Mankhwala osokoneza bongo a lupus erythematosus

Mankhwala osokoneza bongo a lupus erythematosus ndi matenda omwe amayamba chifukwa cha mankhwala.

Mankhwala osokoneza bongo a lupus erythematosus ndi ofanana koma osafanana ndi systemic lupus erythematosus (SLE). Ndi matenda omwe amadzichitira okhaokha. Izi zikutanthauza kuti thupi lanu limagunda minofu yathanzi molakwika. Zimayambitsidwa ndi momwe mankhwala amathandizira. Zinthu zofananira ndizopangidwa ndi mankhwala osokoneza bongo a lupus komanso mankhwala osokoneza bongo a ANCA vasculitis.

Mankhwala odziwika bwino omwe amayambitsa lupus erythematosus omwe amayamba chifukwa cha mankhwalawa ndi awa:

• Isoniazid
• Hydralazine
• Procainamide
• Tumor-necrosis factor (TNF) alpha inhibitors (monga etanercept, infliximab ndi adalimumab)
• Minocycline
• Quinidine

Mankhwala ena omwe siodziwika bwino amathanso kuyambitsa vutoli. Izi zingaphatikizepo:

• Mankhwala oletsa kulanda
• Zamgululi
• Chlorpromazine
• Methyldopa
• Sulfasalazine
• Levamisole, makamaka ngati mankhwala osokoneza bongo a cocaine

Mankhwala a Cancer immunotherapy monga pembrolizumab amathanso kuyambitsa zovuta zosiyanasiyana zomwe zimachitika chifukwa cha lupus.

Zizindikiro za lupus zomwe zimayambitsa mankhwala zimayamba kuchitika mukamamwa mankhwalawa kwa miyezi yosachepera 3 mpaka 6.

Zizindikiro zimaphatikizapo:

• Malungo
• Kumva kudwala (malaise)
• Ululu wophatikizana
• Kutupa pamodzi
• Kutaya njala
• Kupweteka pachifuwa cha Pleuritic
• Ziphuphu zakhungu kumadera omwe kuwala kwa dzuwa kukuchitika

Wopereka chithandizo chamankhwala amayeza thupi ndikumvetsera pachifuwa ndi stethoscope. Wothandizirayo akhoza kumva phokoso lotchedwa kukhululukirana kwa mtima kapena kupukutira kwa phokoso.

Kuyezetsa khungu kumawonetsa kuthamanga.

Magulu atha kukhala otupa komanso ofewa.

Mayeso omwe angachitike ndi awa:

• Mankhwala a antihistone
• Gulu la antiinuclear antibody (ANA)
• Gulu la Antineutrophil cytoplasmic antibody (ANCA)
  
• Kuwerengera kwathunthu kwamagazi (CBC) mosiyanasiyana
• Gulu lathunthu lamagetsi
• Kupenda kwamadzi

X-ray pachifuwa imatha kuwonetsa zizindikiro za pleuritis kapena pericarditis (kutupa mozungulira mapapo kapena mtima). ECG ikhoza kuwonetsa kuti mtima wakhudzidwa.

Nthawi zambiri, zizindikilo zimatha pakadutsa masiku angapo mpaka milungu mutayimitsa mankhwala omwe adayambitsa vutoli.

Chithandizo chingaphatikizepo:

• Mankhwala osagwiritsidwa ntchito poletsa kutupa (NSAIDs) kuti athetse nyamakazi ndi pleurisy
• Mafuta a Corticosteroid ochiza zotupa pakhungu
• Mankhwala osokoneza bongo (hydroxychloroquine) kuchiza khungu ndi nyamakazi

Ngati vutoli likukhudza mtima wanu, impso, kapena dongosolo lamanjenje, mutha kupatsidwa mankhwala okwanira a corticosteroids (prednisone, methylprednisolone) ndi chitetezo chamthupi (azathioprine kapena cyclophosphamide). Izi ndizochepa.

Matendawa akayamba kugwira ntchito, muyenera kuvala zovala zoteteza komanso magalasi kuti muteteze dzuwa.

Nthawi zambiri, lupus erythematosus yochita mankhwala osokoneza bongo siyowopsa ngati SLE. Zizindikiro nthawi zambiri zimatha patatha masiku ochepa kapena milungu mutayimitsa mankhwala omwe mumamwa. Nthawi zambiri, kutupa kwa impso (nephritis) kumatha kukhala ndi lupus yomwe imayambitsa mankhwala osokoneza bongo chifukwa cha TNF inhibitors kapena ndi ANCA vasculitis chifukwa cha hydralazine kapena levamisole. Nephritis ingafune chithandizo ndi mankhwala a prednisone ndi immunosuppressive.

Pewani kumwa mankhwala omwe adadzetsa mtsogolo mtsogolo. Zizindikiro zimatha kubwerera mukatero.

Zovuta zingaphatikizepo:

• Matenda
• Thrombocytopenia purpura - kutuluka magazi pafupi ndi khungu, chifukwa cha kuchuluka kwa magazi othandiza magazi kuundana m'mwazi
• Kuchepa kwa magazi m'thupi
• Myocarditis
• Matenda a m'mapapo
• Nephritis

Itanani omwe akukuthandizani ngati:

• Mumakhala ndi zizindikilo zatsopano mukamamwa mankhwala aliwonse omwe atchulidwa pamwambapa.
• Zizindikiro zanu sizikhala bwino mukasiya kumwa mankhwala omwe adayambitsa vutoli.

Yang'anirani zizindikiro za zomwe mungachite ngati mukumwa mankhwala omwe angayambitse vutoli.

Lupus - mankhwala osokoneza bongo

• Lupus, discoid - kuwona kwa zotupa pachifuwa
• Ma antibodies

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[Adasankhidwa] Dooley MA. Lupus wopangidwa ndi mankhwala osokoneza bongo. Mu: Tsokos GC, mkonzi. Lupus Erythematosus Wodalirika. Cambridge, MA: Atolankhani a Elsevier Academic; 2016: chap 54.

Radhakrishnan J, Perazella MA. Matenda opatsirana ndi mankhwala osokoneza bongo: chisamaliro chimafunikira! Clin J Am Soc Nephrol. 2015; 10 (7): 1287-1290. PMID: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

Richardson BC. Lupus wopangidwa ndi mankhwala osokoneza bongo. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, olemba. Zamatsenga. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2019: mutu 141.

Rubin RL. Lupus wopangidwa ndi mankhwala osokoneza bongo. Katswiri Opin Drug Saf. 2015; 14 (3): 361-378. PMID: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

Vaglio A, PC ya Grayson, Fenaroli P, ndi al. Lupus wopangidwa ndi mankhwala osokoneza bongo: malingaliro achikhalidwe komanso atsopano. Pangani Auto Rev. 2018; 17 (9): 912-918. (Adasankhidwa) PMID: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.