kwa ziwalo za thupi lanu)
  • kulephera kutulutsa umuna
  • kuchepa kwa libido (kuyendetsa pang'ono kapena ayi)

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Zulresso, ndi Zoloft, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Zulresso:
  • sedation yoopsa
  • kutaya chidziwitso (osakhoza kuyankha kumveka kapena kukhudza)
• Zitha kuchitika ndi Zoloft:
  • serotonin syndrome (serotonin wambiri m'thupi)
  • chiopsezo chowonjezeka chakutuluka magazi
  • hyponatremia (otsika sodium)
  • nyimbo yachilendo
  • kusiya
  • chifukwa choletsa Zoloftangle-kutseka glaucoma (kuthamanga kwambiri m'diso lako)
• Zitha kuchitika ndi Zulresso ndi Zoloft:
  • Maganizo ofuna kudzipha mwa achinyamata (ochepera zaka 25)

Kuchita bwino

Zulresso ndi Zoloft ali ndi ntchito zosiyanasiyana zovomerezeka ndi FDA, koma zonsezi zimagwiritsidwa ntchito pochizira PPD. Izi ndizogwiritsa ntchito Zoloft. Musagwiritse ntchito Zoloft kuchiza PPD osalankhula ndi dokotala poyamba.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala, koma kafukufuku wapeza kuti Zulresso ndiyothandiza pochiza PPD.

Kuwunikanso kwamaphunziro angapo azachipatala kunapeza kuti Zoloft anali othandiza kuthana ndi PPD m'maphunziro ena koma osati ena.

Mtengo

Zulresso ndi Zoloft onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya Zulresso, koma pali Zoloft yotchedwa sertraline. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Mtengo wamndandanda wa Zulresso ndi pafupifupi $ 34,000 ya kulowetsedwa musanachotse, malinga ndi lipoti la kotala la wopanga. Kutengera mtengo womwewo ndi mtengo woyerekeza wa Zoloft kuchokera ku GoodRx, Zulresso ndiokwera mtengo kwambiri. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Zulresso vs. Lexapro

Zulresso ndi Lexapro amapatsidwa ntchito zofananira. M'munsimu muli tsatanetsatane wa momwe mankhwalawa alili ofanana komanso osiyana.

Ntchito

Zulresso ndi Lexapro amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse mavuto osiyanasiyana.

Zulresso amavomerezedwa kuti athetse vuto la postpartum (PPD) mwa akuluakulu.

Lexapro imavomerezedwa kuthana ndi vuto lalikulu lachisokonezo mwa anthu azaka 12 kapena kupitilira apo. Amavomerezanso kuthana ndi vuto lapanja mwa achikulire. Lexapro imagwiritsidwa ntchito polemba ma PPD.

Zulresso ili ndi mankhwala a brexanolone. Lexapro lili escitalopram mankhwala.

Mafomu azamankhwala ndi makonzedwe

Zulresso imabwera ngati yankho lomwe limaperekedwa ngati kulowetsedwa kwa mtsempha (IV), komwe kumalowa mumitsempha yanu. Mudzalandira kulowetsedwa m'malo azachipatala kwa nthawi yopitilira maola 60 (masiku 2.5).

Lexapro imabwera ngati piritsi komanso yankho. Mawonekedwe aliwonse amatengedwa pakamwa kamodzi tsiku lililonse.

Zotsatira zoyipa ndi zoopsa

Zulresso ndi Lexapro ali ndi mankhwala osiyanasiyana. Chifukwa chake, amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Zulresso, ndi Lexapro, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Zulresso:
  • chizungulire kapena chizungulire (kumverera ngati ukusuntha pomwe sunapite)
  • kumverera ngati ukukomoka
  • pakamwa pouma
  • kutsuka khungu (kufiira komanso kutentha pakhungu lanu)
• Zitha kuchitika ndi Lexapro:
  • kusowa tulo (kuvuta kugona)
  • nseru
  • thukuta
  • kutopa (kusowa mphamvu)
  • kuchepa kwa libido (kuyendetsa pang'ono kapena ayi)
  • osakhoza kukhala ndi vuto
  • kuchedwa kuthamangitsidwa
• Zitha kuchitika ndi Zulresso ndi Lexapro:
  • sedation (kugona, kuvuta kuganiza bwino, kusakhoza kuyendetsa kapena kugwiritsa ntchito makina olemera)

Zotsatira zoyipa

Mndandandawu uli ndi zitsanzo za zovuta zoyipa zomwe zingachitike ndi Zulresso, ndi Lexapro, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Zulresso:
  • sedation yoopsa
  • kutaya chidziwitso
• Zitha kuchitika ndi Lexapro:
  • serotonin syndrome (serotonin wambiri m'thupi)
  • hyponatremia (otsika sodium)
  • chiopsezo chowonjezeka chakutuluka magazi
  • achire chifukwa kuletsa Lexapro
  • kutseka kwa khungu glaucoma (kuthamanga kowonjezereka m'maso)
• Zitha kuchitika ndi Zulresso ndi Lexapro:
  • Maganizo ofuna kudzipha mwa achinyamata (ochepera zaka 25)

Kuchita bwino

Zulresso ndi Lexapro ali ndi ntchito zosiyanasiyana zovomerezeka ndi FDA, koma zonsezi zimagwiritsidwa ntchito pochizira PPD. Izi ndizogwiritsa ntchito Lexapro. Musagwiritse ntchito Lexapro kuchiza PPD osalankhula ndi dokotala poyamba.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Komabe, kafukufuku apeza kuti Zulresso ndi yothandiza pochiza PPD. Ndipo kuwunika kwamaphunziro kunafotokoza kafukufuku yemwe anapeza kuti Lexapro itha kukhala yothandiza pochiza PPD.

Mtengo

Zulresso ndi Lexapro onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya Zulresso, koma pali Lexapro yotchedwa escitalopram. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Mtengo wamndandanda wa Zulresso ndi pafupifupi $ 34,000 ya kulowetsedwa musanachotse, malinga ndi lipoti la kotala la wopanga. Kutengera mtengo womwewo ndi mtengo woyerekeza wa Lexapro wochokera ku GoodRx, Zulresso ndiokwera mtengo kwambiri. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi.

Momwe Zulresso amaperekera

Mupatsidwa Zulresso ndi dokotala kuchipatala. Mudzaulandira ngati kulowetsedwa kwamitsempha (IV), komwe kumalowa mumitsempha yanu. Kulowetsedwa ndi jakisoni yemwe amakhala nthawi yayitali. Kulowetsedwa kwa Zulresso kumatha pafupifupi maola 60 (masiku 2.5).

Munthawi imeneyi, mudzakhala kuchipatala. Izi zidzalola dokotala wanu kusintha mlingo woyenera. Imawathandizanso kuti akuwunikireni zotsatira zoyipa, monga sedation komanso kutaya chidziwitso.

Ngati muli ndi zovuta zina, monga kutaya chidziwitso, dokotala wanu adzasokoneza kulowetsedwa. Adzakuthandizani zotsatira zanu musanayambitsenso kulowetsedwa. Nthawi zina zomwe dokotala angaganize kuti sizabwino kuti mupitilize kulandira Zulresso, amasiya chithandizo.

Zulresso ikaperekedwa

Zulresso imaperekedwa ngati kulowetsedwa kwa nthawi ya maola 60 (masiku 2.5). Munthawi imeneyi, mudzakhala kuchipatala. Mukutsatira ndandanda yanthawi zonse yodyera komanso kugona mukamalandira chithandizo. Muthanso kucheza ndi alendo, kuphatikiza mwana wanu (kapena ana).

Dokotala wanu angayambe mankhwalawa m'mawa. Izi zimawathandiza kuti akuyang'anireni zotsatira zake masana, pomwe nthawi zambiri mumakhala ogalamuka.

Kutenga Zulresso ndi chakudya

Kulowetsedwa kwa Zulresso kumatenga maola 60 (masiku 2.5), ndiye kuti mwina mudzadya nthawi imeneyo. Malo azachipatala amakupatsani chakudya mukakhala komweko.

Momwe Zulresso imagwirira ntchito

Sizikudziwika momwe Zulresso amathandizira kuthana ndi vuto la postpartum (PPD).

Zokhudza PPD

PPD imayambitsidwa chifukwa cha kusalinganika kwa zochitika za ma neurosteroids ndi mahomoni opsinjika, komanso dongosolo lanu lamanjenje. Neurosteroids ndi ma steroids omwe mwachilengedwe amapezeka mthupi. Zinthu izi zimathandizira pakuwongolera zochitika zamanjenje anu.

Momwe Zulresso ingathandizire

Zulresso ndi mtundu wopangidwa ndi anthu wa allopregnanolone, neurosteroid. Zimaganiziridwa kuti zibwezeretse bwino dongosolo lanu lamanjenje komanso mahomoni opsinjika. Imachita izi powonjezera zochitika za ma neurotransmitters ena (mankhwala omwe amatumiza mauthenga pakati pa maselo amitsempha).

Makamaka, Zulresso imakulitsa ntchito ya gamma aminobutyric acid (GABA), neurotransmitter yomwe imathandizira kutulutsa bata. Ntchito zochulukirapo za GABA zitha kuthandiza kuthetsa zizindikiro za PPD.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Mudzawona kuchepa kwa zizindikiro zanu za PPD patangopita maola ochepa mutayamba kulowetsedwa.

M'maphunziro azachipatala, Zulresso adatsitsa zisonyezo za anthu pasanathe maola awiri atayamba mankhwalawa.

Zulresso ndi mimba

Zulresso sichiyenera kugwiritsidwa ntchito panthawi yapakati. Amavomerezedwa ndi Food and Drug Administration (FDA) kuti agwiritsidwe ntchito panthawi ya "postpartum", yomwe imachitika pambuyo pobereka.

Palibe maphunziro aliwonse a Zulresso omwe amagwiritsidwa ntchito mwa anthu panthawi yapakati. M'maphunziro azinyama, Zulresso adavulaza mwana wosabadwa mayi atalandira mankhwalawo. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Musanatenge Zulresso, uzani dokotala wanu ngati pali mwayi kuti mutha kukhala ndi pakati. Akambirana nanu za kuopsa ndi phindu logwiritsa ntchito Zulresso panthawi yapakati.

Ngati mulandila Zulresso muli ndi pakati, lingalirani kulembetsa m'kaundula wa pakati. Olembetsa oyembekezera amatenga zidziwitso zokhudzana ndi kugwiritsa ntchito mankhwala osokoneza bongo panthawi yapakati kuti athandize madotolo kudziwa zambiri za chitetezo cha mankhwalawa. Mutha kulembetsa ku National Pregnancy Registry for Antidepressants kapena kuyimbira 844-405-6185.

Zulresso ndi kuyamwitsa

Kuyamwitsa mkaka wamankhwala pa Zulresso kumakhala kotetezeka. Kafukufuku wocheperako mwa anthu adapeza kuti Zulresso imadutsa mkaka wa m'mawere. Komabe, amapezeka m'magulu otsika kwambiri mkaka wa m'mawere.

Kuphatikiza apo, ngati mwana amumeza mkaka wa m'mawere womwe uli ndi Zulresso, mankhwalawa sangakhale nawo kanthu. Izi ndichifukwa choti Zulresso yathyoledwa ndipo yasintha m'mimba mwa mwanayo. Chifukwa chake, ana omwe akuyamwitsidwa amangolandira Zulresso wocheperako.

Lankhulani ndi dokotala wanu ngati kuyamwitsa pa chithandizo cha Zulresso ndi njira yabwino kwa inu.

Mafunso wamba za Zulresso

Nawa mayankho pamafunso omwe amafunsidwa zambiri za Zulresso.

Kodi Zulresso imatha kuthana ndi mavuto amtundu wina kupatula kukhumudwa pambuyo pobereka?

Pakadali pano, sizikudziwika ngati Zulresso imatha kuthana ndi mavuto ena. Zulresso adayesedwa kokha kuti akhale otetezeka komanso ogwira ntchito mwa amayi omwe ali ndi vuto la postpartum (PPD).

Ngati muli ndi mafunso ngati Zulresso ndi yoyenera kwa inu, lankhulani ndi dokotala wanu.

Chifukwa chiyani Zulresso imangopezeka pamalo ovomerezeka a REMS?

Zulresso imapezeka kokha pamalo ovomerezeka a REMS chifukwa cha zovuta zake. REMS (Risk Evaluation and Mitigation Strategies) ndi pulogalamu yopangidwa ndi Food and Drug Administration (FDA). Zimathandizira kuwonetsetsa kuti mankhwalawa agwiritsidwa ntchito mosamala komanso amaperekedwa ndi akatswiri azaumoyo.

Zulresso imatha kubweretsa zovuta zoyipa, monga sedation yayikulu. Zizindikiro zimatha kuphatikiza kugona tulo kwambiri, kuvuta kuganiza bwino, komanso kusayendetsa galimoto kapena kugwiritsa ntchito makina olemera. Zulresso ikhozanso kuyambitsa kutaya kwadzidzidzi kwadzidzidzi (osakhoza kuyankha phokoso kapena kukhudza).

Chifukwa cha zovuta izi, Zulresso imangoperekedwa m'malo ena azachipatala. Maofesiwa ali ndi madokotala omwe amaphunzitsidwa mwapadera kuti azitha kuwunika komanso kuthana ndi zovuta za Zulresso. Izi zimathandizira kuti mulandire Zulresso bwinobwino.

Kodi ndifunikirabe kumwa mankhwala opatsirana pogwiritsira ntchito mankhwala a Zulresso?

Mutha. Monga momwe antidepressants samachiritsira mitundu ina ya kupsinjika (imangothandiza kuthetsa zizindikiro), Zulresso sichiritsa PPD. Chifukwa chake, mungafunike mankhwala opitilira kukhumudwa kwanu mukalandira chithandizo ndi Zulresso.

Mukalandira chithandizo cha Zulresso, inu ndi dokotala mupitiliza kugwira ntchito limodzi kuti mupeze njira zabwino zothandizira kuti muzimva bwino. Osasiya kumwa mankhwala opatsirana amwano pokhapokha dokotala atakuwuzani kuti muchite.

Kodi amuna angathenso kukhumudwa pambuyo pobereka? Ngati ndi choncho, kodi angagwiritse ntchito Zulresso?

Amaganiziridwa kuti amuna amathanso kudwala PPD. Kusanthula kwaphatikizidwa kuchokera ku maphunziro m'maiko 22 osiyanasiyana omwe anali ndi amuna oposa 40,000. Kusanthula uku kunapeza kuti pafupifupi 8% ya amuna omwe anali nawo mu phunziroli anali ndi vuto la kubadwa mwana wawo atabadwa. Amuna ambiri akuti amakhala ndi nkhawa miyezi itatu kapena isanu ndi umodzi mwana atabadwa, poyerekeza ndi nthawi zina.

Komabe, sizikudziwika ngati Zulresso ndiyothandiza pochiza PPD mwa amuna. Maphunziro azachipatala a Zulresso amangophatikiza azimayi omwe ali ndi PPD.

Kodi Zulresso ingachiritse matenda a postpartum psychosis?

Osati pa nthawi ino. Zulresso sivomerezedwa ndi FDA kuti ichiritse postpartum psychosis. Mayeso azachipatala a Zulresso sanaphatikizepo azimayi omwe ali ndi psychosis yobereka. Chifukwa chake, sizikudziwika ngati Zulresso ndiyotetezeka komanso yothandiza pochiza vutoli.

Matenda a Postpartum amachititsa mayi kukhala ndi zizindikilo zomwe zingaphatikizepo:

• kumva mawu
• kuwona zinthu zomwe sizikupezeka kwenikweni
• kukhala ndi chisoni chachikulu komanso kuda nkhawa

Zizindikirozi ndizovuta. Ngati mwakumana nazo, itanani 911.

Kodi Zulresso ingathe kuthana ndi vuto lakubereka pambuyo pobereka kwa achinyamata?

Zulresso amavomerezedwa ndi FDA kuti athetse PPD mwa azimayi azaka 18 kapena kupitilira apo. Maphunziro azachipatala sanaphatikizepo akazi ochepera zaka 18. Sizikudziwika ngati Zulresso ndiyotetezeka kapena yothandiza pochiza achinyamata omwe ali ndi PPD.

Zisamaliro za Zulresso

Mankhwalawa amabwera ndi machenjezo angapo.

Chenjezo la FDA: Kuchepetsa kwambiri komanso kutaya chidziwitso mwadzidzidzi

Mankhwalawa ali ndi chenjezo la nkhonya. Chenjezo la nkhonya ndiye chenjezo loopsa kwambiri kuchokera ku Food and Drug Administration (FDA). Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Zulresso imatha kuyambitsa sedation yayikulu. Zizindikiro zimaphatikizanso kugona, kulephera kuganiza bwino, komanso kusayendetsa galimoto kapena kugwiritsa ntchito makina olemera. Zulresso ikhozanso kuyambitsa kutaya kwadzidzidzi kwadzidzidzi (osakhoza kuyankha phokoso kapena kukhudza).

Zulresso imapezeka pokhapokha kudzera m'malo ovomerezeka. Dokotala wanu adzakuyang'anirani mosamala mukalandira chithandizo cha Zulresso. Adzakhalaponso ngati muli ndi mwana wanu (kapena ana) ngati mungakomoke.

Machenjezo ena

Musanatenge Zulresso, kambiranani ndi dokotala za mbiri yanu. Zulresso sangakhale oyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Matenda omaliza a impso. Sidziwika ngati Zulresso ndiotetezeka kwa anthu omwe ali ndi matenda a impso (renal) omaliza. Ngati muli ndi matenda a impso kumapeto ndipo mukufuna Zulresso, lankhulani ndi dokotala wanu za kuopsa ndi maubwino ake. Angakupatseni mankhwala ena.

Zindikirani: Kuti mumve zambiri za zotsatira zoyipa za Zulresso, onani gawo la "Zulresso zoyipa" pamwambapa.

Zambiri za Zulresso

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Zulresso (brexanolone) imavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse vuto la postpartum (PPD) mwa akulu. Ndiwo mankhwala oyamba komanso okhawo omwe a FDA avomereza kuti athandize makamaka PPD.

Njira yogwirira ntchito

Zulresso ndi analog yofananira ya allopregnanolone. Zochita zenizeni za Zulresso sizikudziwika, koma zotsatira zake pa PPD zimaganiziridwa kuti zimakhudzana ndi gamma aminobutyric acid (GABA) yopititsa patsogolo ntchito pogwiritsa ntchito kusinthasintha kwa allosteric. Kusinthasintha kwa Allosteric kumachitika Zulresso ikamangidwa patsamba lina kupatula GABA receptor ndikulitsa zomwe GABA imamangiriza kulandila. Zimaganiziridwa kuti kupititsa patsogolo ntchito za GABA kumawongolera kupsinjika kwa nkhawa mu hypothalamic-pituitary-adrenal axis (HPA). Ntchito za HPA zosagwira bwino zimathandizira PPD.

Pharmacokinetics ndi metabolism

Zulresso amawonetsera pharmacokinetics ofanana. Pali kugawa kwakukulu kumatumba ndikumanga mapuloteni opitilira 99% am'magazi.

Zulresso imagwiritsa ntchito njira zopanda CYP kupita ku ma metabolites osagwira ntchito. Kutha kwa theka la moyo pafupifupi maola asanu ndi anayi. Mu ndowe, 47% ya Zulresso imatulutsidwa, pomwe mkodzo 42% imatulutsidwa.

Zotsatira za matenda a impso kumapeto kwa Zulresso pharmacokinetics sadziwika; Kugwiritsa ntchito Zulresso kuyenera kupewedwa mderali.

Zotsutsana

Palibe zotsutsana ndi kugwiritsa ntchito Zulresso.

Kuzunza komanso kudalira

Zulresso ndi mankhwala olamulidwa, ndipo amadziwika ngati mankhwala a ndandanda 4 (IV).

Yosungirako

Zulresso iyenera kusungidwa mufiriji pa 36⁰F – 46⁰F (2⁰C – 7⁰C). Tetezani mabotolo kuchokera ku kuwala ndipo musamaundane.

Pambuyo pa dilution, Zulresso imatha kusungidwa mu thumba lolowetsedwa kwa maola 12 kutentha. Ngati sichigwiritsidwe ntchito atangotsuka, chimatha kusungidwa kwa maola 96 mufiriji.

Chodzikanira: Healthaline yayesetsa kwambiri kuti zidziwitso zonse zikhale zolondola, zokwanira, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.