Angapo dongosolo atrophy - parkinsonia mtundu

Njira zingapo za atrophy- parkinsonia mtundu (MSA-P) ndizovuta zomwe zimayambitsa zizindikilo zofanana ndi matenda a Parkinson. Komabe, anthu omwe ali ndi MSA-P ali ndi kuwonongeka kofala kwambiri pagawo lamanjenje lomwe limayang'anira ntchito zofunika monga kugunda kwa mtima, kuthamanga kwa magazi, ndi thukuta.

Mtundu wina wa MSA ndi MSA-cerebellar. Zimakhudza kwambiri madera ozama muubongo, pamwamba pamtsempha wa msana.

Zomwe zimayambitsa MSA-P sizikudziwika. Madera omwe akhudzidwa ndiubongo amalowa m'malo omwe amakhudzidwa ndi matenda a Parkinson, okhala ndi zizindikilo zofananira. Pachifukwa ichi, gawo laling'ono la MSA limatchedwa parkinsonian.

MSA-P nthawi zambiri imapezeka mwa amuna akulu kuposa 60.

MSA imawononga dongosolo lamanjenje. Matendawa amayamba kukula msanga. Pafupifupi theka la anthu omwe ali ndi MSA-P ataya luso lawo lamagalimoto m'zaka zisanu kuchokera pomwe matendawa adayamba.

Zizindikiro zimaphatikizapo:

• Kugwedezeka
• Zovuta zakuyenda, monga kuzengereza, kusakhazikika, kusuntha mukamayenda
• Kugwa pafupipafupi
• Zilonda zam'mimba (myalgia), ndi kuuma
• Kusintha nkhope, monga mawonekedwe ngati nkhope kumaso ndikuyang'anitsitsa
• Kuvuta kutafuna kapena kumeza (nthawi zina), osatha kutseka pakamwa
• Kusokoneza magonedwe (nthawi zambiri poyenda mwachangu [REM] kugona usiku)
• Chizungulire kapena kukomoka mukaimirira kapena mukaimirira
• Mavuto okonzekera
• Kutaya mphamvu pamatumbo kapena chikhodzodzo
• Mavuto ndi zochitika zomwe zimafunikira mayendedwe ang'onoang'ono (kutaya luso labwino lamagalimoto), monga kulemba zochepa komanso zovuta kuziwerenga
• Kutaya thukuta mbali iliyonse ya thupi
• Kutha kwa magwiridwe antchito
• Nsautso ndi mavuto ndi chimbudzi
• Mavuto akukhazikika, monga kusakhazikika, kuwerama, kapena kugwa
• Masomphenya amasintha, amachepetsa kapena kusawona bwino
• Kusintha kwa mawu ndi malankhulidwe

Zizindikiro zina zomwe zingachitike ndi matendawa:

• Kusokonezeka
• Kusokonezeka maganizo
• Matenda okhumudwa
• Mavuto okhudzana ndi kugona, kuphatikizapo kugona tulo kapena kutsekeka kwa mpweya womwe umapangitsa kuti phokoso likhale logwedezeka

Wothandizira zaumoyo wanu adzakuyesani, ndikuwonani maso anu, misempha, ndi minofu.

Kuthamanga kwa magazi kwanu kudzatengedwa mukamagona pansi ndikuyimirira.

Palibe mayeso apadera otsimikizira matendawa. Dokotala yemwe amagwiritsa ntchito dongosolo lamanjenje (neurologist) amatha kupanga matendawa kutengera:

• Mbiri ya zizindikiro
• Zotsatira zakuthupi
• Kulamulira zina zomwe zimayambitsa matenda

Kuyesera kuti mutsimikizire kuti matendawa ndi awa:

• MRI ya mutu
• Magulu a plasma norepinephrine
• Kuyeza kwamikodzo pazinthu zowononga norepinephrine (mkodzo katekolamaini)

Palibe mankhwala a MSA-P. Palibe njira yodziwika yotetezera matendawa kuti asakule. Cholinga cha chithandizo ndikuwongolera zizindikilo.

Mankhwala a Dopaminergic, monga levodopa ndi carbidopa, atha kugwiritsidwa ntchito pochepetsa kunjenjemera koyambirira kapena pang'ono.

Koma, kwa anthu ambiri omwe ali ndi MSA-P, mankhwalawa sagwira ntchito bwino.

Mankhwala atha kugwiritsidwa ntchito kuthana ndi kuthamanga kwa magazi.

Chopangira pacemaker chomwe chimakonzekeretsa mtima kuti chigunde mwachangu (mwachangu kuposa kumenya kwa 100 pamphindi) chitha kukulitsa kuthamanga kwa magazi kwa anthu ena.

Kudzimbidwa kumatha kuchiritsidwa ndi zakudya zamafuta ambiri komanso zakumwa zoziziritsa kukhosi. Mankhwala alipo kuti athetse mavuto okomoka.

Zambiri ndi chithandizo kwa anthu omwe ali ndi MSA-P ndi mabanja awo amapezeka ku:

• National Organisation for Rare Disways - rarediseases.org/rare-diseases/multiple-system-atrophy
• Mgwirizano wa MSA - www.multiplesystematrophy.org/msa-resource/

Zotsatira za MSA ndizosauka. Kutaya ntchito zamaganizidwe ndi thupi kumawonjezeka pang'onopang'ono. Kumwalira koyambirira ndikotheka. Anthu amakhala zaka 7 mpaka 9 atazindikira.

Itanani omwe akukuthandizani ngati mukukula ndi matendawa.

Itanani omwe akukuthandizani ngati mwapezeka kuti muli ndi MSA ndipo matenda anu amabwerera kapena kukulira. Itaninso ngati pali zizindikiro zatsopano, kuphatikiza zoyipa zamankhwala, monga:

• Zosintha pakuchenjeza / machitidwe / malingaliro
• Khalidwe lachinyengo
• Chizungulire
• Ziwerengero
• Kusuntha kosadzipereka
• Kutaya kwamalingaliro
• Nseru kapena kusanza
• Kusokonezeka kwakukulu kapena kusokonezeka

Ngati muli ndi wachibale wanu yemwe ali ndi MSA ndipo matenda ake akuchepa mpaka kuti simungathe kusamalira munthuyo kunyumba, pemphani upangiri kwa omwe amakupatsani wachibale wanu.

Shy-Drager matenda; Neurologic orthostatic hypotension; Matenda a Shy-McGee-Drager; Parkinson kuphatikiza matenda; MSA-P; MSA-C

• Central dongosolo lamanjenje ndi zotumphukira zamanjenje

Fanciulli A, Wenning GK. Angapo-dongosolo atrophy. N Engl J Med. 2015; 372 (3): 249-263. PMID: 25587949 pubmed.ncbi.nlm.nih.gov/25587949/.

Matenda a Jankovic J. Parkinson ndi zovuta zina zoyenda. Mu: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, olemba. Neurology ya Bradley mu Kuchita Zachipatala. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2016: chap 96.

Romero-Ortuno R, Wilson KJ, Hampton JL. Kusokonezeka kwa dongosolo lamanjenje lodziyimira palokha. Mu: Fillit HM, Rockwood K, Young J, eds. Brocklehurst's Textbook of Geriatric Medicine ndi Gerontology. 8th ed. Philadelphia, PA: Elsevier; 2017: mutu 63.