Zoledronic Acid jekeseni

Zamkati

• Asanalandire jekeseni wa zoledronic acid,
• Zoledronic acid ingayambitse mavuto. Uzani dokotala wanu ngati chimodzi mwazizindikirozi, kapena zomwe zalembedwa m'magulu a HOW or PRECAUTIONS, ndizowopsa kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, uzani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Zoledronic acid (Reclast) amagwiritsidwa ntchito popewa kapena kuchiza kufooka kwa mafupa (mkhalidwe womwe mafupa amafooka ndi kufooka ndikuphwanya mosavuta) mwa azimayi omwe apita kumapeto ('kusintha kwa moyo,' kutha kwa msambo wokhazikika). Zoledronic acid (Reclast) imagwiritsidwanso ntchito kuchiza kufooka kwa mafupa mwa amuna, komanso kupewa kapena kuchiza kufooka kwa mafupa mwa amuna ndi akazi omwe akumwa glucocorticoids (mtundu wa mankhwala a corticosteroid omwe angayambitse kufooka kwa mafupa). Zoledronic acid (Reclast) imagwiritsidwanso ntchito pochiza matenda a Paget a mafupa (mkhalidwe womwe mafupa ake amakhala ofewa komanso ofooka ndipo amatha kupunduka, kuwawa, kapena kusweka mosavuta). Zoledronic acid (Zometa) amagwiritsidwa ntchito pochiza calcium yambiri m'magazi yomwe imatha kuyambitsidwa ndi mitundu ina ya khansa. Zoledronic acid (Zometa) imagwiritsidwanso ntchito limodzi ndi chemotherapy ya khansa kuti muchepetse kuwonongeka kwa mafupa komwe kumayambitsidwa ndi myeloma yambiri [khansa yomwe imayambira m'maselo am'magazi (maselo oyera amwazi omwe amapanga zinthu zofunika kulimbana ndi matenda)] kapena khansa yomwe idayamba gawo lina la thupi koma lafalikira mpaka mafupa. Zoledronic acid (Zometa) si chemotherapy ya khansa, ndipo siyachedwetsa kapena kuletsa kufalikira kwa khansa. Komabe, itha kugwiritsidwa ntchito kuchiza matenda amfupa kwa odwala omwe ali ndi khansa. Zoledronic acid ili mgulu la mankhwala otchedwa bisphosphonates. Imagwira pakuchepetsa mafupa, kuwonjezeka kwa mafupa (makulidwe), ndikuchepetsa calcium yomwe imatulutsidwa m'mafupa kulowa m'magazi.

Zoledronic acid imabwera ngati yankho (madzi) kuti alowe mumtsinje osachepera mphindi 15. Nthawi zambiri amabayidwa ndi wothandizira zaumoyo kuofesi ya dokotala, kuchipatala, kapena kuchipatala. Pamene jekeseni wa zoledronic acid amagwiritsidwa ntchito pochiza calcium m'magazi ambiri omwe amayamba chifukwa cha khansa nthawi zambiri amapatsidwa ngati mlingo umodzi. Mlingo wachiwiri ungaperekedwe osachepera masiku 7 mutangoyamba kumwa mankhwalawa ngati calcium ya magazi siyatsika msinkhu kapena siyikhala pamiyeso yanthawi zonse. Pamene jekeseni wa zoledronic acid amagwiritsidwa ntchito kuthana ndi kuwonongeka kwa mafupa omwe amabwera chifukwa cha myeloma yambiri kapena khansa yomwe yafalikira m'mafupa, imaperekedwa kamodzi pamasabata atatu kapena anayi. Pamene jekeseni wa zoledronic acid amagwiritsidwa ntchito pochiza kufooka kwa mafupa kwa azimayi omwe atha msambo, kapena mwa amuna, kapena kuchiza kapena kupewa kufooka kwa mafupa kwa anthu omwe akutenga glucocorticoids, nthawi zambiri amapatsidwa kamodzi pachaka. Pamene zoledronic acid imagwiritsidwa ntchito kupewetsa kufooka kwa mafupa kwa azimayi omwe adayamba kusamba, nthawi zambiri amapatsidwa kamodzi zaka ziwiri zilizonse. Pamene zoledronic acid imagwiritsidwa ntchito pochiza matenda a Paget a mafupa, nthawi zambiri amaperekedwa ngati gawo limodzi, koma milingo yowonjezera imatha kuperekedwa pakadutsa nthawi.

Onetsetsani kuti mumamwa magalasi awiri amadzi kapena madzi ena mkati mwa maola ochepa musanalandire zoledronic acid.

Dokotala wanu akhoza kukupatsani mankhwala othandizira calcium komanso mavitamini D okhala ndi vitamini D. Muyenera kumwa mankhwalawa tsiku lililonse malinga ndi malangizo a dokotala. Uzani dokotala wanu ngati pali chifukwa chilichonse choti simudzatha kumwa mankhwalawa mukamalandira mankhwala.

Mutha kukumana ndi zomwe mungachite m'masiku ochepa mutangolandira jakisoni wa zoledronic acid. Zizindikiro za izi zimatha kukhala ngati chimfine, malungo, kupweteka mutu, kuzizira, mafupa, kulumikizana kapena minofu. Zizindikiro izi zimatha kuyamba masiku atatu mutalandira mankhwala a zoledronic acid ndipo mutha kukhala masiku 3 mpaka 14. Dokotala wanu angakuuzeni kuti mutenge mankhwala ochepetsa kupweteka kwa thupi osalandira mankhwala / kuchepetsa kutentha thupi mukalandira zoledronic acid jekeseni kuti muchepetse kapena kuchiza matendawa.

Ngati mukulandira jekeseni wa zoledronic acid kuti muchepetse kapena kuchiza kufooka kwa mafupa, muyenera kupitiliza kulandira mankhwalawa monga munakonzedweratu ngakhale mukumva bwino. Muyenera kulankhula ndi dokotala wanu nthawi ndi nthawi ngati mukufunikirabe kulandira mankhwalawa.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa zoledronic acid ndipo nthawi iliyonse mukalandira mankhwala. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga} kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa zoledronic acid,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la zoledronic acid kapena mankhwala ena aliwonse, kapena china chilichonse chosakanikirana ndi jekeseni wa zoledronic acid. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• muyenera kudziwa kuti zoledronic acid jekeseni imapezeka pansi pa mayina a Zometa ndi Reclast. Muyenera kuthandizidwa ndi imodzi mwazinthu izi nthawi imodzi.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: aminoglycoside maantibayotiki monga amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Neo-Rx, Neo-Fradin), paromomycin (Humatin), streptomycin, ndi tobramycin (Tobi , Nebcin); aspirin ndi mankhwala ena osagwiritsa ntchito kutupa (NSAIDs) monga ibuprofen (Advil, Motrin) ndi naproxen (Aleve, Naprosyn); mankhwala a khansa chemotherapy; digoxin (Lanoxin, mu Digitek); okodzetsa ('mapiritsi amadzi') monga bumetanide (Bumex), ethacrynic acid (Edecrin), ndi furosemide (Lasix); ndi steroids pakamwa monga dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), ndi prednisone (Deltasone). Mankhwala ena ambiri amatha kulumikizana ndi zoledronic acid, chifukwa chake uzani dokotala wanu za mankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• Uzani dokotala wanu ngati mwakhalapo ndi matenda a impso kapena ngati muli ndi mkamwa wouma, mkodzo wakuda, kuchepa thukuta, khungu louma, ndi zizindikilo zina zakusowa madzi m'thupi kapena posachedwapa mwatsegula m'mimba, kusanza, malungo, matenda, kutuluka thukuta kwambiri, kapena alephera kumwa madzi okwanira. Dokotala wanu amadikirira mpaka musadzatheretu madzi musanapatsidwe jakisoni wa zoledronic acid kapena ngati muli ndi mitundu ina ya matenda a impso sangakupatseni mankhwalawa. Uzani dokotala wanu ngati mudakhalako ndi calcium yotsika pang'ono m'magazi anu. Dokotala wanu angayang'ane kuchuluka kwa calcium m'magazi anu musanayambe mankhwala ndipo mwina sangakupatseni mankhwalawa ngati mulingo watsika kwambiri.
• auzeni dokotala ngati mwalandira mankhwala a zoledronic acid kapena ma bisphosphonates ena (Actonel, Actonel + Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax + D, Reclast, Skelid, ndi Zometa) m'mbuyomu; ngati munachitidwapo opaleshoni pamatenda anu a parathyroid (kachingwe kakang'ono m'khosi) kapena chithokomiro kapena opaleshoni yochotsa magawo am'mimba mwanu; ndipo ngati mwakhalapo kapena munakhalapo ndi vuto la mtima (momwe mtima sungapoperere magazi okwanira mbali zina za thupi); kusowa magazi (momwe maselo ofiira amafiira samatha kubweretsa mpweya wokwanira kumadera ena amthupi); vuto lililonse lomwe limaletsa magazi anu kuti asagundike bwino; kashiamu, magnesium, kapena potaziyamu wochepa m'magazi anu; chikhalidwe chilichonse chomwe chimalepheretsa thupi lanu kuti lisamwe zakudya m'thupi; kapena mavuto pakamwa panu, mano, kapena m'kamwa; matenda, makamaka mkamwa mwako; mphumu kapena kupuma, makamaka ngati zawonjezekanso ndikumwa aspirin; kapena matenda a parathyroid kapena chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kugwiritsa ntchito njira yodalirika yolerera popewa kutenga pakati mukalandira zoledronic acid. Mukakhala ndi pakati mukalandira zoledronic acid, itanani dokotala wanu. Zoledronic acid ikhoza kuvulaza mwana wosabadwayo. Lankhulani ndi dokotala wanu ngati mukufuna kutenga pakati nthawi ina iliyonse m'tsogolo chifukwa zoledronic acid ikhoza kukhalabe mthupi lanu kwa zaka zambiri mutasiya kuilandira.
• muyenera kudziwa kuti zoledronic acid jekeseni imatha kupweteketsa mafupa, minofu, kapena mafupa. Mutha kuyamba kumva kupweteka uku pasanathe masiku kapena miyezi mutangolowa zoledronic jakisoni wa asidi. Ngakhale kuwa kwamtunduwu kumatha kuyamba mutalandira jakisoni wa zoledronic acid kwakanthawi, ndikofunikira kuti inu ndi dokotala muzindikire kuti mwina zimayambitsidwa ndi zoledronic acid. Itanani dokotala wanu nthawi yomweyo ngati mukumva kuwawa kwambiri nthawi iliyonse mukamalandira jekeseni wa zoledronic acid. Dokotala wanu akhoza kusiya kukupatsani zoledronic acid jekeseni ndipo ululu wanu ukhoza kutha mukasiya mankhwala ndi mankhwalawa.
• muyenera kudziwa kuti zoledronic acid imatha kubweretsa nsagwada (ONJ, vuto lalikulu la nsagwada), makamaka ngati mwachita opaleshoni yamano kapena chithandizo mukamamwa mankhwalawa. Dokotala wa mano amayenera kuyesa mano anu ndikuchita chithandizo chilichonse chofunikira, kuphatikizapo kuyeretsa, musanayambe kugwiritsa ntchito zoledronic acid. Onetsetsani kutsuka mano ndikutsuka mkamwa mwanu moyenera mukamagwiritsa ntchito zoledronic acid. Lankhulani ndi dokotala musanalandire chithandizo chilichonse cha mano mukamagwiritsa ntchito mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Mukaphonya nthawi kuti mulandire kulowetsedwa kwa zoledronic acid, itanani dokotala wanu mwachangu.

Zoledronic acid ingayambitse mavuto. Uzani dokotala wanu ngati chimodzi mwazizindikirozi, kapena zomwe zalembedwa m'magulu a HOW or PRECAUTIONS, ndizowopsa kapena sizichoka:

• kuyabwa, kufiira, kupweteka, kapena kutupa pamalo pomwe mudalandira jakisoni wanu
• ofiira, otupa, oyabwa, kapena otulutsa maso kapena kutupa mozungulira maso
• kudzimbidwa
• nseru
• kusanza
• kutsegula m'mimba
• kupweteka m'mimba
• kusowa chilakolako
• kuonda
• kutentha pa chifuwa
• zilonda mkamwa
• kuda nkhawa kwambiri
• kubvutika
• kukhumudwa
• kuvuta kugona kapena kugona
• malungo, kuzizira, chifuwa, ndi zizindikiro zina za matenda
• zigamba zoyera pakamwa
• kutupa, kufiira, kuyabwa, kuwotcha, kapena kuyabwa kumaliseche
• kutuluka koyera kumaliseche
• dzanzi kapena kumva kulasalasa pakamwa kapena zala kapena zala zakumapazi
• kutayika tsitsi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, uzani dokotala nthawi yomweyo:

• zidzolo
• ming'oma
• kuyabwa
• kutupa kwa maso, nkhope, milomo, lilime, mmero, manja, mikono, mapazi, akakolo, kapena miyendo yakumunsi
• ukali
• kuvuta kupuma kapena kumeza
• kupweteka pachifuwa chapamwamba
• kugunda kwamtima kosasinthasintha
• kutuluka kwa minofu, kupindika, kapena kukokana
• kuvulaza kapena kutuluka mwachilendo
• nkhama zopweteka kapena zotupa
• kumasula mano
• dzanzi kapena kumverera kolemetsa pachibwano
• Zowawa pakamwa kapena nsagwada zomwe sizichira

Zoledronic acid ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Kuchiritsidwa ndi mankhwala a bisphosphonate monga zoledronic acid jekeseni wa kufooka kwa mafupa kumatha kuonjezera chiopsezo choti mungathyoke mafupa anu. Mungamve kupweteka, kupweteka m'chiuno mwanu, kubuula kwanu, kapena ntchafu zanu kwa milungu ingapo kapena miyezi isanaphwanye mafupa, ndipo mutha kupeza kuti limodzi kapena mafupa anu onse a ntchafu asweka ngakhale simunagwe kapena kudziwa zoopsa zina. Si zachilendo kuti fupa la ntchafu lisweretse anthu athanzi, koma anthu omwe ali ndi matenda ofooka mafupa amatha kuthyola fupalo ngakhale sangalandire jekeseni wa zoledronic acid. Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa zoledronic acid.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Dokotala wanu amasungira mankhwalawa muofesi yake ndikupatsani momwe mungafunikire.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• malungo
• kufooka
• kulimbitsa mwadzidzidzi kwa minofu kapena kukokana kwa minofu
• kuthamanga, kugunda, kapena kugunda kwamtima kosasinthasintha
• chizungulire
• mayendedwe osalamulirika amaso
• masomphenya awiri
• kukhumudwa
• kuyenda movutikira
• kugwedezeka kosalamulirika kwa gawo lina la thupi lanu
• kugwidwa
• chisokonezo
• kupuma movutikira
• kupweteka, kutentha, dzanzi kapena kumva kulasalasa m'manja kapena m'mapazi
• zovuta kuyankhula
• zovuta kumeza
• kuchepa pokodza

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire zoledronic acid.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zosintha^®
• Zometa^®