Jekeseni wa Denosumab

Zamkati

• Jekeseni ya Denosumab (Prolia) imagwiritsidwa ntchito
• Jekeseni ya Denosumab (Xgeva) imagwiritsidwa ntchito jakisoni wa Denosumab ali mgulu la mankhwala otchedwa RANK ligand inhibitors. Zimagwira ntchito popewa kutayika kwa mafupa poletsa wolandila wina mthupi kuti muchepetse kuwonongeka kwa mafupa. Zimagwira ntchito pochiza GCTB poletsa wolandila wina m'maselo otupa omwe amachepetsa chotupacho. Imagwira pantchito yoteteza kashiamu wambiri pochepetsa kuwonongeka kwa mafupa chifukwa cha kuwonongeka kwa mafupa kumatulutsa calcium.
• Asanalandire jekeseni wa denosumab,
• Jekeseni wa Denosumab itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Jekeseni ya Denosumab (Prolia) imagwiritsidwa ntchito

• kuchiza kufooka kwa mafupa (matenda omwe mafupa amafooka ndi kufooka ndikuphwanya mosavuta) mwa amayi omwe atha msambo ('' kusintha kwa moyo; '' kutha kwa msambo) omwe ali ndi chiopsezo chowonjezeka cha mafupa (mafupa osweka) kapena omwe sangamwe kapena sanayankhe mankhwala ena a kufooka kwa mafupa.
• kuchiza amuna omwe ali pachiwopsezo chowonjezeka cha mafupa (mafupa osweka) kapena omwe sangamwe kapena sanayankhe mankhwala ena a kufooka kwa mafupa.
• kuchiza kufooka kwa mafupa komwe kumayambitsidwa ndi mankhwala a corticosteroid mwa abambo ndi amai omwe azitenga mankhwala a corticosteroid kwa miyezi yosachepera 6 ndikukhala ndi chiopsezo chowonjezeka cha mafupa kapena omwe sangatenge kapena osayankha mankhwala ena a kufooka kwa mafupa.
• kuchiza kutayika kwa mafupa mwa amuna omwe akuchiritsidwa ndi khansa ya prostate ndi mankhwala ena omwe amachititsa kuti mafupa atayike,
• kuchiza kutayika kwa mafupa mwa azimayi omwe ali ndi khansa ya m'mawere omwe amalandila mankhwala ena omwe amachulukitsa chiopsezo chaphwanya.

Jekeseni ya Denosumab (Xgeva) imagwiritsidwa ntchito jakisoni wa Denosumab ali mgulu la mankhwala otchedwa RANK ligand inhibitors. Zimagwira ntchito popewa kutayika kwa mafupa poletsa wolandila wina mthupi kuti muchepetse kuwonongeka kwa mafupa. Zimagwira ntchito pochiza GCTB poletsa wolandila wina m'maselo otupa omwe amachepetsa chotupacho. Imagwira pantchito yoteteza kashiamu wambiri pochepetsa kuwonongeka kwa mafupa chifukwa cha kuwonongeka kwa mafupa kumatulutsa calcium.

• Kuchepetsa chiopsezo chothyoka mwa anthu omwe ali ndi myeloma yambiri (khansa yomwe imayambira m'maselo am'magazi am'magazi ndikuwononga mafupa), komanso mwa anthu omwe ali ndi mitundu ina ya khansa yomwe idayamba mbali ina ya thupi koma yafalikira m'mafupa.
• mwa akulu ndi achinyamata ena amachiza chotupa chachikulu cha mafupa (GCTB; mtundu wa chotupa cha mafupa) chomwe sichingachiritsidwe ndi opaleshoni.
• kuchiza milingo yambiri ya calcium yomwe imayambitsidwa ndi khansa mwa anthu omwe sanayankhe mankhwala ena.

Jekeseni ya Denosumab imabwera ngati yankho (madzi) oti mulandire jekeseni (pansi pa khungu) m'manja mwanu, ntchafu, kapena m'mimba. Nthawi zambiri amabayidwa ndi dokotala kapena namwino kuofesi yazachipatala kapena kuchipatala. Jekeseni ya Denosumab (Prolia) imaperekedwa kamodzi pa miyezi isanu ndi umodzi. Pamene jakisoni wa denosumab (Xgeva) amagwiritsidwa ntchito pochepetsa chiopsezo chovulala kuchokera ku myeloma yambiri, kapena khansa yomwe yafalikira m'mafupa, imaperekedwa kamodzi pamilungu inayi iliyonse. Pamene jakisoni wa denosumab (Xgeva) amagwiritsidwa ntchito pochizira chotupa chachikulu cha mafupa, kapena kuchuluka kwa calcium yomwe imayambitsidwa ndi khansa, nthawi zambiri imaperekedwa masiku asanu ndi awiri (7) tsiku loyamba (tsiku 1, tsiku 8, ndi tsiku 15) kenako kamodzi pamasabata 4 kuyambira milungu iwiri itadutsa kaye mankhwala atatu oyamba.

Dokotala wanu angakuuzeni kuti mutenge calcium ndi vitamini D zowonjezerapo mukamalandira jakisoni wa denosumab. Tengani zowonjezera izi monga momwe mwalangizira.

Pamene jekeseni ya denosumab (Prolia) imagwiritsidwa ntchito pochiza kufooka kwa mafupa kapena kutayika kwa mafupa, dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jekeseni ya denosumab ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa denosumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la denosumab (Prolia, Xgeva), mankhwala ena aliwonse, latex, kapena china chilichonse mu jakisoni wa denosumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Muyenera kudziwa kuti jakisoni wa denosumab amapezeka pansi pa mayina a Prolia ndi Xgeva. Simuyenera kulandira zopitilira chimodzi zokhala ndi denosumab nthawi yomweyo. Onetsetsani kuti muuze dokotala ngati mukumwa mankhwalawa.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa.Onetsetsani kuti mwatchulapo izi: angiogenesis inhibitors monga axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), kapena sunitinib (Sutent); bisphosphonates monga alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); mankhwala a khansa chemotherapy; mankhwala omwe amaletsa chitetezo cha mthupi monga azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), ndi tacrolimus (Astagraf XL, Envarsus, Prograf) ; steroids monga dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), ndi prednisone (Rayos); kapena mankhwala omwe amagwiritsidwa ntchito kutsitsa calcium yanu, monga cinacalcet (Sensipar). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati mwakhalapo ndi calcium yotsika pang'ono m'magazi anu. Dokotala wanu angayang'ane kashiamu m'magazi anu musanayambe mankhwala ndipo mwina angakuuzeni kuti musalandire jakisoni wa denosumab ngati mulingo watsika kwambiri.
• uzani adotolo ngati mukulandira mankhwala a dialysis kapena ngati mwakhalapo ndi kuchepa kwa magazi m'thupi (momwe maselo ofiira samabweretsa mpweya wokwanira kumadera onse amthupi); khansa; matenda amtundu uliwonse, makamaka mkamwa mwanu; mavuto mkamwa mwako, mano, nkhama, kapena mano ovekera; mano kapena mano am'kamwa (kuchotsa mano, kupangira mano); vuto lililonse lomwe limaletsa magazi anu kuti asagundike bwino; chikhalidwe chilichonse chomwe chimachepetsa magwiridwe antchito amthupi lanu; opaleshoni pa chithokomiro chanu kapena gland parathyroid (khutu laling'ono m'khosi); opaleshoni kuchotsa gawo la m'mimba mwanu; mavuto am'mimba kapena m'matumbo omwe amalepheretsa thupi lanu kuyamwa michere; polymyalgia rheumatica (matenda omwe amachititsa kupweteka kwa minofu ndi kufooka); shuga, kapena parathyroid kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kukhala ndi mayeso olakwika okhudzana ndi mimba musanayambe chithandizo ndi jakisoni wa denosumab. Simuyenera kutenga pakati mukalandira jekeseni ya denosumab. Muyenera kugwiritsa ntchito njira yodalirika yolerera popewa kutenga pakati mukalandira jakisoni wa denosumab komanso kwa miyezi yosachepera 5 mutalandira chithandizo chomaliza. Mukakhala ndi pakati mukalandira jakisoni wa denosumab, kapena mkati mwa miyezi isanu ya chithandizo chanu, itanani dokotala wanu mwachangu. Denosumab atha kuvulaza mwana wosabadwayo.
• muyenera kudziwa kuti jakisoni wa denosumab amatha kuyambitsa nsagwada (ONJ, vuto lalikulu la nsagwada), makamaka ngati mwachitidwa opareshoni yamazinyo kapena chithandizo mukalandira mankhwalawa. Dokotala wamano ayenera kuwerengetsa mano anu ndikuchita chithandizo chilichonse chofunikira, kuphatikiza kuyeretsa kapena kukonza mano oyenera, musanayambe kulandira jekeseni wa denosumab. Onetsetsani kutsuka mano ndikutsuka mkamwa mwanu moyenera mukalandira jekeseni wa denosumab. Lankhulani ndi dokotala musanalandire chithandizo chilichonse cha mano mukalandira mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yoti mulandire jakisoni wa denosumab, muyenera kuyitanitsa omwe amakuthandizani posachedwa. Mlingo womwe umasowa uyenera kuperekedwa posachedwa pomwe ungakonzedwenso. Pamene jakisoni wa denosumab (Prolia) amagwiritsidwa ntchito kuthana ndi kufooka kwa mafupa kapena kutayika kwa mafupa, mukalandira mankhwala omwe mwaphonya, jakisoni wanu wotsatira uyenera kukonzedwa miyezi 6 kuyambira tsiku lomwe munabayidwa.

Jekeseni wa Denosumab itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• khungu lofiira, louma, kapena loyabwa
• zotupa zotupa pakhungu
• khungu losenda
• kupweteka kwa msana
• kupweteka m'manja mwanu
• kutupa kwa mikono kapena miyendo
• kupweteka kwa minofu kapena molumikizana
• nseru
• kutsegula m'mimba
• kudzimbidwa
• kupweteka m'mimba
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kuuma kwa minofu, kugwedezeka, kukokana, kapena kupuma
• dzanzi kapena kumenyedwa ndi zala zanu, zala zakumapazi, kapena pakamwa panu
• ming'oma, zidzolo, kuyabwa, kupuma movutikira kapena kumeza, kutupa kwa nkhope, maso, mmero, lilime kapena milomo,
• malungo kapena kuzizira
• kufiira, kukoma mtima, kutupa kapena kutentha kwa khungu
• malungo, chifuwa, mpweya wochepa
• ngalande ya khutu kapena kupweteka khutu kwakukulu
• pafupipafupi kapena mwachangu kufunika kokodza, kutentha pamene mukukodza
• kupweteka kwambiri m'mimba
• nkhama zopweteka kapena zotupa, kumasula mano, dzanzi kapena kumva kuwawa nsagwada, machiritso osauka a nsagwada
• kutuluka mwachilendo kapena kuphwanya
• nseru, kusanza, kupweteka mutu, ndi kuchepa kukhala tcheru mutayimitsa denosumab komanso kwa chaka chimodzi pambuyo pake

Jekeseni wa Denosumab imatha kuwonjezera chiopsezo choti mungathyole mafupa anu a ntchafu Mutha kumva kupweteka m'chiuno mwanu, kubuula, kapena ntchafu kwa milungu ingapo kapena miyezi isanachitike fupa, ndipo mutha kupeza kuti limodzi kapena awiri mafupa anu a ntchafu asweka ngakhale simunagwe kapena kukumana ndi zoopsa zina. Si zachilendo kuti fupa la ntchafu lisweke mwa anthu athanzi, koma anthu omwe ali ndi matenda otupa mafupa amatha kuthyola fupa ngakhale sangalandire jakisoni wa denosumab. Jekeseni wa Denosumab itha kupangitsanso mafupa osweka kuti achiritse pang'onopang'ono ndipo imatha kusokoneza kukula kwa mafupa ndikuletsa mano kuti asabwere mwa ana. Lankhulani ndi dokotala wanu za kuopsa kolandila jekeseni ya denosumab.

Jekeseni wa Denosumab ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Musagwedeze jekeseni wa denosumab. Sungani mu firiji ndikuteteza ku kuwala. Osazizira. Jekeseni wa Denosumab imatha kusungidwa kutentha mpaka masiku 14.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti atsimikizire kuti zili bwino kuti mulandire jakisoni wa denosumab ndikuwunika momwe thupi lanu likuyankhira jekeseni wa denosumab.

Musalole kuti wina aliyense agwiritse ntchito mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zotsatira^®
• Xgeva^®