Darunavir

Zamkati

• Musanatenge darunavir,
• Darunavir itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, siyani kumwa darunavir ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

Darunavir imagwiritsidwa ntchito ndi ritonavir (Norvir) ndi mankhwala ena kuchiza matenda a kachirombo ka HIV mwa akulu ndi ana azaka zitatu kapena kupitilira apo. Darunavir ali mgulu la mankhwala otchedwa protease inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka HIV m'magazi. Ngakhale darunavir sichiza kachilombo ka HIV, imatha kuchepetsa mwayi wanu wopeza matenda a immunodeficiency syndrome (AIDS) ndi matenda okhudzana ndi HIV monga matenda akulu kapena khansa. Kumwa mankhwalawa limodzi ndi kuchita zogonana motetezeka ndikusintha zina ndi zina pamoyo kungachepetse chiopsezo chotenga kachirombo ka HIV kwa anthu ena.

Darunavir imabwera ngati piritsi komanso kuyimitsidwa pakamwa (madzi) kuti mutenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya komanso ndi ritonavir kamodzi kapena kawiri patsiku. Tengani darunavir mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani darunavir ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Musatenge darunavir popanda ritonavir.

Kumeza mapiritsi athunthu ndi chakumwa monga madzi kapena mkaka. Osatafuna mapiritsi.

Sambani kuyimitsidwa bwino nthawi iliyonse musanagwiritse ntchito kusakaniza mankhwala mofanana. Gwiritsani ntchito sirinji ya pakamwa yomwe idabwera ndi mankhwalawa kuti muchotse kuyimitsidwa koyenera mu botolo. Mutha kumeza kuyimitsidwa molunjika kuchokera ku syringe. Sambani syringe ndi madzi ndikuilola kuti iume bwino mukatha kugwiritsa ntchito.

Darunavir imayang'anira kachilombo ka HIV koma siyimachiza. Pitilizani kutenga darunavir ngakhale mukumva bwino. Osasiya kumwa darunavir osalankhula ndi dokotala. Mukasiya kumwa darunavir kapena kudumpha mlingo, matenda anu akhoza kukhala ovuta kuchiza. Darunavir yanu ikayamba kuchepa, pezani zambiri kuchokera kwa dokotala kapena wamankhwala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge darunavir,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi darunavir, ritonavir, mankhwala a sulfa, mankhwala ena aliwonse, kapena chilichonse chopezeka m'mapiritsi a darunavir kapena kuyimitsidwa. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza kapena ngati simukudziwa ngati mankhwala omwe simukugwirizana nawo ndi mankhwala a sulfa.
• Uzani dokotala ngati mukumwa mankhwala aliwonse awa: alfuzosin (Uroxatral); cisapride (Propulsid) (sikupezeka ku U.S.); dronearone (Multaq); elbasvir / grazoprevir (Zepatier); mankhwala amtundu wa ergot monga dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, ku Cafergot, ku Migergot), ndi methylergonovine (Methergine); lomitapide (Wowonjezera); lovastatin (Mevacor, mu Advicor); lurasidone (Latuda), midazolam (yoperekedwa ndi pakamwa); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); simvastatin (Zocor, ku Vytorin); Chingwe cha St. kapena triazolam (Halcion). Dokotala wanu angakuuzeni kuti musatenge darunavir. Komanso, ngati muli ndi matenda a impso kapena chiwindi ndipo mukumwa colchicine (Colcrys, Mitigare, ku Col-Probenecid), dokotala wanu angakuuzeni kuti musatenge darunavir.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('ochepera magazi') monga apixaban (Eliquis), rivaroxaban powder (Xarelto), ndi warfarin (Coumadin, Jantoven); antifungals monga itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); artemether / lumefantrine (Coartem); zotchinga beta monga carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, ku Dutoprol, ku Lopressor HCT), ndi timolol (Betimol, Istalol, ku Combigan, ku Cosopt, ena); betamethasone; boceprevir (sakupezekanso ku US; Victrelis); chifuwa (Tracleer); budesonide (Entocort, Pulmicort, Uceris, ena); buprenorphine (Belbuca, Buprenex, Butrans, ku Suboxone, ena); buprenorphine / naloxone (Bunavail, Suboxone, Zubsolv); busipulo; zotchinga calcium-amlodipine (Norvasc, ku Caduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, ena), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), ndi verapamil (Calan, Covera, Verelan, ku Tarka); mankhwala ena a chemotherapy monga dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, ndi vincristine (Marqibo Kit); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet), pravastatin (Pravachol), ndi rosuvastatin (Crestor); ciclesonide (Alvesco); clarithromycin (Biaxin, mu Prevpac); mankhwala ena okhumudwa monga amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), ndi trazodone; dexamethasone; diazepam (Diastat, Valium); estazolam; fentanyl (Abstral, Duragesic, Subsys); fluticasone (Flonase, Flovent, ku Advair); mankhwala ena a kachilombo ka hepatitis C (HCV) monga glecaprevir / pibrentasvir (Mavyret) ndi simeprevir (sakupezekanso ku US; Olysio); Mankhwala ena a HIV kuphatikiza indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), ndi saquinavir (Invirase); njira zolerera za mahomoni (estrogen) (mapiritsi oletsa kubala, zigamba, mphete, zopangira kapena jakisoni); mankhwala a kugunda kwamtima mosasinthasintha kuphatikiza amiodarone (Nexterone, Pacerone), bepridil (yomwe sikupezeka ku US), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), ndi quinidine (ku Nuedexta ); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Equetro, Tegretol, ena), clonazepam (Klonopin), phenobarbital, ndi phenytoin (Dilantin, Phenytek); mankhwala ena omwe amaletsa chitetezo chamthupi monga cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), ndi tacrolimus (Astagraf XL, Prograf); methadone (Dolophine, Methadose); methylprednisolone; mametasone (Asmanex); omeprazole (Prilosec); oxycodone (Xtampza); ena a phosphodiesterase inhibitors (PDE-5 inhibitors) omwe amagwiritsidwa ntchito pa erectile dysfunction monga avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), ndi vardenafil (Levitra, Staxyn); perphenazine; wolosera (Rayos); quetiapine (Seroquel); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); salmeterol (Serevent, ku Advair); tadalafil (Adcirca); thioridazine; maphunziro (Brilinta); tramadol (Conzip); triamcinolone (Nasacort); ndi zolpidem (Ambien, Edluar, Intermezzo). Mankhwala ena ambiri amathanso kulumikizana ndi darunavir, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• ngati mukumwa didanosine (Videx), tengani ola limodzi musanatenge kapena maola awiri mutatenga darunavir.
• uzani dokotala wanu ngati mwakhalapo ndi matenda ashuga kapena shuga wambiri; hemophilia (kutuluka magazi komwe magazi samatseka bwino); matenda otupa chiwindi (kutupa kwa chiwindi chomwe chimayambitsidwa ndi kachilombo), matenda enaake (matenda omwe amayambitsa zipsera zamatenda a chiwindi), kapena matenda ena aliwonse a chiwindi; kapena matenda omwe samatha kapena omwe amabwera ndikudwala monga cytomegalovirus (CMV; matenda opatsirana omwe angayambitse odwala omwe ali ndi chitetezo chamthupi chofooka), mycobacterium avium complex disease (MAC; matenda a bakiteriya omwe angayambitse matenda anthu omwe ali ndi Edzi), chibayo, kapena chifuwa chachikulu (TB; mtundu wa matenda am'mapapo).
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga darunavir, itanani dokotala wanu. Musamayamwitse ngati muli ndi kachilombo ka HIV kapena mukumwa darunavir.
• Muyenera kudziwa kuti darunavir imachepetsa mphamvu yolera yakumapiritsi (mapiritsi oletsa kubala, zigamba, mphete, jakisoni, kapena ma implants). Lankhulani ndi dokotala wanu za njira zolera zosagwiritsira ntchito mahomoni monga njira yotchinga (chida chomwe chimalepheretsa umuna kulowa m'chiberekero monga kondomu kapena chotupa) kuti muteteze mimba mukamamwa mankhwalawa. Funsani dokotala wanu kuti akuthandizeni kusankha njira yolerera yomwe ingakuthandizeni.
• muyenera kudziwa kuti mafuta amthupi lanu amatha kuchuluka kapena kusunthira mbali zosiyanasiyana za thupi lanu monga mabere, kumtunda, khosi, chifuwa, ndi m'mimba. Kutaya mafuta kuchokera kumiyendo, mikono, ndi nkhope kumatha kuchitika.
• muyenera kudziwa kuti mutha kukhala ndi hyperglycemia (kuchuluka kwa shuga m'magazi anu) mukamamwa mankhwalawa, ngakhale mulibe matenda ashuga. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi mukamamwa darunavir: ludzu lokwanira, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kapena kufooka. Ndikofunika kuyimbira dokotala wanu mukangomva izi, chifukwa shuga wambiri yemwe samalandira mankhwala amatha kuyambitsa vuto lalikulu lotchedwa ketoacidosis. Ketoacidosis imatha kukhala pangozi ngati singachiritsidwe koyambirira. Zizindikiro za ketoacidosis zimaphatikizapo: pakamwa pouma, nseru ndi kusanza, kupuma movutikira, mpweya womwe umanunkhira zipatso, ndikuchepetsa chidziwitso.
• muyenera kudziwa kuti pamene mukumwa mankhwala ochizira kachilombo ka HIV, chitetezo chanu cha mthupi chingakhale champhamvu ndikuyamba kulimbana ndi matenda ena omwe anali kale mthupi lanu. Izi zitha kukupangitsani kukhala ndi zizindikilo za matendawa. Ngati muli ndi zizindikiro zatsopano kapena zowonjezereka nthawi iliyonse mukamamwa mankhwala ndi darunavir, onetsetsani kuti mwauza dokotala.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mukumwa darunavir kamodzi patsiku ndipo mwaphonya mlingo wosachepera maola 12, tengani mlingo womwe mwaphonya mukangokumbukira kenako ndikumwa mlingo wotsatira panthawiyo. Komabe, ngati mwaphonya mlingo wa maola opitilira 12, tulukani mulingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mukumwa darunavir kawiri patsiku ndipo mwaphonya mlingo osakwana maola 6, tengani mlingo womwe mwaphonya mukangokumbukira kenako ndikumwa mlingo wotsatira panthawiyo. Komabe, ngati mwaphonya mlingo wa maola opitilira 6, tulukani mulingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Darunavir itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kutsegula m'mimba
• kusanza
• kupweteka m'mimba
• kudzimbidwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, siyani kumwa darunavir ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• zidzolo
• khungu losenda kapena lotupa
• zilonda mkamwa
• ofiira, otupa, oyabwa, kapena misozi
• minofu kapena molumikizana mafupa
• malungo
• kutupa, kukoma mtima, kufiira, kapena zizindikiro zina za matenda
• nseru
• kutopa kwambiri
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• mipando yotumbululuka kapena yakuda

Darunavir ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti atsimikizire kuti zili bwino kuti mutenge darunavir ndikuwunika momwe thupi lanu likuyankhira ku darunavir.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Prezista^®
• Prezcobix^® (yokhala ndi Darunavir, Cobicistat)

• TMC-114