Nilotinib

Zamkati

• Musanatenge nilotinib,
• Nilotinib angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

Nilotinib itha kupangitsa kuti QT iwonjezeke (mtima wosakhazikika womwe ungayambitse kukomoka, kutaya chidziwitso, kugwidwa, kapena kufa mwadzidzidzi). Uzani dokotala wanu ngati inu kapena wina aliyense m'banja mwanu adakhalapo kapena adakhalapo ndi matenda a QT (matenda obadwa nawo momwe munthu amakhala ndi kutalikirana kwa QT) kapena mwakhalapo ndi potaziyamu kapena magnesium m'magazi anu , kugunda kwa mtima, kapena matenda a chiwindi. Uzani dokotala wanu komanso wamankhwala ngati mukumwa amiodarone (Nexterone, Pacerone); antifungals monga ketoconazole, itraconazole (Onmel, Sporanox), kapena voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, mu Prevpac); disopyramide (Norpace); erythromycin (EES, Eryc, PCE); mankhwala ena a kachirombo ka HIV (HIV) kapena matenda opatsirana m'thupi (AIDS) monga atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); haloperidol (Haldol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); kupeza; quinidine (mu Nuedexta); sotalol (Betapace, Betapace AF, ena); telithromycin (Ketek); ndi thioridazine. Ngati mukumane ndi zizindikiro izi, lekani kumwa nilotinib ndikuimbira dokotala nthawi yomweyo: kusala, kupindika, kapena kugunda kwamtima kosasinthasintha; kukomoka; kutaya chidziwitso; kapena kugwidwa.

Musadye chakudya chilichonse kwa ola limodzi musanatenge nilotinib komanso kwa ola limodzi mutamwa mankhwalawa.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena, monga kuyezetsa magazi ndi ma electrocardiograms (EKGs, mayeso omwe amalemba zamagetsi mumtima) musanachitike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti mutenge nilotinib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi nilotinib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kotenga nilotinib.

Nilotinib amagwiritsidwa ntchito pochiza mitundu ina ya matenda a khansa ya myeloid (CML; mtundu wa khansa yamagazi oyera) omwe apeza kuti ali ndi vutoli mwa akulu ndi ana azaka 1 kapena kupitirira. Amagwiritsidwanso ntchito kuthana ndi mitundu ina ya CML yomwe matenda ake sangachiritsidwe bwino ndi imatinib (Gleevec) kapena achikulire omwe sangatenge imatinib. Nilotinib imagwiritsidwanso ntchito kuthana ndi mitundu ina ya CML mwa ana azaka 1 kapena kupitilira apo omwe matenda awo sangachiritsidwe bwino ndi mankhwala ena a tyrosine kinase inhibitor. Nilotinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Nilotinib amabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa opanda chakudya kawiri patsiku. Nilotinib ayenera kumwedwa wopanda kanthu, osachepera maola 2 isanakwane kapena ola limodzi mutadya chakudya chilichonse. Tengani nilotinib mozungulira nthawi yofananira tsiku lililonse. Yesetsani kuyika mlingo wanu pafupifupi maola 12 padera. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani nilotinib ndendende monga momwe mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osagawana, kutafuna, kapena kuwaphwanya. Ngati simungathe kumeza makapisozi onse, sakanizani zomwe zili mu kapisozi mu supuni imodzi ya maapulosi. Kumeza kusakaniza nthawi yomweyo (pasanathe mphindi 15.) Musasunge chisakanizocho kuti mudzagwiritse ntchito mtsogolo.

Dokotala wanu akhoza kuchepetsa mlingo wanu wa nilotinib kapena kuimitsa mankhwala anu kutengera momwe mankhwalawo amakuthandizirani komanso ngati mungakhale ndi zovuta zina. Pitirizani kumwa nilotinib ngakhale mutakhala bwino. Osasiya kumwa nilotinib osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge nilotinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la nilotinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a nilotinib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo mankhwala omwe atchulidwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: ena angiotensin-receptor blockers monga irbesartan (Avapro, ku Avalide) ndi losartan (Cozaar, ku Hyzaar); anticoagulants ('' oonda magazi '') monga warfarin (Coumadin, Jantoven); aripiprazole (Limbikitsani); ena a benzodiazepines monga alprazolam (Xanax), diazepam (Valium), midazolam, ndi triazolam (Halcion); buspirone (Buspar); zotchinga zina za calcium monga amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, ena), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), ndi verapamil (Calan, Verelan, ena) ; mankhwala ochepetsa mafuta m'thupi (ma statins) kuphatikiza atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), ndi simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, chifuwa china ndi zinthu zozizira); dexamethasone; dihydroergotamine (DHH 45, Migranal); ergotamine (mu Cafergot, ku Ergomar); fentanyl (Actiq, Duragesic, Subsys); zachilengedwe (Tambocor); mankhwala ena okhumudwa monga amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); ndi venlafaxine (Effexor); mankhwala ena apakamwa a shuga monga glipizide (Glucotrol) ndi tolbutamide; mankhwala ena omwe amaletsa chitetezo cha mthupi monga cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ndi tacrolimus (Prograf); mankhwala ena ogwidwa monga carbamazepine (Equetro, Tegretol, Teril), phenobarbital, ndi phenytoin (Dilantin, Phenytek); mexiletine; mankhwala ena osagwiritsa ntchito zotupa (NSAIDs) monga celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), ndi piroxicam (Feldene); ondansetron (Zofran); mankhwala (Rythmol); proton-pump inhibitors monga esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ndi rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); mfuti (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, ena); timolol; kuthamanga; tramadol (Ultram, mu Ultracet); trazodone; ndi vincristine. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi nilotinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa maantacid okhala ndi magnesium, aluminium (Maalox, Mylanta, Tums, ena), kapena simethicone, tengani mankhwalawa osatsata mavitamini 2 hours isanakwane kapena osachepera maola awiri mutamwa nilotinib.
• ngati mukumwa mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda monga cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), kapena ranitidine (Zantac), imwani osachepera maola 10 kapena 2 maola mutatenga nilotinib.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala ngati mwadwala stroke kapena opaleshoni kuti muchotse m'mimba monse (gastrectomy yonse). Komanso, uzani dokotala wanu ngati mwakhala mukuchepetsako magazi m'miyendo yanu, mavuto amtima, mavuto akumwa magazi, kapamba (kutupa kwa kapamba, gland kumbuyo kwa komwe kumatulutsa zinthu zothandizira chimbudzi), kapena vuto lililonse Zimakupangitsani kukhala kovuta kwa inu kugaya lactose (mkaka shuga) kapena shuga wina.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga mimba mukamamwa nilotinib. Muyenera kugwiritsa ntchito njira yolerera yothandiza kupewa mimba mukamamwa mankhwala a nilotinib komanso masiku 14 mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukatenga nilotinib, itanani dokotala wanu mwachangu. Nilotinib atha kuvulaza mwana wosabadwayo.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mukamamwa nilotinib komanso masiku 14 mutapatsidwa mankhwala omaliza.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa nilotinib.

Musadye zipatso zamphesa, kumwa madzi amphesa, kapena kutenga chilichonse chowonjezera chomwe chili ndi zipatso za manyumwa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Nilotinib angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• zidzolo
• kuyabwa
• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kutentha pa chifuwa
• mpweya
• kusowa chilakolako
• mutu
• chizungulire
• kutopa
• kuvuta kugona kapena kugona
• thukuta usiku
• kukokana kwa minofu
• msana, fupa, olowa, chiwalo, kapena kupweteka kwa minofu
• kutayika tsitsi
• khungu louma kapena lofiira
• dzanzi, kutentha, kapena kumva kulasalasa m'manja kapena m'mapazi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kutuluka mwachilendo kapena kuphwanya
• magazi mkodzo
• wamagazi kapena wakuda, malo obisalira
• kupweteka mwadzidzidzi, kusokonezeka, kapena kusintha masomphenya
• kutopa kapena kufooka kosazolowereka
• kupweteka pachifuwa kapena kusapeza bwino
• mavuto kuyenda kapena kulankhula
• dzanzi
• sintha mtundu wa khungu
• kupweteka kapena kuzizira kumverera kwa miyendo
• kupweteka m'mimba ndi nseru ndi kusanza
• malungo, kuzizira, zilonda zapakhosi, kutsokomola kosalekeza komanso kuchulukana, kapena zizindikilo zina za matenda
• khungu lotumbululuka
• kupuma movutikira
• kunenepa
• kutupa kwa manja, akakolo, mapazi, kapena nkhope
• kupweteka kapena kusapeza bwino kumtunda kwam'mimba
• chikasu cha khungu ndi maso
• mkodzo wakuda
• kukodza pafupipafupi kuposa masiku onse

Nilotinib atha kupangitsa ana kukula pang'onopang'ono. Dokotala wa mwana wanu adzawona kukula kwa mwana wanu mosamala pamene mwana wanu akutenga nilotinib. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopereka mankhwalawa kwa mwana wanu.

Nilotinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• kusanza
• Kusinza

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Tasigna^®