Autosomal wamkulu

Autosomal yayikulu ndi imodzi mwanjira zambiri zomwe mikhalidwe kapena vuto lomwe lingapitirire kudzera m'mabanja.

Mu matenda opatsirana kwambiri, ngati mungapeze chibadwa chachilendo kuchokera kwa kholo limodzi, mutha kudwala. Nthawi zambiri, m'modzi mwa makolowo amathanso kukhala ndi matendawa.

Kulowa matenda, chikhalidwe, kapena mawonekedwe zimadalira mtundu wa chromosome yomwe yakhudzidwa (nonsex kapena chromosome yakugonana). Zimadaliranso kuti khalidweli ndilopambana kapena lowonjezera.

Jini limodzi losazolowereka pa imodzi mwazomwe ma 22 nonsex (autosomal) chromosomes kuchokera kwa kholo lililonse limatha kuyambitsa vuto la autosomal.

Cholowa chambiri chimatanthauza kuti jini yosazolowereka ya kholo limodzi imatha kuyambitsa matenda. Izi zimachitika ngakhale jini lofananira kuchokera kwa kholo linalo ndilabwino. Mtundu wabwinobwino umalamulira.

Matendawa amathanso kuchitika ngati mwana watsopano pomwe kholo lililonse lakhala ndi jini losazolowereka.

Mayi yemwe ali ndi vuto lotha kukhala ndi autosomal ali ndi mwayi wokhala ndi mwana amene ali ndi vutoli 50%. Izi ndi zoona pa mimba iliyonse.

Zikutanthauza kuti chiopsezo cha mwana aliyense pamatendawo sichidalira kuti abale awo ali ndi matendawa.

Ana omwe samalandira cholowa chachilendo sangakhale ndi matendawa.

Ngati wina amapezeka kuti ali ndi matenda opatsirana pogonana, makolo awo amayeneranso kuti ayesedwe ndi jini losazolowereka.

Zitsanzo zamavuto akulu autosomal ndi Marfan syndrome ndi neurofibromatosis mtundu 1.

Cholowa - autosomal lalikulu; Genetics - wopambana kwambiri

• Mitundu yayikulu yama Autosomal

Nussbaum RL, McInnes RR, Willard HF (Adasankhidwa) Zitsanzo za cholowa cha m'badwo umodzi. Mu: Nussbaum RL, McInnes RR, Willard HF, olemba. Thompson & Thompson Genetics mu Mankhwala. 8th ed. Philadelphia, PA: Elsevier; 2016: mutu 7.

Scott DA, Lee B. Njira zakutengera kwa majini. Mu: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, olemba. Nelson Textbook of Pediatrics. Wolemba 21st..Philadelphia, PA: Elsevier; 2020: chap 97.