Buprenorphine Sublingual ndi Buccal (kudalira opioid)

Zamkati

• Musanatenge buprenorphine kapena buprenorphine ndi naloxone,
• Buprenorphine kapena buprenorphine ndi naloxone zimatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgulu la CHENJEZO kapena MFUNDO ZOCHITIKA, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo izi:

Buprenorphine komanso kuphatikiza kwa buprenorphine ndi naloxone amagwiritsidwa ntchito pochizira kudalira kwa opioid (kumwerekera ndi mankhwala opioid, kuphatikiza heroin ndi mankhwala opha ululu). Buprenorphine ali mgulu la mankhwala otchedwa opioid pang'ono agonist-antagonists ndipo naloxone ali mgulu la mankhwala otchedwa opioid antagonists. Buprenorphine yokha komanso kuphatikiza kwa buprenorphine ndi naloxone kumathandiza kupewa zizindikiritso zakutha munthu wina atasiya kumwa mankhwala opioid popanga zomwezo ndi mankhwalawa.

Buprenorphine imabwera ngati piritsi laling'ono. Kuphatikiza kwa buprenorphine ndi naloxone kumabwera ngati piritsi laling'ono (Zubsolv) komanso ngati kanema wazilankhulo zochepa (Suboxone) woti azitenga pansi pa lilime komanso ngati kanema wa buccal (Bunavail) woti agwiritse ntchito pakati pa chingamu ndi tsaya. Dokotala wanu atasankha mlingo woyenera, mankhwalawa amatengedwa kamodzi patsiku. Kukuthandizani kukumbukira kukumbukira kutenga kapena kugwiritsa ntchito buprenorphine kapena buprenorphine ndi naloxone, tengani kapena muzigwiritsa ntchito nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani kapena ikani buprenorphine kapena buprenorphine ndi naloxone ndendende momwe mwalangizira. Osamutenga kapena kuugwiritsa ntchito pang'ono kapena kumugwiritsa kapena kumugwiritsa ntchito pafupipafupi kuposa momwe adanenera dokotala.

Dokotala wanu angasankhe kuyamba chithandizo chanu ndi buprenorphine, yomwe mudzapita ku ofesi ya dokotala. Muyamba pamlingo wochepa wa buprenorphine ndipo dokotala wanu adzawonjezera mlingo wanu kwa masiku 1 kapena 2 asanakusinthireni ku buprenorphine ndi naloxone. Kutengera mtundu wa opioid yomwe mumamwa, njira ina yomwe dokotala angasankhe ndikuyamba kulandira chithandizo ndi buprenorphine ndi naloxone nthawi yomweyo. Dokotala wanu akhoza kukulitsa kapena kuchepa buprenorphine wanu ndi mlingo wa naloxone kutengera yankho lanu.

Ngati mukumwa mapiritsi okhala ndi zinenero zing'onozing'ono, ikani mapiritsiwa pansi pa lilime mpaka atasungunuka. Ngati mukumwa mapiritsi opitilira awiri, muziwayika onse pansi pa lilime lanu nthawi imodzi kapena muwayike pansi pa lilime lanu mpaka awiri nthawi imodzi. Osatafuna mapiritsi kapena kuwameza onse. Musadye, kumwa, kapena kulankhula mpaka phale litasungunuka kwathunthu.

Ngati mukugwiritsa ntchito kanema wa buccal, gwiritsani ntchito lilime lanu kunyowetsa mkati mwa tsaya lanu kapena kutsuka mkamwa mwanu ndi madzi musanagwiritse ntchito kanemayo. Ikani kanemayo ndi chala chouma mkati mwa tsaya. Kenako chotsani chala chanu ndipo kanemayo amakanirira mkati mwa tsaya lanu. Ngati mukufuna kugwiritsa ntchito mafilimu awiri, ikani kanema wina mkati mwa tsaya lanu nthawi yomweyo. Osayika mafilimu pamwamba pa anzanu ndipo musagwiritse ntchito makanema opitilira awiri mkamwa nthawi imodzi. Siyani kanemayo pakamwa mpaka atasungunuka. Musadule, kung'amba, kutafuna, kumeza, kugwira kapena kusuntha filimuyo ikasungunuka. Musadye kapena kumwa chilichonse mpaka filimuyo itasungunuka kwathunthu.

Ngati mukugwiritsa ntchito kanemayo, muzitsuka pakamwa panu ndi madzi musanayike. Ikani kanemayo ndi chala chouma pansi pa lilime lanu kumanja kapena kumanzere pakati ndikusunga kanemayo kwa masekondi 5. Ngati mukugwiritsa ntchito mafilimu awiri, ikani ina mbali inayo pansi pa lilime. Osayika makanema pamwamba kapena pafupi. Musagwiritse ntchito makanema opitilira awiri nthawi imodzi. Musadule, kung'amba, kutafuna, kumeza, kugwira kapena kusuntha filimuyo ikasungunuka. Musadye kapena kumwa chilichonse mpaka filimuyo itasungunuka kwathunthu.

Ngati mukufuna kusintha kuchokera ku buprenorphine kapena buprenorphine ndi naloxone kupita kwina, dokotala angafunike kusintha mlingo wanu. Nthawi iliyonse mukalandira mankhwala anu, onetsetsani kuti mwalandira mankhwala a buprenorphine omwe adakulamulirani. Funsani wamankhwala wanu ngati simukudziwa kuti mwalandira mankhwala oyenera.

Osasiya kumwa buprenorphine kapena buprenorphine ndi naloxone osalankhula ndi dokotala. Kuyimitsa buprenorphine kapena buprenorphine ndi naloxone mwachangu kumatha kuyambitsa zizindikiritso zakutha. Dokotala wanu angakuuzeni nthawi ndi momwe mungaleke kumwa buprenorphine kapena buprenorphine ndi naloxone. Ngati mwasiya mwadzidzidzi kumwa buprenorphine kapena buprenorphine ndi naloxone, mutha kukumana ndi zizindikiritso zakutha monga kutentha kapena kuzizira, kusakhazikika, maso akung'ambika, mphuno, kutuluka thukuta, kuzizira, kupweteka kwa minofu, kusanza, kapena kutsekula m'mimba.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge buprenorphine kapena buprenorphine ndi naloxone,

• uzani adotolo ndi wazamankhwala ngati muli ndi vuto la buprenorphine, naloxone, mankhwala ena aliwonse, kapena zina zilizonse mu buprenorphine kapena buprenorphine ndi mapiritsi kapena kanema wa naloxone. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni dokotala ndi wazamankhwala mankhwala omwe akupatsani, osavomerezeka, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa. Onetsetsani kuti mwatchulapo izi: antihistamines (yomwe imapezeka m'mankhwala ozizira komanso ozizira); Ma antipsychotic monga aripiprazole (Abilify), asenapine (Saphris), cariprazine (Vraylar), chlorpromazine, clozapine (Versacloz), fluphenazine, haloperidol (Haldol), iloperidone (Fanapt), loxapine, lurasidone (Latuda), molindone, molindone , paliperidone (Invega), perphenazine, pimavanserin (Nuplazid), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, thiothixene, trifluoperazine, ndi ziprasidone (Geodon); benzodiazepines monga alprazolam (Xanax), chlordiazepoxide (Librium), clobazam (Onfi), clonazepam (Klonopin), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam quazepam (Doral), temazepam (Restoril), ndi triazolam (Halcion); okodzetsa ('mapiritsi amadzi'); erythromycin (EES, Eryc, Erythrocin, ena); mankhwala ena a HIV monga atazanavir (Reyataz, ku Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, ku Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ndi ritonavir ( , ku Kaletra, ku Technivie); zamatsenga; ipratropium (Atrovent); mankhwala a matenda opunduka, matumbo, matenda a Parkinson, zilonda, kapena mavuto amikodzo; ketoconazole; mankhwala a mutu waching'alang'ala monga almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Alsuma, Imitrex, ku Treximet), ndi zolmitriptan (Zomig); mirtazapine (Remeron); zotsitsimula minofu monga cyclobenzaprine (Amrix), dantrolene (Dantrium), ndi metaxalone (Skelaxin); opiate (mankhwala osokoneza bongo) mankhwala othandizira kupweteka komanso kutsokomola; rifampin (Rifadin, Rimactane, ku Rifater, ku Rifamate); mankhwala a khunyu monga carbamazepine (Epitol, Tegretol, Teril, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); mankhwala ogonetsa; 5HT₃ otsekemera a serotonin monga alosetron (Lotronex), granisetron (Sancuso, Sustol), ondansetron (Zofran, Zuplenz), kapena palonosetron (Aloxi); serotonin-reuptake inhibitors monga citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, mu Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), ndi sertraline (Zoloft); serotonin ndi norepinephrine reuptake inhibitors monga duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), ndi venlafaxine (Effexor); mapiritsi ogona; tramadol (Conzip); trazodone; kapena tricyclic antidepressants ('mood elevator') monga amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactiline), ndi trimipramine. Komanso uzani dokotala wanu kapena wamankhwala ngati mukumwa kapena kulandira mankhwala otsatirawa a monoamine oxidase (MAO) kapena ngati mwasiya kuwamwa m'masabata awiri apitawa: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil) , selegiline (Eldepryl, Emsam, Zelapar), kapena tranylcypromine (Parnate). Mankhwala ena ambiri amathanso kulumikizana ndi buprenorphine kapena buprenorphine ndi naloxone, onetsetsani kuti mwauza adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. John's ndi tryptophan.
• auzeni adotolo ngati mumamwa kapena mudamwa mowa wambiri komanso ngati mwakhalapo ndi mavuto a adrenal monga matenda a Addison (momwe adrenal gland imatulutsira mahomoni ocheperako kuposa masiku onse); benign prostatic hypertrophy (BPH, kukulitsa kwa prostate gland); zovuta kukodza; kuvulala pamutu; kuyerekezera zinthu m'maganizo (kuwona zinthu kapena kumva mawu omwe kulibe); kupindika kwa msana komwe kumapangitsa kupuma kupuma; matenda a ndulu; Matenda osokoneza bongo (COPD; gulu la matenda omwe amakhudza mapapu ndi njira zowuluka); kapena chithokomiro, impso, chiwindi, kapena matenda am'mapapo.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukatenga buprenorphine kapena buprenorphine ndi naloxone, itanani dokotala wanu. Ngati mumamwa buprenorphine kapena buprenorphine ndi naloxone mapiritsi kapena kanema nthawi zonse mukakhala ndi pakati, mwana wanu amatha kukhala ndi ziwopsezo zochoka pobereka. Uzani dokotala wa mwana wanu nthawi yomweyo ngati mwana wanu akukumana ndi izi: kukwiya, kugwidwa, kugwedezeka kosalamulirika kwa gawo lina la thupi, kusanza, kutsegula m'mimba, kapena kulephera kunenepa.
• Uzani dokotala wanu ngati mukuyamwitsa. Uzani dokotala wa mwana wanu nthawi yomweyo ngati mwana wanu wagona tulo kuposa masiku onse kapena amavutika kupuma mukamamwa mankhwalawa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa buprenorphine kapena buprenorphine ndi naloxone.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kwakumwa buprenorphine kapena buprenorphine ndi naloxone.
• muyenera kudziwa kuti buprenorphine kapena buprenorphine ndi naloxone zitha kukupangitsani kugona. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.
• simuyenera kumwa mowa kapena kumwa mankhwala akuchipatala kapena osalemba omwe ali ndi mowa mukamamwa mankhwalawa.
• muyenera kudziwa kuti buprenorphine kapena buprenorphine ndi naloxone imatha kuyambitsa chizungulire, mutu wopepuka, komanso kukomoka mukadzuka msanga kuchokera pamalo abodza. Izi ndizofala kwambiri mukayamba kumwa buprenorphine kapena buprenorphine ndi naloxone. Pofuna kupewa vutoli, tulukani pabedi pang'onopang'ono, ndikupumitsa mapazi anu pansi kwa mphindi zingapo musanayimirire.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani kapena gwiritsani ntchito mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge kapena kugwiritsa ntchito mlingo wawiri kuti mugwirizane ndi zomwe mwaphonya.

Buprenorphine kapena buprenorphine ndi naloxone zimatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kupweteka m'mimba
• kudzimbidwa
• kuvuta kugona kapena kugona
• dzanzi pakamwa kapena kufiira
• lilime kupweteka
• kusawona bwino
• kupweteka kwa msana

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgulu la CHENJEZO kapena MFUNDO ZOCHITIKA, itanani dokotala wanu mwachangu:

• ming'oma
• zidzolo
• kuyabwa
• kuvuta kupuma kapena kumeza
• kutupa kwa nkhope, mmero, lilime, milomo, maso, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kusakhazikika, kuyerekezera zinthu m'maganizo (kuwona zinthu kapena kumva mawu omwe kulibe), malungo, thukuta, chisokonezo, kugunda kwamtima, kunjenjemera, kuuma minofu mwamphamvu kapena kugwedezeka, kutayika kwa mgwirizano, nseru, kusanza, kapena kutsekula m'mimba
• nseru, kusanza, kusowa kwa njala, kufooka, kapena chizungulire
• Kulephera kupeza kapena kusunga erection
• msambo wosasamba
• Kuchepetsa chilakolako chogonana
• kupuma pang'ono
• kukhumudwa m'mimba
• kutopa kwambiri
• chisokonezo
• kusawona bwino
• mawu osalankhula
• kutuluka mwachilendo kapena kuphwanya
• kusowa mphamvu
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• mkodzo wamtundu wakuda
• mipando yoyera

Buprenorphine kapena buprenorphine ndi naloxone zimatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwalawa m'matumba omwe adalowamo, otsekedwa mwamphamvu, ndipo ana sangathe kuwapeza. Buprenorphine kapena buprenorphine ndi naloxone amatha kukhala chandamale cha anthu omwe amamwa mankhwala osokoneza bongo kapena mankhwala osokoneza bongo. Zisungeni pamalo abwino kuti wina asazigwiritse ntchito mwangozi kapena mwadala. Sungani buprenorphine kapena buprenorphine ndi naloxone kutentha ndikutentha kwambiri ndi chinyezi (osati kubafa). Osazizira buprenorphine kapena buprenorphine ndi naloxone.

Muyenera kutaya nthawi yomweyo mankhwala aliwonse omwe ndi achikale kapena osafunikanso kudzera pulogalamu yobwezeretsanso mankhwala. Ngati mulibe pulogalamu yobwezera pafupi kapena yomwe mungathe kupeza mwachangu, ndiye kuti tayani mapiritsi kapena makanema osafunikira powachotsa m'mapaketi ndikuwaponya mchimbudzi. Itanani foni yanu kapena wopanga ngati muli ndi mafunso kapena mukufuna thandizo kutaya mankhwala osafunikira.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Mukamamwa buprenorphine kapena buprenorphine ndi naloxone, muyenera kuyankhula ndi adotolo za mankhwala opulumutsa omwe amatchedwa naloxone omwe amapezeka mosavuta (mwachitsanzo, kunyumba, ofesi). Naloxone imagwiritsidwa ntchito kusintha zomwe zimawopseza moyo chifukwa cha bongo. Zimagwira ntchito poletsa zotsatira za ma opiate kuti athetse zovuta zomwe zimayambitsidwa ndi ma opiate ambiri m'magazi. Dokotala wanu amathanso kukupatsirani naloxone ngati mukukhala m'nyumba momwe muli ana aang'ono kapena wina yemwe wagwiritsa ntchito mankhwala osokoneza bongo mumsewu. Muyenera kuwonetsetsa kuti inu ndi abale anu, osamalira odwala, kapena anthu omwe mumacheza nanu mukudziwa momwe mungadziwire kuchuluka kwa mankhwala osokoneza bongo, momwe mungagwiritsire ntchito naloxone, ndi zomwe muyenera kuchita mpaka chithandizo chadzidzidzi chidzafike. Dokotala wanu kapena wamankhwala akuwonetsani inu ndi abale anu momwe mungagwiritsire ntchito mankhwalawa. Funsani wamankhwala wanu kuti akupatseni malangizowo kapena pitani patsamba la wopanga kuti mupeze malangizowo. Ngati zizindikilo za bongo zikachitika, mnzanu kapena wachibale akuyenera kupereka mlingo woyamba wa naloxone, itanani 911 mwachangu, ndikukhala nanu ndikukuyang'anirani mpaka thandizo ladzidzidzi litafika. Zizindikiro zanu zimatha kubwerera mkati mwa mphindi zochepa mutalandira naloxone. Ngati zizindikiro zanu zibwerera, munthuyo akuyenera kukupatsaninso mankhwala a naloxone. Mlingo wowonjezerapo ungaperekedwe mphindi ziwiri kapena zitatu zilizonse, ngati zizindikiro zibwerera chithandizo chamankhwala chisanabwere.

Zizindikiro za bongo zingaphatikizepo izi:

• onetsetsani ophunzira
• kugona kapena kuwodzera kwambiri
• chizungulire
• kusawona bwino
• kupuma pang'ono kapena pang'ono
• kuvuta kupuma
• osakhoza kuyankha kapena kudzuka

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu likuyankhira buprenorphine ndi naloxone.

Musanayesedwe mu labotale (makamaka yomwe imakhudza methylene buluu), uzani adotolo ndi ogwira nawo ntchito kuti mukumwa buprenorphine kapena buprenorphine ndi naloxone.

Ngati mwadzidzidzi, inu kapena wachibale wanu muyenera kuuza adotolo kapena ogwira ntchito zadzidzidzi kuti mukumwa buprenorphine kapena buprenorphine ndi naloxone.

Osabaya buprenorphine kapena buprenorphine ndi naloxone yamafilimu kapena mapiritsi. Zovuta zazikulu zitha kuchitika, kuphatikiza zizindikiritso zakutha.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Subutex^®¶

• Kuthawa^® (yokhala ndi Buprenorphine, Naloxone)
• Suboxone^® (yokhala ndi Buprenorphine, Naloxone)^¶
• Zubolv^® (yokhala ndi Buprenorphine, Naloxone)

^¶ Chogulitsa ichi sichikupezeka pamsika. Njira zina zitha kupezeka.