Lenalidomide

Zamkati

• Musanatenge lenalidomide,
• Lenalidomide imatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Kuopsa kwa zolepheretsa kubadwa koopsa zomwe zimayambitsa lenalidomide:

Kwa odwala onse:

Lenalidomide sayenera kutengedwa ndi odwala omwe ali ndi pakati kapena omwe angakhale ndi pakati. Pali chiopsezo chachikulu kuti lenalidomide imatha kubala zopweteka kwambiri (zovuta zomwe zimakhalapo pobadwa) kapena kufa kwa mwana wosabadwa.

Pulogalamu yotchedwa REVLIMID REMS^TM yakhazikitsidwa kuti iwonetsetse kuti amayi apakati samamwa lenalidomide komanso kuti amayi satenga mimba akamamwa lenalidomide. Odwala onse, kuphatikiza azimayi omwe sangatenge mimba ndi abambo, atha kutenga lenalidomide pokhapokha atalembetsa ku REVLIMID REMS, atakhala ndi mankhwala ochokera kwa dokotala yemwe adalembetsa ku REVLIMID REMS, ndikudzaza mankhwalawo ku pharmacy yomwe imalembetsedwa ndi REVLIMID REMS .

Mukalandira zambiri za kuopsa kwakumwa lenalidomide ndipo muyenera kusaina chikalata chololeza kuti mumvetsetsa izi musanalandire mankhwala. Ngati muli ochepera zaka 18, kholo kapena woyang'anira ayenera kusaina chikalata chovomerezera ndikuvomera kuwonetsetsa kuti mukukwaniritsa izi. Muyenera kukaonana ndi dokotala mukamalandira chithandizo kuti mukambirane za momwe mulili komanso mavuto omwe mukukumana nawo kapena kukayezetsa mimba monga momwe pulogalamuyi idanenera. Muyenera kumaliza kafukufuku wachinsinsi kumayambiriro kwa chithandizo chanu komanso nthawi zina panthawi yamankhwala anu kuti mutsimikizire kuti mwalandira ndikumvetsetsa izi komanso kuti mutha kutsatira malangizo kuti mupewe zoopsa kwa makanda omwe sanabadwe.

Uzani dokotala wanu ngati simukumvetsetsa zonse zomwe adauzidwa za lenalidomide ndi pulogalamu ya REVLIMID REMS ndi momwe mungagwiritsire ntchito njira zakulera zomwe mudakambirana ndi adotolo, kapena ngati simukuganiza kuti mudzakwanitsa kusunga nthawi yokumana.

Osapereka magazi mukamamwa lenalidomide, panthawi yopuma, komanso kwa milungu 4 mutalandira mankhwala omaliza.

Osagawana lenalidomide ndi wina aliyense, ngakhale munthu yemwe ali ndi zisonyezo zomwezo zomwe muli nazo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo Cha Mankhwala) mukayamba kulandira mankhwala ndi lenalidomide ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs), tsamba laopanga, kapena tsamba la REVLIMID REMS (http://www.revlimidrems.com) kuti mupeze Buku la Mankhwala.

Lankhulani ndi dokotala wanu za kuopsa kwakumwa lenalidomide.

Kwa odwala achikazi:

Ngati mutha kutenga pakati, muyenera kukwaniritsa zofunikira mukamalandira mankhwala a lenalidomide.Muyenera kugwiritsa ntchito njira ziwiri zovomerezeka zolerera kwa milungu inayi musanatenge lenalidomide, mukamamwa mankhwala, kuphatikiza nthawi zomwe dokotala akukuuzani kuti musiye kumwa lenalidomide, komanso milungu 4 mutatha kumwa. Dokotala wanu angakuwuzeni mitundu yoletsa kubereka yomwe ili yovomerezeka ndipo adzakupatsani zambiri zolembedwa za zolera. Muyenera kugwiritsa ntchito njira ziwirizi zoletsa nthawi zonse pokhapokha mutatsimikizira kuti simudzagonana ndi amuna kwamasabata anayi musanalandire chithandizo, mukamalandira chithandizo, mukasokonezedwa ndi chithandizo chanu, komanso kwa milungu 4 mlingo wanu womaliza.

Ngati mwasankha kumwa lenalidomide, ndiudindo wanu kupewa kutenga mimba kwa milungu inayi isanakwane, mkati, komanso masabata anayi mutatha kumwa. Muyenera kumvetsetsa kuti njira iliyonse yolerera ikhoza kulephera. Chifukwa chake, ndikofunikira kuti muchepetse chiopsezo chotenga mimba mwangozi pogwiritsa ntchito njira ziwiri zakulera. Uzani dokotala wanu ngati simukumvetsa zonse zomwe munauzidwa zakulera kapena simukuganiza kuti mutha kugwiritsa ntchito njira ziwiri zakulera nthawi zonse.

Muyenera kukhala ndi mayeso awiri olakwika okhudzana ndi pakati musanayambe kumwa lenalidomide. Muyeneranso kukayezetsa kuti muli ndi pakati mu labotale nthawi zina mukamalandira chithandizo. Dokotala wanu angakuuzeni nthawi ndi malo omwe mungayesere.

Lekani kumwa lenalidomide ndipo itanani dokotala nthawi yomweyo ngati mukuganiza kuti muli ndi pakati, mumasowa msambo, mumakhala ndi magazi osazolowereka, kapena mumagonana osagwiritsa ntchito njira ziwiri zakulera. Mukakhala ndi pakati mukamalandira chithandizo kapena musanathe masiku 30 mutalandira chithandizo, dokotala wanu alumikizana ndi pulogalamu ya REVLIMID REMS, wopanga lenalidomide, ndi Food and Drug Administration (FDA). Mukambirananso ndi dokotala yemwe amadziwika bwino pamavuto omwe ali ndi pakati omwe angakuthandizeni kupanga zisankho zabwino kwa inu ndi mwana wanu. Zambiri zokhudzana ndi thanzi lanu komanso thanzi la mwana wanu zidzagwiritsidwa ntchito kuthandiza madotolo kuti adziwe zambiri za zotsatira za lenalidomide pa makanda osabadwa.

Kwa odwala amuna:

Lenalidomide amapezeka mumuna wanu mukamamwa mankhwalawa. Muyenera kugwiritsa ntchito kondomu ya latex nthawi zonse, ngakhale mutakhala ndi vasectomy (opareshoni yomwe imalepheretsa abambo kuyambitsa mimba), nthawi iliyonse mukamagonana ndi mayi yemwe ali ndi pakati kapena wokhoza kutenga pakati mukamamwa lenalidomide, Nthawi iliyonse yopuma, ndi masabata 4 mutatha kumwa. Uzani dokotala ngati mukugonana ndi mkazi osagwiritsa ntchito kondomu kapena ngati mnzanu akuganiza kuti ali ndi pakati mukamamwa mankhwala a lenalidomide.

Osapereka umuna mukamamwa lenalidomide, nthawi iliyonse yopuma, komanso milungu 4 mutatha kumwa.

Zowopsa zina zotenga lenalidomide:

Lenalidomide ikhoza kuyambitsa kuchepa kwa mitundu ina yamaselo amwazi mthupi lanu. Dokotala wanu amalamula kuyesedwa kwa labotale nthawi zonse mukamalandira chithandizo kuti muwone kuchuluka kwa maselo amwazi. Dokotala wanu akhoza kuchepetsa mlingo wanu, kusokoneza chithandizo chanu, kapena kukupatsani mankhwala ena kapena mankhwala ngati kuchepa kwa maselo anu a magazi kuli kovuta. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: zilonda zapakhosi, malungo, kuzizira, ndi zizindikilo zina za matenda; kuvulaza kosavuta kapena kutuluka magazi; nkhama zotuluka magazi; kapena kutuluka magazi m'mphuno.

Ngati mukumwa lenalidomide ndi dexamethasone kuti muchiritse myeloma yambiri, pali chiopsezo chowonjezeka choti mutha kukhala ndimagazi m'miyendo mwanu omwe amatha kupyola magazi kupita m'mapapu anu, kapena kudwala mtima kapena sitiroko. Dokotala wanu akhoza kukupatsani mankhwala ena oti mutenge limodzi ndi lenalidomide kuti muchepetse chiopsezo. Uzani dokotala wanu ngati mumasuta, ngati mudadwalapo magazi kwambiri, komanso ngati mwakhalapo ndi kuthamanga kwa magazi kapena kuchuluka kwamafuta m'magazi anu. Muuzeni dokotala wanu za mankhwala onse omwe mukumwa chifukwa mankhwala ena akhoza kuonjezera chiopsezo kuti mudzadwala magazi mukamamwa lenalidomide ndi dexamethasone kuphatikiza darbepoetin (Aranesp), epoetin alfa (Epogen, Procrit), ndi mankhwala okhala ndi estrogen monga mankhwala obwezeretsa mahomoni kapena njira zolerera za mahomoni (mapiritsi oletsa kubereka, zigamba, mphete, zopangira kapena jakisoni). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupuma movutikira; kupweteka pachifuwa komwe kumatha kufalikira ku mikono, khosi, nsana, nsagwada, kapena m'mimba; chifuwa; kufiira kapena kutupa pamkono kapena mwendo; thukuta; nseru; kusanza; kufooka mwadzidzidzi kapena dzanzi, makamaka mbali imodzi ya thupi; mutu; chisokonezo; kapena kuvutika ndi masomphenya, kulankhula, kapena kusamala.

Lenalidomide imagwiritsidwa ntchito pochiza mtundu wina wamatenda a myelodysplastic (gulu lazomwe mongo wa mafupa umatulutsa maselo amwazi omwe amapangika ndipo samatulutsa maselo amwazi okwanira). Lenalidomide imagwiritsidwanso ntchito limodzi ndi dexamethasone pochiza anthu omwe ali ndi myeloma angapo (mtundu wa khansa ya m'mafupa). Amagwiritsidwanso ntchito pochiza anthu omwe ali ndi myeloma angapo atapatsidwa ma hematopoietic stem-cell transplant (HSCT; njira yomwe ma cell amwazi amachotsedwa mthupi ndikubwerera mthupi). Lenalidomide imagwiritsidwanso ntchito kuchiza anthu omwe ali ndi mantle cell lymphoma (khansa yomwe ikukula mwachangu yomwe imayambira m'maselo amthupi) omwe amathandizidwa ndi bortezomib (Velcade) komanso mankhwala ena amodzi. Lenalidomide sayenera kugwiritsidwa ntchito pochiza anthu omwe ali ndi khansa ya m'magazi (mtundu wa khansa yamagazi oyera omwe amafika pang'onopang'ono pang'onopang'ono pakapita nthawi) pokhapokha atachita nawo mayesero azachipatala (kafukufuku wofufuza kuti muwone ngati mankhwala angagwiritsidwe ntchito mosamala komanso Kuchiza bwino vuto linalake). Lenalidomide ali mgulu la mankhwala otchedwa ma immunomodulatory agents. Zimagwira ntchito pothandiza mafupa kupanga maselo abwinobwino amwazi komanso kupha maselo osadziwika m'mafupa.

Lenalidomide amabwera ngati kapisozi kuti atenge pakamwa. Lenalidomide ikagwiritsidwa ntchito pochiza matenda a myelodysplastic, nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Lenalidomide ikagwiritsidwa ntchito pochiza ma myeloma angapo kapena mantle cell lymphoma, imangotengedwa kamodzi kapena kamodzi patsiku masiku 21 oyambira masiku 28. Lenalidomide ikagwiritsidwa ntchito pochiza myeloma yambiri pambuyo pa HSCT, imangotengedwa ndi chakudya kamodzi kapena opanda chakudya kamodzi tsiku lililonse kwa masiku 28 azungulira masiku 28. Ndondomeko yamasiku 28 azungulira imatha kubwerezedwa monga momwe adakulimbikitsira dokotala kutengera momwe thupi lanu likuyankhira mankhwalawa. Tengani lenalidomide mozungulira nthawi yomweyo tsiku lililonse tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani lenalidomide ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi athunthu ndi madzi ambiri; osanyema, kutafuna, kapena kutsegula. Gwiritsani makapisozi pang'ono momwe zingathere. Mukakhudza kapisozi wosweka wa lenalidomide kapena mankhwala omwe ali mu kapisozi, sambani m'dera lanu ndi sopo. Ngati mankhwala omwe ali mu kapisozi akulowa mkamwa, mphuno, kapena maso, tsukeni ndi madzi ambiri.

Dokotala wanu angafunike kusokoneza chithandizo chanu kapena kuchepetsa mlingo wanu ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira mankhwala a lenalidomide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge lenalidomide,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la lenalidomide, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a lenalidomide. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe adatchulidwa mu gawo la CHENJEZO CHENJEZO ndi digoxin (Lanoxin). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• Uzani dokotala wanu ngati mukusagwirizana ndi lactose ndipo ngati mwakhalapo ndi matenda a impso, chithokomiro, kapena chiwindi. Komanso uzani dokotala ngati mudalandirapo thalidomide (Thalomid) ndikupanga zotupa munthawi ya chithandizo.
• uzani dokotala wanu ngati mukuyamwitsa kapena mukukonzekera kuyamwitsa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati padutsa maola 12 kuchokera pomwe mudayenera kumwa mankhwalawo, tengani mlingo womwe mwaphonya mukangokumbukira. Ngati kwakhala kupitilira maola 12, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Lenalidomide imatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• kupweteka m'mimba
• kusowa chilakolako
• kuonda
• kufooka
• chizungulire
• sinthani kuti mulawe
• kupweteka kapena kutentha kwa lilime, pakamwa, kapena pakhosi
• kuchepa kwa kukhudza
• kutentha kapena kumva kulasalasa m'manja kapena m'mapazi
• kuvuta kugona kapena kugona
• kukhumudwa
• kulumikizana, minofu, fupa, kapena kupweteka kwa msana
• pokodza mopweteka, pafupipafupi, kapena mwachangu
• thukuta
• khungu lowuma
• kukula kwatsitsi kwa azimayi
• kugwedezeka kosalamulirika kwa gawo lina la thupi
• amachepetsa chilakolako chogonana kapena kuthekera

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutupa kwa nkhope, mmero, lilime, milomo, maso, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kuvuta kupuma kapena kumeza
• ukali
• kuthamanga, kuchepa, kugunda, kapena kugunda kwamtima mosasinthasintha
• kugwidwa
• zidzolo
• kupweteka kwa khungu
• khungu, khungu, kapena khungu
• zotupa zotupa m'khosi
• kukokana kwa minofu
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• mkodzo wachikuda
• kutopa
• kukodza kwamagazi, mitambo, kapena kupweteka
• kuchulukitsa kapena kuchepa pokodza

Ngati mukumwa lenalidomide kuti muzitha kuchiza matenda a myeloma angapo ndipo mumalandiranso melphalan (Alkeran) kapena kupatsidwa ma cell amwazi, mutha kukhala ndi chiopsezo chachikulu chotenga khansa yatsopano. Lankhulani ndi dokotala wanu za kuopsa kwakumwa lenalidomide. Dokotala wanu amakufufuzirani khansa yatsopano mukamamwa mankhwala a lenalidomide.

Lenalidomide imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Bweretsani mankhwala aliwonse omwe ndi achikale kapena osafunikanso kwa dokotala wanu, ku pharmacy yomwe idakupatsani mankhwalawo, kapena wopanga.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kuyabwa
• ming'oma
• zidzolo

Sungani maimidwe onse ndi dokotala wanu. Dokotala wanu amatha kuyitanitsa mayeso ena musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku lenalidomide.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Mwachifundo^®