Sunitinib

Zamkati

• Musanatenge sunitinib,
• Sunitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgulu la CHENJEZO CHENJEZO kapena ZOCHITIKA ZOCHITIKA, itanani dokotala wanu mwachangu:

Sunitinib ikhoza kuwononga chiwindi. Uzani dokotala wanu ngati mwakhalapo ndi matenda a chiwindi kapena vuto lanu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: kuyabwa, maso achikaso ndi khungu, mkodzo wamdima, kapena kupweteka kapena kusapeza bwino m'mimba chapamwamba. Dokotala wanu ayenera kuchepetsa mlingo wa sunitinib kapena kuimitsa kwamuyaya kapena kwakanthawi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena amwazi musanafike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti mutenge sunitinib ndikuwunika momwe thupi lanu likuyankhira mankhwalawo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi sunitinib ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito sunitinib.

Sunitinib imagwiritsidwa ntchito pochiza zotupa zam'mimba (GIST; mtundu wa chotupa chomwe chimakula m'mimba, m'matumbo (m'matumbo), kapena m'mimba (chubu chomwe chimalumikiza pakhosi ndi m'mimba) mwa anthu omwe ali ndi zotupa zomwe sizinachiritsidwe bwino ndi imatinib ( Sunitinib imagwiritsidwanso ntchito pochizira renal cell carcinoma (RCC, mtundu wa khansa womwe umayambira m'maselo a impso). Sunitinib imagwiritsidwanso ntchito kuthandizira kupewa kubwerera kwa RCC mwa anthu omwe ali ndi RCC yomwe siyinafalikire ndipo yachotsedwa impso.Sunitinib imagwiritsidwanso ntchito pochizira zotupa za kapamba za neuroendocrine (pNET, mtundu wa chotupa chomwe chimayambira m'maselo ena am'mimba) mwa anthu omwe ali ndi zotupa zomwe zawonjezeka ndipo sizingachiritsidwe ndi Sunitinib ali mgulu la mankhwala otchedwa kinase inhibitors. Amagwira ntchito poletsa mapuloteni omwe amachititsa kuti maselo a khansa achuluke. kuchepetsa zotupa.

Sunitinib imabwera ngati kapisozi wotenga pakamwa kapena wopanda chakudya. Pochiza zotupa zam'mimba (GIST), kapena mankhwala a renal cell carcinoma (RCC), sunitinib nthawi zambiri amatengedwa kamodzi patsiku kwa masabata 4 (masiku 28) ndikutsatira masabata awiri musanayambe gawo lotsatira la dosing kubwereza masabata 6 aliwonse malinga ndi momwe dokotala akuvomerezera. Pofuna kupewa RCC, sunitinib nthawi zambiri amatengedwa kamodzi patsiku kwa masabata 4 (masiku 28) kutsatiridwa ndi kupumula kwamasabata awiri musanayambe gawo lotsatira la dosing ndikubwereza milungu isanu ndi umodzi yazaka 9. Pochiza zotupa za pancreatic neuroendocrine (pNET), sunitinib nthawi zambiri amatengedwa kamodzi tsiku lililonse. Tengani sunitinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani sunitinib ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osagawana, kutafuna, kapena kuwaphwanya. Osatsegula makapisozi.

Mungafunike kumwa kapisozi m'modzi kapena angapo nthawi kutengera mtundu wa sunitinib.

Dokotala wanu akhoza kuwonjezera pang'onopang'ono kapena kuchepetsa mlingo wa sunitinib mukamamwa mankhwala. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kutenga sunitinib ngakhale mutakhala bwino. Osasiya kumwa sunitinib osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge sunitinib,

• Uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi sunitinib, zosakaniza zilizonse za mapiritsi a sunitinib, kapena mankhwala ena aliwonse. Funsani wamankhwala wanu kapena onani pepala lazidziwitso za wodwala wopanga (Chithandizo cha Mankhwala) kuti muwone mndandanda wazopangira.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: maantibayotiki ena monga clarithromycin (Biaxin, ku Prevpac), rifampin (Rifadin, Rimactane, Rifamate, Rifater), rifabutin (Mycobutin), rifapentine (Priftin), ndi telithromycin (Ketek); maantifungal ena monga itraconazole (Onmel, Sporanox), ketoconazole, ndi voriconazole (Vfend); dexamethasone; mankhwala a shuga; mankhwala ena opatsirana pogonana (HIV) kapena matenda opatsirana m'thupi (AIDS) kuphatikiza atazanavir (Reyataz, ku Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); nefazodone; mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, ndi phenytoin (Dilantin, Phenytek). Komanso muuzeni dokotala ngati mukumwa kapena mwatenga alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), kapena zoledronic acid jekeseni (Reclast, Zometa), Mankhwala ena amathanso kuyanjana ndi sunitinib, onetsetsani kuti mwauza dokotala wanu za mankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu komanso wazamankhwala zomwe mumamwa mankhwala azitsamba, makamaka wort ya St. Musatenge wort ya St. John mukamamwa sunitinib.
• uzani dokotala wanu ngati mwakhalapo ndi vuto la magazi kapena mwakhalapo; magazi atsekemera m'mapapu; Kutalikirana kwa nthawi ya QT (mtima wosasintha wamtima womwe ungayambitse kukomoka, kutaya chidziwitso, kugwidwa, kapena kufa mwadzidzidzi); kugunda kwapang'onopang'ono, kwachangu, kapena kosasintha; matenda a mtima; mtima kulephera; kuthamanga kwa magazi; kugwidwa; shuga wochepa magazi kapena shuga; misinkhu ya potaziyamu kapena magnesium m'magazi anu; mavuto pakamwa panu, mano kapena m'kamwa; kapena impso, chithokomiro, kapena matenda amtima.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Inu kapena mnzanu simuyenera kutenga mimba mukamamwa sunitinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira mankhwala, ndipo muyenera kugwiritsa ntchito njira zolerera kuti muchepetse kutenga mimba mukamamwa mankhwala a sunitinib komanso kwa masabata anayi mutalandira mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera popewa kutenga mimba mukamamwa sunitinib komanso kwa masabata 7 mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Sunitinib ikhoza kuchepetsa kubereka kwa abambo ndi amai. Komabe, musaganize kuti inu kapena mnzanuyo simungakhale ndi pakati. Ngati inu kapena mnzanu muli ndi pakati mukatenga sunitinib, itanani dokotala wanu. Sunitinib ikhoza kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa sunitinib komanso kwa masabata 4 mutatha kumwa.
• ngati mukuchitidwa opaleshoni uzani dokotala kapena dokotala kuti mukumwa sunitinib. Dokotala wanu angakuuzeni kuti musiye kumwa sunitinib osachepera masabata atatu musanachite opareshoni yanu chifukwa imatha kukhudza machiritso a zilonda. Dokotala wanu angakuuzeni nthawi yoyambiranso kugwiritsa ntchito sunitinib mukatha opaleshoni.
• muyenera kudziwa kuti sunitinib imatha kupangitsa khungu lanu kutembenukira chikaso ndikutsitsimutsa tsitsi lanu ndikutaya utoto. Izi mwina zimayambitsidwa ndi mtundu wachikasu wamankhwala ndipo sizowopsa kapena zopweteka.
• muyenera kudziwa kuti sunitinib imatha kuyambitsa kuthamanga kwa magazi. Kuthamanga kwanu kwa magazi kuyenera kuyang'aniridwa pafupipafupi mukamamwa sunitinib.
• muyenera kudziwa kuti sunitinib imatha kubweretsa nsagwada (ONJ, vuto lalikulu la nsagwada), makamaka ngati mwachitidwa opareshoni yamazinyo kapena chithandizo mukamamwa mankhwalawa. Dokotala wa mano amayenera kuyesa mano anu ndikuchita chithandizo chilichonse chofunikira, kuphatikizapo kuyeretsa kapena kukonza mano ovekera bwino, musanayambe kumwa sunitinib. Onetsetsani kutsuka mano ndikutsuka mkamwa mwanu moyenera mukamamwa sunitinib. Uzani dokotala wanu kapena wamankhwala ngati mwakhala mukumva kupweteka pakamwa, mano, kapena nsagwada; zilonda mkamwa kapena kutupa; dzanzi kapena kumverera kwaulemu nsagwada; kapena mano aliwonse otayirira. Lankhulani ndi dokotala musanalandire chithandizo chilichonse cha mano mukamamwa mankhwalawa.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mwaphonya mlingo wa sunitinib pasanathe maola 12, tengani mlingo womwe mwaphonya mukangokumbukira kenako mutenge mlingo wotsatira panthawiyo. Komabe, ngati mwaphonya mlingo wa maola opitilira 12, tulukani mulingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Sunitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kufooka
• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kutentha pa chifuwa
• mpweya
• zotupa m'mimba
• kupweteka, kukwiya, kapena kutentha kwa milomo, lilime, pakamwa kapena pakhosi
• pakamwa pouma
• sintha momwe zinthu zimamvekera
• kusowa chilakolako
• kulemera kumasintha
• kutayika tsitsi
• zikhadabo zoonda, zopyapyala kapena tsitsi
• mawu odekha
• khungu lotuwa kapena louma
• kugwedezeka
• zolemera, zosasinthasintha, kapena zosowa msambo
• kukhumudwa
• kuvuta kugona kapena kugona
• kuuma, makulidwe, ming'alu, kapena matuza a khungu m'manja ndi pamapazi
• kupweteka kwa minofu, olowa, kumbuyo, kapena kwamiyendo
• Kutuluka magazi pafupipafupi
• Kutuluka magazi m'kamwa mwako
• kusowa kwachilendo pamazizira ozizira

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgulu la CHENJEZO CHENJEZO kapena ZOCHITIKA ZOCHITIKA, itanani dokotala wanu mwachangu:

• kuvulaza kapena kutuluka mwachilendo
• chimbudzi chamagazi kapena chakuda komanso chochedwa
• magazi mkodzo
• masanzi ofiira kwambiri kapena owoneka ngati malo a khofi
• kutsokomola magazi
• kupweteka m'mimba, kutupa, kapena kukoma
• mutu
• malungo
• kutupa, kukoma, kutentha, kapena kufiyira mwendo
• kutupa kwa mapazi kapena akakolo
• kugunda kwamtima msanga, kosasinthasintha, kapena kwamphamvu
• chizungulire kapena kukomoka
• kuchepa kuchepa kapena kusamala
• chisokonezo
• kukhumudwa
• manjenje
• kugwidwa
• masomphenya amasintha
• kupweteka pachifuwa kapena kupanikizika
• kutopa kwambiri
• kupuma movutikira
• kupweteka ndikupuma kozama
• kunenepa kopanda tanthauzo
• kuchepa pokodza
• mkodzo wamtambo
• kutupa kwa maso, nkhope, milomo, lilime, kapena mmero
• zidzolo
• ming'oma
• matuza kapena khungu losenda kapena mkamwa
• zovuta kumeza kapena kupuma
• ukali

Sunitinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena monga ma electrocardiograms (EKG, mayeso omwe amalemba zamagetsi mumtima), ma echocardiograms (mayeso omwe amagwiritsa ntchito mafunde amawu kuti athe kuyeza kuthekera kwa mtima wanu kupopera magazi), ndi kuyesa kwamkodzo musanachitike komanso mukamamwa mankhwala a sunitinib kuwonetsetsa kuti zili bwino kuti mutenge sunitinib, ndikuwunika momwe thupi lanu likuyankhira mankhwalawo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Wolankhula^®